Incidental Mutation 'R4155:Kcnj15'
ID 315112
Institutional Source Beutler Lab
Gene Symbol Kcnj15
Ensembl Gene ENSMUSG00000062609
Gene Name potassium inwardly-rectifying channel, subfamily J, member 15
Synonyms IRKK, Kir4.2, 4930414N08Rik
MMRRC Submission 040999-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4155 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 95058417-95101119 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 95097166 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 263 (K263*)
Ref Sequence ENSEMBL: ENSMUSP00000109493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037154] [ENSMUST00000113854] [ENSMUST00000113855] [ENSMUST00000113856] [ENSMUST00000113858] [ENSMUST00000113859] [ENSMUST00000113861] [ENSMUST00000113862] [ENSMUST00000152516] [ENSMUST00000140222] [ENSMUST00000125847] [ENSMUST00000138329] [ENSMUST00000134166]
AlphaFold O88932
Predicted Effect probably null
Transcript: ENSMUST00000037154
AA Change: K263*
SMART Domains Protein: ENSMUSP00000045218
Gene: ENSMUSG00000062609
AA Change: K263*

DomainStartEndE-ValueType
Pfam:IRK 57 384 4.4e-139 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000113854
AA Change: K236*
SMART Domains Protein: ENSMUSP00000109485
Gene: ENSMUSG00000062609
AA Change: K236*

DomainStartEndE-ValueType
Pfam:IRK 30 365 2.5e-150 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000113855
AA Change: K236*
SMART Domains Protein: ENSMUSP00000109486
Gene: ENSMUSG00000062609
AA Change: K236*

DomainStartEndE-ValueType
Pfam:IRK 30 365 2.5e-150 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000113856
AA Change: K236*
SMART Domains Protein: ENSMUSP00000109487
Gene: ENSMUSG00000062609
AA Change: K236*

DomainStartEndE-ValueType
Pfam:IRK 30 365 2.5e-150 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000113858
AA Change: K236*
SMART Domains Protein: ENSMUSP00000109489
Gene: ENSMUSG00000062609
AA Change: K236*

DomainStartEndE-ValueType
Pfam:IRK 57 392 4.9e-150 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000113859
AA Change: K263*
SMART Domains Protein: ENSMUSP00000109490
Gene: ENSMUSG00000062609
AA Change: K263*

DomainStartEndE-ValueType
Pfam:IRK 57 392 4.9e-150 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000113861
AA Change: K263*
SMART Domains Protein: ENSMUSP00000109492
Gene: ENSMUSG00000062609
AA Change: K263*

DomainStartEndE-ValueType
Pfam:IRK 57 392 4.9e-150 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000113862
AA Change: K263*
SMART Domains Protein: ENSMUSP00000109493
Gene: ENSMUSG00000062609
AA Change: K263*

DomainStartEndE-ValueType
Pfam:IRK 57 392 4.9e-150 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000152516
Predicted Effect probably benign
Transcript: ENSMUST00000140222
Predicted Effect probably benign
Transcript: ENSMUST00000125847
Predicted Effect probably benign
Transcript: ENSMUST00000138329
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232622
Predicted Effect probably benign
Transcript: ENSMUST00000134166
SMART Domains Protein: ENSMUSP00000118992
Gene: ENSMUSG00000062609

DomainStartEndE-ValueType
Pfam:IRK 57 173 8.9e-57 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232605
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
PHENOTYPE: Homozygous knockout mice exhibited impaired balance/coordination in a high-throughput screen. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410004B18Rik T A 3: 145,644,018 (GRCm39) F69I possibly damaging Het
Akt3 A G 1: 176,924,543 (GRCm39) I184T possibly damaging Het
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 117,721,122 (GRCm39) probably benign Het
Armc2 A G 10: 41,887,863 (GRCm39) V40A probably damaging Het
Ash2l A G 8: 26,307,482 (GRCm39) Y485H probably damaging Het
Atr T A 9: 95,770,177 (GRCm39) C1202* probably null Het
Bcl11b A T 12: 107,883,684 (GRCm39) probably null Het
Birc6 C A 17: 74,903,934 (GRCm39) S1242R probably benign Het
Blm GCCTCCTCCTCCTCCTCCTCCTCCTCCTCC GCCTCCTCCTCCTCCTCCTCCTCCTCC 7: 80,162,652 (GRCm39) probably benign Het
Bsx A G 9: 40,787,632 (GRCm39) E102G probably benign Het
Casq2 A T 3: 102,040,418 (GRCm39) probably null Het
Ccpg1 C A 9: 72,919,449 (GRCm39) Q355K probably benign Het
Copa T G 1: 171,928,992 (GRCm39) N251K probably damaging Het
Cst8 C A 2: 148,641,996 (GRCm39) A31E possibly damaging Het
D6Ertd527e C G 6: 87,088,506 (GRCm39) T223S unknown Het
Ecd A G 14: 20,374,632 (GRCm39) S503P probably damaging Het
Fbn2 C A 18: 58,156,359 (GRCm39) E2487* probably null Het
Hoxd9 A G 2: 74,529,667 (GRCm39) I308V probably benign Het
Ica1l G A 1: 60,053,052 (GRCm39) A162V possibly damaging Het
Mettl4 T C 17: 95,048,003 (GRCm39) M213V probably benign Het
Nalf1 T A 8: 9,283,023 (GRCm39) Y342F possibly damaging Het
Ncan C A 8: 70,562,727 (GRCm39) E510D possibly damaging Het
Ndufs4 A T 13: 114,444,390 (GRCm39) S129R probably benign Het
Or14a259 T A 7: 86,013,270 (GRCm39) I92L probably benign Het
Or4c127 A G 2: 89,833,004 (GRCm39) S85G probably benign Het
Or52s19 T C 7: 103,008,363 (GRCm39) T13A probably benign Het
Or8d1b A T 9: 38,887,451 (GRCm39) T160S probably damaging Het
P2rx5 A G 11: 73,062,655 (GRCm39) T455A probably damaging Het
Pcdh1 T A 18: 38,336,159 (GRCm39) T159S probably damaging Het
Poln A G 5: 34,166,993 (GRCm39) V755A possibly damaging Het
Pou4f1 C T 14: 104,705,153 (GRCm39) S6N possibly damaging Het
Rpap1 C T 2: 119,604,660 (GRCm39) R416H probably damaging Het
Samd4 T A 14: 47,290,403 (GRCm39) M170K possibly damaging Het
Srgn A G 10: 62,333,613 (GRCm39) F55L possibly damaging Het
Tmcc1 C T 6: 116,110,765 (GRCm39) G176D probably benign Het
Tmem232 A T 17: 65,743,328 (GRCm39) M321K probably damaging Het
Tnfsf11 A G 14: 78,537,309 (GRCm39) M118T probably benign Het
Tns1 T A 1: 73,953,790 (GRCm39) N1848Y probably damaging Het
Ttc27 T G 17: 75,147,455 (GRCm39) I669S probably benign Het
Uaca A G 9: 60,779,035 (GRCm39) S1141G probably benign Het
Usp34 T A 11: 23,367,676 (GRCm39) V1671E probably damaging Het
Wdr64 T A 1: 175,597,172 (GRCm39) L73H probably benign Het
Zfp410 G A 12: 84,374,206 (GRCm39) R181H probably damaging Het
Other mutations in Kcnj15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00733:Kcnj15 APN 16 95,097,322 (GRCm39) missense probably damaging 1.00
IGL03096:Kcnj15 APN 16 95,097,293 (GRCm39) missense probably damaging 1.00
R1117:Kcnj15 UTSW 16 95,096,484 (GRCm39) missense probably benign 0.28
R3911:Kcnj15 UTSW 16 95,097,329 (GRCm39) missense probably damaging 1.00
R3913:Kcnj15 UTSW 16 95,097,329 (GRCm39) missense probably damaging 1.00
R3928:Kcnj15 UTSW 16 95,097,368 (GRCm39) missense possibly damaging 0.95
R4613:Kcnj15 UTSW 16 95,096,653 (GRCm39) missense probably damaging 1.00
R5334:Kcnj15 UTSW 16 95,097,508 (GRCm39) missense probably damaging 1.00
R6151:Kcnj15 UTSW 16 95,096,527 (GRCm39) nonsense probably null
R6334:Kcnj15 UTSW 16 95,097,095 (GRCm39) missense probably damaging 1.00
R6446:Kcnj15 UTSW 16 95,097,118 (GRCm39) missense probably benign 0.00
R6727:Kcnj15 UTSW 16 95,097,193 (GRCm39) missense probably damaging 1.00
R7070:Kcnj15 UTSW 16 95,096,690 (GRCm39) missense probably damaging 1.00
R8348:Kcnj15 UTSW 16 95,096,609 (GRCm39) missense probably damaging 1.00
R8937:Kcnj15 UTSW 16 95,097,548 (GRCm39) unclassified probably benign
R9018:Kcnj15 UTSW 16 95,097,129 (GRCm39) missense probably damaging 1.00
R9167:Kcnj15 UTSW 16 95,096,741 (GRCm39) missense probably damaging 1.00
R9171:Kcnj15 UTSW 16 95,097,481 (GRCm39) missense probably benign
R9371:Kcnj15 UTSW 16 95,097,556 (GRCm39) missense unknown
R9760:Kcnj15 UTSW 16 95,096,483 (GRCm39) missense probably benign 0.13
Z1088:Kcnj15 UTSW 16 95,096,978 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCGAGCCGAGACCATTAAG -3'
(R):5'- TAGATCTCCTCCGGGATGTAAGAC -3'

Sequencing Primer
(F):5'- GAGACCATTAAGTTCAGCCACTGTG -3'
(R):5'- CTCCGGGATGTAAGACGTTCG -3'
Posted On 2015-05-14