Incidental Mutation 'R4223:Or4g7'
ID 319437
Institutional Source Beutler Lab
Gene Symbol Or4g7
Ensembl Gene ENSMUSG00000044039
Gene Name olfactory receptor family 4 subfamily G member 7
Synonyms Olfr1288, GA_x6K02T2Q125-72530279-72531217, MOR245-9
MMRRC Submission 041043-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R4223 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 111309131-111310069 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 111309489 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 120 (Y120F)
Ref Sequence ENSEMBL: ENSMUSP00000150331 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104889] [ENSMUST00000120021] [ENSMUST00000207494] [ENSMUST00000214816]
AlphaFold Q7TQY0
Predicted Effect probably benign
Transcript: ENSMUST00000104889
AA Change: Y120F

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000100485
Gene: ENSMUSG00000044039
AA Change: Y120F

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 1.3e-43 PFAM
Pfam:7tm_1 41 287 2.5e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120021
Predicted Effect probably benign
Transcript: ENSMUST00000207494
Predicted Effect probably benign
Transcript: ENSMUST00000214816
AA Change: Y120F

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225425
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.6%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik A G 10: 78,930,286 (GRCm39) Y43H probably damaging Het
Aamp A T 1: 74,320,285 (GRCm39) L348Q probably damaging Het
Abcb1b T A 5: 8,863,722 (GRCm39) L226M probably damaging Het
Acap1 A G 11: 69,774,511 (GRCm39) S396P probably damaging Het
Aif1l A T 2: 31,852,251 (GRCm39) S40C probably damaging Het
Atp1a3 T C 7: 24,700,355 (GRCm39) D48G probably benign Het
Bhmt-ps1 T A 4: 26,369,352 (GRCm39) noncoding transcript Het
Ccdc116 A G 16: 16,964,809 (GRCm39) probably benign Het
Cmtm5 T A 14: 55,175,376 (GRCm39) C51S probably damaging Het
Cyb5rl T C 4: 106,938,185 (GRCm39) V214A probably damaging Het
Cyp4x1 A T 4: 114,970,077 (GRCm39) I350N probably damaging Het
Efcab6 C A 15: 83,751,309 (GRCm39) D1498Y probably damaging Het
Eif3c C G 7: 126,165,471 (GRCm39) probably benign Het
Epha3 G A 16: 63,403,902 (GRCm39) S733L probably damaging Het
Esyt1 T C 10: 128,356,517 (GRCm39) Y376C probably damaging Het
Galnt1 T C 18: 24,371,413 (GRCm39) F4L probably benign Het
Glis1 T C 4: 107,425,042 (GRCm39) S218P probably benign Het
Gm15854 A T 6: 129,949,426 (GRCm39) noncoding transcript Het
Gm29125 T C 1: 80,361,236 (GRCm39) noncoding transcript Het
Inpp5a T C 7: 139,138,821 (GRCm39) V263A possibly damaging Het
Itgb1 T G 8: 129,440,624 (GRCm39) I255S probably damaging Het
Kcp A G 6: 29,482,257 (GRCm39) L1547P possibly damaging Het
Kifc3 C A 8: 95,836,610 (GRCm39) L72F probably damaging Het
Lama3 T C 18: 12,583,460 (GRCm39) C683R probably damaging Het
Lrrc55 G A 2: 85,026,460 (GRCm39) A188V possibly damaging Het
Ly6i A T 15: 74,854,884 (GRCm39) S9T probably benign Het
Mfsd14b C T 13: 65,214,422 (GRCm39) probably benign Het
Nipsnap3a T A 4: 52,997,251 (GRCm39) D172E probably benign Het
Oxgr1 T C 14: 120,260,025 (GRCm39) K61E probably damaging Het
Pak2 G T 16: 31,871,028 (GRCm39) N51K probably benign Het
Pcdhgb7 T A 18: 37,886,856 (GRCm39) D675E probably benign Het
Pcolce T A 5: 137,603,389 (GRCm39) probably benign Het
Phc3 A T 3: 30,990,968 (GRCm39) S383R probably damaging Het
Phf1 C T 17: 27,156,474 (GRCm39) R539* probably null Het
Plch1 G A 3: 63,609,321 (GRCm39) T48I probably damaging Het
Plekha2 A G 8: 25,533,036 (GRCm39) S312P probably damaging Het
Pnpla7 T C 2: 24,872,126 (GRCm39) F69L possibly damaging Het
Ppcdc T A 9: 57,321,998 (GRCm39) M181L possibly damaging Het
Ptbp1 T C 10: 79,695,047 (GRCm39) I125T probably benign Het
Rfc3 C A 5: 151,574,637 (GRCm39) probably benign Het
Rpa2 T G 4: 132,504,055 (GRCm39) I69S probably damaging Het
Rtn4 G A 11: 29,656,856 (GRCm39) V337I probably benign Het
Rttn T C 18: 89,113,708 (GRCm39) L1709P probably damaging Het
Sh2b2 G A 5: 136,247,907 (GRCm39) P548L possibly damaging Het
Slc12a2 T A 18: 58,043,328 (GRCm39) S591T probably damaging Het
Slc25a45 A T 19: 5,930,146 (GRCm39) I39F probably damaging Het
Slc38a9 G A 13: 112,850,782 (GRCm39) probably null Het
Slc9a4 T C 1: 40,658,286 (GRCm39) V603A probably damaging Het
Snx19 T G 9: 30,339,744 (GRCm39) V294G possibly damaging Het
Sp140l2 T C 1: 85,090,278 (GRCm39) D83G probably damaging Het
Sspo G T 6: 48,428,091 (GRCm39) V313L possibly damaging Het
Stard9 A G 2: 120,495,472 (GRCm39) T116A possibly damaging Het
Strn3 C T 12: 51,674,638 (GRCm39) R382Q probably damaging Het
Trim43b T A 9: 88,972,692 (GRCm39) Q154L probably benign Het
Trps1 A G 15: 50,710,044 (GRCm39) V98A probably benign Het
Vmn1r220 T A 13: 23,368,148 (GRCm39) M183L probably benign Het
Vmn2r60 A T 7: 41,765,952 (GRCm39) T20S probably benign Het
Wdr81 T C 11: 75,338,828 (GRCm39) T1444A probably benign Het
Xirp2 A T 2: 67,346,837 (GRCm39) E3026V possibly damaging Het
Other mutations in Or4g7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01800:Or4g7 APN 2 111,309,209 (GRCm39) missense probably benign
IGL02021:Or4g7 APN 2 111,309,825 (GRCm39) missense probably benign 0.03
IGL02061:Or4g7 APN 2 111,309,614 (GRCm39) missense possibly damaging 0.94
R2016:Or4g7 UTSW 2 111,309,532 (GRCm39) missense probably benign 0.00
R2017:Or4g7 UTSW 2 111,309,532 (GRCm39) missense probably benign 0.00
R2848:Or4g7 UTSW 2 111,309,699 (GRCm39) missense probably benign 0.00
R2849:Or4g7 UTSW 2 111,309,699 (GRCm39) missense probably benign 0.00
R3421:Or4g7 UTSW 2 111,309,297 (GRCm39) missense probably benign 0.12
R4432:Or4g7 UTSW 2 111,309,757 (GRCm39) nonsense probably null
R4433:Or4g7 UTSW 2 111,309,757 (GRCm39) nonsense probably null
R4476:Or4g7 UTSW 2 111,310,009 (GRCm39) missense possibly damaging 0.58
R4631:Or4g7 UTSW 2 111,309,908 (GRCm39) missense probably damaging 1.00
R6029:Or4g7 UTSW 2 111,309,310 (GRCm39) nonsense probably null
R6036:Or4g7 UTSW 2 111,309,333 (GRCm39) missense probably damaging 1.00
R6036:Or4g7 UTSW 2 111,309,333 (GRCm39) missense probably damaging 1.00
R6084:Or4g7 UTSW 2 111,309,734 (GRCm39) missense probably damaging 1.00
R6329:Or4g7 UTSW 2 111,309,573 (GRCm39) missense possibly damaging 0.90
R7307:Or4g7 UTSW 2 111,309,105 (GRCm39) start gained probably benign
R7516:Or4g7 UTSW 2 111,309,282 (GRCm39) missense probably benign 0.01
R7577:Or4g7 UTSW 2 111,309,477 (GRCm39) missense probably damaging 0.98
R8108:Or4g7 UTSW 2 111,309,579 (GRCm39) missense possibly damaging 0.90
R8210:Or4g7 UTSW 2 111,309,753 (GRCm39) missense possibly damaging 0.89
R8465:Or4g7 UTSW 2 111,309,425 (GRCm39) missense probably benign 0.01
R8717:Or4g7 UTSW 2 111,309,992 (GRCm39) missense probably damaging 1.00
R8730:Or4g7 UTSW 2 111,309,934 (GRCm39) missense probably damaging 1.00
R9360:Or4g7 UTSW 2 111,309,684 (GRCm39) missense probably benign 0.10
Z1177:Or4g7 UTSW 2 111,309,552 (GRCm39) missense probably damaging 1.00
Z1177:Or4g7 UTSW 2 111,309,159 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- CCCATGTATATTCTATTGGCCAACC -3'
(R):5'- TCCATGCATGCAAGTTTAATGACC -3'

Sequencing Primer
(F):5'- AACCTTTCGCTCATTGACTTGGG -3'
(R):5'- GCATGCAAGTTTAATGACCCTTGG -3'
Posted On 2015-06-10