Incidental Mutation 'R0003:Tpp2'
| ID |
32281 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpp2
|
| Ensembl Gene |
ENSMUSG00000041763 |
| Gene Name |
tripeptidyl peptidase II |
| Synonyms |
TppII |
| MMRRC Submission |
038299-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.589)
|
| Stock # |
R0003 (G1)
|
| Quality Score |
211 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
43973130-44042160 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 43999299 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 358
(S358T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140474
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000189388]
|
| AlphaFold |
Q64514 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000087933
AA Change: S358T
PolyPhen 2
Score 0.790 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
AA Change: S358T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186028
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000188302
AA Change: S358T
PolyPhen 2
Score 0.943 (Sensitivity: 0.80; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000140474
Gene: ENSMUSG00000041763
AA Change: S358T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000188313
AA Change: S358T
PolyPhen 2
Score 0.790 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
AA Change: S358T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000189388
AA Change: S358T
PolyPhen 2
Score 0.905 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000140562
Gene: ENSMUSG00000041763
AA Change: S358T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190401
|
| Meta Mutation Damage Score |
0.0929 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.7%
- 20x: 90.7%
|
| Validation Efficiency |
94% (82/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam19 |
T |
A |
11: 46,019,616 (GRCm39) |
C439S |
probably damaging |
Het |
| Adnp2 |
T |
C |
18: 80,174,205 (GRCm39) |
Y68C |
probably damaging |
Het |
| Ahctf1 |
A |
T |
1: 179,591,038 (GRCm39) |
D1247E |
probably benign |
Het |
| Alms1 |
T |
A |
6: 85,606,192 (GRCm39) |
M2614K |
possibly damaging |
Het |
| Alx3 |
A |
G |
3: 107,512,292 (GRCm39) |
H310R |
probably damaging |
Het |
| Ambra1 |
C |
T |
2: 91,741,773 (GRCm39) |
T1016M |
probably damaging |
Het |
| Ankrd35 |
A |
G |
3: 96,591,331 (GRCm39) |
E539G |
probably damaging |
Het |
| Aptx |
A |
G |
4: 40,695,145 (GRCm39) |
|
probably benign |
Het |
| Arsi |
C |
T |
18: 61,050,058 (GRCm39) |
R314C |
probably benign |
Het |
| Atp1a3 |
T |
C |
7: 24,688,989 (GRCm39) |
|
probably benign |
Het |
| Avl9 |
G |
T |
6: 56,713,468 (GRCm39) |
R242L |
probably benign |
Het |
| Bicra |
G |
T |
7: 15,705,812 (GRCm39) |
T1543K |
probably benign |
Het |
| Bltp2 |
T |
A |
11: 78,177,404 (GRCm39) |
V1903E |
possibly damaging |
Het |
| Bzw2 |
A |
C |
12: 36,180,014 (GRCm39) |
I71S |
probably damaging |
Het |
| Camk2a |
C |
T |
18: 61,093,079 (GRCm39) |
A302V |
probably damaging |
Het |
| Ccdc12 |
A |
G |
9: 110,485,665 (GRCm39) |
E12G |
possibly damaging |
Het |
| Cd300lb |
A |
T |
11: 114,819,164 (GRCm39) |
F19Y |
probably benign |
Het |
| Clcn3 |
A |
T |
8: 61,380,330 (GRCm39) |
C535* |
probably null |
Het |
| Cntnap5c |
A |
G |
17: 58,506,012 (GRCm39) |
T679A |
probably benign |
Het |
| Cpsf7 |
G |
A |
19: 10,516,993 (GRCm39) |
S365N |
possibly damaging |
Het |
| Cspg4b |
T |
A |
13: 113,505,310 (GRCm39) |
S2146R |
probably benign |
Het |
| Cyp20a1 |
T |
C |
1: 60,426,285 (GRCm39) |
|
probably benign |
Het |
| Decr2 |
A |
T |
17: 26,302,027 (GRCm39) |
N234K |
probably benign |
Het |
| Def8 |
G |
A |
8: 124,183,234 (GRCm39) |
A278T |
probably damaging |
Het |
| Dnah12 |
T |
C |
14: 26,494,601 (GRCm39) |
F1300L |
probably damaging |
Het |
| Dock1 |
T |
C |
7: 134,331,793 (GRCm39) |
|
probably benign |
Het |
| Dpy19l4 |
A |
T |
4: 11,267,619 (GRCm39) |
N440K |
probably damaging |
Het |
| Eprs1 |
T |
C |
1: 185,146,588 (GRCm39) |
V1206A |
probably damaging |
Het |
| Exoc6b |
A |
G |
6: 84,831,681 (GRCm39) |
|
probably null |
Het |
| Fam184b |
A |
G |
5: 45,712,536 (GRCm39) |
|
probably benign |
Het |
| Fcho1 |
A |
T |
8: 72,161,597 (GRCm39) |
S858T |
probably damaging |
Het |
| Fgfr1 |
A |
G |
8: 26,058,214 (GRCm39) |
D430G |
possibly damaging |
Het |
| Fmnl3 |
T |
C |
15: 99,219,013 (GRCm39) |
T807A |
probably damaging |
Het |
| Gabra5 |
T |
C |
7: 57,063,476 (GRCm39) |
Y316C |
probably damaging |
Het |
| Gh |
A |
G |
11: 106,192,346 (GRCm39) |
L16P |
probably damaging |
Het |
| Glipr2 |
A |
T |
4: 43,970,532 (GRCm39) |
I87F |
probably damaging |
Het |
| Glrb |
T |
A |
3: 80,763,221 (GRCm39) |
I259F |
probably damaging |
Het |
| Gpr63 |
T |
C |
4: 25,007,651 (GRCm39) |
L125P |
probably damaging |
Het |
| Grb2 |
A |
G |
11: 115,546,251 (GRCm39) |
Y37H |
probably damaging |
Het |
| Haus2 |
G |
A |
2: 120,449,449 (GRCm39) |
|
probably benign |
Het |
| Hmgcr |
T |
C |
13: 96,788,653 (GRCm39) |
N749S |
probably damaging |
Het |
| Igf1r |
T |
C |
7: 67,814,990 (GRCm39) |
V297A |
probably damaging |
Het |
| Il12rb2 |
G |
T |
6: 67,293,270 (GRCm39) |
P69H |
probably damaging |
Het |
| Ints3 |
C |
A |
3: 90,315,818 (GRCm39) |
M315I |
probably benign |
Het |
| Izumo2 |
C |
T |
7: 44,364,833 (GRCm39) |
T116I |
probably benign |
Het |
| Kctd19 |
A |
C |
8: 106,121,993 (GRCm39) |
Y185D |
probably damaging |
Het |
| Lama4 |
A |
G |
10: 38,936,218 (GRCm39) |
N631S |
possibly damaging |
Het |
| Lama5 |
T |
G |
2: 179,819,872 (GRCm39) |
|
probably null |
Het |
| Lamc1 |
A |
C |
1: 153,138,185 (GRCm39) |
L223R |
probably damaging |
Het |
| Lgr4 |
G |
A |
2: 109,828,010 (GRCm39) |
|
probably null |
Het |
| Loxhd1 |
T |
C |
18: 77,427,196 (GRCm39) |
L398P |
probably damaging |
Het |
| Mapk9 |
T |
A |
11: 49,757,866 (GRCm39) |
D103E |
possibly damaging |
Het |
| Marchf6 |
T |
C |
15: 31,469,678 (GRCm39) |
|
probably benign |
Het |
| Mlxipl |
G |
A |
5: 135,162,043 (GRCm39) |
|
probably benign |
Het |
| Mrgbp |
C |
A |
2: 180,225,231 (GRCm39) |
D62E |
probably benign |
Het |
| Mtap |
A |
T |
4: 89,070,235 (GRCm39) |
|
probably benign |
Het |
| Myt1 |
G |
A |
2: 181,443,664 (GRCm39) |
G497S |
probably damaging |
Het |
| Naa25 |
T |
G |
5: 121,545,247 (GRCm39) |
|
probably benign |
Het |
| Nfat5 |
C |
T |
8: 108,065,707 (GRCm39) |
R156W |
probably damaging |
Het |
| Nkpd1 |
T |
C |
7: 19,253,852 (GRCm39) |
C73R |
probably benign |
Het |
| Nup210l |
T |
C |
3: 90,027,218 (GRCm39) |
I200T |
probably damaging |
Het |
| Nvl |
C |
A |
1: 180,941,698 (GRCm39) |
D581Y |
probably damaging |
Het |
| Or51a6 |
T |
C |
7: 102,604,185 (GRCm39) |
M208V |
probably benign |
Het |
| Or51f2 |
T |
C |
7: 102,527,068 (GRCm39) |
V247A |
probably benign |
Het |
| Or5t17 |
T |
A |
2: 86,832,710 (GRCm39) |
Y132* |
probably null |
Het |
| Or8b1c |
A |
G |
9: 38,384,612 (GRCm39) |
T190A |
probably benign |
Het |
| Or9q1 |
T |
C |
19: 13,805,050 (GRCm39) |
T237A |
probably damaging |
Het |
| Pcdh7 |
G |
T |
5: 58,070,590 (GRCm39) |
E1089D |
probably benign |
Het |
| Pik3cd |
A |
G |
4: 149,740,836 (GRCm39) |
|
probably null |
Het |
| Plekhh2 |
A |
T |
17: 84,864,820 (GRCm39) |
K69N |
probably damaging |
Het |
| Ptgdr2 |
G |
A |
19: 10,917,792 (GRCm39) |
C103Y |
probably damaging |
Het |
| Rrad |
A |
C |
8: 105,355,299 (GRCm39) |
H236Q |
probably benign |
Het |
| Rslcan18 |
C |
T |
13: 67,246,533 (GRCm39) |
A236T |
probably benign |
Het |
| Ryr2 |
C |
A |
13: 11,839,265 (GRCm39) |
D503Y |
probably damaging |
Het |
| Siglec1 |
T |
C |
2: 130,916,980 (GRCm39) |
T1092A |
probably benign |
Het |
| Siglecf |
A |
G |
7: 43,005,350 (GRCm39) |
T437A |
probably benign |
Het |
| Spta1 |
A |
T |
1: 174,032,839 (GRCm39) |
Q965H |
probably damaging |
Het |
| Stk10 |
A |
T |
11: 32,539,460 (GRCm39) |
E280V |
probably benign |
Het |
| Tfg |
T |
C |
16: 56,511,351 (GRCm39) |
Y326C |
possibly damaging |
Het |
| Trim25 |
G |
T |
11: 88,906,598 (GRCm39) |
V437L |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,574,027 (GRCm39) |
D25622G |
probably damaging |
Het |
| Ube3b |
T |
A |
5: 114,536,912 (GRCm39) |
S303R |
probably benign |
Het |
| Ush2a |
T |
A |
1: 188,310,688 (GRCm39) |
V2088D |
probably damaging |
Het |
| Vmn2r103 |
A |
G |
17: 20,032,241 (GRCm39) |
T672A |
probably damaging |
Het |
| Wdr11 |
G |
T |
7: 129,200,785 (GRCm39) |
G79C |
probably damaging |
Het |
| Wdr89 |
T |
A |
12: 75,679,367 (GRCm39) |
T296S |
probably benign |
Het |
| Zdhhc24 |
T |
A |
19: 4,930,402 (GRCm39) |
L179M |
possibly damaging |
Het |
| Zfp981 |
T |
C |
4: 146,622,217 (GRCm39) |
C381R |
probably damaging |
Het |
| Zim1 |
A |
G |
7: 6,679,947 (GRCm39) |
I572T |
probably benign |
Het |
|
| Other mutations in Tpp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00977:Tpp2
|
APN |
1 |
44,022,451 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01021:Tpp2
|
APN |
1 |
43,973,347 (GRCm39) |
nonsense |
probably null |
|
|
IGL01096:Tpp2
|
APN |
1 |
44,000,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01344:Tpp2
|
APN |
1 |
44,022,422 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01642:Tpp2
|
APN |
1 |
43,993,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02719:Tpp2
|
APN |
1 |
43,979,391 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02890:Tpp2
|
APN |
1 |
44,038,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Tpp2
|
APN |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03175:Tpp2
|
APN |
1 |
44,012,671 (GRCm39) |
missense |
probably benign |
0.35 |
|
beaver
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
billingsly
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
cleaver
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
dow
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
Eddie
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
jerry
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
June
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
landers
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
mathers
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
recurrentis
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
state
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
wally
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
Ward
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
wilson
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
BB010:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB020:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0001:Tpp2
|
UTSW |
1 |
44,010,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0066:Tpp2
|
UTSW |
1 |
44,020,908 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0110:Tpp2
|
UTSW |
1 |
44,017,664 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0110:Tpp2
|
UTSW |
1 |
44,038,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0167:Tpp2
|
UTSW |
1 |
44,009,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0441:Tpp2
|
UTSW |
1 |
44,029,722 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0520:Tpp2
|
UTSW |
1 |
44,029,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Tpp2
|
UTSW |
1 |
44,014,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1118:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1119:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1593:Tpp2
|
UTSW |
1 |
44,014,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1702:Tpp2
|
UTSW |
1 |
44,029,708 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1756:Tpp2
|
UTSW |
1 |
44,017,885 (GRCm39) |
splice site |
probably null |
|
|
R2066:Tpp2
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2171:Tpp2
|
UTSW |
1 |
43,996,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Tpp2
|
UTSW |
1 |
44,038,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2394:Tpp2
|
UTSW |
1 |
44,022,346 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2507:Tpp2
|
UTSW |
1 |
44,040,609 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2879:Tpp2
|
UTSW |
1 |
44,010,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3436:Tpp2
|
UTSW |
1 |
43,979,304 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4106:Tpp2
|
UTSW |
1 |
44,040,617 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4658:Tpp2
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4760:Tpp2
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4963:Tpp2
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Tpp2
|
UTSW |
1 |
44,040,633 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5073:Tpp2
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6010:Tpp2
|
UTSW |
1 |
43,990,373 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6118:Tpp2
|
UTSW |
1 |
43,979,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6155:Tpp2
|
UTSW |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Tpp2
|
UTSW |
1 |
44,022,739 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6236:Tpp2
|
UTSW |
1 |
44,016,477 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6695:Tpp2
|
UTSW |
1 |
44,022,436 (GRCm39) |
missense |
probably benign |
|
|
R6845:Tpp2
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Tpp2
|
UTSW |
1 |
44,022,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7094:Tpp2
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7223:Tpp2
|
UTSW |
1 |
44,008,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7316:Tpp2
|
UTSW |
1 |
44,009,591 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7324:Tpp2
|
UTSW |
1 |
44,017,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Tpp2
|
UTSW |
1 |
44,024,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Tpp2
|
UTSW |
1 |
43,993,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7496:Tpp2
|
UTSW |
1 |
44,022,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7699:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7700:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7804:Tpp2
|
UTSW |
1 |
44,022,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7933:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7979:Tpp2
|
UTSW |
1 |
43,979,297 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8032:Tpp2
|
UTSW |
1 |
44,014,628 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8101:Tpp2
|
UTSW |
1 |
44,009,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tpp2
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Tpp2
|
UTSW |
1 |
43,973,387 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8518:Tpp2
|
UTSW |
1 |
44,019,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Tpp2
|
UTSW |
1 |
44,016,365 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8529:Tpp2
|
UTSW |
1 |
44,022,300 (GRCm39) |
missense |
probably benign |
|
|
R8756:Tpp2
|
UTSW |
1 |
43,999,295 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Tpp2
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8773:Tpp2
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
R8915:Tpp2
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9049:Tpp2
|
UTSW |
1 |
43,992,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9090:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Tpp2
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
R9214:Tpp2
|
UTSW |
1 |
44,031,514 (GRCm39) |
missense |
probably benign |
|
|
R9271:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9316:Tpp2
|
UTSW |
1 |
44,017,604 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9371:Tpp2
|
UTSW |
1 |
43,999,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Tpp2
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9488:Tpp2
|
UTSW |
1 |
44,041,272 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9513:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9514:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9516:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCAGTTACACAGCTTGGAGTCAATG -3'
(R):5'- CTATGCACACTGCTTTTGGGCAC -3'
Sequencing Primer
(F):5'- ACAGCTTGGAGTCAATGTGATTTG -3'
(R):5'- cacaatgtaaagtgactgaaaatacc -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation