Incidental Mutation 'R4304:Vmn1r238'
| ID |
322550 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r238
|
| Ensembl Gene |
ENSMUSG00000091539 |
| Gene Name |
vomeronasal 1 receptor, 238 |
| Synonyms |
|
| MMRRC Submission |
040865-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.058)
|
| Stock # |
R4304 (G1)
|
| Quality Score |
156 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
3122492-3123412 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 3123040 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 125
(R125*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129804
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165255]
|
| AlphaFold |
E9Q373 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000165255
AA Change: R125*
|
| SMART Domains |
Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: R125*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
7 |
302 |
5.3e-8 |
PFAM |
|
Pfam:7tm_1
|
27 |
292 |
8.8e-7 |
PFAM |
|
Pfam:V1R
|
34 |
298 |
1.9e-33 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam32 |
A |
T |
8: 25,391,545 (GRCm39) |
M323K |
probably damaging |
Het |
| Arhgap42 |
A |
G |
9: 9,006,489 (GRCm39) |
S636P |
probably benign |
Het |
| Arhgef5 |
C |
T |
6: 43,256,432 (GRCm39) |
A1180V |
probably damaging |
Het |
| Cep152 |
G |
A |
2: 125,405,643 (GRCm39) |
Q1630* |
probably null |
Het |
| Cfap157 |
G |
A |
2: 32,669,054 (GRCm39) |
R350W |
probably damaging |
Het |
| Cfap47 |
C |
G |
X: 78,541,635 (GRCm39) |
K469N |
probably damaging |
Het |
| Csgalnact1 |
A |
T |
8: 68,825,294 (GRCm39) |
V400D |
possibly damaging |
Het |
| Fam3d |
G |
A |
14: 8,349,324 (GRCm38) |
P209S |
probably damaging |
Het |
| Fig4 |
T |
A |
10: 41,132,423 (GRCm39) |
D461V |
probably benign |
Het |
| Frmd4a |
C |
T |
2: 4,337,889 (GRCm39) |
R32C |
probably benign |
Het |
| Gcfc2 |
G |
A |
6: 81,919,988 (GRCm39) |
R397Q |
probably damaging |
Het |
| Gm20939 |
A |
C |
17: 95,184,709 (GRCm39) |
Q452H |
probably benign |
Het |
| Gm5592 |
A |
T |
7: 40,935,686 (GRCm39) |
M63L |
probably benign |
Het |
| H2-M3 |
T |
C |
17: 37,583,295 (GRCm39) |
M252T |
probably benign |
Het |
| Lsm14a |
C |
A |
7: 34,056,858 (GRCm39) |
|
probably null |
Het |
| Map4k4 |
T |
C |
1: 40,013,132 (GRCm39) |
Y76H |
possibly damaging |
Het |
| Npc1 |
C |
T |
18: 12,343,584 (GRCm39) |
A470T |
possibly damaging |
Het |
| Or4a68 |
A |
T |
2: 89,270,542 (GRCm39) |
V27D |
probably damaging |
Het |
| Prr27 |
A |
G |
5: 87,990,766 (GRCm39) |
H126R |
probably benign |
Het |
| Resf1 |
C |
T |
6: 149,227,736 (GRCm39) |
Q261* |
probably null |
Het |
| Rptn |
C |
A |
3: 93,304,238 (GRCm39) |
H524N |
probably benign |
Het |
| Slc4a11 |
A |
T |
2: 130,530,058 (GRCm39) |
M240K |
probably benign |
Het |
| Smg1 |
T |
C |
7: 117,738,741 (GRCm39) |
I3503V |
probably benign |
Het |
| Snx13 |
A |
G |
12: 35,172,941 (GRCm39) |
K625E |
probably benign |
Het |
| Stk10 |
T |
C |
11: 32,560,634 (GRCm39) |
V663A |
probably damaging |
Het |
| Tex11 |
C |
A |
X: 99,977,021 (GRCm39) |
A487S |
possibly damaging |
Het |
| Tpp1 |
T |
A |
7: 105,399,516 (GRCm39) |
D84V |
possibly damaging |
Het |
| Vmn2r12 |
A |
G |
5: 109,233,872 (GRCm39) |
L780P |
probably damaging |
Het |
| Wfdc15b |
A |
C |
2: 164,057,388 (GRCm39) |
M1R |
probably null |
Het |
| Wnk2 |
C |
T |
13: 49,244,313 (GRCm39) |
D508N |
probably damaging |
Het |
|
| Other mutations in Vmn1r238 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00427:Vmn1r238
|
APN |
18 |
3,123,243 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01385:Vmn1r238
|
APN |
18 |
3,122,770 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL02716:Vmn1r238
|
APN |
18 |
3,123,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1219:Vmn1r238
|
UTSW |
18 |
3,123,135 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1568:Vmn1r238
|
UTSW |
18 |
3,123,358 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1864:Vmn1r238
|
UTSW |
18 |
3,123,040 (GRCm39) |
nonsense |
probably null |
|
|
R3024:Vmn1r238
|
UTSW |
18 |
3,123,305 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4291:Vmn1r238
|
UTSW |
18 |
3,123,214 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Vmn1r238
|
UTSW |
18 |
3,123,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vmn1r238
|
UTSW |
18 |
3,123,300 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5123:Vmn1r238
|
UTSW |
18 |
3,123,243 (GRCm39) |
missense |
probably benign |
|
|
R5430:Vmn1r238
|
UTSW |
18 |
3,122,521 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5834:Vmn1r238
|
UTSW |
18 |
3,123,168 (GRCm39) |
missense |
probably benign |
|
|
R7186:Vmn1r238
|
UTSW |
18 |
3,122,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7206:Vmn1r238
|
UTSW |
18 |
3,122,623 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7308:Vmn1r238
|
UTSW |
18 |
3,122,875 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7346:Vmn1r238
|
UTSW |
18 |
3,123,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7467:Vmn1r238
|
UTSW |
18 |
3,123,393 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7571:Vmn1r238
|
UTSW |
18 |
3,122,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7808:Vmn1r238
|
UTSW |
18 |
3,123,033 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8085:Vmn1r238
|
UTSW |
18 |
3,123,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8086:Vmn1r238
|
UTSW |
18 |
3,123,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8325:Vmn1r238
|
UTSW |
18 |
3,122,529 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8423:Vmn1r238
|
UTSW |
18 |
3,123,365 (GRCm39) |
nonsense |
probably null |
|
|
R8747:Vmn1r238
|
UTSW |
18 |
3,123,232 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8930:Vmn1r238
|
UTSW |
18 |
3,123,127 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8932:Vmn1r238
|
UTSW |
18 |
3,123,127 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9279:Vmn1r238
|
UTSW |
18 |
3,122,994 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9382:Vmn1r238
|
UTSW |
18 |
3,122,676 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9644:Vmn1r238
|
UTSW |
18 |
3,122,635 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9725:Vmn1r238
|
UTSW |
18 |
3,122,577 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn1r238
|
UTSW |
18 |
3,122,505 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTGCTACACTGTCAGAAGC -3'
(R):5'- GCATTTAACGCCCAAAGTCC -3'
Sequencing Primer
(F):5'- TGCTACACTGTCAGAAGCAAACAATG -3'
(R):5'- AGGGTTTCCACAGACAATGTC -3'
|
| Posted On |
2015-06-20 |
Incidental Mutation