Incidental Mutation 'R4179:Or10d1b'
ID 319640
Institutional Source Beutler Lab
Gene Symbol Or10d1b
Ensembl Gene ENSMUSG00000062121
Gene Name olfactory receptor family 10 subfamily D member 1B
Synonyms M31, Olfr149, MOR224-8, GA_x6K02T2PVTD-33400306-33399371
MMRRC Submission 041015-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R4179 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39613128-39614063 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39613387 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 226 (I226T)
Ref Sequence ENSEMBL: ENSMUSP00000149664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082027] [ENSMUST00000215192]
AlphaFold Q60888
Predicted Effect probably benign
Transcript: ENSMUST00000082027
AA Change: I226T

PolyPhen 2 Score 0.303 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000080686
Gene: ENSMUSG00000062121
AA Change: I226T

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.7e-48 PFAM
Pfam:7TM_GPCR_Srsx 33 223 3.8e-9 PFAM
Pfam:7tm_1 39 286 1.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215192
AA Change: I226T

PolyPhen 2 Score 0.303 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34 T C 8: 44,104,128 (GRCm39) M506V probably benign Het
Ano1 A T 7: 144,204,242 (GRCm39) M290K probably damaging Het
Arrdc2 A T 8: 71,289,821 (GRCm39) L34Q probably damaging Het
Cdadc1 G T 14: 59,829,935 (GRCm39) T77N probably benign Het
Cmtr2 C G 8: 110,947,669 (GRCm39) probably null Het
Cnot2 A T 10: 116,334,048 (GRCm39) V374E possibly damaging Het
Crnn T C 3: 93,054,120 (GRCm39) M1T probably null Het
Ctsb A G 14: 63,370,901 (GRCm39) N38D probably benign Het
Dock10 A C 1: 80,488,134 (GRCm39) S2010A probably benign Het
Dqx1 A G 6: 83,036,460 (GRCm39) T155A probably benign Het
Dysf G A 6: 84,163,491 (GRCm39) probably null Het
Eci1 T C 17: 24,655,251 (GRCm39) W119R probably damaging Het
Foxo1 C A 3: 52,252,840 (GRCm39) D334E probably benign Het
Gck T C 11: 5,860,295 (GRCm39) T116A probably benign Het
Gcn1 T C 5: 115,726,109 (GRCm39) V588A probably benign Het
Gm7168 A G 17: 14,169,265 (GRCm39) I211V probably benign Het
Idh3g A T X: 72,825,610 (GRCm39) probably null Het
Jag1 A G 2: 136,943,578 (GRCm39) F206S probably damaging Het
Loxl3 G A 6: 83,014,565 (GRCm39) V158I probably benign Het
Ly6g A G 15: 75,027,567 (GRCm39) probably null Het
Myo1b A G 1: 51,817,685 (GRCm39) F532L probably damaging Het
Naip1 T A 13: 100,562,684 (GRCm39) N827I probably damaging Het
Nlrp9c G A 7: 26,084,086 (GRCm39) H498Y possibly damaging Het
Pak2 C G 16: 31,871,005 (GRCm39) G59A probably benign Het
Pcdha2 T A 18: 37,074,529 (GRCm39) L720Q probably damaging Het
Pcdhb9 T A 18: 37,534,168 (GRCm39) M54K probably benign Het
Pde2a A G 7: 101,130,590 (GRCm39) *71W probably null Het
Pkd2l1 T C 19: 44,180,620 (GRCm39) N32D probably benign Het
Pkhd1l1 A C 15: 44,387,045 (GRCm39) Y1306S probably benign Het
Plec T C 15: 76,064,415 (GRCm39) K1953R possibly damaging Het
Plekhg4 T A 8: 106,108,030 (GRCm39) V1029E possibly damaging Het
Prkd1 C A 12: 50,413,231 (GRCm39) G647C probably damaging Het
Ptch1 C T 13: 63,682,143 (GRCm39) R537H probably damaging Het
Qser1 A G 2: 104,606,729 (GRCm39) I1510T probably benign Het
Ranbp3l T C 15: 9,057,279 (GRCm39) I314T possibly damaging Het
Rgs9 C A 11: 109,172,274 (GRCm39) probably null Het
Riok1 T C 13: 38,232,931 (GRCm39) F216L probably damaging Het
Rrm1 T A 7: 102,106,405 (GRCm39) I308N probably damaging Het
Serpina1f A T 12: 103,658,179 (GRCm39) M242K probably benign Het
Smox G A 2: 131,366,770 (GRCm39) M576I possibly damaging Het
Spaca7 A T 8: 12,636,435 (GRCm39) N87I probably damaging Het
Spink5 A T 18: 44,120,934 (GRCm39) Q296L probably benign Het
Sspo T C 6: 48,475,329 (GRCm39) probably null Het
Sult2b1 T A 7: 45,384,735 (GRCm39) I114F probably damaging Het
Tex12 T C 9: 50,470,587 (GRCm39) probably null Het
Tonsl A G 15: 76,508,675 (GRCm39) L26P probably damaging Het
Top2b T G 14: 16,409,189 (GRCm38) I777M probably damaging Het
Tsen54 T C 11: 115,711,678 (GRCm39) V365A probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Usp47 T C 7: 111,687,091 (GRCm39) L683P probably damaging Het
Wdr18 T C 10: 79,800,875 (GRCm39) L146P probably damaging Het
Zfp709 A G 8: 72,643,750 (GRCm39) Y392C probably damaging Het
Zranb3 A T 1: 127,888,601 (GRCm39) I828N possibly damaging Het
Other mutations in Or10d1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02008:Or10d1b APN 9 39,613,549 (GRCm39) missense probably damaging 1.00
IGL02707:Or10d1b APN 9 39,613,937 (GRCm39) missense probably damaging 0.99
IGL02730:Or10d1b APN 9 39,613,534 (GRCm39) missense probably damaging 1.00
IGL03375:Or10d1b APN 9 39,613,871 (GRCm39) missense probably damaging 1.00
R0244:Or10d1b UTSW 9 39,613,469 (GRCm39) missense probably damaging 0.97
R0358:Or10d1b UTSW 9 39,613,297 (GRCm39) missense possibly damaging 0.95
R5120:Or10d1b UTSW 9 39,613,366 (GRCm39) missense probably benign 0.00
R5185:Or10d1b UTSW 9 39,613,172 (GRCm39) missense probably benign
R5818:Or10d1b UTSW 9 39,613,661 (GRCm39) missense probably benign 0.01
R6029:Or10d1b UTSW 9 39,613,696 (GRCm39) missense probably damaging 1.00
R6207:Or10d1b UTSW 9 39,613,606 (GRCm39) missense probably benign 0.06
R6454:Or10d1b UTSW 9 39,613,130 (GRCm39) makesense probably null
R7451:Or10d1b UTSW 9 39,613,423 (GRCm39) missense probably damaging 0.99
R8193:Or10d1b UTSW 9 39,613,498 (GRCm39) missense possibly damaging 0.90
R8263:Or10d1b UTSW 9 39,613,453 (GRCm39) missense possibly damaging 0.50
R9102:Or10d1b UTSW 9 39,613,984 (GRCm39) missense probably benign 0.24
R9624:Or10d1b UTSW 9 39,613,822 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GGACAGTCCACAGTGATGATTTC -3'
(R):5'- TGTGGCCCCAAAGATGTGAAC -3'

Sequencing Primer
(F):5'- GTAAATTAACGGATTTAGCATAGGGG -3'
(R):5'- GTGGCCCCAAAGATGTGAACTATTAC -3'
Posted On 2015-06-10