Incidental Mutation 'R4087:Gkn3'
ID 317418
Institutional Source Beutler Lab
Gene Symbol Gkn3
Ensembl Gene ENSMUSG00000030048
Gene Name gastrokine 3
Synonyms 1190003M12Rik
MMRRC Submission 040980-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R4087 (G1)
Quality Score 217
Status Validated
Chromosome 6
Chromosomal Location 87360301-87365917 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 87360507 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 163 (A163T)
Ref Sequence ENSEMBL: ENSMUSP00000032127 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032127] [ENSMUST00000032128]
AlphaFold Q9D0T7
Predicted Effect probably damaging
Transcript: ENSMUST00000032127
AA Change: A163T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000032127
Gene: ENSMUSG00000030048
AA Change: A163T

DomainStartEndE-ValueType
transmembrane domain 13 32 N/A INTRINSIC
BRICHOS 63 155 1.47e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000032128
SMART Domains Protein: ENSMUSP00000032128
Gene: ENSMUSG00000030049

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
BRICHOS 54 151 6.63e-34 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.7%
  • 20x: 96.3%
Validation Efficiency 96% (50/52)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik A G 17: 48,473,678 (GRCm39) S80P probably damaging Het
Acss3 T G 10: 106,889,313 (GRCm39) Y169S probably damaging Het
Cep250 G A 2: 155,834,552 (GRCm39) R2159K probably damaging Het
Cldn34c4 A T X: 126,629,011 (GRCm39) V153E probably damaging Het
Col4a4 T A 1: 82,501,643 (GRCm39) Y370F unknown Het
Col6a6 A T 9: 105,661,155 (GRCm39) I318N possibly damaging Het
Csmd1 T A 8: 16,042,738 (GRCm39) I2332F probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Dym T A 18: 75,363,172 (GRCm39) Y559N probably damaging Het
Eif3g A G 9: 20,809,248 (GRCm39) V59A possibly damaging Het
Fam171a1 G A 2: 3,227,333 (GRCm39) R697Q probably damaging Het
Fermt3 T A 19: 6,980,945 (GRCm39) probably null Het
Git2 A G 5: 114,902,466 (GRCm39) Y189H probably damaging Het
Gm7713 C T 15: 59,866,258 (GRCm39) noncoding transcript Het
Gpr108 A G 17: 57,544,925 (GRCm39) Y313H probably damaging Het
Itprid2 C T 2: 79,488,691 (GRCm39) Q925* probably null Het
Kcnh8 T C 17: 53,110,428 (GRCm39) I213T possibly damaging Het
Lpgat1 A T 1: 191,495,728 (GRCm39) I306F possibly damaging Het
Mapk8 T C 14: 33,112,205 (GRCm39) T228A probably benign Het
Med12l T C 3: 59,205,342 (GRCm39) V2101A probably benign Het
Mettl13 T C 1: 162,375,771 (GRCm39) K19E possibly damaging Het
Mta1 A G 12: 113,075,802 (GRCm39) Y22C probably damaging Het
Notch3 T C 17: 32,377,087 (GRCm39) T273A possibly damaging Het
Notch4 T C 17: 34,803,409 (GRCm39) W1443R probably damaging Het
Npy5r T A 8: 67,134,697 (GRCm39) D32V probably damaging Het
Or8k36-ps1 C A 2: 86,437,297 (GRCm39) *206L probably null Het
Rbm47 A G 5: 66,180,080 (GRCm39) M409T probably benign Het
Rnf144a C T 12: 26,377,591 (GRCm39) V51I probably damaging Het
Rxfp1 T A 3: 79,552,256 (GRCm39) T682S probably damaging Het
Sertad2 GCCCC GCCCCC 11: 20,598,664 (GRCm39) probably null Het
Sos1 A G 17: 80,756,781 (GRCm39) V257A probably benign Het
Tdrd9 C T 12: 111,979,920 (GRCm39) Q256* probably null Het
Tmprss11d A T 5: 86,457,138 (GRCm39) S174T probably damaging Het
Tor1b T A 2: 30,846,531 (GRCm39) I238N probably damaging Het
Tppp2 T C 14: 52,156,957 (GRCm39) probably null Het
Traf3ip3 A G 1: 192,863,628 (GRCm39) V414A probably damaging Het
Trim14 T A 4: 46,523,709 (GRCm39) T110S probably benign Het
Trim30d T C 7: 104,137,007 (GRCm39) N66D probably damaging Het
Usp48 A G 4: 137,350,651 (GRCm39) N46S possibly damaging Het
Vmn2r115 A C 17: 23,565,358 (GRCm39) Q415P probably benign Het
Wbp2nl A G 15: 82,192,762 (GRCm39) M149V probably benign Het
Zfp106 T C 2: 120,357,380 (GRCm39) probably null Het
Zfp281 T A 1: 136,553,859 (GRCm39) I279N probably damaging Het
Other mutations in Gkn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02170:Gkn3 APN 6 87,360,493 (GRCm39) missense possibly damaging 0.70
IGL02746:Gkn3 APN 6 87,364,339 (GRCm39) splice site probably benign
IGL03345:Gkn3 APN 6 87,365,798 (GRCm39) missense probably null 0.09
R1758:Gkn3 UTSW 6 87,365,817 (GRCm39) start codon destroyed probably benign
R2303:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2304:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2363:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2365:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2897:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2898:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2983:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R3031:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R3426:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R3433:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4085:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4086:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4088:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4089:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4090:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4163:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4164:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4720:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4721:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4722:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4723:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4766:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4941:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R5004:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R5163:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R6078:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R6079:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R6502:Gkn3 UTSW 6 87,365,786 (GRCm39) missense probably benign 0.01
R6924:Gkn3 UTSW 6 87,365,784 (GRCm39) missense probably benign 0.05
R7695:Gkn3 UTSW 6 87,361,422 (GRCm39) missense probably damaging 1.00
R9240:Gkn3 UTSW 6 87,365,789 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAGGTAGAAATGCACTTATTCCCC -3'
(R):5'- GCTAAGGGGTTACAAAGCGC -3'

Sequencing Primer
(F):5'- CCAGATCACAAGGTTCCATGGG -3'
(R):5'- GGTTACAAAGCGCAATAAAAGAACC -3'
Posted On 2015-05-15