Incidental Mutation 'R4258:Ccdc178'
ID 321927
Institutional Source Beutler Lab
Gene Symbol Ccdc178
Ensembl Gene ENSMUSG00000024306
Gene Name coiled coil domain containing 178
Synonyms 4921528I01Rik
MMRRC Submission 041071-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4258 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 21943954-22304453 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to T at 22150392 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000111503 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025160] [ENSMUST00000115837]
AlphaFold Q8CDV0
Predicted Effect probably null
Transcript: ENSMUST00000025160
SMART Domains Protein: ENSMUSP00000025160
Gene: ENSMUSG00000024306

DomainStartEndE-ValueType
coiled coil region 157 204 N/A INTRINSIC
coiled coil region 226 266 N/A INTRINSIC
coiled coil region 292 404 N/A INTRINSIC
coiled coil region 514 541 N/A INTRINSIC
coiled coil region 570 631 N/A INTRINSIC
coiled coil region 665 705 N/A INTRINSIC
low complexity region 720 732 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000115837
SMART Domains Protein: ENSMUSP00000111503
Gene: ENSMUSG00000024306

DomainStartEndE-ValueType
coiled coil region 157 204 N/A INTRINSIC
coiled coil region 226 266 N/A INTRINSIC
coiled coil region 292 404 N/A INTRINSIC
coiled coil region 514 541 N/A INTRINSIC
coiled coil region 570 631 N/A INTRINSIC
coiled coil region 665 705 N/A INTRINSIC
low complexity region 720 732 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 95% (60/63)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415M13Rik T A 17: 54,031,441 (GRCm39) noncoding transcript Het
Ank3 T C 10: 69,840,592 (GRCm39) I984T probably benign Het
Arnt2 T C 7: 83,960,163 (GRCm39) T204A probably damaging Het
Arsi T C 18: 61,050,388 (GRCm39) W424R probably damaging Het
Aspg A T 12: 112,087,687 (GRCm39) N346I probably benign Het
Brdt A G 5: 107,507,775 (GRCm39) S668G probably damaging Het
Cfap58 A T 19: 47,937,923 (GRCm39) probably null Het
Chaf1a C A 17: 56,363,474 (GRCm39) H319Q unknown Het
Colec12 T C 18: 9,720,950 (GRCm39) S13P probably damaging Het
Cpne9 C T 6: 113,259,984 (GRCm39) probably benign Het
Cyp2c65 A C 19: 39,081,872 (GRCm39) D466A probably benign Het
Cyp3a25 T C 5: 145,928,248 (GRCm39) K266E probably damaging Het
Dennd1b G T 1: 138,990,678 (GRCm39) R214L probably damaging Het
Dock9 T C 14: 121,818,854 (GRCm39) I1533V probably benign Het
Dynlt1a C T 17: 6,361,184 (GRCm39) M102I probably benign Het
Edil3 G T 13: 89,325,272 (GRCm39) L220F probably damaging Het
Eml5 A G 12: 98,831,693 (GRCm39) Y383H probably benign Het
Epc1 T A 18: 6,450,130 (GRCm39) T393S probably benign Het
Fbxo8 A T 8: 57,041,076 (GRCm39) D164V probably benign Het
Gbp4 T A 5: 105,284,841 (GRCm39) N16I probably damaging Het
Gdf6 G A 4: 9,844,877 (GRCm39) V134I probably damaging Het
Gm5475 A G 15: 100,322,117 (GRCm39) probably benign Het
Gm6430 T G 1: 96,952,561 (GRCm39) noncoding transcript Het
Ighv9-4 A T 12: 114,263,765 (GRCm39) V56E probably damaging Het
Il3ra A T 14: 14,347,961 (GRCm38) N36Y probably damaging Het
Kif7 G T 7: 79,360,261 (GRCm39) C325* probably null Het
Lipo2 A T 19: 33,708,328 (GRCm39) F229I possibly damaging Het
Lrba A G 3: 86,352,656 (GRCm39) K1935E probably damaging Het
Mki67 A T 7: 135,297,017 (GRCm39) D2672E possibly damaging Het
Mtf1 A G 4: 124,732,576 (GRCm39) T545A probably benign Het
Mup6 A T 4: 60,004,812 (GRCm39) probably null Het
Myo9b T C 8: 71,808,409 (GRCm39) V1672A probably damaging Het
Nudt16l2 T C 9: 105,020,767 (GRCm39) I165V probably damaging Het
Or10al6 C A 17: 38,082,949 (GRCm39) P135Q probably damaging Het
Or10j5 C T 1: 172,785,205 (GRCm39) T281I possibly damaging Het
Or4k36 A T 2: 111,145,983 (GRCm39) H53L probably benign Het
Or5d37 T A 2: 87,923,362 (GRCm39) N306I probably damaging Het
Pcdhgb2 A T 18: 37,825,102 (GRCm39) I698F probably damaging Het
Pkn3 C T 2: 29,978,572 (GRCm39) H665Y probably damaging Het
Ppil6 T A 10: 41,383,531 (GRCm39) L99* probably null Het
Psg22 T A 7: 18,458,554 (GRCm39) V376E probably damaging Het
Pum1 G A 4: 130,457,591 (GRCm39) R201H probably damaging Het
Rasa2 A T 9: 96,439,433 (GRCm39) probably benign Het
Schip1 T A 3: 68,525,963 (GRCm39) M379K possibly damaging Het
Scn9a A T 2: 66,395,398 (GRCm39) probably benign Het
Sh3tc1 C T 5: 35,864,322 (GRCm39) A622T probably benign Het
Smarcd2 A T 11: 106,156,076 (GRCm39) I292N probably damaging Het
Ssxb17 C T X: 21,041,167 (GRCm39) S45N probably damaging Het
Stab1 G A 14: 30,876,629 (GRCm39) R862C possibly damaging Het
Tdrd5 T A 1: 156,087,312 (GRCm39) H870L probably benign Het
Tnfaip8 A G 18: 50,223,443 (GRCm39) R60G possibly damaging Het
Traf3ip3 C T 1: 192,880,254 (GRCm39) R25Q probably damaging Het
Unc5b T C 10: 60,601,150 (GRCm39) Y892C probably damaging Het
Vmn2r2 T G 3: 64,042,118 (GRCm39) D199A probably damaging Het
Washc2 C A 6: 116,185,202 (GRCm39) P12Q probably damaging Het
Zfp286 T C 11: 62,671,896 (GRCm39) I121V probably benign Het
Zfp606 T A 7: 12,228,267 (GRCm39) probably null Het
Other mutations in Ccdc178
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00489:Ccdc178 APN 18 21,977,968 (GRCm39) missense probably benign 0.05
IGL00743:Ccdc178 APN 18 22,278,501 (GRCm39) splice site probably benign
IGL00906:Ccdc178 APN 18 22,268,225 (GRCm39) nonsense probably null
IGL01352:Ccdc178 APN 18 22,152,031 (GRCm39) splice site probably benign
IGL01553:Ccdc178 APN 18 22,048,063 (GRCm39) missense probably damaging 0.97
IGL01607:Ccdc178 APN 18 22,200,778 (GRCm39) missense probably benign 0.01
IGL01733:Ccdc178 APN 18 22,157,869 (GRCm39) splice site probably benign
IGL01795:Ccdc178 APN 18 22,152,175 (GRCm39) missense probably benign 0.04
IGL01996:Ccdc178 APN 18 22,230,813 (GRCm39) missense probably damaging 0.99
IGL02939:Ccdc178 APN 18 22,253,775 (GRCm39) missense probably benign 0.01
IGL03213:Ccdc178 APN 18 22,253,748 (GRCm39) missense possibly damaging 0.89
IGL03253:Ccdc178 APN 18 21,978,068 (GRCm39) nonsense probably null
IGL03331:Ccdc178 APN 18 21,944,640 (GRCm39) splice site probably null
PIT4520001:Ccdc178 UTSW 18 22,200,470 (GRCm39) missense probably damaging 0.97
R0121:Ccdc178 UTSW 18 21,978,081 (GRCm39) critical splice acceptor site probably null
R0153:Ccdc178 UTSW 18 22,283,492 (GRCm39) missense probably benign 0.00
R0364:Ccdc178 UTSW 18 22,048,119 (GRCm39) missense probably damaging 0.97
R0604:Ccdc178 UTSW 18 22,200,500 (GRCm39) missense probably benign 0.01
R0709:Ccdc178 UTSW 18 22,200,719 (GRCm39) missense probably damaging 0.97
R0961:Ccdc178 UTSW 18 22,152,098 (GRCm39) missense possibly damaging 0.79
R1029:Ccdc178 UTSW 18 22,230,782 (GRCm39) missense possibly damaging 0.89
R1456:Ccdc178 UTSW 18 22,283,481 (GRCm39) missense possibly damaging 0.81
R1481:Ccdc178 UTSW 18 22,238,678 (GRCm39) missense probably benign 0.00
R1596:Ccdc178 UTSW 18 22,153,930 (GRCm39) missense possibly damaging 0.79
R1739:Ccdc178 UTSW 18 22,230,780 (GRCm39) missense possibly damaging 0.92
R1838:Ccdc178 UTSW 18 22,200,695 (GRCm39) missense probably damaging 0.97
R2214:Ccdc178 UTSW 18 22,048,047 (GRCm39) missense possibly damaging 0.73
R2401:Ccdc178 UTSW 18 22,264,471 (GRCm39) critical splice donor site probably null
R2679:Ccdc178 UTSW 18 21,944,613 (GRCm39) missense possibly damaging 0.90
R3051:Ccdc178 UTSW 18 22,268,188 (GRCm39) missense probably benign 0.05
R3150:Ccdc178 UTSW 18 22,200,709 (GRCm39) missense possibly damaging 0.95
R3151:Ccdc178 UTSW 18 21,944,618 (GRCm39) missense probably benign 0.00
R3177:Ccdc178 UTSW 18 22,200,709 (GRCm39) missense possibly damaging 0.95
R3277:Ccdc178 UTSW 18 22,200,709 (GRCm39) missense possibly damaging 0.95
R3903:Ccdc178 UTSW 18 22,156,152 (GRCm39) missense possibly damaging 0.79
R4184:Ccdc178 UTSW 18 22,157,841 (GRCm39) missense probably damaging 1.00
R4319:Ccdc178 UTSW 18 22,166,600 (GRCm39) nonsense probably null
R4321:Ccdc178 UTSW 18 22,166,600 (GRCm39) nonsense probably null
R4323:Ccdc178 UTSW 18 22,166,600 (GRCm39) nonsense probably null
R4509:Ccdc178 UTSW 18 22,200,449 (GRCm39) missense possibly damaging 0.94
R4672:Ccdc178 UTSW 18 22,283,501 (GRCm39) nonsense probably null
R5078:Ccdc178 UTSW 18 22,200,685 (GRCm39) critical splice donor site probably null
R5099:Ccdc178 UTSW 18 22,238,648 (GRCm39) missense probably benign
R5679:Ccdc178 UTSW 18 22,200,486 (GRCm39) missense probably benign
R5683:Ccdc178 UTSW 18 22,263,179 (GRCm39) missense probably benign 0.00
R6120:Ccdc178 UTSW 18 22,230,785 (GRCm39) missense probably benign 0.00
R6318:Ccdc178 UTSW 18 22,253,591 (GRCm39) missense possibly damaging 0.90
R6717:Ccdc178 UTSW 18 22,153,946 (GRCm39) missense probably damaging 0.98
R6853:Ccdc178 UTSW 18 22,242,933 (GRCm39) missense probably benign 0.00
R6980:Ccdc178 UTSW 18 22,238,620 (GRCm39) missense probably benign
R7019:Ccdc178 UTSW 18 22,283,495 (GRCm39) missense probably benign 0.00
R7246:Ccdc178 UTSW 18 22,242,811 (GRCm39) missense possibly damaging 0.92
R7322:Ccdc178 UTSW 18 22,238,606 (GRCm39) missense probably benign 0.15
R7340:Ccdc178 UTSW 18 22,150,518 (GRCm39) missense probably benign 0.17
R7371:Ccdc178 UTSW 18 22,263,195 (GRCm39) missense probably benign 0.01
R8003:Ccdc178 UTSW 18 21,977,944 (GRCm39) critical splice donor site probably null
R8371:Ccdc178 UTSW 18 21,944,561 (GRCm39) missense possibly damaging 0.90
R8670:Ccdc178 UTSW 18 22,230,719 (GRCm39) missense possibly damaging 0.89
R8695:Ccdc178 UTSW 18 22,157,809 (GRCm39) missense probably benign 0.02
R8885:Ccdc178 UTSW 18 22,200,721 (GRCm39) missense probably damaging 0.98
R9504:Ccdc178 UTSW 18 22,238,708 (GRCm39) missense possibly damaging 0.89
R9518:Ccdc178 UTSW 18 22,278,516 (GRCm39) missense possibly damaging 0.92
X0063:Ccdc178 UTSW 18 21,977,969 (GRCm39) missense probably benign 0.12
Z1177:Ccdc178 UTSW 18 22,242,788 (GRCm39) missense possibly damaging 0.79
Predicted Primers PCR Primer
(F):5'- AGTCAGAATACACACAGGGC -3'
(R):5'- TGCTGATGCTGCTTAAAAGCTAG -3'

Sequencing Primer
(F):5'- CACAGGGCACATTAAAAAGTATAATG -3'
(R):5'- TCGTCACTACCGAGCTCACATATG -3'
Posted On 2015-06-20