Incidental Mutation 'R4177:Zfp268'
ID 319549
Institutional Source Beutler Lab
Gene Symbol Zfp268
Ensembl Gene ENSMUSG00000078502
Gene Name zinc finger protein 268
Synonyms Gm13212
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.401) question?
Stock # R4177 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 145311770-145351915 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 145347225 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 43 (L43S)
Ref Sequence ENSEMBL: ENSMUSP00000112918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097794] [ENSMUST00000105739] [ENSMUST00000119718]
AlphaFold B1ASQ7
Predicted Effect probably damaging
Transcript: ENSMUST00000097794
AA Change: L43S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000095402
Gene: ENSMUSG00000078502
AA Change: L43S

DomainStartEndE-ValueType
KRAB 13 72 3.23e-18 SMART
ZnF_C2H2 238 260 1.69e-3 SMART
ZnF_C2H2 266 288 1.18e-2 SMART
ZnF_C2H2 294 316 1.3e-4 SMART
ZnF_C2H2 322 344 1.58e-3 SMART
ZnF_C2H2 350 372 4.24e-4 SMART
ZnF_C2H2 378 400 1.06e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000105739
AA Change: L43S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101365
Gene: ENSMUSG00000078502
AA Change: L43S

DomainStartEndE-ValueType
KRAB 13 72 3.23e-18 SMART
ZnF_C2H2 238 260 1.69e-3 SMART
ZnF_C2H2 266 288 1.18e-2 SMART
ZnF_C2H2 294 316 1.3e-4 SMART
ZnF_C2H2 322 344 1.58e-3 SMART
ZnF_C2H2 350 372 4.24e-4 SMART
ZnF_C2H2 378 400 1.06e-4 SMART
ZnF_C2H2 406 428 1.58e-3 SMART
ZnF_C2H2 434 456 3.39e-3 SMART
ZnF_C2H2 462 484 1.06e-4 SMART
ZnF_C2H2 490 512 1.58e-3 SMART
ZnF_C2H2 518 540 3.39e-3 SMART
ZnF_C2H2 546 568 3.39e-3 SMART
ZnF_C2H2 574 596 3.39e-3 SMART
ZnF_C2H2 602 624 3.39e-3 SMART
ZnF_C2H2 630 652 1.06e-4 SMART
ZnF_C2H2 658 680 1.58e-3 SMART
ZnF_C2H2 686 708 3.39e-3 SMART
ZnF_C2H2 714 736 1.3e-4 SMART
ZnF_C2H2 742 764 1.3e-4 SMART
ZnF_C2H2 770 792 4.79e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000119718
AA Change: L43S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000112918
Gene: ENSMUSG00000078502
AA Change: L43S

DomainStartEndE-ValueType
KRAB 13 72 3.23e-18 SMART
internal_repeat_1 141 211 2.19e-13 PROSPERO
ZnF_C2H2 238 260 1.69e-3 SMART
ZnF_C2H2 266 288 1.18e-2 SMART
low complexity region 320 335 N/A INTRINSIC
low complexity region 350 357 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180968
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aicda A T 6: 122,538,043 (GRCm39) D67V probably benign Het
Arhgap32 A G 9: 32,158,510 (GRCm39) R182G probably null Het
Bbx T C 16: 50,045,221 (GRCm39) K447E probably damaging Het
Bscl2 A G 19: 8,817,120 (GRCm39) D16G possibly damaging Het
Celsr2 A G 3: 108,321,294 (GRCm39) V506A probably damaging Het
Cenpf T A 1: 189,400,816 (GRCm39) Q441L possibly damaging Het
Crebbp A T 16: 3,937,663 (GRCm39) M700K possibly damaging Het
Dhcr7 A G 7: 143,394,910 (GRCm39) Y142C probably damaging Het
Dnajc2 A G 5: 21,962,394 (GRCm39) M602T probably benign Het
Dysf C T 6: 84,044,013 (GRCm39) R254* probably null Het
Ednra A C 8: 78,401,677 (GRCm39) I204M possibly damaging Het
Fabp2 A G 3: 122,690,547 (GRCm39) T77A possibly damaging Het
Gm10322 C A 10: 59,452,052 (GRCm39) N56K probably benign Het
Gnb1 T C 4: 155,625,113 (GRCm39) probably benign Het
Gpc2 T C 5: 138,275,621 (GRCm39) probably benign Het
Kmt2a T C 9: 44,732,280 (GRCm39) probably benign Het
Lypla2 T C 4: 135,696,403 (GRCm39) probably benign Het
Maf A T 8: 116,433,210 (GRCm39) Y131* probably null Het
Mfsd4a T A 1: 131,968,295 (GRCm39) H335L probably damaging Het
Mrgpra9 A G 7: 46,885,302 (GRCm39) Y122H probably damaging Het
Myo10 A T 15: 25,734,137 (GRCm39) Q342L possibly damaging Het
N4bp2 A G 5: 65,955,513 (GRCm39) probably null Het
Or5t15 A T 2: 86,681,745 (GRCm39) M99K possibly damaging Het
Pomt1 A G 2: 32,138,689 (GRCm39) N435S probably damaging Het
Pram1 A G 17: 33,860,203 (GRCm39) I257V probably benign Het
Rab9 G T X: 165,241,296 (GRCm39) S5* probably null Het
Ralgapa2 A T 2: 146,327,083 (GRCm39) Y59N probably damaging Het
Rasgrf2 C T 13: 92,038,717 (GRCm39) G1043D probably damaging Het
Rps6kc1 G A 1: 190,532,616 (GRCm39) T462M possibly damaging Het
Selenoo C T 15: 88,983,662 (GRCm39) probably benign Het
Sptb G C 12: 76,659,953 (GRCm39) D982E probably benign Het
Tab2 A G 10: 7,795,123 (GRCm39) V453A probably damaging Het
Ubald1 A G 16: 4,693,745 (GRCm39) probably benign Het
Ube2d1 T C 10: 71,094,033 (GRCm39) K101R probably damaging Het
Unc5cl A G 17: 48,769,298 (GRCm39) T261A probably benign Het
Zcwpw1 G T 5: 137,798,395 (GRCm39) K197N probably damaging Het
Zfyve19 A G 2: 119,046,693 (GRCm39) T296A possibly damaging Het
Other mutations in Zfp268
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01797:Zfp268 APN 4 145,347,241 (GRCm39) missense probably damaging 0.98
IGL02678:Zfp268 APN 4 145,349,067 (GRCm39) missense probably damaging 1.00
IGL03035:Zfp268 APN 4 145,348,802 (GRCm39) missense possibly damaging 0.77
BB008:Zfp268 UTSW 4 145,349,126 (GRCm39) missense possibly damaging 0.49
BB018:Zfp268 UTSW 4 145,349,126 (GRCm39) missense possibly damaging 0.49
R0090:Zfp268 UTSW 4 145,349,195 (GRCm39) nonsense probably null
R0904:Zfp268 UTSW 4 145,348,745 (GRCm39) missense possibly damaging 0.95
R1617:Zfp268 UTSW 4 145,350,877 (GRCm39) utr 3 prime probably benign
R1851:Zfp268 UTSW 4 145,350,820 (GRCm39) unclassified probably benign
R1864:Zfp268 UTSW 4 145,348,998 (GRCm39) missense possibly damaging 0.92
R2093:Zfp268 UTSW 4 145,349,139 (GRCm39) missense probably benign 0.02
R2132:Zfp268 UTSW 4 145,350,803 (GRCm39) unclassified probably benign
R2240:Zfp268 UTSW 4 145,311,891 (GRCm39) start gained probably benign
R4584:Zfp268 UTSW 4 145,343,747 (GRCm39) critical splice donor site probably null
R4991:Zfp268 UTSW 4 145,348,904 (GRCm39) missense probably benign 0.31
R5164:Zfp268 UTSW 4 145,348,775 (GRCm39) missense probably damaging 1.00
R6175:Zfp268 UTSW 4 145,350,811 (GRCm39) unclassified probably benign
R6176:Zfp268 UTSW 4 145,350,628 (GRCm39) nonsense probably null
R6498:Zfp268 UTSW 4 145,349,459 (GRCm39) missense probably damaging 0.98
R6984:Zfp268 UTSW 4 145,347,186 (GRCm39) missense probably damaging 1.00
R7134:Zfp268 UTSW 4 145,349,375 (GRCm39) missense possibly damaging 0.93
R7931:Zfp268 UTSW 4 145,349,126 (GRCm39) missense possibly damaging 0.49
R8017:Zfp268 UTSW 4 145,349,138 (GRCm39) missense probably benign 0.28
R8282:Zfp268 UTSW 4 145,349,547 (GRCm39) missense possibly damaging 0.94
R9320:Zfp268 UTSW 4 145,349,156 (GRCm39) missense possibly damaging 0.77
R9358:Zfp268 UTSW 4 145,349,613 (GRCm39) missense possibly damaging 0.79
R9435:Zfp268 UTSW 4 145,349,045 (GRCm39) missense
V5622:Zfp268 UTSW 4 145,311,891 (GRCm39) start gained probably benign
Z1176:Zfp268 UTSW 4 145,349,538 (GRCm39) missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- CGTATCTTCAGACACATCTCAATC -3'
(R):5'- AGCACTGGTTACTTTTCCAAAG -3'

Sequencing Primer
(F):5'- CAAGACAGGATTTCTCTGTGCAGC -3'
(R):5'- CTTTTCCAAAGAAAGCAGAGAAATG -3'
Posted On 2015-06-10