Incidental Mutation 'R4095:Or8s10'
ID 317884
Institutional Source Beutler Lab
Gene Symbol Or8s10
Ensembl Gene ENSMUSG00000063780
Gene Name olfactory receptor family 8 subfamily S member 1
Synonyms MOR160-2, Olfr282, GA_x6K02T2NBG7-5293798-5292872
MMRRC Submission 040858-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R4095 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 98335351-98336278 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 98335563 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 71 (L71P)
Ref Sequence ENSEMBL: ENSMUSP00000151156 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075851] [ENSMUST00000205491] [ENSMUST00000213608] [ENSMUST00000215320]
AlphaFold A1L1B4
Predicted Effect probably damaging
Transcript: ENSMUST00000075851
AA Change: L71P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000075248
Gene: ENSMUSG00000063780
AA Change: L71P

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 7.6e-55 PFAM
Pfam:7TM_GPCR_Srsx 35 217 5.7e-6 PFAM
Pfam:7tm_1 41 288 2.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205491
Predicted Effect probably damaging
Transcript: ENSMUST00000213608
AA Change: L71P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000215320
AA Change: L71P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Meta Mutation Damage Score 0.8331 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.8%
Validation Efficiency 97% (59/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap6 A T 12: 53,186,245 (GRCm39) I1220L probably damaging Het
Alas1 G T 9: 106,119,000 (GRCm39) probably null Het
Apba1 A T 19: 23,921,388 (GRCm39) Q737L probably benign Het
Arvcf T A 16: 18,220,327 (GRCm39) D564E probably damaging Het
Bcl11b G T 12: 107,883,094 (GRCm39) P335Q probably damaging Het
Brd9 G A 13: 74,092,918 (GRCm39) V302I probably benign Het
Brinp3 C A 1: 146,777,430 (GRCm39) H626N possibly damaging Het
C1qc T C 4: 136,617,637 (GRCm39) N153S probably benign Het
Casp3 G A 8: 47,087,251 (GRCm39) G66D probably damaging Het
Coq7 T G 7: 118,126,701 (GRCm39) probably null Het
Dach1 C T 14: 98,138,815 (GRCm39) V491M possibly damaging Het
Dda1 A G 8: 71,926,436 (GRCm39) T52A possibly damaging Het
Entpd7 A G 19: 43,692,640 (GRCm39) Y65C probably damaging Het
Fmnl2 A G 2: 52,991,535 (GRCm39) D350G probably damaging Het
Foxn3 G T 12: 99,162,700 (GRCm39) D400E probably damaging Het
Gbp2 A G 3: 142,343,210 (GRCm39) T576A probably benign Het
Gm15446 T A 5: 110,088,590 (GRCm39) probably null Het
Gtf2a1 G T 12: 91,542,411 (GRCm39) T57K possibly damaging Het
Hps5 T C 7: 46,425,218 (GRCm39) E494G probably benign Het
Htr2a G A 14: 74,943,789 (GRCm39) M456I probably benign Het
Hydin A G 8: 111,268,179 (GRCm39) N2886S probably damaging Het
Ighv2-6-8 T C 12: 113,759,773 (GRCm39) Y112C probably damaging Het
Kcnf1 A T 12: 17,225,480 (GRCm39) L247Q possibly damaging Het
Kndc1 A G 7: 139,516,938 (GRCm39) M1606V possibly damaging Het
Krt27 T C 11: 99,236,619 (GRCm39) T431A probably benign Het
Lama4 A T 10: 38,973,118 (GRCm39) I1562F probably damaging Het
Lrig1 T C 6: 94,590,559 (GRCm39) D487G probably benign Het
Lrp1b G A 2: 41,339,203 (GRCm39) T880I probably benign Het
Ltbp4 A G 7: 27,024,641 (GRCm39) V663A possibly damaging Het
Mapt T C 11: 104,201,362 (GRCm39) probably null Het
Mpdz A T 4: 81,302,060 (GRCm39) V229D possibly damaging Het
Or10am5 T A 7: 6,518,252 (GRCm39) S59C possibly damaging Het
Or6e1 T C 14: 54,520,188 (GRCm39) T55A probably benign Het
Parm1 T C 5: 91,742,039 (GRCm39) S136P probably benign Het
Pcdhgb2 T A 18: 37,824,003 (GRCm39) S331R probably benign Het
Pdxk T C 10: 78,300,644 (GRCm39) H13R probably damaging Het
Ppp1r12c T C 7: 4,486,366 (GRCm39) E601G probably damaging Het
Rell1 C A 5: 64,126,013 (GRCm39) V22L probably benign Het
Sema6c T A 3: 95,080,505 (GRCm39) L901Q probably benign Het
Sfswap A G 5: 129,637,805 (GRCm39) S821G possibly damaging Het
Slc22a23 A G 13: 34,489,189 (GRCm39) L116P probably damaging Het
Slit1 A T 19: 41,596,925 (GRCm39) probably benign Het
Spns1 T C 7: 125,969,958 (GRCm39) T481A probably damaging Het
Tmem104 T A 11: 115,134,749 (GRCm39) Y427* probably null Het
Tmem74 G A 15: 43,730,678 (GRCm39) Q122* probably null Het
Tnpo2 T A 8: 85,765,048 (GRCm39) L10Q probably damaging Het
Trav6-2 G T 14: 52,905,272 (GRCm39) A98S probably benign Het
Ttll5 A T 12: 86,003,376 (GRCm39) R214* probably null Het
Ube2b A C 11: 51,888,654 (GRCm39) V39G possibly damaging Het
Vmn1r185 A T 7: 26,311,208 (GRCm39) V99E probably damaging Het
Wnk1 G A 6: 119,925,087 (GRCm39) T1459I probably damaging Het
Zc3h7a T C 16: 10,963,099 (GRCm39) K754R probably damaging Het
Zfp605 A G 5: 110,275,602 (GRCm39) K240R probably damaging Het
Zfp61 A G 7: 23,990,700 (GRCm39) probably null Het
Other mutations in Or8s10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01813:Or8s10 APN 15 98,335,530 (GRCm39) missense possibly damaging 0.95
IGL02724:Or8s10 APN 15 98,335,660 (GRCm39) missense probably benign 0.09
IGL03104:Or8s10 APN 15 98,336,127 (GRCm39) missense possibly damaging 0.93
R0611:Or8s10 UTSW 15 98,336,168 (GRCm39) missense possibly damaging 0.95
R3008:Or8s10 UTSW 15 98,335,857 (GRCm39) missense probably damaging 1.00
R4093:Or8s10 UTSW 15 98,335,563 (GRCm39) missense probably damaging 1.00
R4094:Or8s10 UTSW 15 98,335,563 (GRCm39) missense probably damaging 1.00
R4579:Or8s10 UTSW 15 98,335,560 (GRCm39) missense probably damaging 1.00
R4647:Or8s10 UTSW 15 98,335,457 (GRCm39) missense probably benign 0.00
R5290:Or8s10 UTSW 15 98,336,213 (GRCm39) missense probably damaging 1.00
R7991:Or8s10 UTSW 15 98,335,419 (GRCm39) missense probably benign 0.00
R8927:Or8s10 UTSW 15 98,336,519 (GRCm39) splice site probably benign
R9208:Or8s10 UTSW 15 98,335,614 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TAATGGCCTGGAGCAACCAC -3'
(R):5'- TTTCTCATCACCTGGCCGTAGAG -3'

Sequencing Primer
(F):5'- ACAGCGTCATCACGGAGTTC -3'
(R):5'- CCGTAGAGCAGGGGATGGC -3'
Posted On 2015-05-15