Incidental Mutation 'R4344:Gm5878'
ID 324261
Institutional Source Beutler Lab
Gene Symbol Gm5878
Ensembl Gene ENSMUSG00000072952
Gene Name predicted gene 5878
Synonyms
MMRRC Submission 041101-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R4344 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 85088397-85103076 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 85102633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 31 (R31*)
Ref Sequence ENSEMBL: ENSMUSP00000109433 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113802] [ENSMUST00000204757]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000113802
AA Change: R31*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203386
Predicted Effect probably benign
Transcript: ENSMUST00000204757
SMART Domains Protein: ENSMUSP00000145412
Gene: ENSMUSG00000033735

DomainStartEndE-ValueType
Pfam:adh_short 9 215 5.3e-28 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 98% (39/40)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 G T 1: 25,865,829 (GRCm39) R5S possibly damaging Het
Ccdc168 G A 1: 44,100,151 (GRCm39) L316F possibly damaging Het
Ccdc187 T A 2: 26,170,681 (GRCm39) K599I probably damaging Het
Ccn5 G A 2: 163,670,906 (GRCm39) V138M probably damaging Het
Cd38 A C 5: 44,026,431 (GRCm39) I72L probably benign Het
Cep19 C T 16: 31,925,883 (GRCm39) T97M probably damaging Het
Ces2a T G 8: 105,463,766 (GRCm39) D159E probably damaging Het
Dcc G A 18: 71,507,561 (GRCm39) A917V probably damaging Het
Dennd6b G A 15: 89,072,866 (GRCm39) A196V probably benign Het
Dlgap3 T C 4: 127,108,141 (GRCm39) S475P possibly damaging Het
Doc2a C T 7: 126,450,321 (GRCm39) P156S probably damaging Het
Elmo1 T A 13: 20,445,722 (GRCm39) probably null Het
Fbf1 A G 11: 116,038,568 (GRCm39) V851A probably benign Het
Fhdc1 C A 3: 84,352,133 (GRCm39) V1031F probably benign Het
Klk1b8 C A 7: 43,595,186 (GRCm39) probably benign Het
Lmcd1 T A 6: 112,264,968 (GRCm39) probably benign Het
Lyst T A 13: 13,873,051 (GRCm39) I2750K probably benign Het
Muc4 A G 16: 32,590,666 (GRCm39) N2958S possibly damaging Het
Plod3 G C 5: 137,017,000 (GRCm39) A50P probably benign Het
Ppp1r16b G A 2: 158,591,106 (GRCm39) V163I probably damaging Het
Prkdc T A 16: 15,585,886 (GRCm39) W2475R probably damaging Het
Rad54l C T 4: 115,954,551 (GRCm39) C684Y probably damaging Het
Ralgds T C 2: 28,442,107 (GRCm39) L96P probably damaging Het
Rasef T A 4: 73,663,326 (GRCm39) H167L probably damaging Het
Sh3bp2 T C 5: 34,712,886 (GRCm39) F165L possibly damaging Het
Slc38a9 T C 13: 112,865,749 (GRCm39) I482T probably benign Het
Tmprss6 T A 15: 78,343,627 (GRCm39) probably null Het
Trpm3 A T 19: 22,875,061 (GRCm39) S568C probably damaging Het
Ttc39c T A 18: 12,861,667 (GRCm39) probably null Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ugt2b5 A T 5: 87,287,582 (GRCm39) V195E probably damaging Het
Vmn2r22 C T 6: 123,614,756 (GRCm39) G278D probably damaging Het
Yme1l1 G A 2: 23,063,073 (GRCm39) A215T probably benign Het
Zmynd15 C T 11: 70,351,894 (GRCm39) R38* probably null Het
Other mutations in Gm5878
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02728:Gm5878 APN 6 85,095,574 (GRCm39) missense probably benign
R2426:Gm5878 UTSW 6 85,095,613 (GRCm39) missense probably benign 0.04
R4342:Gm5878 UTSW 6 85,102,633 (GRCm39) nonsense probably null
R4343:Gm5878 UTSW 6 85,102,633 (GRCm39) nonsense probably null
R4345:Gm5878 UTSW 6 85,102,633 (GRCm39) nonsense probably null
R7583:Gm5878 UTSW 6 85,095,682 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- GCAGACCAAAGGCTAATCGC -3'
(R):5'- CCATGGCGCTCAACTAACTC -3'

Sequencing Primer
(F):5'- GCTAATCGCCTGGGAACAATG -3'
(R):5'- TAACTCACCCCAGTGCGG -3'
Posted On 2015-06-24