Incidental Mutation 'R4151:Ano10'
ID 314910
Institutional Source Beutler Lab
Gene Symbol Ano10
Ensembl Gene ENSMUSG00000037949
Gene Name anoctamin 10
Synonyms Tmem16k
MMRRC Submission 040861-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R4151 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 122004940-122123489 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 122090601 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Stop codon at position 237 (W237*)
Ref Sequence ENSEMBL: ENSMUSP00000150161 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042546] [ENSMUST00000214283] [ENSMUST00000214409] [ENSMUST00000214507] [ENSMUST00000216081] [ENSMUST00000216670]
AlphaFold Q8BH79
Predicted Effect probably null
Transcript: ENSMUST00000042546
AA Change: W237*
SMART Domains Protein: ENSMUSP00000045214
Gene: ENSMUSG00000037949
AA Change: W237*

DomainStartEndE-ValueType
Pfam:Anoctamin 200 628 2.2e-115 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000214283
AA Change: W237*
Predicted Effect probably benign
Transcript: ENSMUST00000214409
Predicted Effect probably null
Transcript: ENSMUST00000214507
AA Change: W45*
Predicted Effect probably benign
Transcript: ENSMUST00000216081
Predicted Effect probably null
Transcript: ENSMUST00000216670
AA Change: W237*
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to inhibit anion conductance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a knock-out allele fail to exhibit calcium-activated chloride ion secretion in the jejunum. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armc9 C T 1: 86,092,497 (GRCm39) T87M probably damaging Het
Astn2 C T 4: 65,647,557 (GRCm39) probably null Het
Atxn7l1 G A 12: 33,414,481 (GRCm39) V506M probably damaging Het
Cenpe A G 3: 134,920,914 (GRCm39) N36D probably benign Het
Cfap45 T A 1: 172,359,788 (GRCm39) I96N probably damaging Het
Cyp8b1 A T 9: 121,745,134 (GRCm39) V66D probably damaging Het
Dnajb6 C G 5: 29,961,234 (GRCm39) L118V probably benign Het
Dpy19l4 A G 4: 11,309,485 (GRCm39) S44P possibly damaging Het
Dync2li1 A G 17: 84,935,763 (GRCm39) H20R probably benign Het
Ecpas A T 4: 58,836,254 (GRCm39) S695R possibly damaging Het
Eif3g T C 9: 20,806,429 (GRCm39) D220G probably benign Het
Fbxo38 GTGCTGCTGCTGCTGCTGCTGC GTGCTGCTGCTGCTGCTGC 18: 62,648,399 (GRCm39) probably benign Het
Gata2 T A 6: 88,176,620 (GRCm39) H26Q probably damaging Het
Gle1 T C 2: 29,834,056 (GRCm39) I434T probably damaging Het
Gm5145 A G 17: 20,791,360 (GRCm39) E246G probably damaging Het
Ints10 T A 8: 69,247,250 (GRCm39) probably null Het
Kdr G T 5: 76,117,761 (GRCm39) A664E possibly damaging Het
Klhl1 A C 14: 96,755,752 (GRCm39) M1R probably null Het
Lama4 T A 10: 38,881,424 (GRCm39) F71Y probably benign Het
Madd C A 2: 90,973,428 (GRCm39) R1410L probably benign Het
Magi2 T C 5: 19,432,290 (GRCm39) S2P probably damaging Het
Map4k3 T C 17: 80,951,963 (GRCm39) K228R probably damaging Het
Mrpl43 A G 19: 44,994,175 (GRCm39) L148P possibly damaging Het
Msi2 G C 11: 88,608,870 (GRCm39) S16C probably damaging Het
Myo1e G T 9: 70,204,633 (GRCm39) G78* probably null Het
Notch2 T C 3: 98,054,387 (GRCm39) L2350S possibly damaging Het
Nptn G T 9: 58,550,825 (GRCm39) S168I probably benign Het
Nsmce2 A G 15: 59,473,214 (GRCm39) T244A probably benign Het
Or5aq6 C T 2: 86,923,514 (GRCm39) V76I probably benign Het
Ostn T A 16: 27,140,152 (GRCm39) S22T probably benign Het
Plekhb2 T G 1: 34,903,564 (GRCm39) F102V probably benign Het
Prkdc A G 16: 15,634,637 (GRCm39) D3594G probably benign Het
Psmd6 G C 14: 14,120,157 (GRCm38) L61V probably benign Het
Rbm33 C T 5: 28,592,938 (GRCm39) P573S probably damaging Het
Rfk A C 19: 17,372,672 (GRCm39) I65L probably benign Het
Rnf141 A T 7: 110,436,406 (GRCm39) D7E probably benign Het
Shank2 A T 7: 143,608,565 (GRCm39) K153M probably damaging Het
Slc30a2 A T 4: 134,071,359 (GRCm39) I31F probably benign Het
Slco3a1 G T 7: 74,009,586 (GRCm39) A243E probably damaging Het
Stab2 G A 10: 86,838,847 (GRCm39) T73I probably benign Het
Sufu G A 19: 46,438,411 (GRCm39) probably null Het
Sync C T 4: 129,187,519 (GRCm39) Q184* probably null Het
Tnfrsf25 G T 4: 152,204,258 (GRCm39) A376S probably damaging Het
Tnpo1 A T 13: 98,989,407 (GRCm39) I765N probably damaging Het
Ube2d2b A T 5: 107,978,747 (GRCm39) K133* probably null Het
Ulk3 C T 9: 57,499,650 (GRCm39) S217L possibly damaging Het
Upf2 C A 2: 5,966,516 (GRCm39) Q379K unknown Het
Vegfc T A 8: 54,530,824 (GRCm39) L4Q unknown Het
Vmn2r104 A T 17: 20,250,147 (GRCm39) I708N probably damaging Het
Other mutations in Ano10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00545:Ano10 APN 9 122,090,422 (GRCm39) missense possibly damaging 0.96
IGL00886:Ano10 APN 9 122,100,390 (GRCm39) missense probably benign 0.01
IGL00932:Ano10 APN 9 122,080,297 (GRCm39) nonsense probably null
IGL01613:Ano10 APN 9 122,088,606 (GRCm39) missense possibly damaging 0.75
IGL02109:Ano10 APN 9 122,090,408 (GRCm39) missense probably damaging 1.00
IGL02397:Ano10 APN 9 122,090,458 (GRCm39) missense probably damaging 1.00
IGL02512:Ano10 APN 9 122,101,540 (GRCm39) missense possibly damaging 0.50
IGL03216:Ano10 APN 9 122,086,127 (GRCm39) missense probably damaging 1.00
arna UTSW 9 122,088,630 (GRCm39) missense possibly damaging 0.77
R0624:Ano10 UTSW 9 122,088,661 (GRCm39) splice site probably benign
R1669:Ano10 UTSW 9 122,086,249 (GRCm39) missense possibly damaging 0.94
R1801:Ano10 UTSW 9 122,082,096 (GRCm39) missense probably damaging 1.00
R2511:Ano10 UTSW 9 122,088,011 (GRCm39) missense probably damaging 0.99
R3836:Ano10 UTSW 9 122,092,829 (GRCm39) missense possibly damaging 0.58
R4027:Ano10 UTSW 9 122,081,994 (GRCm39) splice site probably benign
R4590:Ano10 UTSW 9 122,086,231 (GRCm39) missense probably benign 0.22
R4651:Ano10 UTSW 9 122,090,181 (GRCm39) nonsense probably null
R4652:Ano10 UTSW 9 122,090,181 (GRCm39) nonsense probably null
R4676:Ano10 UTSW 9 122,092,853 (GRCm39) missense probably damaging 0.98
R5026:Ano10 UTSW 9 122,101,625 (GRCm39) nonsense probably null
R5281:Ano10 UTSW 9 122,090,552 (GRCm39) missense probably damaging 1.00
R5401:Ano10 UTSW 9 122,090,356 (GRCm39) missense probably damaging 1.00
R6269:Ano10 UTSW 9 122,090,308 (GRCm39) missense probably damaging 0.99
R6449:Ano10 UTSW 9 122,030,754 (GRCm39) intron probably benign
R6702:Ano10 UTSW 9 122,088,630 (GRCm39) missense possibly damaging 0.77
R7010:Ano10 UTSW 9 122,082,190 (GRCm39) missense probably damaging 1.00
R7384:Ano10 UTSW 9 122,005,409 (GRCm39) missense unknown
R7584:Ano10 UTSW 9 122,104,597 (GRCm39) missense probably benign
R8849:Ano10 UTSW 9 122,090,510 (GRCm39) missense probably benign 0.00
R8980:Ano10 UTSW 9 122,090,558 (GRCm39) missense probably benign 0.00
R9328:Ano10 UTSW 9 122,090,168 (GRCm39) missense possibly damaging 0.66
R9653:Ano10 UTSW 9 122,080,221 (GRCm39) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- GCGCAGTTGTCTCTTGTAGC -3'
(R):5'- CACACATCTGCTTATGCTGTG -3'

Sequencing Primer
(F):5'- CCCGTGACTGAATTGATGCCAAG -3'
(R):5'- CACACATCTGCTTATGCTGTGGTAAG -3'
Posted On 2015-05-14