Incidental Mutation 'R4161:Zbtb10'
ID 321512
Institutional Source Beutler Lab
Gene Symbol Zbtb10
Ensembl Gene ENSMUSG00000069114
Gene Name zinc finger and BTB domain containing 10
Synonyms
MMRRC Submission 041004-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.442) question?
Stock # R4161 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 9315662-9350393 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 9345356 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 707 (S707P)
Ref Sequence ENSEMBL: ENSMUSP00000119386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000155203]
AlphaFold E9Q8X5
Predicted Effect probably damaging
Transcript: ENSMUST00000155203
AA Change: S707P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000119386
Gene: ENSMUSG00000069114
AA Change: S707P

DomainStartEndE-ValueType
low complexity region 15 32 N/A INTRINSIC
low complexity region 38 54 N/A INTRINSIC
low complexity region 75 82 N/A INTRINSIC
low complexity region 96 111 N/A INTRINSIC
low complexity region 121 137 N/A INTRINSIC
low complexity region 180 222 N/A INTRINSIC
ZnF_TTF 239 321 7.92e-2 SMART
BTB 357 456 4.02e-20 SMART
internal_repeat_1 648 671 2.82e-12 PROSPERO
internal_repeat_1 672 695 2.82e-12 PROSPERO
ZnF_C2H2 714 736 6.78e-3 SMART
ZnF_C2H2 742 764 2.09e-3 SMART
low complexity region 765 777 N/A INTRINSIC
low complexity region 823 842 N/A INTRINSIC
Meta Mutation Damage Score 0.2555 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 95% (39/41)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ackr2 A G 9: 121,738,588 (GRCm39) Y321C probably benign Het
Angptl3 T C 4: 98,919,728 (GRCm39) S163P probably damaging Het
Ankle2 T C 5: 110,382,234 (GRCm39) M70T probably benign Het
Ankrd1 T A 19: 36,095,273 (GRCm39) K138N probably damaging Het
Ano8 A T 8: 71,935,281 (GRCm39) I339N probably damaging Het
Bltp3a A G 17: 28,103,061 (GRCm39) Y365C probably damaging Het
Cxcl2 A T 5: 91,051,881 (GRCm39) probably null Het
Exosc3 T C 4: 45,320,619 (GRCm39) probably benign Het
Fads2b C A 2: 85,348,853 (GRCm39) K86N probably damaging Het
Fat1 G A 8: 45,489,824 (GRCm39) A3579T probably benign Het
Fat4 G A 3: 38,996,958 (GRCm39) V1726I possibly damaging Het
Grm7 A G 6: 111,230,981 (GRCm39) N468S probably damaging Het
Hmgcll1 A T 9: 75,982,198 (GRCm39) probably benign Het
Igkv3-12 T A 6: 70,495,542 (GRCm39) V23E probably benign Het
Irx6 T C 8: 93,402,919 (GRCm39) C95R possibly damaging Het
Kif16b G A 2: 142,549,324 (GRCm39) H1064Y probably benign Het
Lrrc45 A T 11: 120,609,272 (GRCm39) D377V possibly damaging Het
Oasl1 A G 5: 115,075,073 (GRCm39) K378E possibly damaging Het
Pds5a T C 5: 65,821,839 (GRCm39) T120A possibly damaging Het
Phf8-ps G A 17: 33,285,023 (GRCm39) T593I probably benign Het
Plec T C 15: 76,063,851 (GRCm39) E2141G possibly damaging Het
Pou6f1 A G 15: 100,478,724 (GRCm39) S395P probably damaging Het
Prss12 A T 3: 123,279,176 (GRCm39) K418* probably null Het
Rtn3 G A 19: 7,460,444 (GRCm39) A2V probably benign Het
Rubcnl A G 14: 75,281,898 (GRCm39) T452A possibly damaging Het
Sdk1 A G 5: 142,100,154 (GRCm39) I1395V probably benign Het
Senp7 C A 16: 55,973,832 (GRCm39) P351Q possibly damaging Het
Slco1a7 T C 6: 141,654,322 (GRCm39) K647E probably benign Het
Spred3 A G 7: 28,861,210 (GRCm39) L323P probably damaging Het
Srprb A G 9: 103,078,529 (GRCm39) F67S possibly damaging Het
Tk2 T C 8: 104,965,465 (GRCm39) S101G probably benign Het
Tnxb A G 17: 34,930,491 (GRCm39) T2059A probably damaging Het
Trpm7 A G 2: 126,658,751 (GRCm39) L1135P probably damaging Het
Ush2a G A 1: 188,460,907 (GRCm39) V2723M probably damaging Het
Usp38 C T 8: 81,719,967 (GRCm39) A421T probably damaging Het
Vcan G T 13: 89,833,277 (GRCm39) N3058K probably damaging Het
Vmn1r221 G A 13: 23,402,176 (GRCm39) noncoding transcript Het
Vps11 C G 9: 44,267,017 (GRCm39) G406A probably damaging Het
Wnk2 C T 13: 49,244,313 (GRCm39) D508N probably damaging Het
Other mutations in Zbtb10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02174:Zbtb10 APN 3 9,316,872 (GRCm39) missense probably damaging 0.96
IGL02207:Zbtb10 APN 3 9,345,525 (GRCm39) critical splice donor site probably null
IGL02499:Zbtb10 APN 3 9,316,800 (GRCm39) missense probably damaging 1.00
IGL02506:Zbtb10 APN 3 9,330,297 (GRCm39) missense probably damaging 0.99
IGL03294:Zbtb10 APN 3 9,346,047 (GRCm39) missense probably benign 0.18
R0510:Zbtb10 UTSW 3 9,329,728 (GRCm39) missense probably damaging 1.00
R1859:Zbtb10 UTSW 3 9,345,446 (GRCm39) missense possibly damaging 0.47
R2342:Zbtb10 UTSW 3 9,330,255 (GRCm39) missense possibly damaging 0.60
R3407:Zbtb10 UTSW 3 9,329,926 (GRCm39) missense probably damaging 1.00
R4301:Zbtb10 UTSW 3 9,330,220 (GRCm39) missense probably damaging 0.96
R4698:Zbtb10 UTSW 3 9,329,610 (GRCm39) missense possibly damaging 0.87
R5184:Zbtb10 UTSW 3 9,329,731 (GRCm39) missense probably damaging 0.99
R5443:Zbtb10 UTSW 3 9,345,108 (GRCm39) missense probably benign
R5665:Zbtb10 UTSW 3 9,330,252 (GRCm39) missense probably damaging 0.99
R5744:Zbtb10 UTSW 3 9,329,623 (GRCm39) missense probably damaging 1.00
R5862:Zbtb10 UTSW 3 9,330,276 (GRCm39) missense probably damaging 0.98
R5909:Zbtb10 UTSW 3 9,345,109 (GRCm39) missense probably benign 0.14
R6547:Zbtb10 UTSW 3 9,316,763 (GRCm39) missense probably benign 0.38
R6612:Zbtb10 UTSW 3 9,317,125 (GRCm39) missense possibly damaging 0.87
R7457:Zbtb10 UTSW 3 9,316,538 (GRCm39) missense possibly damaging 0.77
R8985:Zbtb10 UTSW 3 9,345,807 (GRCm39) missense probably damaging 1.00
R9191:Zbtb10 UTSW 3 9,330,295 (GRCm39) missense probably damaging 0.98
R9472:Zbtb10 UTSW 3 9,343,355 (GRCm39) missense probably benign 0.25
R9616:Zbtb10 UTSW 3 9,316,473 (GRCm39) missense probably benign 0.01
Z1177:Zbtb10 UTSW 3 9,343,391 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGCCAGAATCTTGGCCCAC -3'
(R):5'- CATGATCAACAGCGTTTCAAGGC -3'

Sequencing Primer
(F):5'- TTGGCCCACACAAGAAACGTG -3'
(R):5'- GGCACTTACCAGGGAATGTC -3'
Posted On 2015-06-12