Incidental Mutation 'R4169:Or8s8'
ID 320715
Institutional Source Beutler Lab
Gene Symbol Or8s8
Ensembl Gene ENSMUSG00000032987
Gene Name olfactory receptor family 8 subfamily S member 8
Synonyms GA_x6K02T2NBG7-5275017-5274082, Olfr281, MOR160-5
MMRRC Submission 041010-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R4169 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 98354193-98355128 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 98354878 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 229 (E229G)
Ref Sequence ENSEMBL: ENSMUSP00000150530 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109163] [ENSMUST00000217517]
AlphaFold Q8VET6
Predicted Effect probably benign
Transcript: ENSMUST00000109163
AA Change: E229G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000104791
Gene: ENSMUSG00000032987
AA Change: E229G

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.8e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 277 2.2e-5 PFAM
Pfam:7tm_1 41 288 2.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217517
AA Change: E229G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.8%
Validation Efficiency 98% (48/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot7 T C 4: 152,302,250 (GRCm39) C121R probably damaging Het
Ampd1 T A 3: 103,002,157 (GRCm39) M546K probably damaging Het
Birc2 T A 9: 7,849,684 (GRCm39) D535V possibly damaging Het
Btn1a1 A G 13: 23,649,325 (GRCm39) L9P probably benign Het
Cmip A T 8: 118,183,656 (GRCm39) N743I probably damaging Het
Col4a2 C T 8: 11,479,391 (GRCm39) P758L probably benign Het
Ddx50 A T 10: 62,476,549 (GRCm39) Y241* probably null Het
Elk3 A G 10: 93,101,197 (GRCm39) probably null Het
Fbn1 T C 2: 125,205,872 (GRCm39) T1042A possibly damaging Het
Gm5445 A G 13: 12,393,527 (GRCm39) noncoding transcript Het
Gnat3 T C 5: 18,208,862 (GRCm39) F189L probably damaging Het
Hectd1 T C 12: 51,837,008 (GRCm39) T815A probably damaging Het
Hmcn1 A C 1: 150,471,750 (GRCm39) probably null Het
Hrc A G 7: 44,986,181 (GRCm39) D444G probably benign Het
Ighv1-53 T A 12: 115,122,166 (GRCm39) I70F possibly damaging Het
Kat7 A G 11: 95,171,298 (GRCm39) F469L probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Krt81 T A 15: 101,359,193 (GRCm39) M242L probably benign Het
Krtap6-1 A G 16: 88,828,584 (GRCm39) probably null Het
Man2c1 A G 9: 57,045,310 (GRCm39) D473G probably benign Het
Mthfr-ps1 T C 5: 78,622,436 (GRCm39) noncoding transcript Het
Nop53 A T 7: 15,676,244 (GRCm39) W152R probably benign Het
Or5p58 A T 7: 107,694,591 (GRCm39) M62K probably damaging Het
Or6y1 T A 1: 174,277,162 (GRCm39) S324R unknown Het
Pcdh1 A T 18: 38,331,358 (GRCm39) N548K probably damaging Het
Pcdhga12 A G 18: 37,899,467 (GRCm39) I100V probably benign Het
Piezo2 T C 18: 63,183,675 (GRCm39) H1743R probably benign Het
Pkdrej A G 15: 85,700,515 (GRCm39) V1807A probably benign Het
Rabl2 T C 15: 89,474,582 (GRCm39) M1V probably null Het
Rexo5 A G 7: 119,426,621 (GRCm39) probably benign Het
Rfng C G 11: 120,674,772 (GRCm39) G73R probably benign Het
Rps6ka4 A G 19: 6,809,188 (GRCm39) L459P possibly damaging Het
Samd11 T A 4: 156,332,203 (GRCm39) D536V probably damaging Het
Slc9a5 A G 8: 106,084,032 (GRCm39) T451A possibly damaging Het
Snapc1 T A 12: 74,029,265 (GRCm39) N349K probably benign Het
Sox1ot A G 8: 12,480,544 (GRCm39) noncoding transcript Het
Tmem178 C T 17: 81,252,232 (GRCm39) H39Y possibly damaging Het
Trav8n-2 A T 14: 53,583,875 (GRCm39) T111S possibly damaging Het
Ttn T A 2: 76,703,103 (GRCm39) probably benign Het
Ttn T C 2: 76,762,909 (GRCm39) D3250G probably damaging Het
Ube2nl T A 7: 61,199,380 (GRCm39) noncoding transcript Het
Vps25 T C 11: 101,144,918 (GRCm39) S39P probably damaging Het
Zkscan14 G A 5: 145,132,985 (GRCm39) T182I possibly damaging Het
Other mutations in Or8s8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Or8s8 APN 15 98,354,299 (GRCm39) missense possibly damaging 0.61
IGL01016:Or8s8 APN 15 98,354,186 (GRCm39) utr 5 prime probably benign
IGL02372:Or8s8 APN 15 98,354,709 (GRCm39) missense probably damaging 1.00
IGL02730:Or8s8 APN 15 98,354,317 (GRCm39) missense probably damaging 1.00
R0732:Or8s8 UTSW 15 98,354,959 (GRCm39) missense possibly damaging 0.94
R1714:Or8s8 UTSW 15 98,354,614 (GRCm39) missense probably damaging 1.00
R1959:Or8s8 UTSW 15 98,354,634 (GRCm39) missense probably damaging 1.00
R4902:Or8s8 UTSW 15 98,354,796 (GRCm39) missense probably damaging 0.99
R5014:Or8s8 UTSW 15 98,354,857 (GRCm39) missense possibly damaging 0.80
R6082:Or8s8 UTSW 15 98,354,647 (GRCm39) missense probably damaging 0.97
R6378:Or8s8 UTSW 15 98,354,425 (GRCm39) missense probably benign 0.42
R7383:Or8s8 UTSW 15 98,354,578 (GRCm39) missense probably damaging 1.00
R7850:Or8s8 UTSW 15 98,354,949 (GRCm39) missense probably damaging 1.00
R7853:Or8s8 UTSW 15 98,354,866 (GRCm39) missense probably benign 0.42
R7912:Or8s8 UTSW 15 98,354,574 (GRCm39) missense probably benign 0.00
R8750:Or8s8 UTSW 15 98,354,929 (GRCm39) missense probably damaging 0.97
R9326:Or8s8 UTSW 15 98,354,935 (GRCm39) missense probably damaging 1.00
R9786:Or8s8 UTSW 15 98,354,713 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- TGAACCTGGACTTCTGCGAG -3'
(R):5'- TAATGTCCTTCTCACAGCGG -3'

Sequencing Primer
(F):5'- ACTTCTGCGAGGCCTACAC -3'
(R):5'- CCTGGTTCTTCAGGCTGTAGATGAG -3'
Posted On 2015-06-12