Incidental Mutation 'R4308:Gpr33'
ID 324105
Institutional Source Beutler Lab
Gene Symbol Gpr33
Ensembl Gene ENSMUSG00000035148
Gene Name G protein-coupled receptor 33
Synonyms
MMRRC Submission 041659-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4308 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 52069786-52074846 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 52070423 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 205 (C205*)
Ref Sequence ENSEMBL: ENSMUSP00000048059 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040161]
AlphaFold O88416
Predicted Effect probably null
Transcript: ENSMUST00000040161
AA Change: C205*
SMART Domains Protein: ENSMUSP00000048059
Gene: ENSMUSG00000035148
AA Change: C205*

DomainStartEndE-ValueType
Pfam:7tm_1 46 299 3.6e-32 PFAM
Meta Mutation Damage Score 0.9576 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 G A 13: 81,588,311 (GRCm39) T4425M probably damaging Het
Arhgef5 C T 6: 43,256,432 (GRCm39) A1180V probably damaging Het
Asap2 T C 12: 21,279,482 (GRCm39) I426T probably damaging Het
Ascc1 T G 10: 59,849,434 (GRCm39) H108Q probably benign Het
Bod1l A T 5: 41,949,156 (GRCm39) S2989T possibly damaging Het
Cfap157 G A 2: 32,669,054 (GRCm39) R350W probably damaging Het
Cyp39a1 T A 17: 44,041,855 (GRCm39) probably null Het
Dars2 A G 1: 160,869,291 (GRCm39) S653P probably damaging Het
Fancm A T 12: 65,173,305 (GRCm39) K1872N probably benign Het
Fktn C T 4: 53,724,617 (GRCm39) probably benign Het
Gsdmc2 A G 15: 63,720,554 (GRCm39) probably benign Het
Il31 A G 5: 123,618,769 (GRCm39) S6P probably damaging Het
Iqca1 T C 1: 90,072,619 (GRCm39) K87R probably damaging Het
Kif15 T G 9: 122,843,047 (GRCm39) H47Q probably benign Het
L3mbtl3 C T 10: 26,158,690 (GRCm39) A653T unknown Het
Lamb1 T C 12: 31,379,254 (GRCm39) L1737P probably damaging Het
Map2k5 C G 9: 63,142,586 (GRCm39) R353S probably benign Het
Mical2 C A 7: 111,931,199 (GRCm39) L721I probably benign Het
Myo1b T C 1: 51,922,268 (GRCm39) K37E probably benign Het
Myo5b A G 18: 74,864,811 (GRCm39) D1369G possibly damaging Het
Npc1 C T 18: 12,343,584 (GRCm39) A470T possibly damaging Het
Obi1 T A 14: 104,717,029 (GRCm39) N448I probably damaging Het
Or12e13 T C 2: 87,663,614 (GRCm39) I77T probably damaging Het
Or14j10 C T 17: 37,934,627 (GRCm39) V300I possibly damaging Het
Pcdhb1 A T 18: 37,399,714 (GRCm39) D555V probably benign Het
Prr27 A G 5: 87,990,766 (GRCm39) H126R probably benign Het
Rbm20 A G 19: 53,831,691 (GRCm39) S642G probably damaging Het
Rnf144b A G 13: 47,396,418 (GRCm39) N252D probably damaging Het
Rwdd2b A T 16: 87,233,615 (GRCm39) W162R probably damaging Het
Scaf11 A G 15: 96,344,396 (GRCm39) M19T probably benign Het
Sft2d2 A G 1: 165,015,833 (GRCm39) I45T probably benign Het
Skint5 A T 4: 113,341,164 (GRCm39) H1371Q unknown Het
Tas2r124 A G 6: 132,731,954 (GRCm39) I88V probably benign Het
Tasor2 A C 13: 3,619,498 (GRCm39) S2244R probably damaging Het
Ubr4 T C 4: 139,199,820 (GRCm39) V4568A possibly damaging Het
Vmn2r12 A G 5: 109,233,872 (GRCm39) L780P probably damaging Het
Vmn2r18 A T 5: 151,508,268 (GRCm39) Y285* probably null Het
Wnk2 C T 13: 49,244,313 (GRCm39) D508N probably damaging Het
Zfp983 A G 17: 21,881,124 (GRCm39) I351V probably benign Het
Other mutations in Gpr33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01655:Gpr33 APN 12 52,070,343 (GRCm39) missense probably damaging 0.98
IGL02177:Gpr33 APN 12 52,070,863 (GRCm39) missense probably benign 0.00
IGL03090:Gpr33 APN 12 52,070,809 (GRCm39) missense probably damaging 0.99
R0883:Gpr33 UTSW 12 52,070,418 (GRCm39) missense probably benign 0.17
R1112:Gpr33 UTSW 12 52,070,155 (GRCm39) missense probably damaging 1.00
R1127:Gpr33 UTSW 12 52,070,252 (GRCm39) missense probably damaging 1.00
R1742:Gpr33 UTSW 12 52,071,045 (GRCm39) critical splice acceptor site probably null
R1967:Gpr33 UTSW 12 52,070,991 (GRCm39) missense probably benign
R2208:Gpr33 UTSW 12 52,070,236 (GRCm39) missense probably benign 0.00
R2917:Gpr33 UTSW 12 52,070,379 (GRCm39) missense possibly damaging 0.63
R4725:Gpr33 UTSW 12 52,070,892 (GRCm39) missense probably damaging 1.00
R5616:Gpr33 UTSW 12 52,070,377 (GRCm39) missense probably damaging 0.99
R7055:Gpr33 UTSW 12 52,071,036 (GRCm39) start codon destroyed probably null 0.99
R7272:Gpr33 UTSW 12 52,070,848 (GRCm39) missense probably damaging 0.99
R7419:Gpr33 UTSW 12 52,070,050 (GRCm39) missense probably benign 0.00
R8313:Gpr33 UTSW 12 52,070,907 (GRCm39) missense probably benign 0.00
R8514:Gpr33 UTSW 12 52,070,181 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TGTACATGGTAGGGCATCCAAC -3'
(R):5'- TTCATCCAGTGTGGTCCCAG -3'

Sequencing Primer
(F):5'- GGTAGGGCATCCAACACACAAAG -3'
(R):5'- GGCTTCCCGGATTGCCTTG -3'
Posted On 2015-06-24