Incidental Mutation 'R4246:Or5m5'
ID 320409
Institutional Source Beutler Lab
Gene Symbol Or5m5
Ensembl Gene ENSMUSG00000044923
Gene Name olfactory receptor family 5 subfamily M member 5
Synonyms MOR196-2, Olfr1030, GA_x6K02T2Q125-47462755-47463693
MMRRC Submission 041062-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R4246 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 85809656-85815142 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 85814624 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 147 (C147S)
Ref Sequence ENSEMBL: ENSMUSP00000053309 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056849]
AlphaFold Q8VFL5
Predicted Effect possibly damaging
Transcript: ENSMUST00000056849
AA Change: C147S

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000053309
Gene: ENSMUSG00000044923
AA Change: C147S

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.4e-58 PFAM
Pfam:7tm_1 47 296 3.2e-27 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik A G 18: 24,606,013 (GRCm39) N36S possibly damaging Het
Ak1 A G 2: 32,523,384 (GRCm39) T151A possibly damaging Het
Asxl3 A G 18: 22,658,557 (GRCm39) D2189G probably damaging Het
Ccdc91 C T 6: 147,493,646 (GRCm39) A346V unknown Het
Dnah6 C T 6: 73,106,431 (GRCm39) E1769K probably benign Het
Dock6 A T 9: 21,750,786 (GRCm39) probably null Het
Fhod3 A G 18: 25,123,123 (GRCm39) K271R probably null Het
Glyatl3 T A 17: 41,220,989 (GRCm39) D126V probably benign Het
Gnal C G 18: 67,221,654 (GRCm39) P19R unknown Het
Igkv8-21 T A 6: 70,292,436 (GRCm39) M1L possibly damaging Het
Itih4 C A 14: 30,613,359 (GRCm39) H261N probably damaging Het
Jpt1 T C 11: 115,405,119 (GRCm39) probably benign Het
Kif14 G T 1: 136,401,126 (GRCm39) M492I possibly damaging Het
Klhl32 A C 4: 24,800,822 (GRCm39) S3A possibly damaging Het
Kmt2d C T 15: 98,737,970 (GRCm39) probably benign Het
Lamtor5 T C 3: 107,186,354 (GRCm39) V41A probably benign Het
Lmtk3 G A 7: 45,443,486 (GRCm39) C723Y possibly damaging Het
Lrfn1 G T 7: 28,159,367 (GRCm39) V429L probably benign Het
Mapkbp1 T A 2: 119,843,508 (GRCm39) I252N probably damaging Het
Nelfa A G 5: 34,056,373 (GRCm39) F464S probably damaging Het
Nipbl G A 15: 8,361,916 (GRCm39) L1454F probably damaging Het
Nr4a3 C T 4: 48,083,125 (GRCm39) P553S possibly damaging Het
Nrg3 G A 14: 39,194,198 (GRCm39) T187I possibly damaging Het
Or8g36 A G 9: 39,422,899 (GRCm39) V39A probably benign Het
Pcdha8 A G 18: 37,125,950 (GRCm39) E144G probably damaging Het
Pik3cb T C 9: 98,983,229 (GRCm39) probably null Het
Pira1 C T 7: 3,740,348 (GRCm39) G291E probably damaging Het
Pkd1l1 C T 11: 8,815,543 (GRCm39) R1456K possibly damaging Het
Ppp1r3a T A 6: 14,719,780 (GRCm39) E378V probably damaging Het
Psd2 T C 18: 36,139,172 (GRCm39) L540P probably damaging Het
Rnf14 T A 18: 38,434,701 (GRCm39) probably null Het
Satl1 A G X: 111,316,033 (GRCm39) S141P probably benign Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Sh3d19 G A 3: 86,033,995 (GRCm39) V783I probably benign Het
Snca T C 6: 60,710,149 (GRCm39) E110G possibly damaging Het
Sumf1 A C 6: 108,131,974 (GRCm39) V156G probably damaging Het
Trhr A T 15: 44,096,856 (GRCm39) probably null Het
Tsen2 A G 6: 115,524,785 (GRCm39) probably benign Het
Tuft1 C A 3: 94,522,108 (GRCm39) M319I probably benign Het
Vill C A 9: 118,889,461 (GRCm39) N132K probably damaging Het
Wars2 T A 3: 99,123,904 (GRCm39) V255E probably damaging Het
Zcchc14 CTGATGGTGGTGGTGATGGTGGTGG CTGATGGTGGTGG 8: 122,331,031 (GRCm39) probably benign Het
Other mutations in Or5m5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01775:Or5m5 APN 2 85,815,014 (GRCm39) missense probably damaging 0.99
IGL01795:Or5m5 APN 2 85,814,478 (GRCm39) missense probably damaging 1.00
IGL02395:Or5m5 APN 2 85,814,426 (GRCm39) missense possibly damaging 0.76
IGL03277:Or5m5 APN 2 85,814,517 (GRCm39) missense probably damaging 0.99
PIT4468001:Or5m5 UTSW 2 85,814,792 (GRCm39) missense probably benign 0.10
R0458:Or5m5 UTSW 2 85,814,600 (GRCm39) missense probably benign 0.00
R1114:Or5m5 UTSW 2 85,814,651 (GRCm39) missense probably benign
R1642:Or5m5 UTSW 2 85,814,201 (GRCm39) missense probably benign 0.00
R2189:Or5m5 UTSW 2 85,814,412 (GRCm39) missense probably damaging 1.00
R4094:Or5m5 UTSW 2 85,814,562 (GRCm39) missense probably damaging 1.00
R4677:Or5m5 UTSW 2 85,814,315 (GRCm39) missense possibly damaging 0.61
R5537:Or5m5 UTSW 2 85,814,570 (GRCm39) missense possibly damaging 0.83
R6018:Or5m5 UTSW 2 85,815,148 (GRCm39) utr 3 prime probably benign
R6531:Or5m5 UTSW 2 85,814,651 (GRCm39) missense probably benign
R7367:Or5m5 UTSW 2 85,814,687 (GRCm39) missense possibly damaging 0.68
R7611:Or5m5 UTSW 2 85,814,407 (GRCm39) nonsense probably null
R7693:Or5m5 UTSW 2 85,814,979 (GRCm39) missense probably damaging 1.00
R7753:Or5m5 UTSW 2 85,815,060 (GRCm39) missense possibly damaging 0.75
R8940:Or5m5 UTSW 2 85,814,543 (GRCm39) missense probably benign
R8961:Or5m5 UTSW 2 85,814,610 (GRCm39) missense probably damaging 1.00
R9049:Or5m5 UTSW 2 85,814,235 (GRCm39) missense possibly damaging 0.49
R9202:Or5m5 UTSW 2 85,814,801 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- ATGTGACTCCCAAGATGCTGG -3'
(R):5'- TTGGAGAGGTTAAATCCTGCTAC -3'

Sequencing Primer
(F):5'- TGACTCCCAAGATGCTGGTGAAC -3'
(R):5'- GAGGTTAAATCCTGCTACTACAAAC -3'
Posted On 2015-06-12