Mutagenetix > Incidental Mutation

Incidental Mutation 'R4117:Vmn2r7'

315124

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r7

Ensembl Gene

ENSMUSG00000116028

Gene Name

vomeronasal 2, receptor 7

Synonyms

4933425M15Rik

MMRRC Submission

040991-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

R4117 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

64598081-64627023 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to C at 64623138 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000131220 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000161972] [ENSMUST00000168072]

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000050123

Predicted Effect

probably benign
Transcript: ENSMUST00000161972

SMART Domains

Protein: ENSMUSP00000124192
Gene: ENSMUSG00000062200

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	90	507	3.8e-77	PFAM
Pfam:NCD3G	549	602	3.4e-17	PFAM
Pfam:7tm_3	635	869	1.1e-47	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000168072

SMART Domains

Protein: ENSMUSP00000131220
Gene: ENSMUSG00000116028

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	5.1e-72	PFAM
Pfam:Peripla_BP_6	63	245	6.1e-10	PFAM
Pfam:NCD3G	458	511	1.8e-17	PFAM
Pfam:7tm_3	542	779	4.3e-76	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177146

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.9%

Validation Efficiency

97% (31/32)

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss2	T	C	2: 155,398,313 (GRCm39)	F358L	probably damaging	Het
Adamts16	A	G	13: 70,916,111 (GRCm39)	Y775H	probably benign	Het
Bard1	A	T	1: 71,085,922 (GRCm39)	H594Q	probably damaging	Het
Cd109	CATTTATTTATTTATTTATTTATTTATTTATTTAT	CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT	9: 78,619,782 (GRCm39)		probably benign	Het
Cenpt	G	A	8: 106,576,332 (GRCm39)	S73L	probably benign	Het
Ctdnep1	C	A	11: 69,879,497 (GRCm39)	A7D	probably damaging	Het
Fam210b	T	C	2: 172,193,486 (GRCm39)	S100P	probably benign	Het
Fyb1	A	C	15: 6,659,597 (GRCm39)	D434A	probably damaging	Het
H2-T15	T	C	17: 36,368,496 (GRCm39)	D144G	probably damaging	Het
Heph	T	C	X: 95,544,221 (GRCm39)	V615A	probably benign	Het
Icam5	T	A	9: 20,948,886 (GRCm39)	V746E	probably damaging	Het
Maml2	A	G	9: 13,617,230 (GRCm39)	Q192R	probably damaging	Het
Npas4	T	C	19: 5,037,391 (GRCm39)	Y301C	probably damaging	Het
Nup205	C	T	6: 35,217,947 (GRCm39)	Q1767*	probably null	Het
Or51f5	T	A	7: 102,423,684 (GRCm39)		probably null	Het
Pigg	A	G	5: 108,495,908 (GRCm39)	R982G	probably benign	Het
Plekhg2	A	T	7: 28,060,313 (GRCm39)	H1005Q	probably benign	Het
Rdh12	C	T	12: 79,260,419 (GRCm39)	R172C	probably damaging	Het
Rufy4	T	C	1: 74,186,822 (GRCm39)	C537R	probably damaging	Het
Semp2l2b	T	A	10: 21,943,615 (GRCm39)	N122Y	probably benign	Het
Septin4	T	C	11: 87,459,108 (GRCm39)	F494S	probably damaging	Het
Serpinb9	T	A	13: 33,199,579 (GRCm39)	D291E	probably benign	Het
She	A	T	3: 89,759,679 (GRCm39)	Y394F	probably damaging	Het
Sipa1l2	T	C	8: 126,195,249 (GRCm39)	S830G	probably damaging	Het
Stmn4	T	C	14: 66,598,581 (GRCm39)	*217Q	probably null	Het
Stx17	A	G	4: 48,180,689 (GRCm39)	D178G	probably damaging	Het
Tbc1d9	T	G	8: 83,992,776 (GRCm39)	I960S	possibly damaging	Het
Ubxn10	G	T	4: 138,448,276 (GRCm39)	D133E	probably benign	Het
Vmn2r42	T	C	7: 8,197,839 (GRCm39)	Y260C	probably damaging	Het
Zfp143	C	T	7: 109,691,120 (GRCm39)	T557I	probably damaging	Het
Zfp607b	A	G	7: 27,398,107 (GRCm39)	I64V	probably damaging	Het

Other mutations in Vmn2r7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00961:Vmn2r7	APN	3	64,623,234 (GRCm39)	missense	possibly damaging	0.60
IGL01762:Vmn2r7	APN	3	64,598,856 (GRCm39)	missense	probably benign	0.39
IGL01903:Vmn2r7	APN	3	64,626,864 (GRCm39)	missense	probably benign	0.00
IGL02263:Vmn2r7	APN	3	64,598,868 (GRCm39)	missense	probably damaging	1.00
IGL02458:Vmn2r7	APN	3	64,600,446 (GRCm39)	missense	probably damaging	0.97
IGL02593:Vmn2r7	APN	3	64,600,443 (GRCm39)	missense	probably damaging	1.00
IGL02797:Vmn2r7	APN	3	64,598,666 (GRCm39)	missense	possibly damaging	0.80
IGL03047:Vmn2r7	UTSW	3	64,614,639 (GRCm39)	missense	possibly damaging	0.81
PIT4504001:Vmn2r7	UTSW	3	64,623,397 (GRCm39)	missense	probably benign	0.01
R0193:Vmn2r7	UTSW	3	64,598,460 (GRCm39)	missense	probably damaging	1.00
R0329:Vmn2r7	UTSW	3	64,598,439 (GRCm39)	missense	probably damaging	1.00
R0609:Vmn2r7	UTSW	3	64,623,900 (GRCm39)	missense	probably benign	0.44
R0735:Vmn2r7	UTSW	3	64,623,788 (GRCm39)	missense	probably benign	0.02
R0941:Vmn2r7	UTSW	3	64,624,000 (GRCm39)	missense	probably benign
R1065:Vmn2r7	UTSW	3	64,614,559 (GRCm39)	missense	possibly damaging	0.82
R1378:Vmn2r7	UTSW	3	64,599,025 (GRCm39)	missense	possibly damaging	0.59
R1445:Vmn2r7	UTSW	3	64,632,223 (GRCm39)	missense	probably benign	0.01
R1506:Vmn2r7	UTSW	3	64,614,500 (GRCm39)	missense	probably benign
R1509:Vmn2r7	UTSW	3	64,623,881 (GRCm39)	nonsense	probably null
R1519:Vmn2r7	UTSW	3	64,623,876 (GRCm39)	missense	possibly damaging	0.95
R1706:Vmn2r7	UTSW	3	64,598,880 (GRCm39)	missense	possibly damaging	0.79
R2113:Vmn2r7	UTSW	3	64,599,025 (GRCm39)	missense	possibly damaging	0.59
R3725:Vmn2r7	UTSW	3	64,632,412 (GRCm39)	missense	possibly damaging	0.65
R3874:Vmn2r7	UTSW	3	64,627,032 (GRCm39)	missense	possibly damaging	0.69
R3902:Vmn2r7	UTSW	3	64,626,937 (GRCm39)	missense	possibly damaging	0.46
R4084:Vmn2r7	UTSW	3	64,600,414 (GRCm39)	missense	probably benign	0.08
R4333:Vmn2r7	UTSW	3	64,598,199 (GRCm39)	missense	probably damaging	1.00
R4551:Vmn2r7	UTSW	3	64,598,110 (GRCm39)	missense	possibly damaging	0.86
R4643:Vmn2r7	UTSW	3	64,623,825 (GRCm39)	missense	probably damaging	1.00
R4654:Vmn2r7	UTSW	3	64,626,864 (GRCm39)	missense	probably benign	0.00
R5091:Vmn2r7	UTSW	3	64,598,205 (GRCm39)	missense	possibly damaging	0.63
R5109:Vmn2r7	UTSW	3	64,598,088 (GRCm39)	missense	probably null	0.84
R5372:Vmn2r7	UTSW	3	64,623,745 (GRCm39)	missense	probably damaging	1.00
R5415:Vmn2r7	UTSW	3	64,623,658 (GRCm39)	missense	probably benign	0.07
R5740:Vmn2r7	UTSW	3	64,614,654 (GRCm39)	missense	probably benign
R5977:Vmn2r7	UTSW	3	64,623,464 (GRCm39)	nonsense	probably null
R6019:Vmn2r7	UTSW	3	64,623,643 (GRCm39)	missense	probably damaging	1.00
R6058:Vmn2r7	UTSW	3	64,632,436 (GRCm39)	missense	probably benign	0.00
R6139:Vmn2r7	UTSW	3	64,623,339 (GRCm39)	missense	probably damaging	1.00
R6696:Vmn2r7	UTSW	3	64,614,495 (GRCm39)	missense	probably benign	0.01
R6887:Vmn2r7	UTSW	3	64,598,248 (GRCm39)	missense	probably damaging	1.00
R6918:Vmn2r7	UTSW	3	64,598,760 (GRCm39)	missense	probably benign	0.03
R6949:Vmn2r7	UTSW	3	64,598,542 (GRCm39)	missense	probably damaging	0.99
R6980:Vmn2r7	UTSW	3	64,623,987 (GRCm39)	missense	possibly damaging	0.67
R7196:Vmn2r7	UTSW	3	64,623,198 (GRCm39)	missense	probably benign	0.00
R7286:Vmn2r7	UTSW	3	64,598,301 (GRCm39)	missense	probably benign	0.00
R7455:Vmn2r7	UTSW	3	64,624,014 (GRCm39)	missense	probably benign
R7557:Vmn2r7	UTSW	3	64,632,394 (GRCm39)	missense	probably benign
R7864:Vmn2r7	UTSW	3	64,598,947 (GRCm39)	missense	probably benign	0.10
R8046:Vmn2r7	UTSW	3	64,614,479 (GRCm39)	missense	probably damaging	1.00
R8068:Vmn2r7	UTSW	3	64,623,507 (GRCm39)	missense	probably benign	0.01
R8252:Vmn2r7	UTSW	3	64,600,527 (GRCm39)	missense	probably benign	0.00
R8814:Vmn2r7	UTSW	3	64,623,984 (GRCm39)	missense	probably benign	0.14
R9497:Vmn2r7	UTSW	3	64,614,474 (GRCm39)	missense	probably benign	0.04
R9722:Vmn2r7	UTSW	3	64,598,407 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCAATACCTCATGTTTTACTCCTAG -3'
(R):5'- CAAACAATGTCAGACAAGCTGTG -3'

Sequencing Primer
(F):5'- GGGAGACAGGTTTGTTATC -3'
(R):5'- CAGACAAGCTGTGTATCTTTTGGCTC -3'

Posted On

2015-05-14