Incidental Mutation 'R4061:Adam25'
ID 315863
Institutional Source Beutler Lab
Gene Symbol Adam25
Ensembl Gene ENSMUSG00000071937
Gene Name ADAM metallopeptidase domain 25
Synonyms testase 2
MMRRC Submission 040852-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R4061 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 41205245-41209213 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 41206819 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 28 (I28M)
Ref Sequence ENSEMBL: ENSMUSP00000094420 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096663]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000096663
AA Change: I28M

PolyPhen 2 Score 0.665 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000094420
Gene: ENSMUSG00000071937
AA Change: I28M

DomainStartEndE-ValueType
Pfam:Pep_M12B_propep 53 179 3.4e-21 PFAM
Pfam:Reprolysin_5 220 398 1.6e-16 PFAM
Pfam:Reprolysin_4 220 407 2.5e-13 PFAM
Pfam:Reprolysin 221 410 5.6e-46 PFAM
Pfam:Reprolysin_2 222 399 9.7e-14 PFAM
Pfam:Reprolysin_3 246 366 1e-18 PFAM
DISIN 428 503 3.33e-39 SMART
ACR 504 640 8.95e-74 SMART
transmembrane domain 706 728 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210673
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 94% (51/54)
MGI Phenotype FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019A02Rik A T 1: 53,197,928 (GRCm39) L140Q probably damaging Het
Anks1b A G 10: 90,143,484 (GRCm39) S464G probably damaging Het
AU040320 T A 4: 126,729,488 (GRCm39) M550K probably damaging Het
Cab39l A G 14: 59,737,056 (GRCm39) K59E possibly damaging Het
Cdc5l C T 17: 45,721,816 (GRCm39) A485T probably benign Het
Csmd1 A G 8: 15,995,158 (GRCm39) S2626P probably benign Het
Ctss C T 3: 95,450,345 (GRCm39) R99W probably benign Het
Deptor A T 15: 55,072,177 (GRCm39) M219L probably benign Het
Disp1 A G 1: 182,869,264 (GRCm39) V1052A probably damaging Het
Esyt3 C T 9: 99,202,891 (GRCm39) S504N probably damaging Het
Fat1 A T 8: 45,478,518 (GRCm39) E2521D probably benign Het
Folh1 T A 7: 86,406,170 (GRCm39) Y301F possibly damaging Het
Gm14443 G A 2: 175,011,402 (GRCm39) T348I probably benign Het
Gtpbp2 G A 17: 46,478,253 (GRCm39) R467H probably damaging Het
Hnrnpll T C 17: 80,340,201 (GRCm39) H526R probably benign Het
Iars2 A T 1: 185,035,583 (GRCm39) H552Q possibly damaging Het
Il18r1 G A 1: 40,514,096 (GRCm39) V101I probably benign Het
Impdh2 A G 9: 108,440,003 (GRCm39) R182G possibly damaging Het
Krt12 A T 11: 99,306,841 (GRCm39) M487K unknown Het
Lmln C A 16: 32,886,761 (GRCm39) Y89* probably null Het
Lrrc38 T A 4: 143,077,076 (GRCm39) L113Q probably damaging Het
Mast3 A G 8: 71,233,838 (GRCm39) V969A probably damaging Het
Muc5ac A G 7: 141,364,867 (GRCm39) D1947G possibly damaging Het
Myh13 A T 11: 67,221,715 (GRCm39) I177F possibly damaging Het
Nfasc T C 1: 132,525,583 (GRCm39) Y904C probably damaging Het
Obscn G A 11: 58,899,358 (GRCm39) P1000S probably damaging Het
Or52n4 T A 7: 104,293,680 (GRCm39) K298* probably null Het
Or5t7 T A 2: 86,507,162 (GRCm39) I172F probably damaging Het
Otop2 G A 11: 115,220,201 (GRCm39) G347D probably damaging Het
Pclo A G 5: 14,590,580 (GRCm39) E960G unknown Het
Plagl1 TGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCC TGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCCAGAGCC 10: 13,004,515 (GRCm39) probably benign Het
Prl7a1 T C 13: 27,819,832 (GRCm39) I141V possibly damaging Het
Ptpn18 A T 1: 34,512,011 (GRCm39) H45L possibly damaging Het
Sbno1 A T 5: 124,526,635 (GRCm39) M960K probably damaging Het
Slx4ip T A 2: 136,846,937 (GRCm39) S67R probably benign Het
Spata18 A G 5: 73,828,509 (GRCm39) K243E probably damaging Het
Tcp1 A G 17: 13,139,750 (GRCm39) Q265R probably benign Het
Tec C T 5: 72,980,752 (GRCm39) probably benign Het
Thbs4 A G 13: 92,912,605 (GRCm39) probably null Het
Tln1 T A 4: 43,549,177 (GRCm39) Q635L probably damaging Het
Tshz2 A G 2: 169,804,245 (GRCm39) probably benign Het
Uap1 T C 1: 169,986,415 (GRCm39) E189G possibly damaging Het
Usp21 G A 1: 171,112,974 (GRCm39) probably benign Het
Vmn1r118 G T 7: 20,645,933 (GRCm39) Q114K probably damaging Het
Vmn1r38 A T 6: 66,753,832 (GRCm39) C95S possibly damaging Het
Vmn2r12 A T 5: 109,240,058 (GRCm39) N168K possibly damaging Het
Vmn2r84 T A 10: 130,221,898 (GRCm39) E774V probably damaging Het
Other mutations in Adam25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01444:Adam25 APN 8 41,207,958 (GRCm39) missense probably benign
IGL01977:Adam25 APN 8 41,208,134 (GRCm39) missense probably benign 0.00
IGL02098:Adam25 APN 8 41,208,680 (GRCm39) missense probably benign 0.12
IGL02233:Adam25 APN 8 41,208,423 (GRCm39) missense probably damaging 1.00
IGL02458:Adam25 APN 8 41,206,844 (GRCm39) missense probably benign 0.01
IGL02527:Adam25 APN 8 41,206,785 (GRCm39) missense possibly damaging 0.78
IGL02632:Adam25 APN 8 41,208,237 (GRCm39) missense possibly damaging 0.90
IGL02995:Adam25 APN 8 41,206,760 (GRCm39) missense probably benign 0.00
H8786:Adam25 UTSW 8 41,207,261 (GRCm39) missense probably benign 0.00
R0062:Adam25 UTSW 8 41,207,829 (GRCm39) missense probably damaging 1.00
R0062:Adam25 UTSW 8 41,207,829 (GRCm39) missense probably damaging 1.00
R0189:Adam25 UTSW 8 41,208,467 (GRCm39) missense probably damaging 1.00
R0505:Adam25 UTSW 8 41,208,261 (GRCm39) missense probably damaging 1.00
R0532:Adam25 UTSW 8 41,208,987 (GRCm39) missense probably benign 0.00
R0699:Adam25 UTSW 8 41,209,011 (GRCm39) missense probably benign
R0972:Adam25 UTSW 8 41,208,168 (GRCm39) missense probably damaging 1.00
R1053:Adam25 UTSW 8 41,207,768 (GRCm39) missense probably benign 0.30
R1079:Adam25 UTSW 8 41,208,513 (GRCm39) missense possibly damaging 0.87
R1872:Adam25 UTSW 8 41,208,263 (GRCm39) nonsense probably null
R1933:Adam25 UTSW 8 41,207,922 (GRCm39) missense probably benign 0.01
R1934:Adam25 UTSW 8 41,207,922 (GRCm39) missense probably benign 0.01
R4702:Adam25 UTSW 8 41,207,163 (GRCm39) missense probably damaging 1.00
R4703:Adam25 UTSW 8 41,207,163 (GRCm39) missense probably damaging 1.00
R4705:Adam25 UTSW 8 41,207,163 (GRCm39) missense probably damaging 1.00
R4859:Adam25 UTSW 8 41,207,580 (GRCm39) missense probably benign 0.01
R5015:Adam25 UTSW 8 41,207,671 (GRCm39) missense probably benign 0.22
R5249:Adam25 UTSW 8 41,208,991 (GRCm39) missense probably benign
R5628:Adam25 UTSW 8 41,208,747 (GRCm39) missense probably benign 0.00
R5791:Adam25 UTSW 8 41,207,257 (GRCm39) missense probably benign
R6439:Adam25 UTSW 8 41,207,627 (GRCm39) missense possibly damaging 0.92
R6693:Adam25 UTSW 8 41,207,568 (GRCm39) missense probably damaging 1.00
R7041:Adam25 UTSW 8 41,207,121 (GRCm39) missense probably benign 0.04
R7101:Adam25 UTSW 8 41,208,438 (GRCm39) missense probably benign 0.00
R7531:Adam25 UTSW 8 41,206,914 (GRCm39) missense probably damaging 0.99
R7600:Adam25 UTSW 8 41,208,854 (GRCm39) missense probably benign 0.01
R7634:Adam25 UTSW 8 41,207,883 (GRCm39) missense probably benign 0.00
R7964:Adam25 UTSW 8 41,208,576 (GRCm39) missense probably damaging 0.99
R8017:Adam25 UTSW 8 41,207,124 (GRCm39) missense possibly damaging 0.56
R8021:Adam25 UTSW 8 41,207,796 (GRCm39) missense probably damaging 1.00
R8499:Adam25 UTSW 8 41,208,189 (GRCm39) missense probably damaging 1.00
R8686:Adam25 UTSW 8 41,208,521 (GRCm39) missense probably benign 0.44
R8715:Adam25 UTSW 8 41,207,099 (GRCm39) missense probably benign 0.00
R8847:Adam25 UTSW 8 41,206,746 (GRCm39) missense probably benign
R8921:Adam25 UTSW 8 41,207,710 (GRCm39) nonsense probably null
R9120:Adam25 UTSW 8 41,209,141 (GRCm39) utr 3 prime probably benign
R9158:Adam25 UTSW 8 41,208,645 (GRCm39) missense probably damaging 1.00
R9339:Adam25 UTSW 8 41,206,911 (GRCm39) missense probably damaging 1.00
R9348:Adam25 UTSW 8 41,208,953 (GRCm39) missense probably benign
R9454:Adam25 UTSW 8 41,207,486 (GRCm39) missense probably damaging 0.99
R9492:Adam25 UTSW 8 41,206,736 (GRCm39) start codon destroyed probably benign 0.12
R9680:Adam25 UTSW 8 41,208,239 (GRCm39) missense probably damaging 1.00
RF006:Adam25 UTSW 8 41,208,834 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGCCTTTGAACAAACCTCAGC -3'
(R):5'- TGTGAATAAAATGTTTCTGGCCCC -3'

Sequencing Primer
(F):5'- TGGCCTGCCCATACTGAAATACTC -3'
(R):5'- AATGTTTCTGGCCCCCAAAATG -3'
Posted On 2015-05-15