Incidental Mutation 'R4077:Or10ag56'
ID 316595
Institutional Source Beutler Lab
Gene Symbol Or10ag56
Ensembl Gene ENSMUSG00000083706
Gene Name olfactory receptor family 10 subfamily AG member 56
Synonyms Olfr1118, GA_x6K02T2Q125-48795705-48796673, Olfr1118-ps, MOR264-22
MMRRC Submission 041622-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.102) question?
Stock # R4077 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87139108-87140103 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 87139208 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 25 (M25K)
Ref Sequence ENSEMBL: ENSMUSP00000132837 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090717] [ENSMUST00000121296] [ENSMUST00000216396]
AlphaFold A0A1L1STN9
Predicted Effect probably null
Transcript: ENSMUST00000090717
AA Change: M25K

PolyPhen 2 Score 0.418 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000132837
Gene: ENSMUSG00000070855
AA Change: M25K

DomainStartEndE-ValueType
Pfam:7tm_4 22 298 1.1e-53 PFAM
Pfam:7tm_1 32 281 1.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120328
Predicted Effect probably benign
Transcript: ENSMUST00000121296
AA Change: M25K

PolyPhen 2 Score 0.418 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000144143
Gene: ENSMUSG00000083706
AA Change: M25K

DomainStartEndE-ValueType
Pfam:7tm_4 22 298 1.2e-51 PFAM
Pfam:7tm_1 32 281 7.2e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216396
AA Change: M45K

PolyPhen 2 Score 0.594 (Sensitivity: 0.87; Specificity: 0.91)
Meta Mutation Damage Score 0.3189 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 99% (81/82)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12 T A 2: 150,690,379 (GRCm39) probably null Het
Adam33 T C 2: 130,905,444 (GRCm39) probably benign Het
Adrm1b A C 3: 92,336,195 (GRCm39) probably benign Het
Akap8 C T 17: 32,531,272 (GRCm39) R380Q probably damaging Het
Arhgef12 T C 9: 42,886,588 (GRCm39) M1131V probably damaging Het
Atrn T C 2: 130,806,850 (GRCm39) probably null Het
Btaf1 A G 19: 36,963,879 (GRCm39) T817A probably benign Het
C3 C T 17: 57,512,303 (GRCm39) D1542N possibly damaging Het
Cadm3 A G 1: 173,169,236 (GRCm39) V293A probably benign Het
Cdk11b C T 4: 155,724,204 (GRCm39) probably benign Het
Cdnf A G 2: 3,522,060 (GRCm39) Y84C probably damaging Het
Chdh T C 14: 29,757,297 (GRCm39) S407P probably damaging Het
Cmtr1 C A 17: 29,904,949 (GRCm39) T300K probably damaging Het
Dennd2d A T 3: 106,389,939 (GRCm39) probably benign Het
Diaph1 T A 18: 37,986,636 (GRCm39) E1116D possibly damaging Het
Eif1ad3 A G 12: 87,843,401 (GRCm39) K16R unknown Het
Eif1ad3 A T 12: 87,843,710 (GRCm39) D119V possibly damaging Het
Enpp1 A G 10: 24,544,905 (GRCm39) probably null Het
Erbb4 T C 1: 68,079,496 (GRCm39) T1195A probably benign Het
Ermard T A 17: 15,273,638 (GRCm39) S408T probably benign Het
Etl4 A T 2: 20,812,772 (GRCm39) R1442S probably damaging Het
F13b T A 1: 139,429,508 (GRCm39) F9I unknown Het
Fnbp4 C T 2: 90,588,821 (GRCm39) R531* probably null Het
Gdf6 A G 4: 9,844,776 (GRCm39) Y100C probably damaging Het
Gpr3 T C 4: 132,938,226 (GRCm39) T149A probably damaging Het
Grm8 T C 6: 27,760,208 (GRCm39) H374R probably benign Het
Hbs1l T C 10: 21,228,501 (GRCm39) V493A probably damaging Het
Hgs A G 11: 120,368,202 (GRCm39) K277E probably damaging Het
Hnrnpul1 C T 7: 25,426,300 (GRCm39) R517Q probably damaging Het
Hoxa11 A T 6: 52,222,504 (GRCm39) Y66N probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Igdcc4 T A 9: 65,039,047 (GRCm39) L944Q probably damaging Het
Ighv3-1 C A 12: 113,928,107 (GRCm39) S84I probably damaging Het
Iqgap2 T C 13: 95,794,375 (GRCm39) D1199G probably damaging Het
Kcnk10 A T 12: 98,401,205 (GRCm39) M490K probably benign Het
Kirrel1 A G 3: 86,992,387 (GRCm39) probably null Het
Lias A T 5: 65,552,768 (GRCm39) T124S probably benign Het
Lrig3 A C 10: 125,845,656 (GRCm39) E695A probably damaging Het
Lrpap1 A G 5: 35,253,381 (GRCm39) I261T possibly damaging Het
Lrrc37a T A 11: 103,388,808 (GRCm39) T2206S unknown Het
Macf1 T A 4: 123,365,884 (GRCm39) Q2959L probably benign Het
Mis12 A G 11: 70,916,134 (GRCm39) T56A probably benign Het
Or1l4 T A 2: 37,092,024 (GRCm39) I257N possibly damaging Het
Or4k41 A G 2: 111,279,848 (GRCm39) D121G probably damaging Het
Or5b99 T C 19: 12,977,235 (GRCm39) V295A probably damaging Het
Otof A T 5: 30,576,850 (GRCm39) L134Q possibly damaging Het
Pds5b T A 5: 150,717,824 (GRCm39) V1155E possibly damaging Het
Pdss2 A T 10: 43,278,518 (GRCm39) M342L probably benign Het
Phyhipl C T 10: 70,404,903 (GRCm39) V57I probably damaging Het
Plekha5 T A 6: 140,501,647 (GRCm39) probably null Het
Pnck A T X: 72,701,761 (GRCm39) V93E probably damaging Het
Proser1 A G 3: 53,385,962 (GRCm39) T615A probably damaging Het
Ptprk G A 10: 28,139,508 (GRCm39) V78I probably benign Het
Ptprv A G 1: 135,038,168 (GRCm39) noncoding transcript Het
Ranbp3l A G 15: 9,060,838 (GRCm39) N233S probably damaging Het
Rassf2 G A 2: 131,854,522 (GRCm39) P7S probably benign Het
Sart1 A T 19: 5,432,771 (GRCm39) L521Q possibly damaging Het
Scgb1b21 T A 7: 33,227,118 (GRCm39) noncoding transcript Het
Scyl2 A T 10: 89,476,458 (GRCm39) M889K probably benign Het
Secisbp2l A G 2: 125,593,785 (GRCm39) probably benign Het
Svil A G 18: 5,063,522 (GRCm39) E931G probably benign Het
Syce1 C A 7: 140,359,809 (GRCm39) L83F probably damaging Het
Tdrd1 A G 19: 56,819,505 (GRCm39) M2V probably benign Het
Tjp2 A T 19: 24,086,182 (GRCm39) V780E possibly damaging Het
Tram1 A G 1: 13,636,599 (GRCm39) V358A probably benign Het
Unc13c C T 9: 73,643,821 (GRCm39) W1214* probably null Het
Vps13b T C 15: 35,455,274 (GRCm39) C728R probably damaging Het
Wwox A G 8: 115,166,481 (GRCm39) probably benign Het
Zbtb41 G A 1: 139,357,064 (GRCm39) V440I probably benign Het
Zfp777 T C 6: 48,002,456 (GRCm39) S589G probably benign Het
Zfp955a A G 17: 33,460,675 (GRCm39) Y486H probably benign Het
Other mutations in Or10ag56
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01328:Or10ag56 APN 2 87,139,925 (GRCm39) missense possibly damaging 0.95
IGL01458:Or10ag56 APN 2 87,139,826 (GRCm39) missense probably damaging 1.00
IGL02544:Or10ag56 APN 2 87,139,471 (GRCm39) missense possibly damaging 0.91
IGL02748:Or10ag56 APN 2 87,140,009 (GRCm39) missense probably damaging 1.00
IGL03077:Or10ag56 APN 2 87,140,056 (GRCm39) makesense probably null
R0411:Or10ag56 UTSW 2 87,139,402 (GRCm39) missense probably benign 0.07
R0525:Or10ag56 UTSW 2 87,139,693 (GRCm39) missense probably benign 0.10
R1703:Or10ag56 UTSW 2 87,139,754 (GRCm39) missense probably benign 0.00
R1750:Or10ag56 UTSW 2 87,139,196 (GRCm39) missense probably benign 0.02
R2005:Or10ag56 UTSW 2 87,139,792 (GRCm39) missense probably benign 0.24
R2090:Or10ag56 UTSW 2 87,139,762 (GRCm39) missense probably benign 0.02
R3846:Or10ag56 UTSW 2 87,139,526 (GRCm39) missense probably benign 0.15
R4011:Or10ag56 UTSW 2 87,139,555 (GRCm39) missense probably benign 0.03
R5132:Or10ag56 UTSW 2 87,139,282 (GRCm39) missense probably damaging 1.00
R5368:Or10ag56 UTSW 2 87,139,126 (GRCm39) splice site probably null
R7355:Or10ag56 UTSW 2 87,139,754 (GRCm39) missense probably benign 0.00
R7405:Or10ag56 UTSW 2 87,139,339 (GRCm39) missense probably benign 0.00
R7437:Or10ag56 UTSW 2 87,139,687 (GRCm39) missense probably benign
R7554:Or10ag56 UTSW 2 87,139,349 (GRCm39) missense probably damaging 1.00
R7609:Or10ag56 UTSW 2 87,139,853 (GRCm39) missense probably benign 0.01
R8156:Or10ag56 UTSW 2 87,139,318 (GRCm39) missense probably damaging 0.97
R8482:Or10ag56 UTSW 2 87,139,726 (GRCm39) missense probably benign 0.07
R8558:Or10ag56 UTSW 2 87,139,583 (GRCm39) missense probably benign 0.11
R9136:Or10ag56 UTSW 2 87,139,219 (GRCm39) missense possibly damaging 0.95
R9229:Or10ag56 UTSW 2 87,139,165 (GRCm39) missense probably benign 0.00
R9326:Or10ag56 UTSW 2 87,139,730 (GRCm39) missense probably benign 0.37
RF010:Or10ag56 UTSW 2 87,139,184 (GRCm39) missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- GTGTCAACTCTTCAAAGAATCTGAG -3'
(R):5'- AATACATTTGTGTTGCACAGGC -3'

Sequencing Primer
(F):5'- GTGTCATACATGCCTATGATTCAG -3'
(R):5'- GCACAGGCAAACACAGAAATG -3'
Posted On 2015-05-15