Incidental Mutation 'R0396:Jmjd1c'
| ID |
32060 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Jmjd1c
|
| Ensembl Gene |
ENSMUSG00000037876 |
| Gene Name |
jumonji domain containing 1C |
| Synonyms |
D630035I23Rik, TRIP8, 5430433L24Rik |
| MMRRC Submission |
038602-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.655)
|
| Stock # |
R0396 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
66932189-67092105 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 67055302 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 528
(T528A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134551
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051446]
[ENSMUST00000173689]
[ENSMUST00000174317]
[ENSMUST00000174408]
|
| AlphaFold |
Q69ZK6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000051446
AA Change: T528A
PolyPhen 2
Score 0.209 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000056227
Gene: ENSMUSG00000037876
AA Change: T528A
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2236 |
N/A |
BLAST |
|
JmjC
|
2264 |
2488 |
3.29e-53 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173187
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173661
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173689
AA Change: T347A
PolyPhen 2
Score 0.209 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000133700
Gene: ENSMUSG00000037876
AA Change: T347A
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
2056 |
N/A |
BLAST |
|
JmjC
|
2084 |
2308 |
3.29e-53 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000174317
AA Change: T241A
PolyPhen 2
Score 0.760 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000134246
Gene: ENSMUSG00000037876
AA Change: T241A
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
744 |
N/A |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000174408
AA Change: T528A
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000134551
Gene: ENSMUSG00000037876
AA Change: T528A
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2237 |
N/A |
BLAST |
|
JmjC
|
2265 |
2489 |
3.29e-53 |
SMART |
|
| Meta Mutation Damage Score |
0.0602 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.0%
- 10x: 95.5%
- 20x: 89.8%
|
| Validation Efficiency |
92% (96/104) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit an age-dependent male infertility phenotype, characterized by early loss of undifferentiated spermatogonia, and a progressive reduction in testis size/weight and male germ cells, partly due to increased male germ cell apoptosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933405L10Rik |
G |
A |
8: 106,436,412 (GRCm39) |
V194I |
probably benign |
Het |
| Acsm1 |
A |
T |
7: 119,235,678 (GRCm39) |
I133F |
probably damaging |
Het |
| Adamts9 |
T |
A |
6: 92,774,986 (GRCm39) |
T1676S |
probably benign |
Het |
| Adcy4 |
T |
C |
14: 56,009,745 (GRCm39) |
D769G |
probably benign |
Het |
| Aif1 |
T |
C |
17: 35,390,085 (GRCm39) |
*148W |
probably null |
Het |
| Akna |
C |
T |
4: 63,310,363 (GRCm39) |
|
probably benign |
Het |
| Arhgap32 |
G |
A |
9: 32,156,551 (GRCm39) |
|
probably null |
Het |
| Atpaf1 |
G |
A |
4: 115,642,449 (GRCm39) |
E92K |
possibly damaging |
Het |
| Bltp2 |
T |
C |
11: 78,159,203 (GRCm39) |
V467A |
possibly damaging |
Het |
| C1s1 |
T |
C |
6: 124,510,313 (GRCm39) |
E378G |
probably benign |
Het |
| Caprin1 |
T |
A |
2: 103,599,914 (GRCm39) |
Q108L |
probably damaging |
Het |
| Car13 |
A |
T |
3: 14,721,299 (GRCm39) |
H154L |
probably benign |
Het |
| Cdon |
C |
A |
9: 35,381,426 (GRCm39) |
N605K |
probably damaging |
Het |
| Ceacam10 |
G |
A |
7: 24,480,439 (GRCm39) |
G70E |
probably damaging |
Het |
| Cfap221 |
G |
A |
1: 119,881,930 (GRCm39) |
T286M |
probably benign |
Het |
| Cfap61 |
T |
C |
2: 145,791,864 (GRCm39) |
F107S |
possibly damaging |
Het |
| Coil |
C |
A |
11: 88,872,449 (GRCm39) |
T270N |
probably benign |
Het |
| Crocc2 |
T |
G |
1: 93,151,936 (GRCm39) |
|
probably benign |
Het |
| Crot |
T |
C |
5: 9,019,959 (GRCm39) |
E461G |
probably damaging |
Het |
| D130052B06Rik |
G |
T |
11: 33,573,391 (GRCm39) |
R41L |
unknown |
Het |
| D630045J12Rik |
T |
C |
6: 38,173,671 (GRCm39) |
S166G |
possibly damaging |
Het |
| Dennd4a |
T |
G |
9: 64,769,673 (GRCm39) |
V460G |
probably damaging |
Het |
| Depdc7 |
A |
T |
2: 104,557,668 (GRCm39) |
|
probably benign |
Het |
| Dgkb |
G |
A |
12: 38,240,134 (GRCm39) |
|
probably null |
Het |
| Dhx57 |
T |
G |
17: 80,582,226 (GRCm39) |
S407R |
probably benign |
Het |
| Dnase2a |
G |
T |
8: 85,636,392 (GRCm39) |
|
probably benign |
Het |
| Dqx1 |
T |
G |
6: 83,035,986 (GRCm39) |
M106R |
probably benign |
Het |
| Eno1b |
T |
C |
18: 48,180,806 (GRCm39) |
I328T |
probably benign |
Het |
| Ephx2 |
T |
G |
14: 66,345,512 (GRCm39) |
I151L |
probably benign |
Het |
| Gdf3 |
C |
T |
6: 122,584,094 (GRCm39) |
G91D |
probably damaging |
Het |
| Gpc5 |
T |
A |
14: 115,665,620 (GRCm39) |
N481K |
possibly damaging |
Het |
| Gsdme |
T |
A |
6: 50,198,087 (GRCm39) |
H291L |
probably benign |
Het |
| H2-T13 |
A |
G |
17: 36,394,614 (GRCm39) |
I103T |
possibly damaging |
Het |
| Hif3a |
G |
A |
7: 16,785,946 (GRCm39) |
|
probably benign |
Het |
| Hmox2 |
A |
T |
16: 4,583,627 (GRCm39) |
I232L |
probably benign |
Het |
| Itgb2 |
A |
G |
10: 77,397,023 (GRCm39) |
Y686C |
probably damaging |
Het |
| Kdr |
T |
C |
5: 76,121,388 (GRCm39) |
I541V |
possibly damaging |
Het |
| Khdrbs2 |
C |
A |
1: 32,559,054 (GRCm39) |
V343L |
probably damaging |
Het |
| Kif16b |
C |
T |
2: 142,695,579 (GRCm39) |
R175H |
probably damaging |
Het |
| Klri2 |
T |
G |
6: 129,717,251 (GRCm39) |
E44A |
possibly damaging |
Het |
| Kmt2b |
G |
T |
7: 30,276,180 (GRCm39) |
T1773K |
probably damaging |
Het |
| Lair1 |
A |
G |
7: 4,013,785 (GRCm39) |
L154P |
probably damaging |
Het |
| Larp1b |
G |
A |
3: 40,924,996 (GRCm39) |
V158M |
probably damaging |
Het |
| Lgi3 |
T |
A |
14: 70,772,280 (GRCm39) |
I275N |
probably damaging |
Het |
| Lrba |
A |
G |
3: 86,202,486 (GRCm39) |
N246D |
probably damaging |
Het |
| Lrrc45 |
T |
A |
11: 120,605,733 (GRCm39) |
|
probably benign |
Het |
| Mdh2 |
G |
T |
5: 135,818,533 (GRCm39) |
V263L |
probably benign |
Het |
| Myom1 |
T |
A |
17: 71,341,688 (GRCm39) |
V149E |
probably damaging |
Het |
| Nanos1 |
A |
T |
19: 60,745,479 (GRCm39) |
D259V |
probably damaging |
Het |
| Nedd4l |
T |
A |
18: 65,294,725 (GRCm39) |
|
probably benign |
Het |
| Npas3 |
A |
G |
12: 53,878,528 (GRCm39) |
Y150C |
probably damaging |
Het |
| Or10ab4 |
A |
T |
7: 107,655,170 (GRCm39) |
H327L |
probably benign |
Het |
| Or10ag59 |
T |
A |
2: 87,405,911 (GRCm39) |
V161D |
possibly damaging |
Het |
| Or2h1b |
C |
T |
17: 37,462,446 (GRCm39) |
C139Y |
probably damaging |
Het |
| Or2y1f |
A |
T |
11: 49,184,165 (GRCm39) |
I6F |
probably benign |
Het |
| Or52e15 |
G |
A |
7: 104,645,913 (GRCm39) |
A66V |
probably damaging |
Het |
| Or8k28 |
T |
C |
2: 86,286,363 (GRCm39) |
N84S |
possibly damaging |
Het |
| Pde4c |
A |
G |
8: 71,202,725 (GRCm39) |
N637S |
probably benign |
Het |
| Pds5b |
T |
A |
5: 150,702,740 (GRCm39) |
V824D |
possibly damaging |
Het |
| Pole2 |
A |
T |
12: 69,269,160 (GRCm39) |
|
probably benign |
Het |
| Ppig |
C |
T |
2: 69,566,320 (GRCm39) |
|
probably benign |
Het |
| Prep |
A |
G |
10: 44,968,772 (GRCm39) |
Y90C |
probably damaging |
Het |
| Proca1 |
A |
T |
11: 78,085,731 (GRCm39) |
R11S |
probably damaging |
Het |
| Prph |
T |
A |
15: 98,954,872 (GRCm39) |
W313R |
probably benign |
Het |
| Prune2 |
C |
T |
19: 17,100,444 (GRCm39) |
P1983S |
probably benign |
Het |
| Ptbp2 |
G |
A |
3: 119,517,847 (GRCm39) |
|
probably benign |
Het |
| Rsph6a |
C |
T |
7: 18,808,031 (GRCm39) |
P398L |
probably damaging |
Het |
| Sdk2 |
T |
C |
11: 113,720,793 (GRCm39) |
I1379V |
probably benign |
Het |
| Sf3b1 |
C |
T |
1: 55,058,430 (GRCm39) |
G53E |
probably damaging |
Het |
| Slc9a3 |
T |
C |
13: 74,305,903 (GRCm39) |
|
probably null |
Het |
| Smarcal1 |
A |
T |
1: 72,665,632 (GRCm39) |
H710L |
probably benign |
Het |
| Soat2 |
GAGAAG |
GAG |
15: 102,059,142 (GRCm39) |
|
probably benign |
Het |
| Sptan1 |
T |
C |
2: 29,881,045 (GRCm39) |
V438A |
probably damaging |
Het |
| Sstr4 |
T |
A |
2: 148,238,181 (GRCm39) |
V264D |
probably damaging |
Het |
| Susd2 |
A |
G |
10: 75,475,745 (GRCm39) |
L418P |
probably damaging |
Het |
| Synj1 |
A |
G |
16: 90,735,528 (GRCm39) |
V1475A |
probably benign |
Het |
| Szt2 |
G |
A |
4: 118,233,544 (GRCm39) |
|
probably benign |
Het |
| Tbc1d4 |
T |
C |
14: 101,695,499 (GRCm39) |
|
probably null |
Het |
| Tesk1 |
A |
G |
4: 43,446,000 (GRCm39) |
E311G |
probably damaging |
Het |
| Tmed5 |
A |
T |
5: 108,273,882 (GRCm39) |
V119E |
probably damaging |
Het |
| Tmem260 |
T |
C |
14: 48,724,324 (GRCm39) |
S201P |
possibly damaging |
Het |
| Tnxb |
A |
G |
17: 34,890,707 (GRCm39) |
Y350C |
probably damaging |
Het |
| Tpte |
T |
C |
8: 22,825,624 (GRCm39) |
|
probably benign |
Het |
| Trim37 |
A |
T |
11: 87,037,794 (GRCm39) |
D161V |
probably damaging |
Het |
| Trrap |
C |
A |
5: 144,751,366 (GRCm39) |
Q1640K |
probably damaging |
Het |
| Tspoap1 |
T |
C |
11: 87,667,172 (GRCm39) |
|
probably benign |
Het |
| Ttk |
T |
A |
9: 83,729,313 (GRCm39) |
|
probably benign |
Het |
| Vmn1r172 |
A |
G |
7: 23,359,957 (GRCm39) |
S281G |
probably benign |
Het |
| Vmn1r177 |
A |
G |
7: 23,565,022 (GRCm39) |
S285P |
probably damaging |
Het |
| Vmn1r231 |
C |
T |
17: 21,110,661 (GRCm39) |
V85I |
probably damaging |
Het |
| Vmn2r100 |
C |
A |
17: 19,742,382 (GRCm39) |
P252Q |
possibly damaging |
Het |
| Vmn2r118 |
T |
C |
17: 55,915,643 (GRCm39) |
I436V |
probably benign |
Het |
| Vmn2r12 |
T |
C |
5: 109,240,765 (GRCm39) |
K116R |
probably benign |
Het |
| Vmn2r28 |
T |
A |
7: 5,491,513 (GRCm39) |
I245L |
probably benign |
Het |
| Wdr26 |
A |
T |
1: 181,008,216 (GRCm39) |
|
probably benign |
Het |
| Xrcc3 |
A |
T |
12: 111,776,391 (GRCm39) |
H67Q |
probably benign |
Het |
| Zbbx |
A |
T |
3: 74,985,802 (GRCm39) |
S417T |
possibly damaging |
Het |
| Zc3h13 |
A |
G |
14: 75,560,922 (GRCm39) |
D504G |
unknown |
Het |
| Zfp1005 |
G |
A |
2: 150,109,973 (GRCm39) |
G221D |
probably damaging |
Het |
| Zfp217 |
C |
T |
2: 169,957,382 (GRCm39) |
A539T |
probably benign |
Het |
| Zyg11b |
A |
T |
4: 108,112,505 (GRCm39) |
F388I |
probably damaging |
Het |
|
| Other mutations in Jmjd1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01062:Jmjd1c
|
APN |
10 |
67,062,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01604:Jmjd1c
|
APN |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Jmjd1c
|
APN |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02081:Jmjd1c
|
APN |
10 |
67,055,305 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02128:Jmjd1c
|
APN |
10 |
67,079,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02134:Jmjd1c
|
APN |
10 |
67,056,171 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02215:Jmjd1c
|
APN |
10 |
67,056,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Jmjd1c
|
APN |
10 |
67,062,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02502:Jmjd1c
|
APN |
10 |
67,061,640 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02546:Jmjd1c
|
APN |
10 |
67,061,115 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02943:Jmjd1c
|
APN |
10 |
67,055,433 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03171:Jmjd1c
|
APN |
10 |
67,061,277 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03261:Jmjd1c
|
APN |
10 |
67,067,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Accordion
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Jmjd1c
|
UTSW |
10 |
67,065,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0126:Jmjd1c
|
UTSW |
10 |
67,055,105 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0133:Jmjd1c
|
UTSW |
10 |
67,076,587 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0201:Jmjd1c
|
UTSW |
10 |
67,054,888 (GRCm39) |
missense |
unknown |
|
|
R0401:Jmjd1c
|
UTSW |
10 |
67,056,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0452:Jmjd1c
|
UTSW |
10 |
67,091,261 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0488:Jmjd1c
|
UTSW |
10 |
67,076,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0504:Jmjd1c
|
UTSW |
10 |
67,061,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Jmjd1c
|
UTSW |
10 |
67,061,568 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0673:Jmjd1c
|
UTSW |
10 |
67,062,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0718:Jmjd1c
|
UTSW |
10 |
67,054,725 (GRCm39) |
splice site |
probably null |
|
|
R0755:Jmjd1c
|
UTSW |
10 |
66,932,378 (GRCm39) |
intron |
probably benign |
|
|
R1142:Jmjd1c
|
UTSW |
10 |
67,061,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Jmjd1c
|
UTSW |
10 |
67,075,015 (GRCm39) |
splice site |
probably benign |
|
|
R1413:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1619:Jmjd1c
|
UTSW |
10 |
67,055,654 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1676:Jmjd1c
|
UTSW |
10 |
67,060,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1751:Jmjd1c
|
UTSW |
10 |
67,061,469 (GRCm39) |
missense |
probably benign |
|
|
R1950:Jmjd1c
|
UTSW |
10 |
67,075,701 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1968:Jmjd1c
|
UTSW |
10 |
67,061,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2049:Jmjd1c
|
UTSW |
10 |
66,993,777 (GRCm39) |
nonsense |
probably null |
|
|
R2061:Jmjd1c
|
UTSW |
10 |
67,054,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2203:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2256:Jmjd1c
|
UTSW |
10 |
67,061,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Jmjd1c
|
UTSW |
10 |
67,074,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2349:Jmjd1c
|
UTSW |
10 |
67,091,279 (GRCm39) |
missense |
probably benign |
|
|
R2392:Jmjd1c
|
UTSW |
10 |
67,065,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3015:Jmjd1c
|
UTSW |
10 |
66,993,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3110:Jmjd1c
|
UTSW |
10 |
67,075,863 (GRCm39) |
splice site |
probably benign |
|
|
R4043:Jmjd1c
|
UTSW |
10 |
67,055,245 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4097:Jmjd1c
|
UTSW |
10 |
67,054,787 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4118:Jmjd1c
|
UTSW |
10 |
67,055,532 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4193:Jmjd1c
|
UTSW |
10 |
66,932,460 (GRCm39) |
intron |
probably benign |
|
|
R4352:Jmjd1c
|
UTSW |
10 |
67,080,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4577:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Jmjd1c
|
UTSW |
10 |
66,993,753 (GRCm39) |
nonsense |
probably null |
|
|
R4717:Jmjd1c
|
UTSW |
10 |
66,993,830 (GRCm39) |
nonsense |
probably null |
|
|
R4741:Jmjd1c
|
UTSW |
10 |
67,060,718 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4774:Jmjd1c
|
UTSW |
10 |
67,060,571 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R4836:Jmjd1c
|
UTSW |
10 |
67,069,225 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4914:Jmjd1c
|
UTSW |
10 |
67,054,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4939:Jmjd1c
|
UTSW |
10 |
67,081,916 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5211:Jmjd1c
|
UTSW |
10 |
67,067,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Jmjd1c
|
UTSW |
10 |
67,076,480 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5514:Jmjd1c
|
UTSW |
10 |
67,053,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5530:Jmjd1c
|
UTSW |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Jmjd1c
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5640:Jmjd1c
|
UTSW |
10 |
67,061,857 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5654:Jmjd1c
|
UTSW |
10 |
67,065,785 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5742:Jmjd1c
|
UTSW |
10 |
67,056,112 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5764:Jmjd1c
|
UTSW |
10 |
67,062,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6118:Jmjd1c
|
UTSW |
10 |
67,075,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Jmjd1c
|
UTSW |
10 |
67,083,827 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6256:Jmjd1c
|
UTSW |
10 |
67,056,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6266:Jmjd1c
|
UTSW |
10 |
67,085,439 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6358:Jmjd1c
|
UTSW |
10 |
67,061,718 (GRCm39) |
missense |
probably benign |
|
|
R6430:Jmjd1c
|
UTSW |
10 |
67,059,939 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6455:Jmjd1c
|
UTSW |
10 |
67,061,795 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6887:Jmjd1c
|
UTSW |
10 |
67,025,599 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6895:Jmjd1c
|
UTSW |
10 |
67,052,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7041:Jmjd1c
|
UTSW |
10 |
67,056,388 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7095:Jmjd1c
|
UTSW |
10 |
67,055,411 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7113:Jmjd1c
|
UTSW |
10 |
66,993,780 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7225:Jmjd1c
|
UTSW |
10 |
67,061,844 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7249:Jmjd1c
|
UTSW |
10 |
67,025,596 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7361:Jmjd1c
|
UTSW |
10 |
67,054,143 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7383:Jmjd1c
|
UTSW |
10 |
67,025,537 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7460:Jmjd1c
|
UTSW |
10 |
67,052,815 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7475:Jmjd1c
|
UTSW |
10 |
67,061,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7502:Jmjd1c
|
UTSW |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7699:Jmjd1c
|
UTSW |
10 |
67,054,195 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7745:Jmjd1c
|
UTSW |
10 |
67,052,824 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7897:Jmjd1c
|
UTSW |
10 |
67,075,644 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Jmjd1c
|
UTSW |
10 |
67,061,621 (GRCm39) |
missense |
probably benign |
|
|
R7911:Jmjd1c
|
UTSW |
10 |
67,067,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Jmjd1c
|
UTSW |
10 |
67,085,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Jmjd1c
|
UTSW |
10 |
67,090,274 (GRCm39) |
missense |
not run |
|
|
R8224:Jmjd1c
|
UTSW |
10 |
67,080,628 (GRCm39) |
missense |
noncoding transcript |
|
|
R8251:Jmjd1c
|
UTSW |
10 |
67,075,068 (GRCm39) |
missense |
noncoding transcript |
|
|
R8797:Jmjd1c
|
UTSW |
10 |
67,060,616 (GRCm39) |
missense |
probably benign |
|
|
R8833:Jmjd1c
|
UTSW |
10 |
67,054,162 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9262:Jmjd1c
|
UTSW |
10 |
67,083,793 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9354:Jmjd1c
|
UTSW |
10 |
67,059,875 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9373:Jmjd1c
|
UTSW |
10 |
66,932,495 (GRCm39) |
intron |
probably benign |
|
|
R9477:Jmjd1c
|
UTSW |
10 |
66,993,734 (GRCm39) |
nonsense |
probably null |
|
|
R9519:Jmjd1c
|
UTSW |
10 |
66,993,798 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9701:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9802:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
RF011:Jmjd1c
|
UTSW |
10 |
67,055,978 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1088:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,081,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACTCTCCGTTCATCTGAGCAAGCC -3'
(R):5'- TGATCCTCTGTGACAGAAACTGCAC -3'
Sequencing Primer
(F):5'- GCAAGCCACAGTTGCTGAC -3'
(R):5'- CTCTGTGACAGAAACTGCACTTAATG -3'
|
| Posted On |
2013-04-24 |
Incidental Mutation