Incidental Mutation 'R4119:Zfp472'
ID 315246
Institutional Source Beutler Lab
Gene Symbol Zfp472
Ensembl Gene ENSMUSG00000053600
Gene Name zinc finger protein 472
Synonyms Krim-1B, Krim-1, Krim-1A
MMRRC Submission 040992-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4119 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 33184805-33198185 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 33197189 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 421 (Y421*)
Ref Sequence ENSEMBL: ENSMUSP00000036514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039132]
AlphaFold B0V2W5
Predicted Effect probably null
Transcript: ENSMUST00000039132
AA Change: Y421*
SMART Domains Protein: ENSMUSP00000036514
Gene: ENSMUSG00000053600
AA Change: Y421*

DomainStartEndE-ValueType
KRAB 10 62 4.36e-15 SMART
ZnF_C2H2 197 219 2.45e0 SMART
ZnF_C2H2 225 247 2.75e-3 SMART
ZnF_C2H2 253 275 1.76e-1 SMART
ZnF_C2H2 281 303 3.58e-2 SMART
ZnF_C2H2 309 331 3.29e-1 SMART
ZnF_C2H2 337 359 6.08e0 SMART
ZnF_C2H2 365 387 2.32e-1 SMART
ZnF_C2H2 393 415 6.57e-1 SMART
ZnF_C2H2 421 443 1.5e-4 SMART
ZnF_C2H2 449 471 2.2e-2 SMART
ZnF_C2H2 477 499 1.01e-1 SMART
ZnF_C2H2 505 527 8.94e-3 SMART
Meta Mutation Damage Score 0.9717 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 98% (46/47)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013D24Rik A G 6: 124,333,863 (GRCm39) L39P probably damaging Het
Abcc1 A G 16: 14,211,877 (GRCm39) M138V probably benign Het
Abl1 T A 2: 31,691,739 (GRCm39) I1067N probably damaging Het
Adam6a C T 12: 113,508,194 (GRCm39) T189I probably benign Het
Ankfy1 G A 11: 72,605,310 (GRCm39) probably null Het
Aplnr T C 2: 84,967,310 (GRCm39) Y112H possibly damaging Het
Arhgap17 A G 7: 122,906,217 (GRCm39) F313S probably damaging Het
Arid1b T C 17: 5,046,069 (GRCm39) probably benign Het
Bcas1 G C 2: 170,220,735 (GRCm39) P394A probably benign Het
Ccdc116 A G 16: 16,960,051 (GRCm39) S213P probably damaging Het
Cdh15 T C 8: 123,590,162 (GRCm39) V365A probably damaging Het
Cenpf A G 1: 189,385,242 (GRCm39) I2346T probably benign Het
Chd7 A G 4: 8,785,658 (GRCm39) probably benign Het
Ezh2 A C 6: 47,521,482 (GRCm39) N390K probably benign Het
Fbxo7 C A 10: 85,857,759 (GRCm39) probably benign Het
Fibin A G 2: 110,193,035 (GRCm39) Y36H probably damaging Het
Gpr37 C T 6: 25,688,425 (GRCm39) R224H possibly damaging Het
Hars2 A T 18: 36,923,541 (GRCm39) N363I probably damaging Het
Ip6k2 G A 9: 108,682,847 (GRCm39) R319Q probably benign Het
Itpr1 G A 6: 108,371,316 (GRCm39) D1140N probably benign Het
Lrig2 A G 3: 104,374,511 (GRCm39) V190A probably benign Het
Ltk T A 2: 119,588,429 (GRCm39) probably benign Het
Morc2a C A 11: 3,633,868 (GRCm39) T660N probably benign Het
Msh3 A G 13: 92,490,519 (GRCm39) probably benign Het
Myo15b T C 11: 115,764,318 (GRCm39) S1311P probably benign Het
Nbeal1 A T 1: 60,331,029 (GRCm39) I2213L probably damaging Het
Or10ag57 T A 2: 87,218,187 (GRCm39) M46K possibly damaging Het
Or5d16 A G 2: 87,773,787 (GRCm39) Y62H probably damaging Het
P2ry12 T C 3: 59,125,262 (GRCm39) T138A probably benign Het
Pirb T C 7: 3,720,574 (GRCm39) D308G probably damaging Het
Pkn3 A G 2: 29,973,049 (GRCm39) probably benign Het
Ripor1 T A 8: 106,345,489 (GRCm39) probably benign Het
Ryr2 T C 13: 11,794,153 (GRCm39) T942A probably benign Het
Spata31e5 A T 1: 28,817,054 (GRCm39) V326D probably damaging Het
Sptbn5 T A 2: 119,895,010 (GRCm39) D798V possibly damaging Het
Synpo2 T A 3: 122,910,799 (GRCm39) D282V probably damaging Het
Tnik T C 3: 28,720,324 (GRCm39) F1287L probably damaging Het
Tshz1 T G 18: 84,032,314 (GRCm39) K698T probably benign Het
Ttc23l A C 15: 10,540,006 (GRCm39) V159G probably damaging Het
Urb2 T A 8: 124,773,979 (GRCm39) D1503E probably benign Het
Usp29 T A 7: 6,965,805 (GRCm39) N549K probably benign Het
Vmn2r39 G A 7: 9,026,673 (GRCm39) H443Y probably benign Het
Zfp24 A G 18: 24,147,626 (GRCm39) Y229H possibly damaging Het
Zkscan3 T C 13: 21,578,119 (GRCm39) E256G possibly damaging Het
Other mutations in Zfp472
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Zfp472 APN 17 33,196,498 (GRCm39) missense possibly damaging 0.47
IGL03012:Zfp472 APN 17 33,196,545 (GRCm39) missense probably benign 0.18
IGL03184:Zfp472 APN 17 33,196,390 (GRCm39) nonsense probably null
IGL03223:Zfp472 APN 17 33,196,248 (GRCm39) missense probably benign 0.03
R0421:Zfp472 UTSW 17 33,194,897 (GRCm39) missense possibly damaging 0.71
R0463:Zfp472 UTSW 17 33,194,936 (GRCm39) missense probably damaging 0.98
R0614:Zfp472 UTSW 17 33,196,908 (GRCm39) missense possibly damaging 0.53
R1348:Zfp472 UTSW 17 33,196,794 (GRCm39) missense probably benign 0.44
R1557:Zfp472 UTSW 17 33,194,900 (GRCm39) missense probably benign 0.32
R1630:Zfp472 UTSW 17 33,196,952 (GRCm39) nonsense probably null
R1725:Zfp472 UTSW 17 33,196,311 (GRCm39) missense possibly damaging 0.53
R1856:Zfp472 UTSW 17 33,184,887 (GRCm39) missense possibly damaging 0.53
R1964:Zfp472 UTSW 17 33,196,848 (GRCm39) missense possibly damaging 0.79
R2115:Zfp472 UTSW 17 33,196,988 (GRCm39) missense possibly damaging 0.73
R2249:Zfp472 UTSW 17 33,197,109 (GRCm39) missense possibly damaging 0.87
R2252:Zfp472 UTSW 17 33,195,257 (GRCm39) nonsense probably null
R3709:Zfp472 UTSW 17 33,196,685 (GRCm39) nonsense probably null
R4406:Zfp472 UTSW 17 33,197,134 (GRCm39) missense probably benign 0.01
R4485:Zfp472 UTSW 17 33,196,542 (GRCm39) missense possibly damaging 0.96
R4650:Zfp472 UTSW 17 33,196,631 (GRCm39) missense possibly damaging 0.86
R4820:Zfp472 UTSW 17 33,196,416 (GRCm39) missense probably benign 0.01
R5369:Zfp472 UTSW 17 33,196,717 (GRCm39) missense probably damaging 0.98
R5438:Zfp472 UTSW 17 33,197,193 (GRCm39) missense probably damaging 0.96
R5529:Zfp472 UTSW 17 33,197,407 (GRCm39) missense possibly damaging 0.92
R5950:Zfp472 UTSW 17 33,196,481 (GRCm39) missense possibly damaging 0.53
R6158:Zfp472 UTSW 17 33,197,363 (GRCm39) nonsense probably null
R7012:Zfp472 UTSW 17 33,196,220 (GRCm39) missense probably benign 0.00
R8108:Zfp472 UTSW 17 33,196,977 (GRCm39) missense possibly damaging 0.86
R8290:Zfp472 UTSW 17 33,197,088 (GRCm39) missense probably benign
R8905:Zfp472 UTSW 17 33,197,455 (GRCm39) missense possibly damaging 0.82
R9747:Zfp472 UTSW 17 33,196,271 (GRCm39) missense possibly damaging 0.53
Predicted Primers PCR Primer
(F):5'- GTGCCTGCTATTATCACGAAAG -3'
(R):5'- AGTGCGAGAAATATTAGCCACTG -3'

Sequencing Primer
(F):5'- TTCACACTGGAGAGAAGCCCTG -3'
(R):5'- TGGAACAGGTGAACGCTTTCC -3'
Posted On 2015-05-14