Incidental Mutation 'R4258:Dynlt1a'
ID 321921
Institutional Source Beutler Lab
Gene Symbol Dynlt1a
Ensembl Gene ENSMUSG00000092074
Gene Name dynein light chain Tctex-type 1A
Synonyms
MMRRC Submission 041071-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.234) question?
Stock # R4258 (G1)
Quality Score 119
Status Not validated
Chromosome 17
Chromosomal Location 6356619-6367749 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 6361184 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 102 (M102I)
Ref Sequence ENSEMBL: ENSMUSP00000127990 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088940] [ENSMUST00000169415] [ENSMUST00000232383] [ENSMUST00000232499]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000088940
SMART Domains Protein: ENSMUSP00000086333
Gene: ENSMUSG00000038141

DomainStartEndE-ValueType
transmembrane domain 17 36 N/A INTRINSIC
Pfam:MIG-14_Wnt-bd 127 422 1e-100 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169415
AA Change: M102I

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000127990
Gene: ENSMUSG00000092074
AA Change: M102I

DomainStartEndE-ValueType
Pfam:Tctex-1 16 112 5.4e-36 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181052
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228334
Predicted Effect probably benign
Transcript: ENSMUST00000232383
Predicted Effect probably benign
Transcript: ENSMUST00000232499
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232591
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 95% (60/63)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415M13Rik T A 17: 54,031,441 (GRCm39) noncoding transcript Het
Ank3 T C 10: 69,840,592 (GRCm39) I984T probably benign Het
Arnt2 T C 7: 83,960,163 (GRCm39) T204A probably damaging Het
Arsi T C 18: 61,050,388 (GRCm39) W424R probably damaging Het
Aspg A T 12: 112,087,687 (GRCm39) N346I probably benign Het
Brdt A G 5: 107,507,775 (GRCm39) S668G probably damaging Het
Ccdc178 C T 18: 22,150,392 (GRCm39) probably null Het
Cfap58 A T 19: 47,937,923 (GRCm39) probably null Het
Chaf1a C A 17: 56,363,474 (GRCm39) H319Q unknown Het
Colec12 T C 18: 9,720,950 (GRCm39) S13P probably damaging Het
Cpne9 C T 6: 113,259,984 (GRCm39) probably benign Het
Cyp2c65 A C 19: 39,081,872 (GRCm39) D466A probably benign Het
Cyp3a25 T C 5: 145,928,248 (GRCm39) K266E probably damaging Het
Dennd1b G T 1: 138,990,678 (GRCm39) R214L probably damaging Het
Dock9 T C 14: 121,818,854 (GRCm39) I1533V probably benign Het
Edil3 G T 13: 89,325,272 (GRCm39) L220F probably damaging Het
Eml5 A G 12: 98,831,693 (GRCm39) Y383H probably benign Het
Epc1 T A 18: 6,450,130 (GRCm39) T393S probably benign Het
Fbxo8 A T 8: 57,041,076 (GRCm39) D164V probably benign Het
Gbp4 T A 5: 105,284,841 (GRCm39) N16I probably damaging Het
Gdf6 G A 4: 9,844,877 (GRCm39) V134I probably damaging Het
Gm5475 A G 15: 100,322,117 (GRCm39) probably benign Het
Gm6430 T G 1: 96,952,561 (GRCm39) noncoding transcript Het
Ighv9-4 A T 12: 114,263,765 (GRCm39) V56E probably damaging Het
Il3ra A T 14: 14,347,961 (GRCm38) N36Y probably damaging Het
Kif7 G T 7: 79,360,261 (GRCm39) C325* probably null Het
Lipo2 A T 19: 33,708,328 (GRCm39) F229I possibly damaging Het
Lrba A G 3: 86,352,656 (GRCm39) K1935E probably damaging Het
Mki67 A T 7: 135,297,017 (GRCm39) D2672E possibly damaging Het
Mtf1 A G 4: 124,732,576 (GRCm39) T545A probably benign Het
Mup6 A T 4: 60,004,812 (GRCm39) probably null Het
Myo9b T C 8: 71,808,409 (GRCm39) V1672A probably damaging Het
Nudt16l2 T C 9: 105,020,767 (GRCm39) I165V probably damaging Het
Or10al6 C A 17: 38,082,949 (GRCm39) P135Q probably damaging Het
Or10j5 C T 1: 172,785,205 (GRCm39) T281I possibly damaging Het
Or4k36 A T 2: 111,145,983 (GRCm39) H53L probably benign Het
Or5d37 T A 2: 87,923,362 (GRCm39) N306I probably damaging Het
Pcdhgb2 A T 18: 37,825,102 (GRCm39) I698F probably damaging Het
Pkn3 C T 2: 29,978,572 (GRCm39) H665Y probably damaging Het
Ppil6 T A 10: 41,383,531 (GRCm39) L99* probably null Het
Psg22 T A 7: 18,458,554 (GRCm39) V376E probably damaging Het
Pum1 G A 4: 130,457,591 (GRCm39) R201H probably damaging Het
Rasa2 A T 9: 96,439,433 (GRCm39) probably benign Het
Schip1 T A 3: 68,525,963 (GRCm39) M379K possibly damaging Het
Scn9a A T 2: 66,395,398 (GRCm39) probably benign Het
Sh3tc1 C T 5: 35,864,322 (GRCm39) A622T probably benign Het
Smarcd2 A T 11: 106,156,076 (GRCm39) I292N probably damaging Het
Ssxb17 C T X: 21,041,167 (GRCm39) S45N probably damaging Het
Stab1 G A 14: 30,876,629 (GRCm39) R862C possibly damaging Het
Tdrd5 T A 1: 156,087,312 (GRCm39) H870L probably benign Het
Tnfaip8 A G 18: 50,223,443 (GRCm39) R60G possibly damaging Het
Traf3ip3 C T 1: 192,880,254 (GRCm39) R25Q probably damaging Het
Unc5b T C 10: 60,601,150 (GRCm39) Y892C probably damaging Het
Vmn2r2 T G 3: 64,042,118 (GRCm39) D199A probably damaging Het
Washc2 C A 6: 116,185,202 (GRCm39) P12Q probably damaging Het
Zfp286 T C 11: 62,671,896 (GRCm39) I121V probably benign Het
Zfp606 T A 7: 12,228,267 (GRCm39) probably null Het
Other mutations in Dynlt1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Dynlt1a APN 17 6,362,062 (GRCm39) missense possibly damaging 0.50
IGL01809:Dynlt1a APN 17 6,361,147 (GRCm39) splice site probably null
R0266:Dynlt1a UTSW 17 6,367,670 (GRCm39) missense probably benign 0.00
R6525:Dynlt1a UTSW 17 6,362,014 (GRCm39) missense probably benign 0.10
R7732:Dynlt1a UTSW 17 6,365,220 (GRCm39) missense probably benign 0.01
R8026:Dynlt1a UTSW 17 6,362,089 (GRCm39) missense possibly damaging 0.56
R8225:Dynlt1a UTSW 17 6,361,628 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GGCTGAAGTCATGTGGTTCC -3'
(R):5'- ATCTCTGTGAGTTTGAGGCCC -3'

Sequencing Primer
(F):5'- AAGTCATGTGGTTCCTGTGAC -3'
(R):5'- TCTCAAAACATTCTGGGGGC -3'
Posted On 2015-06-20