Incidental Mutation 'R4196:Vmn1r225'
ID |
318577 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r225
|
Ensembl Gene |
ENSMUSG00000043537 |
Gene Name |
vomeronasal 1 receptor 225 |
Synonyms |
V1re5 |
MMRRC Submission |
041027-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.066)
|
Stock # |
R4196 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
20722561-20723457 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 20723237 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Lysine
at position 226
(M226K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000056068
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061660]
|
AlphaFold |
Q8R2A5 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000061660
AA Change: M226K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
SMART Domains |
Protein: ENSMUSP00000056068 Gene: ENSMUSG00000043537 AA Change: M226K
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
1 |
287 |
8.9e-15 |
PFAM |
Pfam:V1R
|
11 |
291 |
3.1e-24 |
PFAM |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.8%
|
Validation Efficiency |
100% (39/39) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acmsd |
T |
G |
1: 127,676,931 (GRCm39) |
L152R |
probably damaging |
Het |
Ankle2 |
A |
G |
5: 110,392,409 (GRCm39) |
K472E |
possibly damaging |
Het |
Aup1 |
T |
C |
6: 83,032,211 (GRCm39) |
V126A |
probably damaging |
Het |
Baz1a |
T |
C |
12: 54,958,200 (GRCm39) |
Y1014C |
probably damaging |
Het |
Bcl9 |
A |
T |
3: 97,123,684 (GRCm39) |
|
probably benign |
Het |
Bltp2 |
A |
G |
11: 78,154,382 (GRCm39) |
|
probably benign |
Het |
Cnot2 |
A |
T |
10: 116,337,209 (GRCm39) |
N221K |
possibly damaging |
Het |
Col19a1 |
G |
A |
1: 24,573,133 (GRCm39) |
S213L |
unknown |
Het |
Eif4enif1 |
T |
C |
11: 3,193,186 (GRCm39) |
V675A |
possibly damaging |
Het |
Elp1 |
A |
T |
4: 56,755,353 (GRCm39) |
N1295K |
probably damaging |
Het |
Elp3 |
A |
G |
14: 65,785,451 (GRCm39) |
L450P |
probably damaging |
Het |
Erbb4 |
C |
T |
1: 68,383,014 (GRCm39) |
D328N |
possibly damaging |
Het |
Fbll1 |
T |
A |
11: 35,688,699 (GRCm39) |
H188L |
possibly damaging |
Het |
Frem2 |
A |
G |
3: 53,446,689 (GRCm39) |
F2360L |
possibly damaging |
Het |
Gm2396 |
A |
G |
9: 88,799,715 (GRCm39) |
|
noncoding transcript |
Het |
Gulo |
G |
T |
14: 66,225,702 (GRCm39) |
P375T |
possibly damaging |
Het |
Hspd1 |
T |
C |
1: 55,126,068 (GRCm39) |
M11V |
probably benign |
Het |
Itgav |
A |
G |
2: 83,598,671 (GRCm39) |
T243A |
probably benign |
Het |
Lipg |
C |
T |
18: 75,078,902 (GRCm39) |
R450H |
probably damaging |
Het |
Lrp3 |
T |
A |
7: 34,902,835 (GRCm39) |
S504C |
probably damaging |
Het |
Mrps9 |
T |
G |
1: 42,940,254 (GRCm39) |
|
probably benign |
Het |
Nlgn1 |
A |
G |
3: 25,488,556 (GRCm39) |
V564A |
probably damaging |
Het |
Ntf3 |
T |
C |
6: 126,079,138 (GRCm39) |
T110A |
probably benign |
Het |
Pkd1l1 |
T |
A |
11: 8,859,929 (GRCm39) |
I560F |
probably damaging |
Het |
Prepl |
T |
C |
17: 85,388,582 (GRCm39) |
T174A |
probably benign |
Het |
Ptprg |
A |
T |
14: 12,122,002 (GRCm38) |
T289S |
possibly damaging |
Het |
Rab11fip2 |
T |
C |
19: 59,924,213 (GRCm39) |
T222A |
probably damaging |
Het |
Rhbdd3 |
G |
T |
11: 5,049,460 (GRCm39) |
|
probably benign |
Het |
Septin4 |
C |
A |
11: 87,479,598 (GRCm39) |
D239E |
probably damaging |
Het |
Shprh |
A |
G |
10: 11,083,604 (GRCm39) |
|
probably benign |
Het |
Slc3a1 |
T |
A |
17: 85,368,306 (GRCm39) |
W525R |
probably damaging |
Het |
Trim75 |
A |
G |
8: 65,435,416 (GRCm39) |
S345P |
probably damaging |
Het |
Usp5 |
C |
T |
6: 124,801,901 (GRCm39) |
E72K |
possibly damaging |
Het |
Wnk4 |
T |
A |
11: 101,160,457 (GRCm39) |
V697E |
probably damaging |
Het |
Zbtb9 |
C |
T |
17: 27,192,853 (GRCm39) |
T86I |
probably benign |
Het |
|
Other mutations in Vmn1r225 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01093:Vmn1r225
|
APN |
17 |
20,723,081 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01830:Vmn1r225
|
APN |
17 |
20,722,717 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02943:Vmn1r225
|
APN |
17 |
20,722,567 (GRCm39) |
missense |
possibly damaging |
0.67 |
R0544:Vmn1r225
|
UTSW |
17 |
20,722,718 (GRCm39) |
missense |
probably benign |
0.44 |
R1126:Vmn1r225
|
UTSW |
17 |
20,722,588 (GRCm39) |
missense |
probably benign |
0.03 |
R1809:Vmn1r225
|
UTSW |
17 |
20,722,918 (GRCm39) |
missense |
probably benign |
0.04 |
R1928:Vmn1r225
|
UTSW |
17 |
20,723,071 (GRCm39) |
missense |
probably benign |
0.00 |
R2044:Vmn1r225
|
UTSW |
17 |
20,722,852 (GRCm39) |
missense |
possibly damaging |
0.50 |
R2191:Vmn1r225
|
UTSW |
17 |
20,723,147 (GRCm39) |
missense |
probably damaging |
0.98 |
R2206:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
R2207:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
R2680:Vmn1r225
|
UTSW |
17 |
20,723,055 (GRCm39) |
missense |
probably benign |
0.00 |
R3740:Vmn1r225
|
UTSW |
17 |
20,723,261 (GRCm39) |
missense |
possibly damaging |
0.56 |
R3807:Vmn1r225
|
UTSW |
17 |
20,723,114 (GRCm39) |
nonsense |
probably null |
|
R4970:Vmn1r225
|
UTSW |
17 |
20,722,831 (GRCm39) |
missense |
possibly damaging |
0.74 |
R5129:Vmn1r225
|
UTSW |
17 |
20,723,378 (GRCm39) |
missense |
probably damaging |
1.00 |
R5130:Vmn1r225
|
UTSW |
17 |
20,723,047 (GRCm39) |
missense |
possibly damaging |
0.81 |
R5187:Vmn1r225
|
UTSW |
17 |
20,723,177 (GRCm39) |
missense |
probably damaging |
0.96 |
R5580:Vmn1r225
|
UTSW |
17 |
20,723,101 (GRCm39) |
missense |
probably damaging |
1.00 |
R6563:Vmn1r225
|
UTSW |
17 |
20,722,763 (GRCm39) |
missense |
probably benign |
0.03 |
R6674:Vmn1r225
|
UTSW |
17 |
20,723,377 (GRCm39) |
missense |
probably benign |
0.06 |
R7003:Vmn1r225
|
UTSW |
17 |
20,723,416 (GRCm39) |
missense |
probably null |
0.01 |
R7143:Vmn1r225
|
UTSW |
17 |
20,722,646 (GRCm39) |
missense |
probably benign |
0.22 |
R7422:Vmn1r225
|
UTSW |
17 |
20,723,059 (GRCm39) |
missense |
probably benign |
0.25 |
R7651:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
R7952:Vmn1r225
|
UTSW |
17 |
20,722,589 (GRCm39) |
missense |
probably damaging |
0.98 |
R8097:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
R8696:Vmn1r225
|
UTSW |
17 |
20,723,419 (GRCm39) |
missense |
probably damaging |
1.00 |
R8823:Vmn1r225
|
UTSW |
17 |
20,722,823 (GRCm39) |
missense |
probably benign |
0.08 |
R9007:Vmn1r225
|
UTSW |
17 |
20,723,449 (GRCm39) |
missense |
probably damaging |
0.96 |
R9041:Vmn1r225
|
UTSW |
17 |
20,722,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
R9147:Vmn1r225
|
UTSW |
17 |
20,722,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
R9148:Vmn1r225
|
UTSW |
17 |
20,722,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
R9312:Vmn1r225
|
UTSW |
17 |
20,722,960 (GRCm39) |
missense |
probably benign |
0.39 |
R9401:Vmn1r225
|
UTSW |
17 |
20,722,912 (GRCm39) |
missense |
probably damaging |
1.00 |
R9401:Vmn1r225
|
UTSW |
17 |
20,722,911 (GRCm39) |
nonsense |
probably null |
|
R9488:Vmn1r225
|
UTSW |
17 |
20,722,793 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1177:Vmn1r225
|
UTSW |
17 |
20,722,753 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
Predicted Primers |
PCR Primer
(F):5'- CTTTGAATGCATCCACCAAAAGG -3'
(R):5'- TCATCACAAATGGACCTAAAGTAGG -3'
Sequencing Primer
(F):5'- AAGAGAGGTTTTGAATTCTGCCTCTC -3'
(R):5'- GAAAACACATAGAAATGATGGATGTG -3'
|
Posted On |
2015-06-10 |