Incidental Mutation 'R4306:Zfp459'
ID 324042
Institutional Source Beutler Lab
Gene Symbol Zfp459
Ensembl Gene ENSMUSG00000055560
Gene Name zinc finger protein 459
Synonyms Rslcan-14, 9930025G17Rik
MMRRC Submission 041092-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4306 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 67553831-67569537 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 67561307 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 47 (K47R)
Ref Sequence ENSEMBL: ENSMUSP00000063027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056470] [ENSMUST00000223644] [ENSMUST00000224113]
AlphaFold Q8BZ17
Predicted Effect probably damaging
Transcript: ENSMUST00000056470
AA Change: K47R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000063027
Gene: ENSMUSG00000055560
AA Change: K47R

DomainStartEndE-ValueType
KRAB 2 62 2.22e-30 SMART
ZnF_C2H2 106 128 5.9e-3 SMART
ZnF_C2H2 134 156 2.2e-2 SMART
ZnF_C2H2 162 184 2.4e-3 SMART
ZnF_C2H2 190 210 2.97e1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000223644
AA Change: K17R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000224113
AA Change: K47R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224496
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225810
Meta Mutation Damage Score 0.3091 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 97% (33/34)
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik C A 1: 12,042,300 (GRCm39) S440* probably null Het
Chrdl2 A G 7: 99,671,229 (GRCm39) T116A probably damaging Het
Chst12 T C 5: 140,510,401 (GRCm39) F343L probably damaging Het
Cpeb2 T A 5: 43,392,578 (GRCm39) probably benign Het
Cyp27b1 A G 10: 126,886,957 (GRCm39) D391G probably benign Het
Dll3 T C 7: 28,001,082 (GRCm39) probably null Het
Dnah7b T A 1: 46,260,932 (GRCm39) I2030N probably damaging Het
Fap C T 2: 62,361,051 (GRCm39) probably null Het
Frmd4a C T 2: 4,337,889 (GRCm39) R32C probably benign Het
Fzd7 T C 1: 59,523,566 (GRCm39) V483A probably damaging Het
Gpm6a T C 8: 55,500,428 (GRCm39) probably null Het
Gprc6a T C 10: 51,492,735 (GRCm39) H539R probably damaging Het
Irs1 C T 1: 82,265,685 (GRCm39) A844T probably benign Het
Myo1a T G 10: 127,549,950 (GRCm39) S477A probably benign Het
Naga C T 15: 82,221,095 (GRCm39) W67* probably null Het
Or51ah3 G C 7: 103,210,380 (GRCm39) R232T possibly damaging Het
Or51ah3 A T 7: 103,210,379 (GRCm39) R232* probably null Het
Osbpl1a T C 18: 12,952,652 (GRCm39) E87G probably benign Het
Prr27 A G 5: 87,990,766 (GRCm39) H126R probably benign Het
Rb1 G A 14: 73,500,135 (GRCm39) T504I probably damaging Het
Rnf144b A G 13: 47,396,418 (GRCm39) N252D probably damaging Het
Slit2 T A 5: 48,460,125 (GRCm39) N1385K possibly damaging Het
Spaca7b T A 8: 11,728,590 (GRCm39) N27I probably damaging Het
Tas2r124 A G 6: 132,731,954 (GRCm39) I88V probably benign Het
Trip11 A G 12: 101,853,198 (GRCm39) F465L probably benign Het
Usp31 G A 7: 121,306,152 (GRCm39) P109S possibly damaging Het
Vmn2r12 A G 5: 109,233,872 (GRCm39) L780P probably damaging Het
Vmn2r71 G T 7: 85,273,360 (GRCm39) D725Y probably damaging Het
Other mutations in Zfp459
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03115:Zfp459 APN 13 67,556,796 (GRCm39) nonsense probably null
FR4304:Zfp459 UTSW 13 67,556,393 (GRCm39) frame shift probably null
FR4589:Zfp459 UTSW 13 67,556,394 (GRCm39) frame shift probably null
FR4976:Zfp459 UTSW 13 67,556,395 (GRCm39) frame shift probably null
FR4976:Zfp459 UTSW 13 67,556,394 (GRCm39) frame shift probably null
FR4976:Zfp459 UTSW 13 67,556,393 (GRCm39) frame shift probably null
R1185:Zfp459 UTSW 13 67,556,600 (GRCm39) missense probably benign 0.00
R1185:Zfp459 UTSW 13 67,556,600 (GRCm39) missense probably benign 0.00
R1185:Zfp459 UTSW 13 67,556,600 (GRCm39) missense probably benign 0.00
R2130:Zfp459 UTSW 13 67,556,395 (GRCm39) missense probably benign 0.04
R2994:Zfp459 UTSW 13 67,556,853 (GRCm39) missense possibly damaging 0.73
R4180:Zfp459 UTSW 13 67,556,562 (GRCm39) missense probably benign 0.41
R5306:Zfp459 UTSW 13 67,561,249 (GRCm39) missense probably damaging 0.99
R5493:Zfp459 UTSW 13 67,556,498 (GRCm39) missense probably damaging 1.00
R7683:Zfp459 UTSW 13 67,556,615 (GRCm39) missense probably damaging 1.00
R9004:Zfp459 UTSW 13 67,556,714 (GRCm39) missense probably damaging 1.00
R9145:Zfp459 UTSW 13 67,556,735 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGAGACATGTCCTTCTCTGGAAG -3'
(R):5'- ACAGTCTGGACATTGTATGTTCC -3'

Sequencing Primer
(F):5'- GACATGTCCTTCTCTGGAAGCAAAG -3'
(R):5'- GTCTGGACATTGTATGTTCCAATATG -3'
Posted On 2015-06-24