|Institutional Source||Beutler Lab|
|Gene Name||guanine nucleotide binding protein, alpha transducing 3|
|Synonyms||Gtn, Ggust, alpha-gustducin|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4169 (G1)|
|Chromosomal Location||17962549-18019834 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 18003864 bp|
|Amino Acid Change||Phenylalanine to Leucine at position 189 (F189L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000030561 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000030561]|
|Predicted Effect||probably damaging
AA Change: F189L
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: F189L
|Coding Region Coverage||
|Validation Efficiency||98% (48/49)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015]
PHENOTYPE: Homozygous mutation of this gene results in abnormal taste sensitivity. Mice show reduced behavioral and electrophysiological responses to bitter, sweet, and unami compounds. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gnat3||
(F):5'- GCCCATCAGATCAGTAGCATG -3'
(R):5'- TGGGCTACCACTTGTTTGAG -3'
(F):5'- GCCCATCAGATCAGTAGCATGATAAC -3'
(R):5'- CCACTTGTTTGAGAAATGCAGCC -3'