Incidental Mutation 'R4196:Vmn1r225'
ID 318577
Institutional Source Beutler Lab
Gene Symbol Vmn1r225
Ensembl Gene ENSMUSG00000043537
Gene Name vomeronasal 1 receptor 225
Synonyms V1re5
MMRRC Submission 041027-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R4196 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 20722561-20723457 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 20723237 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 226 (M226K)
Ref Sequence ENSEMBL: ENSMUSP00000056068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061660]
AlphaFold Q8R2A5
Predicted Effect probably benign
Transcript: ENSMUST00000061660
AA Change: M226K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000056068
Gene: ENSMUSG00000043537
AA Change: M226K

DomainStartEndE-ValueType
Pfam:TAS2R 1 287 8.9e-15 PFAM
Pfam:V1R 11 291 3.1e-24 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.8%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acmsd T G 1: 127,676,931 (GRCm39) L152R probably damaging Het
Ankle2 A G 5: 110,392,409 (GRCm39) K472E possibly damaging Het
Aup1 T C 6: 83,032,211 (GRCm39) V126A probably damaging Het
Baz1a T C 12: 54,958,200 (GRCm39) Y1014C probably damaging Het
Bcl9 A T 3: 97,123,684 (GRCm39) probably benign Het
Bltp2 A G 11: 78,154,382 (GRCm39) probably benign Het
Cnot2 A T 10: 116,337,209 (GRCm39) N221K possibly damaging Het
Col19a1 G A 1: 24,573,133 (GRCm39) S213L unknown Het
Eif4enif1 T C 11: 3,193,186 (GRCm39) V675A possibly damaging Het
Elp1 A T 4: 56,755,353 (GRCm39) N1295K probably damaging Het
Elp3 A G 14: 65,785,451 (GRCm39) L450P probably damaging Het
Erbb4 C T 1: 68,383,014 (GRCm39) D328N possibly damaging Het
Fbll1 T A 11: 35,688,699 (GRCm39) H188L possibly damaging Het
Frem2 A G 3: 53,446,689 (GRCm39) F2360L possibly damaging Het
Gm2396 A G 9: 88,799,715 (GRCm39) noncoding transcript Het
Gulo G T 14: 66,225,702 (GRCm39) P375T possibly damaging Het
Hspd1 T C 1: 55,126,068 (GRCm39) M11V probably benign Het
Itgav A G 2: 83,598,671 (GRCm39) T243A probably benign Het
Lipg C T 18: 75,078,902 (GRCm39) R450H probably damaging Het
Lrp3 T A 7: 34,902,835 (GRCm39) S504C probably damaging Het
Mrps9 T G 1: 42,940,254 (GRCm39) probably benign Het
Nlgn1 A G 3: 25,488,556 (GRCm39) V564A probably damaging Het
Ntf3 T C 6: 126,079,138 (GRCm39) T110A probably benign Het
Pkd1l1 T A 11: 8,859,929 (GRCm39) I560F probably damaging Het
Prepl T C 17: 85,388,582 (GRCm39) T174A probably benign Het
Ptprg A T 14: 12,122,002 (GRCm38) T289S possibly damaging Het
Rab11fip2 T C 19: 59,924,213 (GRCm39) T222A probably damaging Het
Rhbdd3 G T 11: 5,049,460 (GRCm39) probably benign Het
Septin4 C A 11: 87,479,598 (GRCm39) D239E probably damaging Het
Shprh A G 10: 11,083,604 (GRCm39) probably benign Het
Slc3a1 T A 17: 85,368,306 (GRCm39) W525R probably damaging Het
Trim75 A G 8: 65,435,416 (GRCm39) S345P probably damaging Het
Usp5 C T 6: 124,801,901 (GRCm39) E72K possibly damaging Het
Wnk4 T A 11: 101,160,457 (GRCm39) V697E probably damaging Het
Zbtb9 C T 17: 27,192,853 (GRCm39) T86I probably benign Het
Other mutations in Vmn1r225
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01093:Vmn1r225 APN 17 20,723,081 (GRCm39) missense probably damaging 1.00
IGL01830:Vmn1r225 APN 17 20,722,717 (GRCm39) missense probably damaging 0.96
IGL02943:Vmn1r225 APN 17 20,722,567 (GRCm39) missense possibly damaging 0.67
R0544:Vmn1r225 UTSW 17 20,722,718 (GRCm39) missense probably benign 0.44
R1126:Vmn1r225 UTSW 17 20,722,588 (GRCm39) missense probably benign 0.03
R1809:Vmn1r225 UTSW 17 20,722,918 (GRCm39) missense probably benign 0.04
R1928:Vmn1r225 UTSW 17 20,723,071 (GRCm39) missense probably benign 0.00
R2044:Vmn1r225 UTSW 17 20,722,852 (GRCm39) missense possibly damaging 0.50
R2191:Vmn1r225 UTSW 17 20,723,147 (GRCm39) missense probably damaging 0.98
R2206:Vmn1r225 UTSW 17 20,722,611 (GRCm39) missense possibly damaging 0.56
R2207:Vmn1r225 UTSW 17 20,722,611 (GRCm39) missense possibly damaging 0.56
R2680:Vmn1r225 UTSW 17 20,723,055 (GRCm39) missense probably benign 0.00
R3740:Vmn1r225 UTSW 17 20,723,261 (GRCm39) missense possibly damaging 0.56
R3807:Vmn1r225 UTSW 17 20,723,114 (GRCm39) nonsense probably null
R4970:Vmn1r225 UTSW 17 20,722,831 (GRCm39) missense possibly damaging 0.74
R5129:Vmn1r225 UTSW 17 20,723,378 (GRCm39) missense probably damaging 1.00
R5130:Vmn1r225 UTSW 17 20,723,047 (GRCm39) missense possibly damaging 0.81
R5187:Vmn1r225 UTSW 17 20,723,177 (GRCm39) missense probably damaging 0.96
R5580:Vmn1r225 UTSW 17 20,723,101 (GRCm39) missense probably damaging 1.00
R6563:Vmn1r225 UTSW 17 20,722,763 (GRCm39) missense probably benign 0.03
R6674:Vmn1r225 UTSW 17 20,723,377 (GRCm39) missense probably benign 0.06
R7003:Vmn1r225 UTSW 17 20,723,416 (GRCm39) missense probably null 0.01
R7143:Vmn1r225 UTSW 17 20,722,646 (GRCm39) missense probably benign 0.22
R7422:Vmn1r225 UTSW 17 20,723,059 (GRCm39) missense probably benign 0.25
R7651:Vmn1r225 UTSW 17 20,722,611 (GRCm39) missense possibly damaging 0.56
R7952:Vmn1r225 UTSW 17 20,722,589 (GRCm39) missense probably damaging 0.98
R8097:Vmn1r225 UTSW 17 20,722,611 (GRCm39) missense possibly damaging 0.56
R8696:Vmn1r225 UTSW 17 20,723,419 (GRCm39) missense probably damaging 1.00
R8823:Vmn1r225 UTSW 17 20,722,823 (GRCm39) missense probably benign 0.08
R9007:Vmn1r225 UTSW 17 20,723,449 (GRCm39) missense probably damaging 0.96
R9041:Vmn1r225 UTSW 17 20,722,577 (GRCm39) missense possibly damaging 0.53
R9147:Vmn1r225 UTSW 17 20,722,577 (GRCm39) missense possibly damaging 0.53
R9148:Vmn1r225 UTSW 17 20,722,577 (GRCm39) missense possibly damaging 0.53
R9312:Vmn1r225 UTSW 17 20,722,960 (GRCm39) missense probably benign 0.39
R9401:Vmn1r225 UTSW 17 20,722,912 (GRCm39) missense probably damaging 1.00
R9401:Vmn1r225 UTSW 17 20,722,911 (GRCm39) nonsense probably null
R9488:Vmn1r225 UTSW 17 20,722,793 (GRCm39) missense probably damaging 0.99
Z1177:Vmn1r225 UTSW 17 20,722,753 (GRCm39) missense possibly damaging 0.65
Predicted Primers PCR Primer
(F):5'- CTTTGAATGCATCCACCAAAAGG -3'
(R):5'- TCATCACAAATGGACCTAAAGTAGG -3'

Sequencing Primer
(F):5'- AAGAGAGGTTTTGAATTCTGCCTCTC -3'
(R):5'- GAAAACACATAGAAATGATGGATGTG -3'
Posted On 2015-06-10