Incidental Mutation 'R4171:Rab29'
ID 318122
Institutional Source Beutler Lab
Gene Symbol Rab29
Ensembl Gene ENSMUSG00000026433
Gene Name RAB29, member RAS oncogene family
Synonyms Rab7l1
MMRRC Submission 041011-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4171 (G1)
Quality Score 202
Status Validated
Chromosome 1
Chromosomal Location 131794962-131800625 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 131795475 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 29 (Q29R)
Ref Sequence ENSEMBL: ENSMUSP00000108005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027693] [ENSMUST00000112386] [ENSMUST00000125925]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000027693
AA Change: Q29R

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000027693
Gene: ENSMUSG00000026433
AA Change: Q29R

DomainStartEndE-ValueType
RAB 8 176 2.25e-63 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112386
AA Change: Q29R

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000108005
Gene: ENSMUSG00000026433
AA Change: Q29R

DomainStartEndE-ValueType
RAB 8 176 2.25e-63 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125925
AA Change: Q29R

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187084
Meta Mutation Damage Score 0.0954 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
2310022A10Rik A G 7: 27,265,109 (GRCm39) N87S probably benign Het
Apmap A G 2: 150,425,987 (GRCm39) V387A probably benign Het
B130024G19Rik C T 7: 70,038,454 (GRCm39) noncoding transcript Het
Cd200r1 A G 16: 44,613,127 (GRCm39) I244M probably damaging Het
Clic6 T C 16: 92,293,949 (GRCm39) probably benign Het
Col11a1 A G 3: 114,001,863 (GRCm39) D429G probably damaging Het
Dsg4 T A 18: 20,591,636 (GRCm39) Y458* probably null Het
Elapor1 G T 3: 108,368,259 (GRCm39) Q885K probably benign Het
Fbxl13 A G 5: 21,748,786 (GRCm39) Y378H probably benign Het
Ifi203 A C 1: 173,761,341 (GRCm39) probably benign Het
Ifna6 T C 4: 88,746,038 (GRCm39) V129A probably benign Het
Igkv3-4 G A 6: 70,649,324 (GRCm39) A108T probably damaging Het
Itga1 G A 13: 115,167,422 (GRCm39) Q165* probably null Het
Kdm4c T A 4: 74,199,135 (GRCm39) Y108N possibly damaging Het
Lap3 T C 5: 45,666,833 (GRCm39) S412P probably benign Het
Lrfn5 G A 12: 61,890,168 (GRCm39) V486I probably damaging Het
Mep1b A T 18: 21,228,163 (GRCm39) probably null Het
Mettl6 T C 14: 31,215,624 (GRCm39) N52S probably damaging Het
Nup54 A G 5: 92,565,343 (GRCm39) I458T possibly damaging Het
Or1e16 A C 11: 73,286,365 (GRCm39) L161R probably damaging Het
Or6c204 G A 10: 129,022,453 (GRCm39) A279V probably benign Het
Pecr A T 1: 72,315,428 (GRCm39) N107K probably damaging Het
Pnpla6 A G 8: 3,593,997 (GRCm39) Q1307R probably benign Het
Poll T C 19: 45,544,492 (GRCm39) K310E probably damaging Het
Reg2 G A 6: 78,383,574 (GRCm39) G99D probably damaging Het
Rftn2 G A 1: 55,253,429 (GRCm39) S58L probably damaging Het
Rps6kb1 T C 11: 86,435,405 (GRCm39) E43G possibly damaging Het
Sdk2 T C 11: 113,757,815 (GRCm39) probably null Het
Slc38a6 T A 12: 73,397,326 (GRCm39) Y323N probably benign Het
Sp100 T C 1: 85,634,562 (GRCm39) S152P probably benign Het
Tmc5 A G 7: 118,248,810 (GRCm39) Y605C probably damaging Het
Txndc17 T C 11: 72,098,537 (GRCm39) Y30H probably damaging Het
Vmn1r44 T A 6: 89,870,996 (GRCm39) F247L probably damaging Het
Zbtb39 C T 10: 127,578,236 (GRCm39) T270I possibly damaging Het
Zfp512b G A 2: 181,232,391 (GRCm39) probably null Het
Zwilch T A 9: 64,065,997 (GRCm39) R255* probably null Het
Other mutations in Rab29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01539:Rab29 APN 1 131,798,445 (GRCm39) missense probably damaging 1.00
IGL02339:Rab29 APN 1 131,799,880 (GRCm39) missense probably benign 0.08
IGL02528:Rab29 APN 1 131,797,749 (GRCm39) splice site probably benign
R1728:Rab29 UTSW 1 131,799,848 (GRCm39) missense probably benign
R1729:Rab29 UTSW 1 131,799,848 (GRCm39) missense probably benign
R1730:Rab29 UTSW 1 131,799,848 (GRCm39) missense probably benign
R1739:Rab29 UTSW 1 131,799,848 (GRCm39) missense probably benign
R1762:Rab29 UTSW 1 131,799,848 (GRCm39) missense probably benign
R1783:Rab29 UTSW 1 131,799,848 (GRCm39) missense probably benign
R1784:Rab29 UTSW 1 131,799,848 (GRCm39) missense probably benign
R1785:Rab29 UTSW 1 131,799,848 (GRCm39) missense probably benign
R4193:Rab29 UTSW 1 131,797,700 (GRCm39) missense possibly damaging 0.61
R4516:Rab29 UTSW 1 131,795,469 (GRCm39) missense possibly damaging 0.94
R4559:Rab29 UTSW 1 131,800,305 (GRCm39) nonsense probably null
R7739:Rab29 UTSW 1 131,799,923 (GRCm39) missense probably damaging 0.99
R9310:Rab29 UTSW 1 131,799,860 (GRCm39) missense probably damaging 0.98
R9483:Rab29 UTSW 1 131,795,508 (GRCm39) missense possibly damaging 0.63
Predicted Primers PCR Primer
(F):5'- TGGAGATGCCTGACTTCAATTGG -3'
(R):5'- CTCTCTGCGGTGAATAGTCC -3'

Sequencing Primer
(F):5'- TTCAATTGGAAGAGAACCCGG -3'
(R):5'- TGAATAGTCCCCGGCTCAGAC -3'
Posted On 2015-06-10