Incidental Mutation 'R4239:Zfp157'
ID 321250
Institutional Source Beutler Lab
Gene Symbol Zfp157
Ensembl Gene ENSMUSG00000036898
Gene Name zinc finger protein 157
Synonyms 2610020C11Rik, Roma, A630094N24Rik
MMRRC Submission 041056-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R4239 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 138439730-138458956 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 138445803 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 53 (I53V)
Ref Sequence ENSEMBL: ENSMUSP00000098093 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085856] [ENSMUST00000100524] [ENSMUST00000110912]
AlphaFold Q6PCM4
Predicted Effect probably damaging
Transcript: ENSMUST00000085856
AA Change: I53V

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000083018
Gene: ENSMUSG00000036898
AA Change: I53V

DomainStartEndE-ValueType
KRAB 4 64 3.64e-35 SMART
ZnF_C2H2 183 205 3.69e-4 SMART
ZnF_C2H2 211 233 3.16e-3 SMART
ZnF_C2H2 239 261 3.63e-3 SMART
ZnF_C2H2 267 289 2.24e-3 SMART
ZnF_C2H2 295 317 1.47e-3 SMART
ZnF_C2H2 323 345 1.95e-3 SMART
ZnF_C2H2 351 373 1.28e-3 SMART
ZnF_C2H2 379 401 2.4e-3 SMART
ZnF_C2H2 407 429 9.73e-4 SMART
ZnF_C2H2 435 457 4.4e-2 SMART
ZnF_C2H2 463 485 1.01e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000100524
AA Change: I53V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000098093
Gene: ENSMUSG00000036898
AA Change: I53V

DomainStartEndE-ValueType
KRAB 4 64 3.64e-35 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000110912
AA Change: I53V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000106537
Gene: ENSMUSG00000036898
AA Change: I53V

DomainStartEndE-ValueType
KRAB 4 64 3.64e-35 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134706
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137711
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151095
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 95% (55/58)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele display accelerated ductal elongation during puberty and accelerated alveologenesis during pregnancy. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563M21Rik T C 9: 55,888,126 (GRCm39) D397G probably benign Het
Alpk2 T A 18: 65,433,212 (GRCm39) I1765F probably damaging Het
Ano5 T A 7: 51,237,414 (GRCm39) I696N probably damaging Het
Areg A T 5: 91,291,375 (GRCm39) N106I probably damaging Het
Atad2b A G 12: 5,035,710 (GRCm39) N759D probably benign Het
B4galnt4 T C 7: 140,641,239 (GRCm39) L18P probably damaging Het
Boc T C 16: 44,312,247 (GRCm39) D605G probably damaging Het
Cfap46 G T 7: 139,246,203 (GRCm39) Q387K possibly damaging Het
Cfap74 C A 4: 155,547,529 (GRCm39) H1238Q probably benign Het
Clip2 A G 5: 134,564,051 (GRCm39) probably benign Het
Cog4 T C 8: 111,585,244 (GRCm39) I303T probably damaging Het
Col18a1 C T 10: 76,932,001 (GRCm39) V363I unknown Het
Crip3 A T 17: 46,742,156 (GRCm39) K184* probably null Het
Ddi1 A G 9: 6,265,799 (GRCm39) M190T probably benign Het
Dnah3 G A 7: 119,628,248 (GRCm39) Q1459* probably null Het
Dpp8 A G 9: 64,962,205 (GRCm39) D415G probably benign Het
Ehhadh T G 16: 21,581,438 (GRCm39) D518A probably damaging Het
Erbb2 A G 11: 98,318,869 (GRCm39) K549R probably benign Het
Fbxl3 G A 14: 103,326,854 (GRCm39) S176L probably damaging Het
Gm1979 T C 5: 26,206,119 (GRCm39) T154A probably benign Het
Gm6871 G T 7: 41,195,204 (GRCm39) T511K probably damaging Het
Gtf2h1 C T 7: 46,454,489 (GRCm39) A157V probably benign Het
Hexb T C 13: 97,313,259 (GRCm39) probably benign Het
Ifi214 A T 1: 173,352,509 (GRCm39) S307T possibly damaging Het
Ighv3-4 A T 12: 114,217,533 (GRCm39) D19E probably benign Het
Klk6 A G 7: 43,478,597 (GRCm39) H168R probably benign Het
Large2 A G 2: 92,196,950 (GRCm39) probably benign Het
Myo5c T C 9: 75,191,224 (GRCm39) I1086T probably benign Het
Nes C A 3: 87,886,666 (GRCm39) P1598T probably damaging Het
Or13a25 A G 7: 140,247,496 (GRCm39) N99D probably benign Het
Or51f1d T C 7: 102,701,003 (GRCm39) V166A probably benign Het
Or5g25 T A 2: 85,478,647 (GRCm39) Q6L probably damaging Het
Otud7a A G 7: 63,300,702 (GRCm39) D47G probably damaging Het
Phactr1 T A 13: 43,248,363 (GRCm39) N437K possibly damaging Het
Plcb1 A T 2: 135,186,078 (GRCm39) I682F probably damaging Het
Plcz1 T A 6: 139,986,344 (GRCm39) probably null Het
Prl7a1 T A 13: 27,821,549 (GRCm39) Q129L possibly damaging Het
Prrt4 T C 6: 29,170,163 (GRCm39) Y763C probably damaging Het
Psma7 T C 2: 179,681,304 (GRCm39) probably benign Het
Serpinb6b G C 13: 33,156,246 (GRCm39) C112S probably damaging Het
Slc14a2 G A 18: 78,250,283 (GRCm39) R62C probably damaging Het
Slc35f5 G A 1: 125,500,211 (GRCm39) A242T possibly damaging Het
Speer4b T C 5: 27,706,311 (GRCm39) R19G probably benign Het
Trank1 A G 9: 111,196,103 (GRCm39) I1376V probably benign Het
Trbv12-2 A G 6: 41,095,831 (GRCm39) N12D probably benign Het
Uba7 T C 9: 107,854,001 (GRCm39) probably null Het
Upf3a A G 8: 13,846,591 (GRCm39) R324G probably benign Het
Usp46 T G 5: 74,192,928 (GRCm39) probably benign Het
Vmn2r14 T G 5: 109,364,277 (GRCm39) probably null Het
Wbp2 G A 11: 115,971,373 (GRCm39) probably benign Het
Wdpcp T A 11: 21,645,269 (GRCm39) N232K probably damaging Het
Wdpcp T A 11: 21,645,271 (GRCm39) M233K probably benign Het
Other mutations in Zfp157
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01322:Zfp157 APN 5 138,445,840 (GRCm39) missense probably benign 0.02
IGL02377:Zfp157 APN 5 138,445,859 (GRCm39) nonsense probably null
R1476:Zfp157 UTSW 5 138,453,357 (GRCm39) critical splice donor site probably null
R1883:Zfp157 UTSW 5 138,443,102 (GRCm39) missense probably damaging 1.00
R1884:Zfp157 UTSW 5 138,443,102 (GRCm39) missense probably damaging 1.00
R3401:Zfp157 UTSW 5 138,455,273 (GRCm39) missense probably benign 0.35
R4237:Zfp157 UTSW 5 138,445,803 (GRCm39) missense probably damaging 1.00
R4573:Zfp157 UTSW 5 138,455,191 (GRCm39) missense probably damaging 0.97
R4785:Zfp157 UTSW 5 138,443,051 (GRCm39) missense probably damaging 1.00
R4914:Zfp157 UTSW 5 138,454,557 (GRCm39) missense possibly damaging 0.85
R5476:Zfp157 UTSW 5 138,455,443 (GRCm39) missense possibly damaging 0.92
R6128:Zfp157 UTSW 5 138,453,281 (GRCm39) missense possibly damaging 0.95
R6473:Zfp157 UTSW 5 138,454,188 (GRCm39) missense probably damaging 0.99
R6572:Zfp157 UTSW 5 138,455,313 (GRCm39) missense possibly damaging 0.92
R6990:Zfp157 UTSW 5 138,454,772 (GRCm39) nonsense probably null
R7638:Zfp157 UTSW 5 138,454,172 (GRCm39) missense probably benign 0.04
R7966:Zfp157 UTSW 5 138,445,833 (GRCm39) missense probably benign 0.14
R7994:Zfp157 UTSW 5 138,453,450 (GRCm39) splice site probably null
R8057:Zfp157 UTSW 5 138,454,336 (GRCm39) missense probably damaging 1.00
R8397:Zfp157 UTSW 5 138,454,518 (GRCm39) missense probably damaging 1.00
Z1088:Zfp157 UTSW 5 138,455,461 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGGTAGCTATTTTGAATGGGAATGT -3'
(R):5'- ACAAACTGACACAGAGTTCCTCA -3'

Sequencing Primer
(F):5'- TTTTGACTCTGTGGTTTTTCTCTAG -3'
(R):5'- ACTGACACAGAGTTCCTCATTTGG -3'
Posted On 2015-06-12