Incidental Mutation 'R4177:Rab9'
ID 319577
Institutional Source Beutler Lab
Gene Symbol Rab9
Ensembl Gene ENSMUSG00000079316
Gene Name RAB9, member RAS oncogene family
Synonyms SID 99, 2410064E05Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R4177 (G1)
Quality Score 222
Status Validated
Chromosome X
Chromosomal Location 165240249-165262863 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 165241296 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Stop codon at position 5 (S5*)
Ref Sequence ENSEMBL: ENSMUSP00000119240 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049435] [ENSMUST00000112091] [ENSMUST00000149315]
AlphaFold Q9R0M6
Predicted Effect probably null
Transcript: ENSMUST00000049435
AA Change: S19*
SMART Domains Protein: ENSMUSP00000045127
Gene: ENSMUSG00000079316
AA Change: S19*

DomainStartEndE-ValueType
RAB 22 189 1.01e-92 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112091
AA Change: S5*
SMART Domains Protein: ENSMUSP00000123325
Gene: ENSMUSG00000079316
AA Change: S5*

DomainStartEndE-ValueType
RAB 8 175 1.01e-92 SMART
Predicted Effect probably null
Transcript: ENSMUST00000149315
AA Change: S5*
SMART Domains Protein: ENSMUSP00000119240
Gene: ENSMUSG00000079316
AA Change: S5*

DomainStartEndE-ValueType
Pfam:Miro 9 59 1.6e-6 PFAM
Pfam:Ras 9 59 3.4e-16 PFAM
Meta Mutation Damage Score 0.9712 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (46/46)
MGI Phenotype PHENOTYPE: Male chimeras hemizygous for a gene trapped allele appear normal at E9.5. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aicda A T 6: 122,538,043 (GRCm39) D67V probably benign Het
Arhgap32 A G 9: 32,158,510 (GRCm39) R182G probably null Het
Bbx T C 16: 50,045,221 (GRCm39) K447E probably damaging Het
Bscl2 A G 19: 8,817,120 (GRCm39) D16G possibly damaging Het
Celsr2 A G 3: 108,321,294 (GRCm39) V506A probably damaging Het
Cenpf T A 1: 189,400,816 (GRCm39) Q441L possibly damaging Het
Crebbp A T 16: 3,937,663 (GRCm39) M700K possibly damaging Het
Dhcr7 A G 7: 143,394,910 (GRCm39) Y142C probably damaging Het
Dnajc2 A G 5: 21,962,394 (GRCm39) M602T probably benign Het
Dysf C T 6: 84,044,013 (GRCm39) R254* probably null Het
Ednra A C 8: 78,401,677 (GRCm39) I204M possibly damaging Het
Fabp2 A G 3: 122,690,547 (GRCm39) T77A possibly damaging Het
Gm10322 C A 10: 59,452,052 (GRCm39) N56K probably benign Het
Gnb1 T C 4: 155,625,113 (GRCm39) probably benign Het
Gpc2 T C 5: 138,275,621 (GRCm39) probably benign Het
Kmt2a T C 9: 44,732,280 (GRCm39) probably benign Het
Lypla2 T C 4: 135,696,403 (GRCm39) probably benign Het
Maf A T 8: 116,433,210 (GRCm39) Y131* probably null Het
Mfsd4a T A 1: 131,968,295 (GRCm39) H335L probably damaging Het
Mrgpra9 A G 7: 46,885,302 (GRCm39) Y122H probably damaging Het
Myo10 A T 15: 25,734,137 (GRCm39) Q342L possibly damaging Het
N4bp2 A G 5: 65,955,513 (GRCm39) probably null Het
Or5t15 A T 2: 86,681,745 (GRCm39) M99K possibly damaging Het
Pomt1 A G 2: 32,138,689 (GRCm39) N435S probably damaging Het
Pram1 A G 17: 33,860,203 (GRCm39) I257V probably benign Het
Ralgapa2 A T 2: 146,327,083 (GRCm39) Y59N probably damaging Het
Rasgrf2 C T 13: 92,038,717 (GRCm39) G1043D probably damaging Het
Rps6kc1 G A 1: 190,532,616 (GRCm39) T462M possibly damaging Het
Selenoo C T 15: 88,983,662 (GRCm39) probably benign Het
Sptb G C 12: 76,659,953 (GRCm39) D982E probably benign Het
Tab2 A G 10: 7,795,123 (GRCm39) V453A probably damaging Het
Ubald1 A G 16: 4,693,745 (GRCm39) probably benign Het
Ube2d1 T C 10: 71,094,033 (GRCm39) K101R probably damaging Het
Unc5cl A G 17: 48,769,298 (GRCm39) T261A probably benign Het
Zcwpw1 G T 5: 137,798,395 (GRCm39) K197N probably damaging Het
Zfp268 T C 4: 145,347,225 (GRCm39) L43S probably damaging Het
Zfyve19 A G 2: 119,046,693 (GRCm39) T296A possibly damaging Het
Other mutations in Rab9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Rab9 APN X 165,240,860 (GRCm39) nonsense probably null
IGL03400:Rab9 APN X 165,240,744 (GRCm39) missense probably benign
R8703:Rab9 UTSW X 165,240,754 (GRCm39) missense probably benign 0.00
R8704:Rab9 UTSW X 165,240,754 (GRCm39) missense probably benign 0.00
R8705:Rab9 UTSW X 165,240,754 (GRCm39) missense probably benign 0.00
R8731:Rab9 UTSW X 165,240,754 (GRCm39) missense probably benign 0.00
R8732:Rab9 UTSW X 165,240,754 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAAATGGCGTCCTCAGGCTTC -3'
(R):5'- ATCTCCAGTCAGTGAACTGGG -3'

Sequencing Primer
(F):5'- GCCAGCTGTGTCCCAAATCTG -3'
(R):5'- CTCCAGTCAGTGAACTGGGGATTAAG -3'
Posted On 2015-06-10