Mutagenetix > Incidental Mutation

Incidental Mutation 'R4333:Vmn2r7'

323658

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r7

Ensembl Gene

ENSMUSG00000116028

Gene Name

vomeronasal 2, receptor 7

Synonyms

4933425M15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

R4333 (G1)

Quality Score

100

Status

Not validated

Chromosome

Chromosomal Location

64598081-64627023 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 64598199 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 786 (N786S)

Ref Sequence

ENSEMBL: ENSMUSP00000131220 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000161972] [ENSMUST00000168072]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000161972
AA Change: N877S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000124192
Gene: ENSMUSG00000062200
AA Change: N877S

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	90	507	3.8e-77	PFAM
Pfam:NCD3G	549	602	3.4e-17	PFAM
Pfam:7tm_3	635	869	1.1e-47	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000168072
AA Change: N786S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000131220
Gene: ENSMUSG00000116028
AA Change: N786S

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	5.1e-72	PFAM
Pfam:Peripla_BP_6	63	245	6.1e-10	PFAM
Pfam:NCD3G	458	511	1.8e-17	PFAM
Pfam:7tm_3	542	779	4.3e-76	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177146

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.6%
20x: 95.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgb	C	T	10: 10,318,246 (GRCm39)	V193I	possibly damaging	Het
Cadps	C	T	14: 12,467,031 (GRCm38)	R967H	probably damaging	Het
Cwh43	A	G	5: 73,598,722 (GRCm39)	D647G	probably damaging	Het
Dab2ip	T	A	2: 35,551,632 (GRCm39)	*164R	probably null	Het
Ddx18	A	T	1: 121,492,331 (GRCm39)	D125E	probably benign	Het
Fbxw7	T	C	3: 84,879,802 (GRCm39)	C375R	probably damaging	Het
Iqca1l	A	G	5: 24,749,368 (GRCm39)	L710P	probably damaging	Het
Khnyn	A	G	14: 56,131,499 (GRCm39)	D536G	probably damaging	Het
Lamp3	T	C	16: 19,492,186 (GRCm39)	I353V	probably benign	Het
Med13	A	G	11: 86,179,009 (GRCm39)	F1429S	probably benign	Het
Mybl1	T	C	1: 9,742,523 (GRCm39)	K621E	probably damaging	Het
Myo19	G	A	11: 84,799,114 (GRCm39)	A816T	probably benign	Het
Or10d1c	A	G	9: 38,893,884 (GRCm39)	I152T	possibly damaging	Het
Or51h7	A	T	7: 102,591,176 (GRCm39)	L203I	possibly damaging	Het
Rnf2	T	C	1: 151,348,827 (GRCm39)	T98A	possibly damaging	Het
Samm50	A	G	15: 84,087,031 (GRCm39)	K280R	probably benign	Het
Satb2	T	C	1: 56,884,745 (GRCm39)	N511S	probably damaging	Het
Tbc1d19	A	G	5: 54,029,619 (GRCm39)	T327A	possibly damaging	Het
Ttn	A	T	2: 76,641,587 (GRCm39)	L5176Q	possibly damaging	Het

Other mutations in Vmn2r7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00961:Vmn2r7	APN	3	64,623,234 (GRCm39)	missense	possibly damaging	0.60
IGL01762:Vmn2r7	APN	3	64,598,856 (GRCm39)	missense	probably benign	0.39
IGL01903:Vmn2r7	APN	3	64,626,864 (GRCm39)	missense	probably benign	0.00
IGL02263:Vmn2r7	APN	3	64,598,868 (GRCm39)	missense	probably damaging	1.00
IGL02458:Vmn2r7	APN	3	64,600,446 (GRCm39)	missense	probably damaging	0.97
IGL02593:Vmn2r7	APN	3	64,600,443 (GRCm39)	missense	probably damaging	1.00
IGL02797:Vmn2r7	APN	3	64,598,666 (GRCm39)	missense	possibly damaging	0.80
IGL03047:Vmn2r7	UTSW	3	64,614,639 (GRCm39)	missense	possibly damaging	0.81
PIT4504001:Vmn2r7	UTSW	3	64,623,397 (GRCm39)	missense	probably benign	0.01
R0193:Vmn2r7	UTSW	3	64,598,460 (GRCm39)	missense	probably damaging	1.00
R0329:Vmn2r7	UTSW	3	64,598,439 (GRCm39)	missense	probably damaging	1.00
R0609:Vmn2r7	UTSW	3	64,623,900 (GRCm39)	missense	probably benign	0.44
R0735:Vmn2r7	UTSW	3	64,623,788 (GRCm39)	missense	probably benign	0.02
R0941:Vmn2r7	UTSW	3	64,624,000 (GRCm39)	missense	probably benign
R1065:Vmn2r7	UTSW	3	64,614,559 (GRCm39)	missense	possibly damaging	0.82
R1378:Vmn2r7	UTSW	3	64,599,025 (GRCm39)	missense	possibly damaging	0.59
R1445:Vmn2r7	UTSW	3	64,632,223 (GRCm39)	missense	probably benign	0.01
R1506:Vmn2r7	UTSW	3	64,614,500 (GRCm39)	missense	probably benign
R1509:Vmn2r7	UTSW	3	64,623,881 (GRCm39)	nonsense	probably null
R1519:Vmn2r7	UTSW	3	64,623,876 (GRCm39)	missense	possibly damaging	0.95
R1706:Vmn2r7	UTSW	3	64,598,880 (GRCm39)	missense	possibly damaging	0.79
R2113:Vmn2r7	UTSW	3	64,599,025 (GRCm39)	missense	possibly damaging	0.59
R3725:Vmn2r7	UTSW	3	64,632,412 (GRCm39)	missense	possibly damaging	0.65
R3874:Vmn2r7	UTSW	3	64,627,032 (GRCm39)	missense	possibly damaging	0.69
R3902:Vmn2r7	UTSW	3	64,626,937 (GRCm39)	missense	possibly damaging	0.46
R4084:Vmn2r7	UTSW	3	64,600,414 (GRCm39)	missense	probably benign	0.08
R4117:Vmn2r7	UTSW	3	64,623,138 (GRCm39)	intron	probably benign
R4551:Vmn2r7	UTSW	3	64,598,110 (GRCm39)	missense	possibly damaging	0.86
R4643:Vmn2r7	UTSW	3	64,623,825 (GRCm39)	missense	probably damaging	1.00
R4654:Vmn2r7	UTSW	3	64,626,864 (GRCm39)	missense	probably benign	0.00
R5091:Vmn2r7	UTSW	3	64,598,205 (GRCm39)	missense	possibly damaging	0.63
R5109:Vmn2r7	UTSW	3	64,598,088 (GRCm39)	missense	probably null	0.84
R5372:Vmn2r7	UTSW	3	64,623,745 (GRCm39)	missense	probably damaging	1.00
R5415:Vmn2r7	UTSW	3	64,623,658 (GRCm39)	missense	probably benign	0.07
R5740:Vmn2r7	UTSW	3	64,614,654 (GRCm39)	missense	probably benign
R5977:Vmn2r7	UTSW	3	64,623,464 (GRCm39)	nonsense	probably null
R6019:Vmn2r7	UTSW	3	64,623,643 (GRCm39)	missense	probably damaging	1.00
R6058:Vmn2r7	UTSW	3	64,632,436 (GRCm39)	missense	probably benign	0.00
R6139:Vmn2r7	UTSW	3	64,623,339 (GRCm39)	missense	probably damaging	1.00
R6696:Vmn2r7	UTSW	3	64,614,495 (GRCm39)	missense	probably benign	0.01
R6887:Vmn2r7	UTSW	3	64,598,248 (GRCm39)	missense	probably damaging	1.00
R6918:Vmn2r7	UTSW	3	64,598,760 (GRCm39)	missense	probably benign	0.03
R6949:Vmn2r7	UTSW	3	64,598,542 (GRCm39)	missense	probably damaging	0.99
R6980:Vmn2r7	UTSW	3	64,623,987 (GRCm39)	missense	possibly damaging	0.67
R7196:Vmn2r7	UTSW	3	64,623,198 (GRCm39)	missense	probably benign	0.00
R7286:Vmn2r7	UTSW	3	64,598,301 (GRCm39)	missense	probably benign	0.00
R7455:Vmn2r7	UTSW	3	64,624,014 (GRCm39)	missense	probably benign
R7557:Vmn2r7	UTSW	3	64,632,394 (GRCm39)	missense	probably benign
R7864:Vmn2r7	UTSW	3	64,598,947 (GRCm39)	missense	probably benign	0.10
R8046:Vmn2r7	UTSW	3	64,614,479 (GRCm39)	missense	probably damaging	1.00
R8068:Vmn2r7	UTSW	3	64,623,507 (GRCm39)	missense	probably benign	0.01
R8252:Vmn2r7	UTSW	3	64,600,527 (GRCm39)	missense	probably benign	0.00
R8814:Vmn2r7	UTSW	3	64,623,984 (GRCm39)	missense	probably benign	0.14
R9497:Vmn2r7	UTSW	3	64,614,474 (GRCm39)	missense	probably benign	0.04
R9722:Vmn2r7	UTSW	3	64,598,407 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TATTACCCATGAGCATCCGC -3'
(R):5'- ATGTATCACTTTTGGAATGCTGGTC -3'

Sequencing Primer
(F):5'- CGCAGCTGCTTGAAAAACAATGTTC -3'
(R):5'- CACTTTTGGAATGCTGGTCTTTTTC -3'

Posted On

2015-06-24