Incidental Mutation 'R4345:Gm5878'
ID 324294
Institutional Source Beutler Lab
Gene Symbol Gm5878
Ensembl Gene ENSMUSG00000072952
Gene Name predicted gene 5878
Synonyms
MMRRC Submission 041666-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R4345 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 85088397-85103076 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 85102633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 31 (R31*)
Ref Sequence ENSEMBL: ENSMUSP00000109433 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113802] [ENSMUST00000204757]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000113802
AA Change: R31*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203386
Predicted Effect probably benign
Transcript: ENSMUST00000204757
SMART Domains Protein: ENSMUSP00000145412
Gene: ENSMUSG00000033735

DomainStartEndE-ValueType
Pfam:adh_short 9 215 5.3e-28 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 96% (47/49)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asap2 T C 12: 21,280,832 (GRCm39) W449R probably damaging Het
Astn1 T A 1: 158,329,602 (GRCm39) probably null Het
C3ar1 T C 6: 122,827,659 (GRCm39) D186G probably damaging Het
Fbf1 A G 11: 116,038,568 (GRCm39) V851A probably benign Het
Foxp4 G A 17: 48,185,573 (GRCm39) T500M unknown Het
Gramd4 T C 15: 86,019,094 (GRCm39) S581P probably damaging Het
Heatr5b A T 17: 79,067,940 (GRCm39) V1816E possibly damaging Het
Igf2r C T 17: 12,928,398 (GRCm39) E982K possibly damaging Het
Il1r1 A G 1: 40,337,084 (GRCm39) D224G probably benign Het
Kcnv1 G A 15: 44,977,840 (GRCm39) T66M probably damaging Het
Lactb2 T A 1: 13,730,574 (GRCm39) Y34F probably damaging Het
Lepr G A 4: 101,622,349 (GRCm39) probably null Het
Loxhd1 A G 18: 77,486,697 (GRCm39) I1261V possibly damaging Het
Map4k3 A G 17: 80,904,980 (GRCm39) probably null Het
Mcee T C 7: 64,061,686 (GRCm39) L109P probably damaging Het
Mier3 A G 13: 111,841,817 (GRCm39) D124G probably damaging Het
Mrpl43 T C 19: 44,994,549 (GRCm39) Y64C probably damaging Het
Nfasc A G 1: 132,559,443 (GRCm39) F229S probably damaging Het
Nsd3 G C 8: 26,131,333 (GRCm39) G233R probably benign Het
Or2ak7 A G 11: 58,574,771 (GRCm39) D24G possibly damaging Het
Or8k27 T A 2: 86,276,189 (GRCm39) I46F probably damaging Het
Pdzd8 T C 19: 59,288,560 (GRCm39) T947A probably benign Het
Plod3 G C 5: 137,017,000 (GRCm39) A50P probably benign Het
Pno1 A G 11: 17,159,095 (GRCm39) S158P possibly damaging Het
Prr14l A G 5: 32,985,920 (GRCm39) S1192P probably damaging Het
Setbp1 T A 18: 79,129,794 (GRCm39) E146V probably damaging Het
Slc9a5 T C 8: 106,076,087 (GRCm39) S27P probably benign Het
Sri G T 5: 8,109,427 (GRCm39) probably null Het
Stard9 G A 2: 120,532,427 (GRCm39) V2895I probably benign Het
Tgfbrap1 T C 1: 43,095,866 (GRCm39) D524G probably benign Het
Them4 A G 3: 94,237,172 (GRCm39) T211A possibly damaging Het
Thoc2l A G 5: 104,669,315 (GRCm39) E1279G probably benign Het
Trpm3 A T 19: 22,875,061 (GRCm39) S568C probably damaging Het
Ttl T C 2: 128,917,778 (GRCm39) L80P probably damaging Het
Ttn G T 2: 76,586,660 (GRCm39) N13423K possibly damaging Het
Usp10 T A 8: 120,681,553 (GRCm39) L670Q probably damaging Het
Usp4 T A 9: 108,245,222 (GRCm39) probably benign Het
Vmn1r72 T A 7: 11,403,963 (GRCm39) T162S possibly damaging Het
Zmym5 T C 14: 57,034,083 (GRCm39) N376S probably benign Het
Zswim6 G T 13: 107,863,466 (GRCm39) noncoding transcript Het
Other mutations in Gm5878
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02728:Gm5878 APN 6 85,095,574 (GRCm39) missense probably benign
R2426:Gm5878 UTSW 6 85,095,613 (GRCm39) missense probably benign 0.04
R4342:Gm5878 UTSW 6 85,102,633 (GRCm39) nonsense probably null
R4343:Gm5878 UTSW 6 85,102,633 (GRCm39) nonsense probably null
R4344:Gm5878 UTSW 6 85,102,633 (GRCm39) nonsense probably null
R7583:Gm5878 UTSW 6 85,095,682 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- GGCAGACCAAAGGCTAATCG -3'
(R):5'- TGGCGCTCAACTAACTCAC -3'

Sequencing Primer
(F):5'- GCTAATCGCCTGGGAACAATG -3'
(R):5'- TAACTCACCCCAGTGCGG -3'
Posted On 2015-06-24