Incidental Mutation 'R4244:Nav3'
ID 320352
Institutional Source Beutler Lab
Gene Symbol Nav3
Ensembl Gene ENSMUSG00000020181
Gene Name neuron navigator 3
Synonyms Pomfil1p, 9630020C08Rik, POMFIL1, steerin 3, 4732483H20Rik, unc53H3
MMRRC Submission 041060-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4244 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 109517120-110292065 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 109605157 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 972 (D972G)
Ref Sequence ENSEMBL: ENSMUSP00000032719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032719]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000032719
AA Change: D972G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000032719
Gene: ENSMUSG00000020181
AA Change: D972G

DomainStartEndE-ValueType
CH 79 182 4.41e-12 SMART
low complexity region 184 194 N/A INTRINSIC
low complexity region 318 329 N/A INTRINSIC
low complexity region 353 363 N/A INTRINSIC
low complexity region 427 439 N/A INTRINSIC
low complexity region 522 536 N/A INTRINSIC
low complexity region 713 724 N/A INTRINSIC
low complexity region 807 818 N/A INTRINSIC
low complexity region 873 896 N/A INTRINSIC
low complexity region 904 916 N/A INTRINSIC
low complexity region 1077 1095 N/A INTRINSIC
low complexity region 1160 1173 N/A INTRINSIC
low complexity region 1207 1229 N/A INTRINSIC
low complexity region 1256 1266 N/A INTRINSIC
low complexity region 1274 1285 N/A INTRINSIC
low complexity region 1293 1312 N/A INTRINSIC
low complexity region 1327 1341 N/A INTRINSIC
low complexity region 1383 1397 N/A INTRINSIC
low complexity region 1462 1474 N/A INTRINSIC
low complexity region 1550 1563 N/A INTRINSIC
coiled coil region 1565 1656 N/A INTRINSIC
low complexity region 1675 1692 N/A INTRINSIC
low complexity region 1722 1733 N/A INTRINSIC
low complexity region 1756 1781 N/A INTRINSIC
low complexity region 1782 1795 N/A INTRINSIC
coiled coil region 1801 1842 N/A INTRINSIC
low complexity region 1848 1871 N/A INTRINSIC
AAA 2029 2184 4.94e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161582
SMART Domains Protein: ENSMUSP00000124591
Gene: ENSMUSG00000020181

DomainStartEndE-ValueType
low complexity region 84 95 N/A INTRINSIC
low complexity region 150 173 N/A INTRINSIC
low complexity region 181 193 N/A INTRINSIC
low complexity region 354 372 N/A INTRINSIC
low complexity region 437 450 N/A INTRINSIC
low complexity region 484 506 N/A INTRINSIC
low complexity region 533 543 N/A INTRINSIC
low complexity region 551 562 N/A INTRINSIC
low complexity region 570 589 N/A INTRINSIC
low complexity region 604 618 N/A INTRINSIC
low complexity region 660 674 N/A INTRINSIC
low complexity region 739 751 N/A INTRINSIC
low complexity region 827 840 N/A INTRINSIC
coiled coil region 842 933 N/A INTRINSIC
low complexity region 952 969 N/A INTRINSIC
low complexity region 992 1003 N/A INTRINSIC
low complexity region 1026 1051 N/A INTRINSIC
low complexity region 1052 1065 N/A INTRINSIC
coiled coil region 1071 1112 N/A INTRINSIC
low complexity region 1118 1141 N/A INTRINSIC
AAA 1299 1454 4.94e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163071
SMART Domains Protein: ENSMUSP00000124856
Gene: ENSMUSG00000020181

DomainStartEndE-ValueType
low complexity region 19 33 N/A INTRINSIC
low complexity region 75 89 N/A INTRINSIC
low complexity region 140 152 N/A INTRINSIC
Meta Mutation Damage Score 0.0736 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr1b T C 1: 36,740,911 (GRCm39) Y171C possibly damaging Het
Ap1g1 G A 8: 110,560,122 (GRCm39) S281N probably benign Het
Arfgef3 C A 10: 18,506,168 (GRCm39) G878V probably damaging Het
Ccdc137 T C 11: 120,352,844 (GRCm39) F196S probably damaging Het
Ccdc18 C T 5: 108,296,838 (GRCm39) Q214* probably null Het
Ccrl2 T C 9: 110,884,422 (GRCm39) I359V probably benign Het
Cdh20 C T 1: 104,869,868 (GRCm39) T196I probably damaging Het
Cfap20dc T C 14: 8,482,521 (GRCm38) T551A probably benign Het
Col6a3 G T 1: 90,714,361 (GRCm39) T1683K unknown Het
Copa A G 1: 171,938,285 (GRCm39) I524V probably benign Het
Cyld A T 8: 89,457,383 (GRCm39) R536* probably null Het
Dock10 T A 1: 80,544,472 (GRCm39) E905V probably benign Het
Dock5 A G 14: 68,012,031 (GRCm39) F1348L probably benign Het
Efcab3 A T 11: 105,002,629 (GRCm39) K5664I probably damaging Het
Gm5174 C A 10: 86,492,144 (GRCm39) noncoding transcript Het
Gm9892 A T 8: 52,649,435 (GRCm39) noncoding transcript Het
Grm4 A G 17: 27,721,709 (GRCm39) I144T probably damaging Het
Kcnv1 G A 15: 44,977,840 (GRCm39) T66M probably damaging Het
Krt28 G T 11: 99,265,376 (GRCm39) S97Y probably damaging Het
Map3k6 T C 4: 132,979,258 (GRCm39) Y1204H possibly damaging Het
Mfsd2b G T 12: 4,924,356 (GRCm39) probably benign Het
Or2ak6 T G 11: 58,593,277 (GRCm39) L250R probably damaging Het
Or2y3 C T 17: 38,393,321 (GRCm39) V183I probably benign Het
Or5d39 T C 2: 87,979,632 (GRCm39) T244A probably benign Het
Prex1 G A 2: 166,412,256 (GRCm39) R392W probably damaging Het
Ptpn5 C T 7: 46,741,296 (GRCm39) W38* probably null Het
Rab3gap1 T C 1: 127,865,304 (GRCm39) probably null Het
Rfx7 A G 9: 72,499,051 (GRCm39) T72A possibly damaging Het
Scn7a T C 2: 66,572,345 (GRCm39) I209V probably benign Het
Sh3d21 C T 4: 126,044,511 (GRCm39) probably benign Het
Slc27a1 A G 8: 72,037,617 (GRCm39) T535A probably benign Het
Slc5a5 A G 8: 71,342,930 (GRCm39) V210A probably benign Het
Snx25 A G 8: 46,558,291 (GRCm39) C239R probably damaging Het
Sp5 T C 2: 70,307,382 (GRCm39) F356L probably damaging Het
Spaca9 T C 2: 28,582,998 (GRCm39) I141V probably benign Het
Tbcd T A 11: 121,485,107 (GRCm39) L763H probably damaging Het
Thnsl1 A G 2: 21,217,059 (GRCm39) E271G probably benign Het
Vmn1r79 T A 7: 11,910,971 (GRCm39) C284* probably null Het
Vwa5a T C 9: 38,649,112 (GRCm39) probably benign Het
Zar1 T C 5: 72,737,736 (GRCm39) E121G possibly damaging Het
Zscan29 C T 2: 120,995,275 (GRCm39) probably null Het
Other mutations in Nav3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Nav3 APN 10 109,677,594 (GRCm39) missense probably damaging 0.99
IGL00425:Nav3 APN 10 109,539,368 (GRCm39) missense probably benign 0.13
IGL00465:Nav3 APN 10 109,688,607 (GRCm39) missense probably damaging 0.99
IGL00531:Nav3 APN 10 109,539,171 (GRCm39) missense probably null 0.99
IGL00575:Nav3 APN 10 109,600,626 (GRCm39) missense probably damaging 0.98
IGL00770:Nav3 APN 10 109,652,124 (GRCm39) missense probably damaging 1.00
IGL00774:Nav3 APN 10 109,652,124 (GRCm39) missense probably damaging 1.00
IGL00858:Nav3 APN 10 109,578,493 (GRCm39) missense probably damaging 0.98
IGL00935:Nav3 APN 10 109,541,527 (GRCm39) missense probably benign
IGL01638:Nav3 APN 10 109,688,724 (GRCm39) missense probably damaging 1.00
IGL01662:Nav3 APN 10 109,605,119 (GRCm39) missense possibly damaging 0.56
IGL01670:Nav3 APN 10 109,550,102 (GRCm39) missense possibly damaging 0.92
IGL01885:Nav3 APN 10 109,578,521 (GRCm39) nonsense probably null
IGL01979:Nav3 APN 10 109,540,790 (GRCm39) missense probably benign 0.01
IGL02121:Nav3 APN 10 109,594,897 (GRCm39) missense probably damaging 0.99
IGL02210:Nav3 APN 10 109,602,851 (GRCm39) missense probably benign
IGL02523:Nav3 APN 10 109,605,157 (GRCm39) missense probably damaging 1.00
IGL02573:Nav3 APN 10 109,702,835 (GRCm39) missense probably benign 0.23
IGL02633:Nav3 APN 10 109,527,997 (GRCm39) missense probably benign 0.09
IGL02810:Nav3 APN 10 109,652,135 (GRCm39) missense probably damaging 1.00
IGL02964:Nav3 APN 10 109,572,814 (GRCm39) missense probably damaging 0.99
IGL03015:Nav3 APN 10 109,554,158 (GRCm39) missense probably damaging 0.98
IGL03288:Nav3 APN 10 109,594,878 (GRCm39) missense probably damaging 1.00
IGL03310:Nav3 APN 10 109,660,433 (GRCm39) critical splice donor site probably null
PIT4377001:Nav3 UTSW 10 109,552,466 (GRCm39) missense probably damaging 0.99
R0010:Nav3 UTSW 10 109,659,087 (GRCm39) splice site probably benign
R0043:Nav3 UTSW 10 109,603,379 (GRCm39) missense possibly damaging 0.95
R0053:Nav3 UTSW 10 109,602,778 (GRCm39) splice site probably benign
R0053:Nav3 UTSW 10 109,602,778 (GRCm39) splice site probably benign
R0077:Nav3 UTSW 10 109,552,503 (GRCm39) missense possibly damaging 0.87
R0219:Nav3 UTSW 10 109,702,791 (GRCm39) critical splice donor site probably null
R0310:Nav3 UTSW 10 109,602,989 (GRCm39) missense possibly damaging 0.82
R0380:Nav3 UTSW 10 109,594,740 (GRCm39) splice site probably benign
R0403:Nav3 UTSW 10 109,602,964 (GRCm39) missense probably damaging 0.98
R0480:Nav3 UTSW 10 109,689,161 (GRCm39) missense probably damaging 1.00
R0626:Nav3 UTSW 10 109,659,325 (GRCm39) missense probably damaging 1.00
R0637:Nav3 UTSW 10 109,606,058 (GRCm39) missense probably benign 0.25
R0847:Nav3 UTSW 10 109,739,718 (GRCm39) missense possibly damaging 0.94
R0988:Nav3 UTSW 10 109,552,389 (GRCm39) missense probably damaging 1.00
R1272:Nav3 UTSW 10 109,572,860 (GRCm39) missense probably damaging 0.98
R1295:Nav3 UTSW 10 109,527,963 (GRCm39) missense probably damaging 1.00
R1405:Nav3 UTSW 10 109,606,194 (GRCm39) splice site probably benign
R1406:Nav3 UTSW 10 109,719,495 (GRCm39) missense possibly damaging 0.64
R1406:Nav3 UTSW 10 109,719,495 (GRCm39) missense possibly damaging 0.64
R1420:Nav3 UTSW 10 109,659,115 (GRCm39) missense probably benign 0.02
R1449:Nav3 UTSW 10 109,689,372 (GRCm39) missense probably benign 0.13
R1458:Nav3 UTSW 10 109,555,905 (GRCm39) missense probably damaging 1.00
R1469:Nav3 UTSW 10 109,596,369 (GRCm39) missense probably damaging 1.00
R1469:Nav3 UTSW 10 109,596,369 (GRCm39) missense probably damaging 1.00
R1472:Nav3 UTSW 10 109,563,802 (GRCm39) missense probably damaging 0.99
R1537:Nav3 UTSW 10 109,702,846 (GRCm39) missense probably damaging 1.00
R1539:Nav3 UTSW 10 109,603,031 (GRCm39) missense probably damaging 0.99
R1581:Nav3 UTSW 10 109,659,289 (GRCm39) missense probably damaging 1.00
R1586:Nav3 UTSW 10 109,689,115 (GRCm39) missense probably damaging 1.00
R1654:Nav3 UTSW 10 109,688,984 (GRCm39) missense possibly damaging 0.85
R1725:Nav3 UTSW 10 109,659,451 (GRCm39) missense probably damaging 1.00
R1742:Nav3 UTSW 10 109,605,074 (GRCm39) missense probably benign
R1793:Nav3 UTSW 10 109,539,233 (GRCm39) missense probably benign 0.00
R1830:Nav3 UTSW 10 109,659,184 (GRCm39) missense probably damaging 1.00
R1834:Nav3 UTSW 10 109,555,883 (GRCm39) missense probably damaging 0.99
R1881:Nav3 UTSW 10 109,688,420 (GRCm39) missense probably damaging 0.96
R1922:Nav3 UTSW 10 109,541,467 (GRCm39) missense probably benign 0.43
R1944:Nav3 UTSW 10 109,552,391 (GRCm39) missense probably damaging 0.99
R1981:Nav3 UTSW 10 109,554,951 (GRCm39) splice site probably benign
R1985:Nav3 UTSW 10 109,606,045 (GRCm39) splice site probably benign
R1996:Nav3 UTSW 10 109,689,262 (GRCm39) missense probably damaging 1.00
R2051:Nav3 UTSW 10 109,660,536 (GRCm39) missense probably damaging 0.99
R2062:Nav3 UTSW 10 109,555,882 (GRCm39) missense probably damaging 1.00
R2139:Nav3 UTSW 10 109,688,996 (GRCm39) missense probably benign 0.22
R2248:Nav3 UTSW 10 109,532,088 (GRCm39) missense probably damaging 1.00
R2420:Nav3 UTSW 10 109,699,674 (GRCm39) missense probably damaging 0.98
R2444:Nav3 UTSW 10 109,600,776 (GRCm39) missense probably benign 0.09
R3026:Nav3 UTSW 10 109,660,465 (GRCm39) missense probably damaging 0.99
R3052:Nav3 UTSW 10 109,739,613 (GRCm39) missense probably damaging 0.99
R3441:Nav3 UTSW 10 109,540,789 (GRCm39) missense probably benign 0.01
R3845:Nav3 UTSW 10 109,689,237 (GRCm39) missense possibly damaging 0.82
R3929:Nav3 UTSW 10 109,520,064 (GRCm39) missense probably damaging 1.00
R3932:Nav3 UTSW 10 109,529,896 (GRCm39) missense probably damaging 0.99
R4056:Nav3 UTSW 10 109,716,394 (GRCm39) critical splice donor site probably null
R4057:Nav3 UTSW 10 109,716,394 (GRCm39) critical splice donor site probably null
R4120:Nav3 UTSW 10 109,739,605 (GRCm39) critical splice donor site probably null
R4361:Nav3 UTSW 10 109,688,847 (GRCm39) missense probably damaging 1.00
R4512:Nav3 UTSW 10 109,529,943 (GRCm39) missense possibly damaging 0.89
R4514:Nav3 UTSW 10 109,529,943 (GRCm39) missense possibly damaging 0.89
R4700:Nav3 UTSW 10 109,600,796 (GRCm39) missense probably benign 0.10
R4815:Nav3 UTSW 10 109,659,413 (GRCm39) missense probably benign
R4981:Nav3 UTSW 10 109,716,553 (GRCm39) missense probably benign
R5042:Nav3 UTSW 10 109,605,129 (GRCm39) missense probably benign 0.27
R5251:Nav3 UTSW 10 109,689,114 (GRCm39) missense probably damaging 0.99
R5252:Nav3 UTSW 10 109,550,152 (GRCm39) small deletion probably benign
R5273:Nav3 UTSW 10 109,528,899 (GRCm39) critical splice donor site probably null
R5288:Nav3 UTSW 10 109,688,966 (GRCm39) missense probably benign 0.10
R5407:Nav3 UTSW 10 109,702,796 (GRCm39) missense probably benign 0.28
R5533:Nav3 UTSW 10 109,719,539 (GRCm39) missense possibly damaging 0.61
R5561:Nav3 UTSW 10 109,552,413 (GRCm39) missense probably damaging 1.00
R5577:Nav3 UTSW 10 109,605,264 (GRCm39) missense probably damaging 1.00
R5656:Nav3 UTSW 10 109,600,494 (GRCm39) missense probably damaging 0.96
R5872:Nav3 UTSW 10 109,600,648 (GRCm39) missense probably damaging 1.00
R6023:Nav3 UTSW 10 109,659,376 (GRCm39) missense possibly damaging 0.95
R6061:Nav3 UTSW 10 109,702,845 (GRCm39) nonsense probably null
R6189:Nav3 UTSW 10 109,555,880 (GRCm39) missense probably damaging 0.98
R6214:Nav3 UTSW 10 109,688,426 (GRCm39) missense probably damaging 1.00
R6215:Nav3 UTSW 10 109,688,426 (GRCm39) missense probably damaging 1.00
R6264:Nav3 UTSW 10 109,524,694 (GRCm39) missense probably damaging 0.97
R6500:Nav3 UTSW 10 109,600,617 (GRCm39) missense probably damaging 1.00
R6524:Nav3 UTSW 10 109,555,891 (GRCm39) missense probably damaging 0.99
R6868:Nav3 UTSW 10 109,529,027 (GRCm39) missense possibly damaging 0.49
R7079:Nav3 UTSW 10 109,603,153 (GRCm39) missense probably benign 0.16
R7099:Nav3 UTSW 10 109,539,195 (GRCm39) missense probably benign 0.11
R7139:Nav3 UTSW 10 109,689,338 (GRCm39) missense probably benign 0.44
R7238:Nav3 UTSW 10 109,689,185 (GRCm39) missense possibly damaging 0.75
R7338:Nav3 UTSW 10 109,605,073 (GRCm39) missense probably benign 0.04
R7343:Nav3 UTSW 10 109,739,619 (GRCm39) missense probably damaging 0.98
R7383:Nav3 UTSW 10 109,552,532 (GRCm39) missense probably damaging 0.98
R7391:Nav3 UTSW 10 109,539,317 (GRCm39) missense probably benign 0.07
R7399:Nav3 UTSW 10 109,688,795 (GRCm39) missense possibly damaging 0.74
R7457:Nav3 UTSW 10 109,532,189 (GRCm39) nonsense probably null
R7462:Nav3 UTSW 10 109,659,439 (GRCm39) missense probably damaging 1.00
R7542:Nav3 UTSW 10 109,659,394 (GRCm39) missense possibly damaging 0.89
R7659:Nav3 UTSW 10 109,602,851 (GRCm39) missense probably benign 0.09
R7749:Nav3 UTSW 10 109,539,213 (GRCm39) missense probably damaging 0.99
R7794:Nav3 UTSW 10 109,524,717 (GRCm39) missense probably benign 0.08
R7876:Nav3 UTSW 10 109,689,359 (GRCm39) missense probably benign 0.26
R8048:Nav3 UTSW 10 109,600,779 (GRCm39) missense probably benign 0.13
R8104:Nav3 UTSW 10 109,594,828 (GRCm39) missense probably damaging 0.99
R8125:Nav3 UTSW 10 109,688,520 (GRCm39) missense probably damaging 0.99
R8275:Nav3 UTSW 10 109,527,984 (GRCm39) missense noncoding transcript
R8325:Nav3 UTSW 10 109,541,464 (GRCm39) missense probably benign 0.24
R8336:Nav3 UTSW 10 109,603,430 (GRCm39) missense probably damaging 0.99
R8523:Nav3 UTSW 10 109,659,138 (GRCm39) missense probably damaging 1.00
R8529:Nav3 UTSW 10 109,689,192 (GRCm39) missense probably benign 0.09
R8745:Nav3 UTSW 10 109,659,311 (GRCm39) missense probably benign 0.08
R8752:Nav3 UTSW 10 109,596,165 (GRCm39) intron probably benign
R8794:Nav3 UTSW 10 109,605,032 (GRCm39) nonsense probably null
R8816:Nav3 UTSW 10 109,699,721 (GRCm39) missense possibly damaging 0.69
R9029:Nav3 UTSW 10 109,699,613 (GRCm39) missense possibly damaging 0.68
R9117:Nav3 UTSW 10 109,520,100 (GRCm39) missense probably benign 0.41
R9126:Nav3 UTSW 10 109,541,524 (GRCm39) missense probably benign
R9258:Nav3 UTSW 10 109,550,243 (GRCm39) missense probably damaging 0.99
R9347:Nav3 UTSW 10 109,738,955 (GRCm39) missense probably damaging 0.98
R9353:Nav3 UTSW 10 109,554,065 (GRCm39) missense probably damaging 0.99
R9366:Nav3 UTSW 10 109,659,364 (GRCm39) missense probably damaging 0.99
R9384:Nav3 UTSW 10 109,554,158 (GRCm39) missense probably damaging 0.98
R9428:Nav3 UTSW 10 109,605,176 (GRCm39) missense probably benign
R9454:Nav3 UTSW 10 109,835,864 (GRCm39) missense probably benign 0.01
R9516:Nav3 UTSW 10 109,520,015 (GRCm39) missense probably damaging 1.00
R9521:Nav3 UTSW 10 109,835,845 (GRCm39) missense possibly damaging 0.95
R9622:Nav3 UTSW 10 109,603,103 (GRCm39) missense probably benign
R9689:Nav3 UTSW 10 109,605,034 (GRCm39) missense probably damaging 1.00
R9796:Nav3 UTSW 10 109,527,969 (GRCm39) missense probably damaging 0.99
X0012:Nav3 UTSW 10 109,527,958 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTCAGCAGAGACTATCCCAAG -3'
(R):5'- AATAGAATCGTCTCTTGCGTTCTTCTG -3'

Sequencing Primer
(F):5'- GCGACAAGCCTACCAGG -3'
(R):5'- AAACTGCATTTCAGCTCTGGG -3'
Posted On 2015-06-12