Incidental Mutation 'R4167:Krt74'
ID |
320634 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Krt74
|
Ensembl Gene |
ENSMUSG00000067596 |
Gene Name |
keratin 74 |
Synonyms |
Kb37 |
MMRRC Submission |
041008-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R4167 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
15 |
Chromosomal Location |
101662694-101671939 bp(-) (GRCm39) |
Type of Mutation |
exon |
DNA Base Change (assembly) |
A to G
at 101667304 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088018]
|
AlphaFold |
no structure available at present |
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000088018
|
SMART Domains |
Protein: ENSMUSP00000085335 Gene: ENSMUSG00000067596
Domain | Start | End | E-Value | Type |
Pfam:Keratin_2_head
|
1 |
102 |
9e-21 |
PFAM |
Filament
|
105 |
418 |
6.41e-143 |
SMART |
low complexity region
|
425 |
440 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229279
|
Meta Mutation Damage Score |
0.3429 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.5%
- 20x: 96.0%
|
Validation Efficiency |
94% (31/33) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 29 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Casp6 |
A |
G |
3: 129,706,993 (GRCm39) |
H201R |
probably damaging |
Het |
Cd200r3 |
T |
A |
16: 44,774,552 (GRCm39) |
D188E |
probably benign |
Het |
Cdh16 |
A |
G |
8: 105,344,362 (GRCm39) |
L59P |
probably benign |
Het |
Dcp2 |
T |
A |
18: 44,529,034 (GRCm39) |
Y50N |
probably damaging |
Het |
Elk3 |
A |
G |
10: 93,101,197 (GRCm39) |
|
probably null |
Het |
Fam78b |
T |
C |
1: 166,829,301 (GRCm39) |
V51A |
possibly damaging |
Het |
Gabrb2 |
A |
T |
11: 42,312,155 (GRCm39) |
|
probably benign |
Het |
Glyctk |
G |
T |
9: 106,034,961 (GRCm39) |
A35E |
probably benign |
Het |
Kat14 |
A |
G |
2: 144,236,030 (GRCm39) |
E254G |
probably damaging |
Het |
Kcng1 |
T |
A |
2: 168,104,617 (GRCm39) |
S410C |
probably damaging |
Het |
Lrp12 |
T |
C |
15: 39,748,409 (GRCm39) |
T70A |
probably damaging |
Het |
Man2c1 |
A |
G |
9: 57,045,310 (GRCm39) |
D473G |
probably benign |
Het |
Mindy4 |
G |
A |
6: 55,201,331 (GRCm39) |
G339S |
possibly damaging |
Het |
Naip1 |
C |
T |
13: 100,580,794 (GRCm39) |
G151D |
probably benign |
Het |
Ndufaf7 |
G |
A |
17: 79,252,415 (GRCm39) |
V275I |
probably benign |
Het |
Nppb |
T |
A |
4: 148,071,431 (GRCm39) |
L121* |
probably null |
Het |
Oog2 |
A |
T |
4: 143,922,782 (GRCm39) |
Q349L |
probably benign |
Het |
Or5d39 |
T |
C |
2: 87,980,189 (GRCm39) |
H58R |
probably damaging |
Het |
Or5v1b |
T |
C |
17: 37,840,897 (GRCm39) |
S10P |
possibly damaging |
Het |
Pcdhgb8 |
T |
G |
18: 37,895,596 (GRCm39) |
V222G |
possibly damaging |
Het |
Plcd3 |
A |
T |
11: 102,969,290 (GRCm39) |
C226S |
probably damaging |
Het |
Plxdc2 |
A |
G |
2: 16,570,196 (GRCm39) |
E125G |
probably damaging |
Het |
Rnf213 |
A |
G |
11: 119,332,069 (GRCm39) |
E2426G |
probably damaging |
Het |
Rraga |
T |
C |
4: 86,494,304 (GRCm39) |
V50A |
possibly damaging |
Het |
Scmh1 |
T |
C |
4: 120,386,473 (GRCm39) |
|
probably benign |
Het |
Slc9a9 |
A |
G |
9: 95,110,952 (GRCm39) |
Y590C |
probably damaging |
Het |
Snx20 |
C |
T |
8: 89,354,013 (GRCm39) |
R239Q |
probably benign |
Het |
Vmn2r59 |
A |
G |
7: 41,670,732 (GRCm39) |
|
probably benign |
Het |
Zfp128 |
A |
G |
7: 12,624,289 (GRCm39) |
D219G |
probably benign |
Het |
|
Other mutations in Krt74 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02027:Krt74
|
APN |
15 |
101,665,229 (GRCm39) |
exon |
noncoding transcript |
|
IGL02376:Krt74
|
APN |
15 |
101,662,938 (GRCm39) |
exon |
noncoding transcript |
|
IGL02507:Krt74
|
APN |
15 |
101,669,059 (GRCm39) |
exon |
noncoding transcript |
|
IGL03374:Krt74
|
APN |
15 |
101,668,937 (GRCm39) |
splice site |
noncoding transcript |
|
R0032:Krt74
|
UTSW |
15 |
101,669,887 (GRCm39) |
exon |
noncoding transcript |
|
R0032:Krt74
|
UTSW |
15 |
101,669,887 (GRCm39) |
exon |
noncoding transcript |
|
R0110:Krt74
|
UTSW |
15 |
101,671,751 (GRCm39) |
exon |
noncoding transcript |
|
R0450:Krt74
|
UTSW |
15 |
101,671,751 (GRCm39) |
exon |
noncoding transcript |
|
R0469:Krt74
|
UTSW |
15 |
101,671,751 (GRCm39) |
exon |
noncoding transcript |
|
R0510:Krt74
|
UTSW |
15 |
101,671,751 (GRCm39) |
exon |
noncoding transcript |
|
R0550:Krt74
|
UTSW |
15 |
101,669,114 (GRCm39) |
splice site |
noncoding transcript |
|
R0558:Krt74
|
UTSW |
15 |
101,669,398 (GRCm39) |
exon |
noncoding transcript |
|
R1663:Krt74
|
UTSW |
15 |
101,665,109 (GRCm39) |
exon |
noncoding transcript |
|
R2392:Krt74
|
UTSW |
15 |
101,665,236 (GRCm39) |
splice site |
noncoding transcript |
|
R3772:Krt74
|
UTSW |
15 |
101,670,630 (GRCm39) |
exon |
noncoding transcript |
|
R4670:Krt74
|
UTSW |
15 |
101,667,304 (GRCm39) |
exon |
noncoding transcript |
|
R4741:Krt74
|
UTSW |
15 |
101,669,876 (GRCm39) |
exon |
noncoding transcript |
|
R5470:Krt74
|
UTSW |
15 |
101,662,900 (GRCm39) |
exon |
noncoding transcript |
|
R5639:Krt74
|
UTSW |
15 |
101,665,195 (GRCm39) |
exon |
noncoding transcript |
|
R5664:Krt74
|
UTSW |
15 |
101,669,014 (GRCm39) |
exon |
noncoding transcript |
|
R6274:Krt74
|
UTSW |
15 |
101,671,872 (GRCm39) |
exon |
noncoding transcript |
|
|
Predicted Primers |
PCR Primer
(F):5'- GCCAGAGATAGATGGTGTCTTC -3'
(R):5'- CCTGAGTTCCAGCTTCACTG -3'
Sequencing Primer
(F):5'- TCCCCATTCTGATACAAGGTGAG -3'
(R):5'- AGCTTCACTGCCTCCACTTGAG -3'
|
Posted On |
2015-06-12 |