Incidental Mutation 'R4190:Zfp202'
| ID |
319918 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp202
|
| Ensembl Gene |
ENSMUSG00000025602 |
| Gene Name |
zinc finger protein 202 |
| Synonyms |
C130037E22Rik |
| MMRRC Submission |
041021-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4190 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
40103612-40124900 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 40122633 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 465
(V465A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000026693
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026693]
[ENSMUST00000168691]
[ENSMUST00000168832]
|
| AlphaFold |
Q8C879 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000026693
AA Change: V465A
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000026693
Gene: ENSMUSG00000025602
AA Change: V465A
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
154 |
1.19e-75 |
SMART |
|
KRAB
|
237 |
297 |
1.7e-17 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
473 |
495 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
501 |
523 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
529 |
551 |
1.64e-1 |
SMART |
|
ZnF_C2H2
|
557 |
579 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
585 |
607 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
613 |
635 |
3.39e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168691
|
| SMART Domains |
Protein: ENSMUSP00000130163
Gene: ENSMUSG00000025602
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
132 |
1.03e-56 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168832
|
| SMART Domains |
Protein: ENSMUSP00000132131
Gene: ENSMUSG00000025602
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
154 |
1.19e-75 |
SMART |
|
KRAB
|
237 |
277 |
5.32e-2 |
SMART |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
96% (50/52) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 43 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acot4 |
T |
C |
12: 84,089,948 (GRCm39) |
|
probably benign |
Het |
| Adgre1 |
A |
G |
17: 57,709,811 (GRCm39) |
Y156C |
unknown |
Het |
| Ankrd13b |
G |
A |
11: 77,367,201 (GRCm39) |
A21V |
probably damaging |
Het |
| Atf7ip |
T |
C |
6: 136,564,499 (GRCm39) |
V914A |
probably damaging |
Het |
| C230029F24Rik |
AGAAAG |
A |
1: 49,350,088 (GRCm39) |
|
noncoding transcript |
Het |
| Calcr |
T |
A |
6: 3,717,106 (GRCm39) |
D118V |
possibly damaging |
Het |
| Cdc42bpg |
T |
C |
19: 6,371,711 (GRCm39) |
V1330A |
probably damaging |
Het |
| Cfap54 |
T |
C |
10: 92,720,885 (GRCm39) |
E2567G |
unknown |
Het |
| Ctse |
T |
A |
1: 131,590,479 (GRCm39) |
V67D |
probably benign |
Het |
| Ddx19b |
A |
T |
8: 111,737,980 (GRCm39) |
L256Q |
probably damaging |
Het |
| Dipk1b |
T |
C |
2: 26,526,193 (GRCm39) |
Y376H |
probably damaging |
Het |
| Fahd2a |
C |
T |
2: 127,280,486 (GRCm39) |
V156I |
probably benign |
Het |
| Fam185a |
T |
A |
5: 21,630,122 (GRCm39) |
|
probably benign |
Het |
| Fam234a |
A |
T |
17: 26,432,834 (GRCm39) |
L467Q |
probably damaging |
Het |
| Gabra2 |
G |
A |
5: 71,165,341 (GRCm39) |
P210S |
probably benign |
Het |
| Heatr3 |
T |
C |
8: 88,864,888 (GRCm39) |
|
probably benign |
Het |
| Herc2 |
T |
C |
7: 55,772,196 (GRCm39) |
V1125A |
probably benign |
Het |
| Itga11 |
T |
A |
9: 62,639,391 (GRCm39) |
C129S |
probably damaging |
Het |
| Lama2 |
A |
G |
10: 27,142,660 (GRCm39) |
L606P |
probably damaging |
Het |
| Macf1 |
A |
G |
4: 123,366,835 (GRCm39) |
F1077S |
possibly damaging |
Het |
| Mtmr10 |
G |
T |
7: 63,963,934 (GRCm39) |
W223L |
probably benign |
Het |
| Nlgn1 |
T |
A |
3: 25,488,062 (GRCm39) |
T758S |
probably benign |
Het |
| Nr4a1 |
T |
C |
15: 101,171,993 (GRCm39) |
S556P |
probably damaging |
Het |
| Or4c126 |
C |
A |
2: 89,823,918 (GRCm39) |
Y60* |
probably null |
Het |
| Or5p64 |
T |
C |
7: 107,855,330 (GRCm39) |
D5G |
probably benign |
Het |
| Or6c201 |
T |
C |
10: 128,968,836 (GRCm39) |
N267S |
possibly damaging |
Het |
| Or6c33 |
A |
T |
10: 129,853,847 (GRCm39) |
I206F |
probably damaging |
Het |
| Pcdhgb8 |
G |
C |
18: 37,896,594 (GRCm39) |
D555H |
probably damaging |
Het |
| Plscr5 |
T |
C |
9: 92,080,651 (GRCm39) |
S46P |
probably benign |
Het |
| Ppp2r3d |
T |
C |
9: 124,424,123 (GRCm38) |
|
probably benign |
Het |
| Prodh |
C |
T |
16: 17,891,504 (GRCm39) |
V480I |
probably benign |
Het |
| Senp2 |
G |
T |
16: 21,865,417 (GRCm39) |
W580L |
probably damaging |
Het |
| Sorcs3 |
T |
C |
19: 48,737,812 (GRCm39) |
V743A |
possibly damaging |
Het |
| Sp110 |
C |
G |
1: 85,516,839 (GRCm39) |
E219D |
probably damaging |
Het |
| Stab2 |
G |
T |
10: 86,714,808 (GRCm39) |
N119K |
probably damaging |
Het |
| Telo2 |
T |
C |
17: 25,320,987 (GRCm39) |
T743A |
probably benign |
Het |
| Trav6-1 |
A |
G |
14: 52,875,976 (GRCm39) |
N2S |
probably benign |
Het |
| Trmt44 |
C |
A |
5: 35,732,314 (GRCm39) |
V26L |
possibly damaging |
Het |
| Ttbk1 |
A |
T |
17: 46,790,173 (GRCm39) |
C91S |
probably damaging |
Het |
| Vit |
A |
G |
17: 78,894,255 (GRCm39) |
H219R |
probably benign |
Het |
| Vmn2r84 |
A |
T |
10: 130,227,163 (GRCm39) |
L225* |
probably null |
Het |
| Vmn2r87 |
A |
G |
10: 130,308,556 (GRCm39) |
Y561H |
probably damaging |
Het |
| Yars1 |
T |
A |
4: 129,093,820 (GRCm39) |
C60* |
probably null |
Het |
|
| Other mutations in Zfp202 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00662:Zfp202
|
APN |
9 |
40,122,339 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01862:Zfp202
|
APN |
9 |
40,123,124 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL03069:Zfp202
|
APN |
9 |
40,122,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0028:Zfp202
|
UTSW |
9 |
40,123,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0158:Zfp202
|
UTSW |
9 |
40,120,212 (GRCm39) |
nonsense |
probably null |
|
|
R0278:Zfp202
|
UTSW |
9 |
40,119,778 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1132:Zfp202
|
UTSW |
9 |
40,122,318 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1404:Zfp202
|
UTSW |
9 |
40,122,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1404:Zfp202
|
UTSW |
9 |
40,122,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1764:Zfp202
|
UTSW |
9 |
40,121,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1928:Zfp202
|
UTSW |
9 |
40,121,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2929:Zfp202
|
UTSW |
9 |
40,122,984 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3153:Zfp202
|
UTSW |
9 |
40,119,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3948:Zfp202
|
UTSW |
9 |
40,119,721 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4273:Zfp202
|
UTSW |
9 |
40,118,790 (GRCm39) |
nonsense |
probably null |
|
|
R6181:Zfp202
|
UTSW |
9 |
40,118,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6182:Zfp202
|
UTSW |
9 |
40,118,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Zfp202
|
UTSW |
9 |
40,123,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Zfp202
|
UTSW |
9 |
40,121,531 (GRCm39) |
splice site |
probably null |
|
|
R7382:Zfp202
|
UTSW |
9 |
40,122,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7493:Zfp202
|
UTSW |
9 |
40,118,640 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7542:Zfp202
|
UTSW |
9 |
40,122,443 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7689:Zfp202
|
UTSW |
9 |
40,121,829 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7832:Zfp202
|
UTSW |
9 |
40,121,758 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8084:Zfp202
|
UTSW |
9 |
40,122,538 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8349:Zfp202
|
UTSW |
9 |
40,118,976 (GRCm39) |
nonsense |
probably null |
|
|
R8449:Zfp202
|
UTSW |
9 |
40,118,976 (GRCm39) |
nonsense |
probably null |
|
|
R8879:Zfp202
|
UTSW |
9 |
40,123,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9135:Zfp202
|
UTSW |
9 |
40,120,237 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9411:Zfp202
|
UTSW |
9 |
40,118,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9785:Zfp202
|
UTSW |
9 |
40,120,233 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0012:Zfp202
|
UTSW |
9 |
40,122,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTAGGCACTTAAGAACTCACACAGG -3'
(R):5'- CTGCTCACTGAAGTTCTCGC -3'
Sequencing Primer
(F):5'- TTAAGAACTCACACAGGAGAAAAAC -3'
(R):5'- TAGGGCTTGCCTCCAACATG -3'
|
| Posted On |
2015-06-10 |
Incidental Mutation