Incidental Mutation 'R4331:Vmn1r60'
| ID |
323588 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r60
|
| Ensembl Gene |
ENSMUSG00000090794 |
| Gene Name |
vomeronasal 1 receptor 60 |
| Synonyms |
Gm7184 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R4331 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
5547196-5548098 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 5547364 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Stop codon
at position 245
(C245*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133943
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000173782]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000172111
AA Change: C245*
|
| SMART Domains |
Protein: ENSMUSP00000133113
Gene: ENSMUSG00000090794
AA Change: C245*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
294 |
1.1e-10 |
PFAM |
|
Pfam:7tm_1
|
20 |
280 |
7.3e-12 |
PFAM |
|
Pfam:V1R
|
31 |
299 |
1.3e-18 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000173782
AA Change: C245*
|
| SMART Domains |
Protein: ENSMUSP00000133943
Gene: ENSMUSG00000090794
AA Change: C245*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
304 |
4.7e-10 |
PFAM |
|
Pfam:7tm_1
|
30 |
289 |
7.2e-6 |
PFAM |
|
Pfam:V1R
|
41 |
309 |
1.8e-17 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 18 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A4galt |
T |
C |
15: 83,111,880 (GRCm39) |
Y301C |
probably damaging |
Het |
| Ahnak |
G |
A |
19: 8,993,184 (GRCm39) |
D4823N |
probably damaging |
Het |
| Angptl2 |
A |
T |
2: 33,118,760 (GRCm39) |
D178V |
probably damaging |
Het |
| Capn8 |
A |
T |
1: 182,432,019 (GRCm39) |
D330V |
probably damaging |
Het |
| Clec16a |
T |
C |
16: 10,389,533 (GRCm39) |
V200A |
probably benign |
Het |
| Fcrla |
C |
T |
1: 170,749,245 (GRCm39) |
R96Q |
possibly damaging |
Het |
| Lrpprc |
A |
G |
17: 85,047,970 (GRCm39) |
|
probably null |
Het |
| Map4k5 |
A |
T |
12: 69,874,148 (GRCm39) |
S425T |
probably benign |
Het |
| Mthfsl |
A |
G |
9: 88,570,834 (GRCm39) |
V195A |
probably damaging |
Het |
| Myocd |
A |
T |
11: 65,114,590 (GRCm39) |
H49Q |
probably benign |
Het |
| Nlk |
A |
G |
11: 78,481,774 (GRCm39) |
I229T |
possibly damaging |
Het |
| Plxna4 |
G |
A |
6: 32,127,480 (GRCm39) |
Q1876* |
probably null |
Het |
| Ramp1 |
C |
T |
1: 91,151,067 (GRCm39) |
T144I |
possibly damaging |
Het |
| Rhbdf2 |
A |
G |
11: 116,493,122 (GRCm39) |
Y375H |
probably damaging |
Het |
| Scpep1 |
G |
A |
11: 88,826,729 (GRCm39) |
Q236* |
probably null |
Het |
| Ssc5d |
G |
A |
7: 4,945,725 (GRCm39) |
G919D |
probably benign |
Het |
| Vmn2r103 |
T |
A |
17: 20,014,495 (GRCm39) |
M429K |
probably benign |
Het |
| Zfp28 |
A |
T |
7: 6,396,700 (GRCm39) |
Q378H |
probably benign |
Het |
|
| Other mutations in Vmn1r60 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01869:Vmn1r60
|
APN |
7 |
5,547,228 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01892:Vmn1r60
|
APN |
7 |
5,547,309 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02427:Vmn1r60
|
APN |
7 |
5,547,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03071:Vmn1r60
|
APN |
7 |
5,547,368 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0200:Vmn1r60
|
UTSW |
7 |
5,547,379 (GRCm39) |
missense |
probably benign |
|
|
R0457:Vmn1r60
|
UTSW |
7 |
5,548,118 (GRCm39) |
start gained |
probably benign |
|
|
R1175:Vmn1r60
|
UTSW |
7 |
5,547,621 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1199:Vmn1r60
|
UTSW |
7 |
5,547,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1529:Vmn1r60
|
UTSW |
7 |
5,547,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1859:Vmn1r60
|
UTSW |
7 |
5,547,549 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2033:Vmn1r60
|
UTSW |
7 |
5,547,819 (GRCm39) |
missense |
probably benign |
|
|
R2405:Vmn1r60
|
UTSW |
7 |
5,547,912 (GRCm39) |
missense |
probably benign |
|
|
R3408:Vmn1r60
|
UTSW |
7 |
5,548,148 (GRCm39) |
splice site |
probably null |
|
|
R3771:Vmn1r60
|
UTSW |
7 |
5,547,710 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3773:Vmn1r60
|
UTSW |
7 |
5,547,710 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3852:Vmn1r60
|
UTSW |
7 |
5,548,026 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4236:Vmn1r60
|
UTSW |
7 |
5,547,803 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4439:Vmn1r60
|
UTSW |
7 |
5,547,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5099:Vmn1r60
|
UTSW |
7 |
5,547,816 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5325:Vmn1r60
|
UTSW |
7 |
5,547,201 (GRCm39) |
missense |
probably benign |
|
|
R5415:Vmn1r60
|
UTSW |
7 |
5,547,416 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5818:Vmn1r60
|
UTSW |
7 |
5,548,098 (GRCm39) |
start codon destroyed |
probably benign |
0.04 |
|
R6375:Vmn1r60
|
UTSW |
7 |
5,548,017 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6378:Vmn1r60
|
UTSW |
7 |
5,547,782 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6478:Vmn1r60
|
UTSW |
7 |
5,547,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6572:Vmn1r60
|
UTSW |
7 |
5,547,599 (GRCm39) |
missense |
probably benign |
0.40 |
|
R6586:Vmn1r60
|
UTSW |
7 |
5,547,446 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7061:Vmn1r60
|
UTSW |
7 |
5,547,310 (GRCm39) |
nonsense |
probably null |
|
|
R7506:Vmn1r60
|
UTSW |
7 |
5,547,861 (GRCm39) |
missense |
|
|
|
R7589:Vmn1r60
|
UTSW |
7 |
5,547,688 (GRCm39) |
missense |
|
|
|
R8182:Vmn1r60
|
UTSW |
7 |
5,547,876 (GRCm39) |
missense |
|
|
|
R9295:Vmn1r60
|
UTSW |
7 |
5,547,218 (GRCm39) |
missense |
probably null |
|
|
R9408:Vmn1r60
|
UTSW |
7 |
5,547,918 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- GACCTTATTATCGCTCTGTAATGGC -3'
(R):5'- TGCGGTTTTCCCATGACATC -3'
Sequencing Primer
(F):5'- GTAATGGCTCCCTCCATCACATG -3'
(R):5'- TATTCCTTAATATCATGGCCTGGAC -3'
|
| Posted On |
2015-06-24 |
Incidental Mutation