Incidental Mutation 'R4153:Vmn1r171'
ID 314990
Institutional Source Beutler Lab
Gene Symbol Vmn1r171
Ensembl Gene ENSMUSG00000062483
Gene Name vomeronasal 1 receptor 171
Synonyms V1rd7, V3R7
MMRRC Submission 040997-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R4153 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 23331413-23332993 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23332077 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 89 (K89E)
Ref Sequence ENSEMBL: ENSMUSP00000153978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078458] [ENSMUST00000226128] [ENSMUST00000226321] [ENSMUST00000226733] [ENSMUST00000226771] [ENSMUST00000227386] [ENSMUST00000227774] [ENSMUST00000228484] [ENSMUST00000228681] [ENSMUST00000228228] [ENSMUST00000228674] [ENSMUST00000228559] [ENSMUST00000227866]
AlphaFold Q9EPS6
Predicted Effect probably damaging
Transcript: ENSMUST00000078458
AA Change: K101E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077552
Gene: ENSMUSG00000062483
AA Change: K101E

DomainStartEndE-ValueType
Pfam:TAS2R 20 307 1.7e-14 PFAM
Pfam:7tm_1 42 300 3.4e-7 PFAM
Pfam:V1R 53 307 1.1e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226128
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226321
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226733
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226771
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227386
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227774
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228484
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228681
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228228
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228674
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228559
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227866
AA Change: K89E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 96% (53/55)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik T C 13: 77,341,292 (GRCm39) V47A probably benign Het
4932414N04Rik A T 2: 68,498,941 (GRCm39) probably benign Het
Acat2 T A 17: 13,171,153 (GRCm39) H159L possibly damaging Het
Acsl5 A G 19: 55,269,895 (GRCm39) E253G probably benign Het
Adam34l T A 8: 44,079,564 (GRCm39) Y220F probably benign Het
Ddx41 G A 13: 55,682,293 (GRCm39) R205W possibly damaging Het
Ebf2 T G 14: 67,472,672 (GRCm39) V30G probably damaging Het
Erlin1 T A 19: 44,056,056 (GRCm39) T60S probably benign Het
Fanca A G 8: 124,031,617 (GRCm39) V358A possibly damaging Het
Fastkd3 T C 13: 68,738,257 (GRCm39) F602S probably damaging Het
Fras1 C A 5: 96,924,594 (GRCm39) N3678K probably benign Het
Gopc T C 10: 52,225,239 (GRCm39) I277V probably damaging Het
Gpd2 A G 2: 57,245,783 (GRCm39) T438A probably damaging Het
Gzma T C 13: 113,232,802 (GRCm39) K97E possibly damaging Het
Gzmn T A 14: 56,405,299 (GRCm39) T62S probably damaging Het
Hip1 T C 5: 135,441,560 (GRCm39) E570G probably damaging Het
Hs3st6 T C 17: 24,977,339 (GRCm39) V273A possibly damaging Het
Jarid2 C A 13: 45,063,902 (GRCm39) S873R probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Mast2 T C 4: 116,173,160 (GRCm39) N548S possibly damaging Het
Mthfr G T 4: 148,135,932 (GRCm39) R335L probably damaging Het
Ndst3 T C 3: 123,465,876 (GRCm39) Y32C probably damaging Het
Nwd1 T C 8: 73,408,564 (GRCm39) L808P probably damaging Het
Or52b1 T C 7: 104,978,592 (GRCm39) N269S probably damaging Het
Or56a3b A T 7: 104,771,516 (GRCm39) H284L probably damaging Het
Or8g52 A C 9: 39,631,296 (GRCm39) M258L probably benign Het
Pgk2 A G 17: 40,519,149 (GRCm39) V93A probably damaging Het
Pigk G A 3: 152,445,766 (GRCm39) V126I probably damaging Het
Plcl2 A T 17: 50,913,389 (GRCm39) K133* probably null Het
Pofut2 A G 10: 77,104,500 (GRCm39) K426E probably benign Het
Rbpj T A 5: 53,806,789 (GRCm39) H230Q probably damaging Het
Rnf213 A G 11: 119,300,308 (GRCm39) K269E probably benign Het
Shh A T 5: 28,662,947 (GRCm39) I407N probably damaging Het
Sntg1 A T 1: 8,653,569 (GRCm39) probably null Het
Svep1 A T 4: 58,089,426 (GRCm39) F1661Y possibly damaging Het
Tep1 G A 14: 51,075,051 (GRCm39) H1755Y possibly damaging Het
Thrap3 A C 4: 126,067,235 (GRCm39) probably null Het
Thumpd1 C T 7: 119,319,816 (GRCm39) C50Y probably damaging Het
Tmem131 T C 1: 36,847,874 (GRCm39) probably benign Het
Tnrc18 T C 5: 142,751,747 (GRCm39) D1368G possibly damaging Het
Tubd1 G A 11: 86,440,296 (GRCm39) G107S probably damaging Het
Ugt1a6a A G 1: 88,066,193 (GRCm39) probably null Het
Uty A G Y: 1,158,327 (GRCm39) V572A possibly damaging Het
Vmn2r100 AAAACAGGAGTATTGATTGGAAAC AAAAC 17: 19,743,681 (GRCm39) probably null Het
Vmn2r106 A G 17: 20,488,080 (GRCm39) L773P probably damaging Het
Vps13b T A 15: 35,792,173 (GRCm39) probably null Het
Other mutations in Vmn1r171
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Vmn1r171 APN 7 23,332,252 (GRCm39) missense probably damaging 1.00
IGL02963:Vmn1r171 APN 7 23,332,113 (GRCm39) missense possibly damaging 0.62
FR4304:Vmn1r171 UTSW 7 23,332,105 (GRCm39) missense probably benign 0.26
R0412:Vmn1r171 UTSW 7 23,332,080 (GRCm39) missense possibly damaging 0.81
R0602:Vmn1r171 UTSW 7 23,332,602 (GRCm39) missense probably benign 0.01
R0710:Vmn1r171 UTSW 7 23,332,426 (GRCm39) missense probably damaging 1.00
R1758:Vmn1r171 UTSW 7 23,331,781 (GRCm39) missense probably benign 0.25
R2007:Vmn1r171 UTSW 7 23,332,012 (GRCm39) missense probably damaging 1.00
R4799:Vmn1r171 UTSW 7 23,332,369 (GRCm39) missense probably benign 0.31
R5038:Vmn1r171 UTSW 7 23,332,188 (GRCm39) missense probably benign 0.00
R6087:Vmn1r171 UTSW 7 23,332,429 (GRCm39) missense probably damaging 1.00
R6906:Vmn1r171 UTSW 7 23,331,804 (GRCm39) missense probably benign 0.00
R7745:Vmn1r171 UTSW 7 23,332,035 (GRCm39) missense probably benign 0.00
R8954:Vmn1r171 UTSW 7 23,332,525 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGTTGGAACTGCAGTCAAC -3'
(R):5'- CTGACTTTCATTGGAATGTGAGC -3'

Sequencing Primer
(F):5'- GGTTGGAACTGCAGTCAACATTTTTC -3'
(R):5'- GCATTATTTAAGACACTGGACAACC -3'
Posted On 2015-05-14