Incidental Mutation 'R4085:Dynlrb1'
ID 317067
Institutional Source Beutler Lab
Gene Symbol Dynlrb1
Ensembl Gene ENSMUSG00000047459
Gene Name dynein light chain roadblock-type 1
Synonyms km23-1, 2010320M17Rik, 2010012N15Rik, DNLC2A, Dncl2a
MMRRC Submission 040979-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4085 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 155078453-155092197 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) G to T at 155091896 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109682] [ENSMUST00000150602]
AlphaFold P62627
Predicted Effect noncoding transcript
Transcript: ENSMUST00000054912
Predicted Effect probably benign
Transcript: ENSMUST00000109682
SMART Domains Protein: ENSMUSP00000105304
Gene: ENSMUSG00000047459

DomainStartEndE-ValueType
Robl_LC7 4 92 1.92e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135831
Predicted Effect probably benign
Transcript: ENSMUST00000150602
SMART Domains Protein: ENSMUSP00000114928
Gene: ENSMUSG00000047459

DomainStartEndE-ValueType
Robl_LC7 12 100 1.92e-21 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
Abca15 T C 7: 119,981,949 (GRCm39) V1088A probably damaging Het
Adgrl3 A G 5: 81,660,391 (GRCm39) I319V probably benign Het
Atraid A T 5: 31,209,650 (GRCm39) probably benign Het
Aurkaip1 A T 4: 155,917,362 (GRCm39) K172N probably benign Het
Bicd2 T A 13: 49,538,438 (GRCm39) probably null Het
Ccr1 C T 9: 123,763,987 (GRCm39) R181H probably benign Het
Cep250 G A 2: 155,834,552 (GRCm39) R2159K probably damaging Het
Cldn34c4 A T X: 126,629,011 (GRCm39) V153E probably damaging Het
Col4a4 C A 1: 82,448,909 (GRCm39) probably null Het
Coro1b T C 19: 4,203,618 (GRCm39) V451A probably benign Het
Dcc T A 18: 71,959,240 (GRCm39) Q177H probably benign Het
Ddx4 A G 13: 112,750,295 (GRCm39) V386A probably benign Het
Ehbp1 A T 11: 22,045,898 (GRCm39) L592Q possibly damaging Het
Fam20b T C 1: 156,533,445 (GRCm39) D57G probably benign Het
Fbxo33 A G 12: 59,247,591 (GRCm39) probably benign Het
Fndc4 A G 5: 31,451,121 (GRCm39) I190T probably damaging Het
Gad1 G T 2: 70,420,192 (GRCm39) A359S probably benign Het
Gkn3 C T 6: 87,360,507 (GRCm39) A163T probably damaging Het
Gm43517 A G 12: 49,437,897 (GRCm39) probably benign Het
Hectd1 A T 12: 51,821,533 (GRCm39) V1052D possibly damaging Het
Herc6 G A 6: 57,624,054 (GRCm39) C608Y probably benign Het
Itpr2 T A 6: 146,045,746 (GRCm39) D2573V probably damaging Het
Kank2 A G 9: 21,706,415 (GRCm39) L201P probably damaging Het
Kdm1a A C 4: 136,279,273 (GRCm39) Y762* probably null Het
Mef2c C T 13: 83,723,821 (GRCm39) T9M probably damaging Het
Ndst4 A G 3: 125,403,131 (GRCm39) I413V probably benign Het
Nlrp1b T C 11: 71,052,588 (GRCm39) T947A probably damaging Het
Nlrp5 C A 7: 23,129,523 (GRCm39) N863K probably damaging Het
Opn1sw A G 6: 29,380,143 (GRCm39) I91T possibly damaging Het
Or2y13 T C 11: 49,414,955 (GRCm39) I135T probably benign Het
Pmfbp1 A G 8: 110,221,579 (GRCm39) K15E possibly damaging Het
Ppp3cb A G 14: 20,558,611 (GRCm39) C484R possibly damaging Het
Rassf2 C A 2: 131,846,299 (GRCm39) G153C probably damaging Het
Rbm15b T C 9: 106,762,936 (GRCm39) N411D possibly damaging Het
Rbm47 A G 5: 66,180,080 (GRCm39) M409T probably benign Het
Sall1 C T 8: 89,755,137 (GRCm39) V1281M probably benign Het
Sall3 A T 18: 81,015,348 (GRCm39) M860K probably damaging Het
Sik2 A T 9: 50,846,685 (GRCm39) probably benign Het
Sim2 A G 16: 93,910,213 (GRCm39) Y205C possibly damaging Het
Styxl1 G A 5: 135,788,019 (GRCm39) T92I unknown Het
Sypl2 A G 3: 108,124,992 (GRCm39) I123T possibly damaging Het
Taok2 T C 7: 126,473,897 (GRCm39) E403G possibly damaging Het
Tedc2 A T 17: 24,438,813 (GRCm39) V168E probably benign Het
Tle6 A G 10: 81,430,349 (GRCm39) probably null Het
Traf3ip3 A G 1: 192,863,628 (GRCm39) V414A probably damaging Het
Trim14 T A 4: 46,523,709 (GRCm39) T110S probably benign Het
Ucp1 T C 8: 84,020,580 (GRCm39) I130T probably benign Het
Urb2 A G 8: 124,757,680 (GRCm39) H1129R probably benign Het
Vmn2r111 C T 17: 22,778,096 (GRCm39) G528R probably benign Het
Wbp2nl A G 15: 82,192,762 (GRCm39) M149V probably benign Het
Xdh A T 17: 74,223,874 (GRCm39) M506K probably benign Het
Other mutations in Dynlrb1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3078:Dynlrb1 UTSW 2 155,091,865 (GRCm39) missense probably damaging 1.00
R8359:Dynlrb1 UTSW 2 155,091,870 (GRCm39) missense probably benign 0.00
R8558:Dynlrb1 UTSW 2 155,084,728 (GRCm39) critical splice donor site probably null
R9320:Dynlrb1 UTSW 2 155,089,860 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- ACTTGGCAGCAGACAGTAAG -3'
(R):5'- CTCATTCCAAAGCCTGCAAGG -3'

Sequencing Primer
(F):5'- AGGAACTTGGTTACTTCCTGC -3'
(R):5'- CTGCAAGGGCGAACTGATTC -3'
Posted On 2015-05-15