Mutagenetix > Incidental Mutation

Incidental Mutation 'R4159:Vmn2r102'

315675

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r102

Ensembl Gene

ENSMUSG00000095961

Gene Name

vomeronasal 2, receptor 102

Synonyms

EG224572

MMRRC Submission

041002-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4159 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19880661-19915010 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 19898088 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 368 (C368S)

Ref Sequence

ENSEMBL: ENSMUSP00000126559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171741]

AlphaFold

L7N279

Predicted Effect

probably damaging
Transcript: ENSMUST00000171741
AA Change: C368S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: C368S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	448	5.2e-38	PFAM
Pfam:NCD3G	509	562	1.1e-21	PFAM
Pfam:7tm_3	595	830	1.8e-53	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.6%

Validation Efficiency

96% (45/47)

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam4	T	G	12: 81,466,806 (GRCm39)	D605A	probably damaging	Het
Adcy1	A	G	11: 7,013,889 (GRCm39)	H97R	probably damaging	Het
Amdhd1	A	G	10: 93,370,512 (GRCm39)	Y109H	probably damaging	Het
Ankhd1	A	G	18: 36,722,593 (GRCm39)	N372S	possibly damaging	Het
Aoc2	G	A	11: 101,216,122 (GRCm39)	M68I	probably damaging	Het
Aspscr1	G	A	11: 120,599,502 (GRCm39)	A377T	probably damaging	Het
Bltp1	T	A	3: 36,985,232 (GRCm39)	M854K	probably benign	Het
Bltp3a	A	G	17: 28,103,061 (GRCm39)	Y365C	probably damaging	Het
Cacnb1	G	C	11: 97,903,100 (GRCm39)	C154W	probably damaging	Het
Ccdc186	G	A	19: 56,781,924 (GRCm39)	R27*	probably null	Het
Clnk	C	A	5: 38,899,138 (GRCm39)		probably benign	Het
Dse	A	G	10: 34,029,330 (GRCm39)	F587L	probably damaging	Het
Fut8	T	C	12: 77,440,523 (GRCm39)	L170P	probably damaging	Het
G3bp2	T	C	5: 92,212,260 (GRCm39)	H217R	probably benign	Het
Gm19345	G	A	7: 19,588,886 (GRCm39)		probably benign	Het
Hjurp	G	C	1: 88,204,937 (GRCm39)		probably benign	Het
Kcne4	A	G	1: 78,795,819 (GRCm39)	N156D	probably benign	Het
Met	G	T	6: 17,562,271 (GRCm39)		probably null	Het
Mfsd3	T	C	15: 76,585,945 (GRCm39)	L26P	probably damaging	Het
Oasl1	A	G	5: 115,075,073 (GRCm39)	K378E	possibly damaging	Het
Pde8a	A	G	7: 80,970,407 (GRCm39)	I510V	probably benign	Het
Pds5a	T	C	5: 65,821,839 (GRCm39)	T120A	possibly damaging	Het
Phf8-ps	G	A	17: 33,285,023 (GRCm39)	T593I	probably benign	Het
Phkb	T	A	8: 86,748,162 (GRCm39)		probably null	Het
Ptprz1	A	T	6: 23,001,683 (GRCm39)	K1258*	probably null	Het
Senp7	C	A	16: 55,973,832 (GRCm39)	P351Q	possibly damaging	Het
Slc15a5	G	T	6: 138,049,938 (GRCm39)	T159K	possibly damaging	Het
Slc39a6	A	G	18: 24,730,885 (GRCm39)	V362A	possibly damaging	Het
Spef2	A	T	15: 9,676,407 (GRCm39)	D721E	probably damaging	Het
Sting1	A	T	18: 35,872,272 (GRCm39)	Y77N	probably damaging	Het
Tex11	C	A	X: 99,977,021 (GRCm39)	A487S	possibly damaging	Het
Tnxb	A	G	17: 34,930,491 (GRCm39)	T2059A	probably damaging	Het
Ttll8	T	C	15: 88,801,444 (GRCm39)	N415D	probably benign	Het
Ube2d2a	A	T	18: 35,903,577 (GRCm39)		probably benign	Het
Unc79	A	G	12: 103,036,512 (GRCm39)		probably benign	Het
Ush2a	G	A	1: 188,460,907 (GRCm39)	V2723M	probably damaging	Het
Vmn2r3	G	A	3: 64,194,850 (GRCm39)	Q23*	probably null	Het

Other mutations in Vmn2r102

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00944:Vmn2r102	APN	17	19,899,154 (GRCm39)	missense	probably damaging	1.00
IGL00974:Vmn2r102	APN	17	19,897,771 (GRCm39)	missense	possibly damaging	0.93
IGL00978:Vmn2r102	APN	17	19,899,185 (GRCm39)	splice site	probably null
IGL01589:Vmn2r102	APN	17	19,899,066 (GRCm39)	missense	probably benign
IGL01738:Vmn2r102	APN	17	19,898,020 (GRCm39)	missense	probably damaging	1.00
IGL01994:Vmn2r102	APN	17	19,880,731 (GRCm39)	missense	probably benign	0.00
IGL02066:Vmn2r102	APN	17	19,914,191 (GRCm39)	missense	probably benign	0.01
IGL02525:Vmn2r102	APN	17	19,901,447 (GRCm39)	missense	probably benign
IGL02589:Vmn2r102	APN	17	19,901,480 (GRCm39)	missense	probably damaging	1.00
IGL02814:Vmn2r102	APN	17	19,898,170 (GRCm39)	missense	probably damaging	1.00
IGL03028:Vmn2r102	APN	17	19,914,328 (GRCm39)	missense	possibly damaging	0.92
IGL03162:Vmn2r102	APN	17	19,914,286 (GRCm39)	missense	probably damaging	1.00
PIT4431001:Vmn2r102	UTSW	17	19,896,958 (GRCm39)	missense	possibly damaging	0.68
R0042:Vmn2r102	UTSW	17	19,880,851 (GRCm39)	missense	probably damaging	0.98
R0131:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0131:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0132:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0268:Vmn2r102	UTSW	17	19,898,112 (GRCm39)	missense	probably benign	0.00
R0441:Vmn2r102	UTSW	17	19,914,630 (GRCm39)	missense	probably damaging	1.00
R0583:Vmn2r102	UTSW	17	19,897,043 (GRCm39)	missense	probably benign	0.01
R0600:Vmn2r102	UTSW	17	19,898,277 (GRCm39)	missense	probably benign	0.00
R0606:Vmn2r102	UTSW	17	19,899,106 (GRCm39)	missense	possibly damaging	0.93
R0674:Vmn2r102	UTSW	17	19,898,129 (GRCm39)	missense	probably benign	0.00
R0709:Vmn2r102	UTSW	17	19,897,881 (GRCm39)	missense	probably benign	0.01
R0879:Vmn2r102	UTSW	17	19,914,454 (GRCm39)	missense	probably damaging	1.00
R1349:Vmn2r102	UTSW	17	19,880,887 (GRCm39)	splice site	probably benign
R1473:Vmn2r102	UTSW	17	19,914,843 (GRCm39)	missense	probably benign	0.00
R1630:Vmn2r102	UTSW	17	19,899,032 (GRCm39)	missense	possibly damaging	0.60
R1727:Vmn2r102	UTSW	17	19,897,770 (GRCm39)	missense	probably damaging	0.99
R1759:Vmn2r102	UTSW	17	19,914,755 (GRCm39)	missense	probably damaging	1.00
R1809:Vmn2r102	UTSW	17	19,897,881 (GRCm39)	missense	probably benign	0.01
R2013:Vmn2r102	UTSW	17	19,897,006 (GRCm39)	missense	probably benign	0.03
R2086:Vmn2r102	UTSW	17	19,896,949 (GRCm39)	missense	probably damaging	1.00
R2241:Vmn2r102	UTSW	17	19,897,003 (GRCm39)	missense	probably benign	0.00
R2378:Vmn2r102	UTSW	17	19,914,930 (GRCm39)	missense	probably damaging	1.00
R3814:Vmn2r102	UTSW	17	19,899,093 (GRCm39)	missense	probably damaging	0.98
R3827:Vmn2r102	UTSW	17	19,914,787 (GRCm39)	missense	probably damaging	1.00
R4505:Vmn2r102	UTSW	17	19,880,845 (GRCm39)	missense	probably benign	0.00
R4515:Vmn2r102	UTSW	17	19,901,475 (GRCm39)	missense	probably damaging	1.00
R4517:Vmn2r102	UTSW	17	19,901,475 (GRCm39)	missense	probably damaging	1.00
R4534:Vmn2r102	UTSW	17	19,914,975 (GRCm39)	missense	probably benign
R4535:Vmn2r102	UTSW	17	19,914,975 (GRCm39)	missense	probably benign
R4662:Vmn2r102	UTSW	17	19,901,424 (GRCm39)	missense	probably damaging	1.00
R4708:Vmn2r102	UTSW	17	19,914,576 (GRCm39)	missense	probably benign	0.00
R4734:Vmn2r102	UTSW	17	19,897,795 (GRCm39)	missense	probably damaging	1.00
R4834:Vmn2r102	UTSW	17	19,898,203 (GRCm39)	missense	probably damaging	0.99
R4927:Vmn2r102	UTSW	17	19,880,661 (GRCm39)	start codon destroyed	probably benign	0.00
R5077:Vmn2r102	UTSW	17	19,897,834 (GRCm39)	missense	probably benign	0.20
R5181:Vmn2r102	UTSW	17	19,897,003 (GRCm39)	missense	probably benign	0.00
R5277:Vmn2r102	UTSW	17	19,914,393 (GRCm39)	missense	possibly damaging	0.49
R5418:Vmn2r102	UTSW	17	19,914,415 (GRCm39)	missense	probably damaging	1.00
R5810:Vmn2r102	UTSW	17	19,897,804 (GRCm39)	missense	probably benign	0.20
R5864:Vmn2r102	UTSW	17	19,914,943 (GRCm39)	missense	possibly damaging	0.55
R6168:Vmn2r102	UTSW	17	19,914,402 (GRCm39)	missense	possibly damaging	0.83
R6266:Vmn2r102	UTSW	17	19,899,007 (GRCm39)	missense	probably benign
R6432:Vmn2r102	UTSW	17	19,901,483 (GRCm39)	missense	possibly damaging	0.61
R6487:Vmn2r102	UTSW	17	19,898,169 (GRCm39)	missense	probably damaging	1.00
R6597:Vmn2r102	UTSW	17	19,914,450 (GRCm39)	missense	probably damaging	0.99
R6797:Vmn2r102	UTSW	17	19,880,694 (GRCm39)	nonsense	probably null
R7009:Vmn2r102	UTSW	17	19,914,456 (GRCm39)	missense	probably damaging	0.99
R7098:Vmn2r102	UTSW	17	19,914,670 (GRCm39)	missense	probably damaging	1.00
R7134:Vmn2r102	UTSW	17	19,897,749 (GRCm39)	missense	probably benign	0.01
R7463:Vmn2r102	UTSW	17	19,896,886 (GRCm39)	missense	probably damaging	1.00
R7511:Vmn2r102	UTSW	17	19,901,405 (GRCm39)	missense	probably damaging	1.00
R7512:Vmn2r102	UTSW	17	19,914,363 (GRCm39)	missense	probably damaging	1.00
R7556:Vmn2r102	UTSW	17	19,898,093 (GRCm39)	missense	probably benign
R8126:Vmn2r102	UTSW	17	19,880,712 (GRCm39)	missense	probably benign	0.02
R8385:Vmn2r102	UTSW	17	19,914,088 (GRCm39)	missense	possibly damaging	0.89
R8410:Vmn2r102	UTSW	17	19,898,196 (GRCm39)	missense	possibly damaging	0.85
R9045:Vmn2r102	UTSW	17	19,880,841 (GRCm39)	missense	probably benign	0.00
R9267:Vmn2r102	UTSW	17	19,896,928 (GRCm39)	missense	probably damaging	1.00
R9325:Vmn2r102	UTSW	17	19,897,558 (GRCm39)	missense	probably damaging	1.00
R9363:Vmn2r102	UTSW	17	19,897,614 (GRCm39)	missense	probably benign	0.04
R9524:Vmn2r102	UTSW	17	19,897,564 (GRCm39)	missense	possibly damaging	0.74
R9747:Vmn2r102	UTSW	17	19,898,129 (GRCm39)	missense	probably benign	0.00
Z1176:Vmn2r102	UTSW	17	19,914,305 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GAACATCATGTTATTGACAGAGCTGAC -3'
(R):5'- TACCTGCCATGGAAAGAACACTATC -3'

Sequencing Primer
(F):5'- GAGCTGACTATTTCATGTTAGACAC -3'
(R):5'- TGGAAAGAACACTATCCCTTTGC -3'

Posted On

2015-05-14