Incidental Mutation 'R4302:Clic4'
ID 322449
Institutional Source Beutler Lab
Gene Symbol Clic4
Ensembl Gene ENSMUSG00000037242
Gene Name chloride intracellular channel 4
Synonyms mc3s5, mtCLIC, D0Jmb3
MMRRC Submission 041089-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4302 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 134941280-135000071 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 134953350 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 98 (V98A)
Ref Sequence ENSEMBL: ENSMUSP00000041453 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037099]
AlphaFold Q9QYB1
Predicted Effect probably benign
Transcript: ENSMUST00000037099
AA Change: V98A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000041453
Gene: ENSMUSG00000037242
AA Change: V98A

DomainStartEndE-ValueType
Pfam:GST_N_3 31 103 7.3e-9 PFAM
Pfam:GST_C_2 134 223 2.7e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143370
Meta Mutation Damage Score 0.0616 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for null mutations may display decreased survival, body weight and female fertility, impaired angiogenesis, increased suscpetibility to Listeria infection, increased resistance to LPS treatment, skin erosions and/or delayed wound healing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl T C 3: 116,540,279 (GRCm39) Y1445C probably damaging Het
Arhgef12 G A 9: 42,929,645 (GRCm39) Q217* probably null Het
Bcas1 A G 2: 170,260,547 (GRCm39) V44A probably benign Het
Cfap251 T C 5: 123,431,873 (GRCm39) I549T probably benign Het
Col6a3 A T 1: 90,735,336 (GRCm39) I771N probably damaging Het
Creb3l1 T C 2: 91,823,664 (GRCm39) I183V probably damaging Het
Dnhd1 T A 7: 105,343,161 (GRCm39) W1502R probably damaging Het
Dync2h1 A T 9: 7,077,880 (GRCm39) S2941T probably benign Het
Gm973 A G 1: 59,590,399 (GRCm39) Y302C possibly damaging Het
Hcfc1 A G X: 72,992,972 (GRCm39) S1398P probably benign Het
Igsf10 T C 3: 59,226,171 (GRCm39) I2501V probably damaging Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Loxl4 T A 19: 42,596,030 (GRCm39) Y141F probably benign Het
Man2a2 T A 7: 80,001,487 (GRCm39) E1140V possibly damaging Het
Mgam A G 6: 40,740,019 (GRCm39) D1664G probably benign Het
Mill2 A T 7: 18,590,456 (GRCm39) T179S probably damaging Het
Ncf4 T C 15: 78,144,962 (GRCm39) probably benign Het
Nol12 T C 15: 78,824,341 (GRCm39) S154P probably damaging Het
Nup58 A G 14: 60,484,875 (GRCm39) S50P probably benign Het
Or11j4 T C 14: 50,630,903 (GRCm39) I230T probably benign Het
Or12d16-ps1 T A 17: 37,706,377 (GRCm39) N315K probably benign Het
Or7g30 A G 9: 19,352,295 (GRCm39) T29A probably benign Het
Pdss1 T C 2: 22,805,517 (GRCm39) I265T probably damaging Het
Piezo2 T C 18: 63,257,801 (GRCm39) probably null Het
Rad50 T A 11: 53,592,832 (GRCm39) N106I probably benign Het
Rhpn2 A G 7: 35,090,270 (GRCm39) T631A probably benign Het
Rps11 T C 7: 44,772,368 (GRCm39) M80V probably benign Het
Rrm1 T C 7: 102,097,031 (GRCm39) Y104H probably benign Het
Sgsm3 T A 15: 80,894,502 (GRCm39) probably benign Het
Slc9c1 A T 16: 45,365,154 (GRCm39) L162F probably benign Het
Son A G 16: 91,455,299 (GRCm39) T1349A possibly damaging Het
Stk24 A G 14: 121,529,494 (GRCm39) L386S probably benign Het
Tfcp2 G T 15: 100,412,730 (GRCm39) N307K possibly damaging Het
Trbv21 T A 6: 41,179,702 (GRCm39) V6D probably benign Het
Trip11 A T 12: 101,860,027 (GRCm39) D282E probably damaging Het
Ttn G T 2: 76,706,811 (GRCm39) probably benign Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Vmn2r38 A G 7: 9,100,562 (GRCm39) probably null Het
Vps8 T A 16: 21,314,664 (GRCm39) L158Q probably damaging Het
Other mutations in Clic4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01564:Clic4 APN 4 134,944,504 (GRCm39) missense probably damaging 0.99
IGL01674:Clic4 APN 4 134,966,204 (GRCm39) missense probably benign 0.01
IGL03343:Clic4 APN 4 134,945,889 (GRCm39) missense possibly damaging 0.91
IGL03372:Clic4 APN 4 134,945,925 (GRCm39) missense probably damaging 0.99
R1643:Clic4 UTSW 4 134,966,206 (GRCm39) missense possibly damaging 0.69
R2201:Clic4 UTSW 4 134,950,850 (GRCm39) missense probably damaging 1.00
R4181:Clic4 UTSW 4 134,953,350 (GRCm39) missense probably benign 0.00
R4335:Clic4 UTSW 4 134,945,916 (GRCm39) missense probably benign 0.15
R4600:Clic4 UTSW 4 134,966,300 (GRCm39) splice site probably null
R4939:Clic4 UTSW 4 134,950,852 (GRCm39) missense probably benign 0.16
R5359:Clic4 UTSW 4 134,944,446 (GRCm39) missense probably benign 0.00
R5437:Clic4 UTSW 4 134,944,557 (GRCm39) missense probably damaging 1.00
R5902:Clic4 UTSW 4 134,999,869 (GRCm39) missense probably benign
R7670:Clic4 UTSW 4 134,944,516 (GRCm39) missense probably damaging 1.00
R9630:Clic4 UTSW 4 134,944,476 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCATTCTGCCACTGACTAAGC -3'
(R):5'- TCTCATTGCAGTGCTGTGC -3'

Sequencing Primer
(F):5'- AAGCATTACTCTTACAAGCGTGTCC -3'
(R):5'- GACTTGCCCCACTGAGAACTTG -3'
Posted On 2015-06-20