Incidental Mutation 'R4077:Kcnk10'
ID 316641
Institutional Source Beutler Lab
Gene Symbol Kcnk10
Ensembl Gene ENSMUSG00000033854
Gene Name potassium channel, subfamily K, member 10
Synonyms Trek2, 3010005K24Rik, 1700024D23Rik
MMRRC Submission 041622-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R4077 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 98395691-98544472 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 98401205 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 490 (M490K)
Ref Sequence ENSEMBL: ENSMUSP00000152473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110113] [ENSMUST00000221240]
AlphaFold Q8BUW1
Predicted Effect probably benign
Transcript: ENSMUST00000110113
AA Change: M476K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000105740
Gene: ENSMUSG00000033854
AA Change: M476K

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Ion_trans 55 207 9.3e-8 PFAM
Pfam:Ion_trans_2 126 204 3.3e-20 PFAM
Pfam:Ion_trans_2 223 321 8.5e-21 PFAM
low complexity region 449 462 N/A INTRINSIC
low complexity region 479 489 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000221240
AA Change: M490K

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
Meta Mutation Damage Score 0.0591 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 99% (81/82)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit normal glucose hyperpolarization of hypothalamic neurons in response to glucose. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12 T A 2: 150,690,379 (GRCm39) probably null Het
Adam33 T C 2: 130,905,444 (GRCm39) probably benign Het
Adrm1b A C 3: 92,336,195 (GRCm39) probably benign Het
Akap8 C T 17: 32,531,272 (GRCm39) R380Q probably damaging Het
Arhgef12 T C 9: 42,886,588 (GRCm39) M1131V probably damaging Het
Atrn T C 2: 130,806,850 (GRCm39) probably null Het
Btaf1 A G 19: 36,963,879 (GRCm39) T817A probably benign Het
C3 C T 17: 57,512,303 (GRCm39) D1542N possibly damaging Het
Cadm3 A G 1: 173,169,236 (GRCm39) V293A probably benign Het
Cdk11b C T 4: 155,724,204 (GRCm39) probably benign Het
Cdnf A G 2: 3,522,060 (GRCm39) Y84C probably damaging Het
Chdh T C 14: 29,757,297 (GRCm39) S407P probably damaging Het
Cmtr1 C A 17: 29,904,949 (GRCm39) T300K probably damaging Het
Dennd2d A T 3: 106,389,939 (GRCm39) probably benign Het
Diaph1 T A 18: 37,986,636 (GRCm39) E1116D possibly damaging Het
Eif1ad3 A G 12: 87,843,401 (GRCm39) K16R unknown Het
Eif1ad3 A T 12: 87,843,710 (GRCm39) D119V possibly damaging Het
Enpp1 A G 10: 24,544,905 (GRCm39) probably null Het
Erbb4 T C 1: 68,079,496 (GRCm39) T1195A probably benign Het
Ermard T A 17: 15,273,638 (GRCm39) S408T probably benign Het
Etl4 A T 2: 20,812,772 (GRCm39) R1442S probably damaging Het
F13b T A 1: 139,429,508 (GRCm39) F9I unknown Het
Fnbp4 C T 2: 90,588,821 (GRCm39) R531* probably null Het
Gdf6 A G 4: 9,844,776 (GRCm39) Y100C probably damaging Het
Gpr3 T C 4: 132,938,226 (GRCm39) T149A probably damaging Het
Grm8 T C 6: 27,760,208 (GRCm39) H374R probably benign Het
Hbs1l T C 10: 21,228,501 (GRCm39) V493A probably damaging Het
Hgs A G 11: 120,368,202 (GRCm39) K277E probably damaging Het
Hnrnpul1 C T 7: 25,426,300 (GRCm39) R517Q probably damaging Het
Hoxa11 A T 6: 52,222,504 (GRCm39) Y66N probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Igdcc4 T A 9: 65,039,047 (GRCm39) L944Q probably damaging Het
Ighv3-1 C A 12: 113,928,107 (GRCm39) S84I probably damaging Het
Iqgap2 T C 13: 95,794,375 (GRCm39) D1199G probably damaging Het
Kirrel1 A G 3: 86,992,387 (GRCm39) probably null Het
Lias A T 5: 65,552,768 (GRCm39) T124S probably benign Het
Lrig3 A C 10: 125,845,656 (GRCm39) E695A probably damaging Het
Lrpap1 A G 5: 35,253,381 (GRCm39) I261T possibly damaging Het
Lrrc37a T A 11: 103,388,808 (GRCm39) T2206S unknown Het
Macf1 T A 4: 123,365,884 (GRCm39) Q2959L probably benign Het
Mis12 A G 11: 70,916,134 (GRCm39) T56A probably benign Het
Or10ag56 T A 2: 87,139,208 (GRCm39) M25K probably null Het
Or1l4 T A 2: 37,092,024 (GRCm39) I257N possibly damaging Het
Or4k41 A G 2: 111,279,848 (GRCm39) D121G probably damaging Het
Or5b99 T C 19: 12,977,235 (GRCm39) V295A probably damaging Het
Otof A T 5: 30,576,850 (GRCm39) L134Q possibly damaging Het
Pds5b T A 5: 150,717,824 (GRCm39) V1155E possibly damaging Het
Pdss2 A T 10: 43,278,518 (GRCm39) M342L probably benign Het
Phyhipl C T 10: 70,404,903 (GRCm39) V57I probably damaging Het
Plekha5 T A 6: 140,501,647 (GRCm39) probably null Het
Pnck A T X: 72,701,761 (GRCm39) V93E probably damaging Het
Proser1 A G 3: 53,385,962 (GRCm39) T615A probably damaging Het
Ptprk G A 10: 28,139,508 (GRCm39) V78I probably benign Het
Ptprv A G 1: 135,038,168 (GRCm39) noncoding transcript Het
Ranbp3l A G 15: 9,060,838 (GRCm39) N233S probably damaging Het
Rassf2 G A 2: 131,854,522 (GRCm39) P7S probably benign Het
Sart1 A T 19: 5,432,771 (GRCm39) L521Q possibly damaging Het
Scgb1b21 T A 7: 33,227,118 (GRCm39) noncoding transcript Het
Scyl2 A T 10: 89,476,458 (GRCm39) M889K probably benign Het
Secisbp2l A G 2: 125,593,785 (GRCm39) probably benign Het
Svil A G 18: 5,063,522 (GRCm39) E931G probably benign Het
Syce1 C A 7: 140,359,809 (GRCm39) L83F probably damaging Het
Tdrd1 A G 19: 56,819,505 (GRCm39) M2V probably benign Het
Tjp2 A T 19: 24,086,182 (GRCm39) V780E possibly damaging Het
Tram1 A G 1: 13,636,599 (GRCm39) V358A probably benign Het
Unc13c C T 9: 73,643,821 (GRCm39) W1214* probably null Het
Vps13b T C 15: 35,455,274 (GRCm39) C728R probably damaging Het
Wwox A G 8: 115,166,481 (GRCm39) probably benign Het
Zbtb41 G A 1: 139,357,064 (GRCm39) V440I probably benign Het
Zfp777 T C 6: 48,002,456 (GRCm39) S589G probably benign Het
Zfp955a A G 17: 33,460,675 (GRCm39) Y486H probably benign Het
Other mutations in Kcnk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00977:Kcnk10 APN 12 98,484,792 (GRCm39) missense probably damaging 0.99
IGL01409:Kcnk10 APN 12 98,456,322 (GRCm39) missense probably damaging 1.00
IGL02149:Kcnk10 APN 12 98,485,099 (GRCm39) splice site probably benign
R0467:Kcnk10 UTSW 12 98,456,204 (GRCm39) missense probably benign 0.43
R0558:Kcnk10 UTSW 12 98,402,560 (GRCm39) missense possibly damaging 0.89
R0665:Kcnk10 UTSW 12 98,406,944 (GRCm39) missense probably benign 0.00
R1033:Kcnk10 UTSW 12 98,484,929 (GRCm39) missense possibly damaging 0.93
R1036:Kcnk10 UTSW 12 98,462,445 (GRCm39) splice site probably benign
R1398:Kcnk10 UTSW 12 98,402,485 (GRCm39) missense probably damaging 0.99
R1482:Kcnk10 UTSW 12 98,456,207 (GRCm39) missense probably damaging 0.99
R1675:Kcnk10 UTSW 12 98,462,547 (GRCm39) missense probably benign 0.31
R2858:Kcnk10 UTSW 12 98,401,548 (GRCm39) missense possibly damaging 0.64
R2871:Kcnk10 UTSW 12 98,401,072 (GRCm39) missense probably benign 0.41
R2871:Kcnk10 UTSW 12 98,401,072 (GRCm39) missense probably benign 0.41
R3736:Kcnk10 UTSW 12 98,456,171 (GRCm39) missense probably benign 0.31
R3845:Kcnk10 UTSW 12 98,407,003 (GRCm39) missense probably benign 0.11
R4541:Kcnk10 UTSW 12 98,402,536 (GRCm39) missense probably damaging 1.00
R4605:Kcnk10 UTSW 12 98,456,219 (GRCm39) missense probably damaging 1.00
R4841:Kcnk10 UTSW 12 98,401,175 (GRCm39) missense probably benign 0.00
R4842:Kcnk10 UTSW 12 98,401,175 (GRCm39) missense probably benign 0.00
R4886:Kcnk10 UTSW 12 98,401,418 (GRCm39) missense possibly damaging 0.89
R4968:Kcnk10 UTSW 12 98,401,161 (GRCm39) missense probably benign 0.01
R4977:Kcnk10 UTSW 12 98,406,946 (GRCm39) missense probably benign 0.07
R5108:Kcnk10 UTSW 12 98,401,560 (GRCm39) missense probably benign 0.39
R5166:Kcnk10 UTSW 12 98,401,254 (GRCm39) missense probably damaging 0.98
R5936:Kcnk10 UTSW 12 98,456,191 (GRCm39) missense probably benign 0.12
R6193:Kcnk10 UTSW 12 98,407,031 (GRCm39) missense probably benign 0.07
R7107:Kcnk10 UTSW 12 98,485,002 (GRCm39) nonsense probably null
R7611:Kcnk10 UTSW 12 98,484,899 (GRCm39) missense probably damaging 1.00
R7687:Kcnk10 UTSW 12 98,401,355 (GRCm39) missense probably damaging 0.97
R8225:Kcnk10 UTSW 12 98,406,849 (GRCm39) critical splice donor site probably null
R8270:Kcnk10 UTSW 12 98,401,358 (GRCm39) missense
R9040:Kcnk10 UTSW 12 98,401,098 (GRCm39) missense probably benign 0.00
R9094:Kcnk10 UTSW 12 98,484,775 (GRCm39) missense probably benign 0.01
X0067:Kcnk10 UTSW 12 98,485,083 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TAAGGCACGTGTCTCAGTG -3'
(R):5'- GCGCTTCTGAGGACAACATC -3'

Sequencing Primer
(F):5'- ACGTGTCTCAGTGTGAATATTAAAAC -3'
(R):5'- TCATCAACAAGTTTGGGTCCAC -3'
Posted On 2015-05-15