Incidental Mutation 'R4127:Lzts3'
ID 315425
Institutional Source Beutler Lab
Gene Symbol Lzts3
Ensembl Gene ENSMUSG00000037703
Gene Name leucine zipper, putative tumor suppressor family member 3
Synonyms Prosapip1
MMRRC Submission 040860-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.206) question?
Stock # R4127 (G1)
Quality Score 186
Status Not validated
Chromosome 2
Chromosomal Location 130474759-130484723 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 130477285 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 502 (S502P)
Ref Sequence ENSEMBL: ENSMUSP00000086990 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045761] [ENSMUST00000089561] [ENSMUST00000110260]
AlphaFold A2AHG0
Predicted Effect probably damaging
Transcript: ENSMUST00000045761
AA Change: S502P

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000037109
Gene: ENSMUSG00000037703
AA Change: S502P

DomainStartEndE-ValueType
low complexity region 86 107 N/A INTRINSIC
low complexity region 147 158 N/A INTRINSIC
low complexity region 240 250 N/A INTRINSIC
low complexity region 253 265 N/A INTRINSIC
low complexity region 285 297 N/A INTRINSIC
low complexity region 301 333 N/A INTRINSIC
low complexity region 337 346 N/A INTRINSIC
low complexity region 349 361 N/A INTRINSIC
low complexity region 402 436 N/A INTRINSIC
Pfam:Fez1 465 665 1.4e-62 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000089561
AA Change: S502P

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000086990
Gene: ENSMUSG00000037703
AA Change: S502P

DomainStartEndE-ValueType
low complexity region 86 107 N/A INTRINSIC
low complexity region 147 158 N/A INTRINSIC
low complexity region 240 250 N/A INTRINSIC
low complexity region 253 265 N/A INTRINSIC
low complexity region 285 297 N/A INTRINSIC
low complexity region 301 333 N/A INTRINSIC
low complexity region 337 346 N/A INTRINSIC
low complexity region 349 361 N/A INTRINSIC
low complexity region 402 436 N/A INTRINSIC
Pfam:Fez1 465 666 2.1e-74 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000110260
AA Change: S388P

PolyPhen 2 Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000105889
Gene: ENSMUSG00000037703
AA Change: S388P

DomainStartEndE-ValueType
low complexity region 126 136 N/A INTRINSIC
low complexity region 139 151 N/A INTRINSIC
low complexity region 171 183 N/A INTRINSIC
low complexity region 187 219 N/A INTRINSIC
low complexity region 223 232 N/A INTRINSIC
low complexity region 235 247 N/A INTRINSIC
low complexity region 288 322 N/A INTRINSIC
Pfam:Fez1 351 552 1.5e-74 PFAM
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,141,973 (GRCm39) H3R probably benign Het
Actg2 A T 6: 83,499,866 (GRCm39) F128Y possibly damaging Het
Ankrd6 G A 4: 32,822,241 (GRCm39) T176M probably damaging Het
Atp6ap1l T C 13: 91,046,826 (GRCm39) D117G probably damaging Het
Cd209b A G 8: 3,968,714 (GRCm39) I284T probably damaging Het
Cfl2 C T 12: 54,908,143 (GRCm39) A123T probably benign Het
Cgnl1 T C 9: 71,631,822 (GRCm39) T510A probably benign Het
Chn2 G T 6: 54,249,963 (GRCm39) R24M probably damaging Het
Cyfip2 T C 11: 46,161,474 (GRCm39) I339V probably benign Het
Etl4 C T 2: 20,748,886 (GRCm39) P539L possibly damaging Het
Fras1 A G 5: 96,918,512 (GRCm39) D3516G probably benign Het
Frem2 T C 3: 53,433,317 (GRCm39) Y2669C probably damaging Het
Gga2 G T 7: 121,601,943 (GRCm39) H205N probably damaging Het
Gm5592 G A 7: 40,938,491 (GRCm39) G591D probably benign Het
Gtf3c1 A T 7: 125,246,622 (GRCm39) C1562* probably null Het
Heatr3 T A 8: 88,864,939 (GRCm39) C59S probably damaging Het
Heatr5b A G 17: 79,060,603 (GRCm39) M2024T possibly damaging Het
Jarid2 T C 13: 45,055,732 (GRCm39) S313P probably damaging Het
Or5d36 A G 2: 87,901,579 (GRCm39) V49A probably benign Het
Pcdhb2 A T 18: 37,428,594 (GRCm39) D189V probably damaging Het
Pias3 G T 3: 96,606,982 (GRCm39) G82C probably damaging Het
Polg T C 7: 79,105,285 (GRCm39) E753G probably damaging Het
Pus10 T C 11: 23,668,654 (GRCm39) probably null Het
Pxn A G 5: 115,684,966 (GRCm39) R264G probably damaging Het
Rag1 A G 2: 101,472,416 (GRCm39) Y909H probably damaging Het
Rell2 A G 18: 38,091,267 (GRCm39) H144R probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Ryr2 C T 13: 11,602,323 (GRCm39) V4520I possibly damaging Het
Scp2 A G 4: 107,921,181 (GRCm39) F10L probably benign Het
Slc9b2 T C 3: 135,035,598 (GRCm39) Y356H probably benign Het
Sorcs1 T C 19: 50,210,597 (GRCm39) D756G probably benign Het
Stra6 T A 9: 58,058,501 (GRCm39) V454E probably damaging Het
Tbc1d8 T C 1: 39,411,512 (GRCm39) N1108S probably benign Het
Tep1 C T 14: 51,081,191 (GRCm39) R1349Q possibly damaging Het
Tmem132d T C 5: 128,345,884 (GRCm39) R213G probably benign Het
Ubash3a T C 17: 31,456,249 (GRCm39) Y506H probably damaging Het
Xcr1 A C 9: 123,685,561 (GRCm39) V67G probably damaging Het
Zranb2 C A 3: 157,243,227 (GRCm39) C74* probably null Het
Other mutations in Lzts3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01072:Lzts3 APN 2 130,477,365 (GRCm39) missense probably damaging 0.99
IGL01541:Lzts3 APN 2 130,478,126 (GRCm39) missense probably damaging 0.99
IGL01649:Lzts3 APN 2 130,477,351 (GRCm39) missense probably damaging 0.98
IGL02746:Lzts3 APN 2 130,478,261 (GRCm39) missense probably damaging 0.98
IGL02927:Lzts3 APN 2 130,479,877 (GRCm39) utr 5 prime probably benign
R0069:Lzts3 UTSW 2 130,478,460 (GRCm39) missense probably benign 0.16
R0069:Lzts3 UTSW 2 130,478,460 (GRCm39) missense probably benign 0.16
R0173:Lzts3 UTSW 2 130,476,688 (GRCm39) makesense probably null
R1381:Lzts3 UTSW 2 130,477,219 (GRCm39) missense probably damaging 0.99
R4301:Lzts3 UTSW 2 130,478,358 (GRCm39) missense probably damaging 0.99
R4588:Lzts3 UTSW 2 130,476,686 (GRCm39) makesense probably null
R5289:Lzts3 UTSW 2 130,478,021 (GRCm39) missense probably benign 0.18
R5878:Lzts3 UTSW 2 130,478,459 (GRCm39) missense probably damaging 1.00
R5964:Lzts3 UTSW 2 130,478,208 (GRCm39) missense probably damaging 0.99
R6193:Lzts3 UTSW 2 130,479,306 (GRCm39) missense probably damaging 0.97
R7692:Lzts3 UTSW 2 130,477,306 (GRCm39) missense probably benign 0.27
R8195:Lzts3 UTSW 2 130,477,105 (GRCm39) missense probably benign 0.01
R8273:Lzts3 UTSW 2 130,476,801 (GRCm39) missense possibly damaging 0.66
R9126:Lzts3 UTSW 2 130,477,248 (GRCm39) missense possibly damaging 0.66
R9129:Lzts3 UTSW 2 130,476,865 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- GCTGGTTGCGCTGATACATC -3'
(R):5'- CCCTATGAGTGCTTAGTGCC -3'

Sequencing Primer
(F):5'- GGAGCTGTTTCTGATACTCAATGACC -3'
(R):5'- CCTTTGGAGATAGATCTGGGAGC -3'
Posted On 2015-05-14