Incidental Mutation 'R4301:Trim80'
ID 322423
Institutional Source Beutler Lab
Gene Symbol Trim80
Ensembl Gene ENSMUSG00000070332
Gene Name tripartite motif-containing 80
Synonyms 4933422H20Rik
MMRRC Submission 041088-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R4301 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 115331371-115339094 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 115335939 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000091442 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093914]
AlphaFold Q3V061
Predicted Effect probably null
Transcript: ENSMUST00000093914
SMART Domains Protein: ENSMUSP00000091442
Gene: ENSMUSG00000070332

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
RING 71 114 4.48e-7 SMART
Blast:BBOX 154 202 7e-22 BLAST
Pfam:zf-B_box 207 246 2.2e-10 PFAM
Blast:PRY 441 496 2e-18 BLAST
Pfam:SPRY 499 621 3.9e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175355
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp T A 16: 56,377,266 (GRCm39) V95D probably damaging Het
Adamtsl2 A G 2: 26,977,295 (GRCm39) D252G probably null Het
Adgra3 T C 5: 50,118,420 (GRCm39) R1043G possibly damaging Het
Atxn7l1 A G 12: 33,417,237 (GRCm39) D562G probably damaging Het
Ccdc70 T C 8: 22,463,228 (GRCm39) V6A possibly damaging Het
Cdc25a T C 9: 109,718,810 (GRCm39) V337A probably benign Het
Chil4 G A 3: 106,111,043 (GRCm39) P284S possibly damaging Het
Crb1 A G 1: 139,176,568 (GRCm39) S472P probably benign Het
Fam193b G A 13: 55,690,417 (GRCm39) R740* probably null Het
Fer G T 17: 64,385,905 (GRCm39) L292F probably damaging Het
Gmppa G A 1: 75,419,140 (GRCm39) R349H possibly damaging Het
Hspa1a T C 17: 35,189,482 (GRCm39) I474V probably benign Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Lrrc30 A G 17: 67,939,563 (GRCm39) S6P probably damaging Het
Lzts3 A G 2: 130,478,358 (GRCm39) S133P probably damaging Het
Mrtfb T C 16: 13,216,169 (GRCm39) Y294H probably damaging Het
Mtmr12 T A 15: 12,236,106 (GRCm39) F122I possibly damaging Het
Mypn A G 10: 62,954,263 (GRCm39) Y124H probably damaging Het
Nfat5 T C 8: 108,082,327 (GRCm39) probably benign Het
Npr2 T C 4: 43,641,332 (GRCm39) probably null Het
Or5a3 T C 19: 12,400,081 (GRCm39) L136P probably damaging Het
Pgm2 G A 5: 64,261,140 (GRCm39) W51* probably null Het
Phip G A 9: 82,841,766 (GRCm39) R48* probably null Het
Piezo2 T C 18: 63,217,911 (GRCm39) T1075A probably damaging Het
Ppat G T 5: 77,076,348 (GRCm39) probably benign Het
Ppp2r2b T A 18: 43,031,811 (GRCm39) E23D probably null Het
Prickle1 T C 15: 93,406,517 (GRCm39) I169V possibly damaging Het
Rab37 T A 11: 115,049,390 (GRCm39) D95E possibly damaging Het
Sash1 A G 10: 8,627,234 (GRCm39) V50A probably benign Het
Siae C A 9: 37,545,009 (GRCm39) Q335K possibly damaging Het
Snx14 A T 9: 88,292,676 (GRCm39) I217K probably damaging Het
Son A G 16: 91,455,299 (GRCm39) T1349A possibly damaging Het
Sptb A G 12: 76,659,471 (GRCm39) L1143S probably damaging Het
Trpm3 T C 19: 22,964,656 (GRCm39) S1374P probably benign Het
Vldlr C A 19: 27,215,802 (GRCm39) D266E possibly damaging Het
Vmn2r79 A G 7: 86,651,099 (GRCm39) H166R possibly damaging Het
Zbtb10 A T 3: 9,330,220 (GRCm39) Q526L probably damaging Het
Zfr2 T C 10: 81,078,018 (GRCm39) probably benign Het
Zswim8 G A 14: 20,763,977 (GRCm39) R449H possibly damaging Het
Zzef1 T C 11: 72,779,861 (GRCm39) V1878A probably damaging Het
Other mutations in Trim80
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00899:Trim80 APN 11 115,338,491 (GRCm39) missense probably benign 0.21
IGL00921:Trim80 APN 11 115,338,490 (GRCm39) missense probably benign 0.00
IGL02948:Trim80 APN 11 115,332,419 (GRCm39) missense possibly damaging 0.81
IGL03037:Trim80 APN 11 115,332,419 (GRCm39) missense possibly damaging 0.81
R0019:Trim80 UTSW 11 115,338,768 (GRCm39) missense probably damaging 1.00
R0019:Trim80 UTSW 11 115,338,768 (GRCm39) missense probably damaging 1.00
R0409:Trim80 UTSW 11 115,332,039 (GRCm39) missense probably damaging 1.00
R1069:Trim80 UTSW 11 115,338,909 (GRCm39) missense probably damaging 1.00
R1832:Trim80 UTSW 11 115,337,619 (GRCm39) missense probably benign
R1952:Trim80 UTSW 11 115,332,155 (GRCm39) nonsense probably null
R2892:Trim80 UTSW 11 115,338,849 (GRCm39) missense possibly damaging 0.81
R4748:Trim80 UTSW 11 115,338,964 (GRCm39) missense possibly damaging 0.84
R4795:Trim80 UTSW 11 115,338,769 (GRCm39) missense probably damaging 1.00
R4819:Trim80 UTSW 11 115,338,769 (GRCm39) missense probably damaging 1.00
R4910:Trim80 UTSW 11 115,337,281 (GRCm39) missense probably damaging 0.99
R5245:Trim80 UTSW 11 115,332,398 (GRCm39) missense probably damaging 1.00
R5288:Trim80 UTSW 11 115,338,843 (GRCm39) missense probably benign 0.07
R5384:Trim80 UTSW 11 115,338,843 (GRCm39) missense probably benign 0.07
R5386:Trim80 UTSW 11 115,338,843 (GRCm39) missense probably benign 0.07
R5508:Trim80 UTSW 11 115,335,904 (GRCm39) missense probably benign 0.06
R5645:Trim80 UTSW 11 115,337,611 (GRCm39) missense probably damaging 1.00
R5785:Trim80 UTSW 11 115,337,301 (GRCm39) nonsense probably null
R5822:Trim80 UTSW 11 115,338,747 (GRCm39) missense probably damaging 0.99
R6754:Trim80 UTSW 11 115,339,000 (GRCm39) missense probably damaging 1.00
R6785:Trim80 UTSW 11 115,332,027 (GRCm39) missense probably damaging 0.99
R6788:Trim80 UTSW 11 115,338,843 (GRCm39) missense probably benign 0.07
R7336:Trim80 UTSW 11 115,332,042 (GRCm39) missense probably damaging 1.00
R8316:Trim80 UTSW 11 115,332,006 (GRCm39) missense probably damaging 1.00
R8386:Trim80 UTSW 11 115,335,900 (GRCm39) missense probably damaging 0.99
R8955:Trim80 UTSW 11 115,331,538 (GRCm39) missense probably benign
R9764:Trim80 UTSW 11 115,338,757 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- CTGGTCTTGGGTTCACTAAAGC -3'
(R):5'- CGCATGGTCTGAATCAGTTTC -3'

Sequencing Primer
(F):5'- CCTGTGAATTGGCAGTCAGATCTC -3'
(R):5'- AATCAGTTTCTGAGGTAGATGTGCAG -3'
Posted On 2015-06-20