Mutagenetix > Incidental Mutation

Incidental Mutation 'R4066:Rnps1-ps'

316114

Institutional Source

Beutler Lab

Gene Symbol

Rnps1-ps

Ensembl Gene

ENSMUSG00000096403

Gene Name

RNA binding protein with serine rich domain 1, pseudogene

Synonyms

Gm9825

MMRRC Submission

040973-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.881) question?

Stock #

R4066 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

7982541-7983383 bp(-) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

T to A at 7983009 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000178598

SMART Domains

Protein: ENSMUSP00000136814
Gene: ENSMUSG00000096403

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
low complexity region	32	134	N/A	INTRINSIC
RRM	139	213	5.12e-21	SMART
low complexity region	220	282	N/A	INTRINSIC

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.5%

Validation Efficiency

96% (50/52)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam23	A	T	1: 63,602,584 (GRCm39)	H582L	probably damaging	Het
Ankrd13d	C	T	19: 4,320,388 (GRCm39)	A118T	probably benign	Het
Arhgap30	C	T	1: 171,235,891 (GRCm39)	T755I	probably benign	Het
Cab39l	A	G	14: 59,784,454 (GRCm39)	H285R	probably benign	Het
Dpyd	AAT	AATGTATATATAT	3: 118,690,738 (GRCm39)		probably benign	Het
Dspp	T	A	5: 104,325,060 (GRCm39)	N474K	unknown	Het
Fanci	T	C	7: 79,062,505 (GRCm39)		probably null	Het
Fras1	T	A	5: 96,918,542 (GRCm39)	I3526K	possibly damaging	Het
Fut8	T	A	12: 77,510,835 (GRCm39)	Y421N	probably damaging	Het
Gm12258	C	T	11: 58,749,352 (GRCm39)	L176F	probably benign	Het
Gm8220	A	T	14: 44,523,095 (GRCm39)	R12*	probably null	Het
Hecw1	T	C	13: 14,491,016 (GRCm39)	S659G	probably damaging	Het
Hnrnpr	C	A	4: 136,066,657 (GRCm39)		probably benign	Het
Htt	C	T	5: 35,036,191 (GRCm39)	T2046I	probably benign	Het
Kat7	T	C	11: 95,174,967 (GRCm39)	D259G	possibly damaging	Het
Klra9	T	C	6: 130,165,707 (GRCm39)	T103A	probably benign	Het
Lad1	A	G	1: 135,755,165 (GRCm39)	E147G	probably damaging	Het
Lipo2	T	C	19: 33,698,259 (GRCm39)	I373V	probably benign	Het
Ltb4r1	G	T	14: 56,004,952 (GRCm39)	W85L	probably damaging	Het
Ltn1	T	C	16: 87,213,118 (GRCm39)	Y481C	possibly damaging	Het
Man1c1	G	C	4: 134,430,749 (GRCm39)	P11R	probably damaging	Het
Muc4	A	T	16: 32,569,869 (GRCm39)	I310F	possibly damaging	Het
Myl10	A	G	5: 136,724,304 (GRCm39)	K70E	probably damaging	Het
Nptx2	G	T	5: 144,493,122 (GRCm39)	W403L	probably damaging	Het
Nyap2	A	G	1: 81,219,550 (GRCm39)	Y524C	probably damaging	Het
Or4a72	T	A	2: 89,405,523 (GRCm39)	L182F	probably damaging	Het
Or6b2b	A	G	1: 92,418,911 (GRCm39)	C189R	probably damaging	Het
Or8b1	T	A	9: 38,399,778 (GRCm39)	M151K	probably benign	Het
Pde9a	A	G	17: 31,662,812 (GRCm39)	*64W	probably null	Het
Ppp2r5b	T	C	19: 6,279,360 (GRCm39)	Y379C	probably damaging	Het
Rd3l	T	G	12: 111,945,945 (GRCm39)	N178T	probably benign	Het
Recql4	A	G	15: 76,590,027 (GRCm39)	Y673H	probably damaging	Het
Shcbp1	A	G	8: 4,798,716 (GRCm39)	I401T	probably damaging	Het
Shd	A	T	17: 56,278,581 (GRCm39)	D48V	probably damaging	Het
Slc14a1	A	G	18: 78,154,592 (GRCm39)	W209R	probably damaging	Het
Slc2a9	T	C	5: 38,640,692 (GRCm39)	K6E	probably benign	Het
Slco6d1	A	G	1: 98,391,571 (GRCm39)		probably benign	Het
Spic	T	C	10: 88,511,545 (GRCm39)	H237R	possibly damaging	Het
Stau2	A	G	1: 16,464,283 (GRCm39)	S156P	possibly damaging	Het
Stmn2	T	C	3: 8,574,668 (GRCm39)		probably benign	Het
Togaram2	C	A	17: 72,023,233 (GRCm39)		probably benign	Het
Trpc5	T	A	X: 143,202,594 (GRCm39)	R545*	probably null	Het
Ugcg	C	T	4: 59,207,798 (GRCm39)	P46S	probably benign	Het
Wdfy3	C	T	5: 102,070,313 (GRCm39)	V1152I	probably benign	Het
Xpo4	G	T	14: 57,825,511 (GRCm39)	H939N	probably benign	Het

Other mutations in Rnps1-ps

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL03031:Rnps1-ps	APN	6	7,982,857 (GRCm39)	exon	noncoding transcript
R1677:Rnps1-ps	UTSW	6	7,982,943 (GRCm39)	exon	noncoding transcript
R1778:Rnps1-ps	UTSW	6	7,983,124 (GRCm39)	exon	noncoding transcript
R3975:Rnps1-ps	UTSW	6	7,983,149 (GRCm39)	exon	noncoding transcript
R3976:Rnps1-ps	UTSW	6	7,983,149 (GRCm39)	exon	noncoding transcript
R5622:Rnps1-ps	UTSW	6	7,982,605 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- GCATAGCCTTTGGAGAGGTGAG -3'
(R):5'- TCGTGGCAGAGATAAGACTCG -3'

Sequencing Primer
(F):5'- GGATGCATCCTCTCGACAG -3'
(R):5'- AGGTCTAGGTCCAGCTCAAC -3'

Posted On

2015-05-15