Incidental Mutation 'R4091:Wdcp'
ID 317627
Institutional Source Beutler Lab
Gene Symbol Wdcp
Ensembl Gene ENSMUSG00000051721
Gene Name WD repeat and coiled coil containing
Synonyms BC068281
MMRRC Submission 041626-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.707) question?
Stock # R4091 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 4893303-4910043 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 4905279 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 600 (N600S)
Ref Sequence ENSEMBL: ENSMUSP00000151585 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053034] [ENSMUST00000085793] [ENSMUST00000085793] [ENSMUST00000220170] [ENSMUST00000220215] [ENSMUST00000223551]
AlphaFold Q6NV72
Predicted Effect probably benign
Transcript: ENSMUST00000053034
SMART Domains Protein: ENSMUSP00000054102
Gene: ENSMUSG00000051721

DomainStartEndE-ValueType
Pfam:DUF4613 2 610 1.9e-260 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000085793
AA Change: N600S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000082948
Gene: ENSMUSG00000051721
AA Change: N600S

DomainStartEndE-ValueType
Pfam:DUF4613 2 643 2.4e-280 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000085793
AA Change: N600S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000082948
Gene: ENSMUSG00000051721
AA Change: N600S

DomainStartEndE-ValueType
Pfam:DUF4613 2 643 2.4e-280 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000220170
Predicted Effect probably null
Transcript: ENSMUST00000220215
AA Change: N600S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably null
Transcript: ENSMUST00000223551
AA Change: N600S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency 98% (61/62)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik T C 2: 68,575,722 (GRCm39) S674P possibly damaging Het
Abca3 C T 17: 24,616,456 (GRCm39) T966M probably damaging Het
Adam2 A T 14: 66,267,172 (GRCm39) Y696N probably damaging Het
Alas1 G T 9: 106,119,000 (GRCm39) probably null Het
Arhgap25 G T 6: 87,440,017 (GRCm39) S543R probably benign Het
Bckdk C A 7: 127,504,590 (GRCm39) R105S probably damaging Het
Bltp1 G A 3: 37,084,738 (GRCm39) A3897T probably benign Het
Carns1 C T 19: 4,221,682 (GRCm39) R191Q probably damaging Het
Casp8ap2 C A 4: 32,643,611 (GRCm39) P895T probably damaging Het
Col12a1 T A 9: 79,609,646 (GRCm39) I287F probably damaging Het
Cystm1 A G 18: 36,499,600 (GRCm39) N5S unknown Het
Dnah8 T C 17: 30,988,813 (GRCm39) V3261A probably damaging Het
Dnajc11 A G 4: 152,062,550 (GRCm39) probably benign Het
Dock4 T C 12: 40,894,266 (GRCm39) S1847P probably damaging Het
Dync2h1 A G 9: 7,131,881 (GRCm39) V1642A probably benign Het
Eftud2 T C 11: 102,730,242 (GRCm39) probably null Het
Fam221b A G 4: 43,665,987 (GRCm39) I208T probably benign Het
Gpr141b T A 13: 19,913,635 (GRCm39) noncoding transcript Het
Gpr37l1 T C 1: 135,089,301 (GRCm39) I255V probably benign Het
Grm7 G A 6: 110,891,301 (GRCm39) S178N probably damaging Het
Hspa12b T A 2: 130,975,408 (GRCm39) probably null Het
Kctd3 A T 1: 188,727,917 (GRCm39) probably benign Het
Kynu G A 2: 43,569,884 (GRCm39) V389M possibly damaging Het
Lcat A G 8: 106,666,538 (GRCm39) L328P probably benign Het
Lrrn2 C T 1: 132,865,390 (GRCm39) Q152* probably null Het
Maml1 G A 11: 50,182,656 (GRCm39) P78L probably benign Het
Mef2b G A 8: 70,617,752 (GRCm39) V37M probably damaging Het
Mindy2 A T 9: 70,541,342 (GRCm39) M281K probably damaging Het
Mon2 C T 10: 122,874,415 (GRCm39) R311H probably damaging Het
Mtr A T 13: 12,245,943 (GRCm39) V394E probably damaging Het
Myh14 T A 7: 44,282,415 (GRCm39) T745S possibly damaging Het
Nme9 T A 9: 99,346,580 (GRCm39) D131E possibly damaging Het
Nphp4 C A 4: 152,631,475 (GRCm39) Q792K probably damaging Het
Nrxn2 T A 19: 6,523,444 (GRCm39) C479S probably damaging Het
Nsmf T C 2: 24,950,871 (GRCm39) I406T probably damaging Het
Or10a49 G A 7: 108,467,650 (GRCm39) A237V probably damaging Het
Or5an9 A T 19: 12,187,143 (GRCm39) D71V probably damaging Het
Or8g28 T A 9: 39,169,330 (GRCm39) I213F possibly damaging Het
Pbrm1 A G 14: 30,757,960 (GRCm39) T197A probably benign Het
Pla2r1 T A 2: 60,262,937 (GRCm39) N1034I probably damaging Het
Rps6-ps2 A G 8: 89,533,319 (GRCm39) noncoding transcript Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Rxfp1 A T 3: 79,552,068 (GRCm39) D744E probably benign Het
Samd9l T C 6: 3,376,887 (GRCm39) N125D probably benign Het
Serpina3a G A 12: 104,082,625 (GRCm39) V133I probably benign Het
Slc22a30 C T 19: 8,381,909 (GRCm39) V121M probably damaging Het
Smarcc1 T A 9: 109,993,897 (GRCm39) D247E possibly damaging Het
Smg9 T A 7: 24,120,292 (GRCm39) L422Q probably null Het
Speer3 C G 5: 13,846,394 (GRCm39) A238G possibly damaging Het
Tle5 G A 10: 81,401,418 (GRCm39) G162D probably damaging Het
Ttc23l CT CTTGGATT 15: 10,537,648 (GRCm39) probably benign Het
Ttc23l G A 15: 10,537,652 (GRCm39) S206L probably benign Het
Utrn T A 10: 12,585,915 (GRCm39) D954V probably benign Het
Vmn1r227 T A 17: 20,955,778 (GRCm39) noncoding transcript Het
Vmn2r11 A C 5: 109,202,616 (GRCm39) probably null Het
Vmn2r84 A T 10: 130,227,238 (GRCm39) M200K probably damaging Het
Vmn2r88 T A 14: 51,652,883 (GRCm39) Y469N probably damaging Het
Wdfy4 T G 14: 32,847,837 (GRCm39) R838S possibly damaging Het
Other mutations in Wdcp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00770:Wdcp APN 12 4,905,303 (GRCm39) missense probably damaging 1.00
IGL00774:Wdcp APN 12 4,905,303 (GRCm39) missense probably damaging 1.00
IGL02327:Wdcp APN 12 4,901,115 (GRCm39) missense possibly damaging 0.95
IGL02725:Wdcp APN 12 4,901,206 (GRCm39) missense probably damaging 1.00
IGL03377:Wdcp APN 12 4,900,691 (GRCm39) nonsense probably null
IGL03381:Wdcp APN 12 4,901,926 (GRCm39) missense probably damaging 1.00
R0152:Wdcp UTSW 12 4,901,583 (GRCm39) missense probably benign 0.06
R0317:Wdcp UTSW 12 4,901,583 (GRCm39) missense probably benign 0.06
R1077:Wdcp UTSW 12 4,900,685 (GRCm39) missense probably damaging 1.00
R1136:Wdcp UTSW 12 4,901,655 (GRCm39) missense possibly damaging 0.78
R1571:Wdcp UTSW 12 4,901,924 (GRCm39) nonsense probably null
R1653:Wdcp UTSW 12 4,901,815 (GRCm39) missense probably damaging 1.00
R1848:Wdcp UTSW 12 4,900,245 (GRCm39) missense possibly damaging 0.86
R5126:Wdcp UTSW 12 4,900,617 (GRCm39) missense probably damaging 0.98
R6148:Wdcp UTSW 12 4,900,621 (GRCm39) missense possibly damaging 0.74
R6529:Wdcp UTSW 12 4,901,143 (GRCm39) missense probably damaging 1.00
R6800:Wdcp UTSW 12 4,901,358 (GRCm39) missense probably damaging 1.00
R7432:Wdcp UTSW 12 4,900,246 (GRCm39) missense probably damaging 1.00
R7821:Wdcp UTSW 12 4,907,975 (GRCm39) missense probably benign 0.07
R8182:Wdcp UTSW 12 4,901,850 (GRCm39) missense probably damaging 1.00
R8553:Wdcp UTSW 12 4,902,024 (GRCm39) intron probably benign
R8845:Wdcp UTSW 12 4,901,439 (GRCm39) missense probably benign 0.26
R9134:Wdcp UTSW 12 4,901,533 (GRCm39) nonsense probably null
R9609:Wdcp UTSW 12 4,900,258 (GRCm39) missense probably damaging 0.98
U24488:Wdcp UTSW 12 4,900,405 (GRCm39) missense probably damaging 1.00
X0026:Wdcp UTSW 12 4,901,077 (GRCm39) nonsense probably null
Z1088:Wdcp UTSW 12 4,900,825 (GRCm39) missense probably damaging 1.00
Z1176:Wdcp UTSW 12 4,901,785 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CGTGACTTCAAAGAGTGTGTG -3'
(R):5'- ACAGTTCCATTTCCATTCCTGAAG -3'

Sequencing Primer
(F):5'- AGATAGGGTCTCACTGTGTAAGCC -3'
(R):5'- TGAAGCTTCAGAACAGAAGGGATG -3'
Posted On 2015-05-15