Incidental Mutation 'R4328:Cwf19l2'
ID 324470
Institutional Source Beutler Lab
Gene Symbol Cwf19l2
Ensembl Gene ENSMUSG00000025898
Gene Name CWF19 like cell cycle control factor 2
Synonyms 3230401L03Rik
MMRRC Submission 041098-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.934) question?
Stock # R4328 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 3403592-3479236 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 3458878 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 776 (I776F)
Ref Sequence ENSEMBL: ENSMUSP00000027027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027027]
AlphaFold Q8BG79
Predicted Effect probably damaging
Transcript: ENSMUST00000027027
AA Change: I776F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000027027
Gene: ENSMUSG00000025898
AA Change: I776F

DomainStartEndE-ValueType
low complexity region 64 114 N/A INTRINSIC
coiled coil region 165 196 N/A INTRINSIC
low complexity region 403 418 N/A INTRINSIC
coiled coil region 496 524 N/A INTRINSIC
Pfam:CwfJ_C_1 655 779 1.8e-40 PFAM
Pfam:CwfJ_C_2 788 882 4.6e-34 PFAM
Meta Mutation Damage Score 0.1084 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 98% (56/57)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300009A05Rik T C 9: 63,306,238 (GRCm39) K89R probably damaging Het
Aadacl4fm2 T A 4: 144,282,164 (GRCm39) K209N possibly damaging Het
Alcam T C 16: 52,073,579 (GRCm39) N549S possibly damaging Het
Arap2 A T 5: 62,779,206 (GRCm39) H1461Q possibly damaging Het
Bin3 A G 14: 70,356,054 (GRCm39) I4V probably benign Het
Brd10 G T 19: 29,720,961 (GRCm39) T688K probably benign Het
C9orf72 T A 4: 35,225,985 (GRCm39) probably benign Het
Cd55 C T 1: 130,375,104 (GRCm39) probably benign Het
Cd55 A T 1: 130,380,220 (GRCm39) C253S probably damaging Het
Col12a1 T A 9: 79,607,671 (GRCm39) T386S possibly damaging Het
Col13a1 T C 10: 61,699,758 (GRCm39) T476A unknown Het
Crym C T 7: 119,794,562 (GRCm39) G219E probably damaging Het
Eif1ad16 T A 12: 87,985,285 (GRCm39) D86V possibly damaging Het
Erlec1 C T 11: 30,899,972 (GRCm39) E166K probably benign Het
Gm3336 C T 8: 71,173,234 (GRCm39) T82I probably benign Het
Gm3604 A T 13: 62,517,079 (GRCm39) S425R possibly damaging Het
Gpn2 T C 4: 133,315,919 (GRCm39) V203A probably benign Het
Gskip T C 12: 105,666,960 (GRCm39) Y113H probably damaging Het
Hcn2 T C 10: 79,560,445 (GRCm39) Y259H probably damaging Het
Hira C A 16: 18,715,362 (GRCm39) Q87K probably benign Het
Ip6k2 G A 9: 108,682,847 (GRCm39) R319Q probably benign Het
Kirrel1 T C 3: 86,992,081 (GRCm39) probably benign Het
Klhl40 A G 9: 121,607,956 (GRCm39) D372G probably benign Het
Lingo2 T A 4: 35,708,462 (GRCm39) D506V probably damaging Het
Ly6e C A 15: 74,830,370 (GRCm39) N73K probably damaging Het
Med12l T C 3: 59,172,688 (GRCm39) S1813P probably benign Het
Med24 A G 11: 98,597,942 (GRCm39) probably null Het
Niban1 T C 1: 151,512,169 (GRCm39) S24P possibly damaging Het
Nup210l C A 3: 90,083,142 (GRCm39) probably null Het
Or2t1 T A 14: 14,328,193 (GRCm38) F27L probably damaging Het
Or5w12 C A 2: 87,502,008 (GRCm39) R234S possibly damaging Het
Or7g34 T A 9: 19,478,318 (GRCm39) M121L possibly damaging Het
Or8d1 T C 9: 38,767,132 (GRCm39) M258T possibly damaging Het
Pafah1b1 T C 11: 74,573,066 (GRCm39) T333A probably benign Het
Pak3 T C X: 142,516,205 (GRCm39) probably null Het
Palm G A 10: 79,643,520 (GRCm39) G83S probably benign Het
Pax8 A G 2: 24,331,663 (GRCm39) F140S possibly damaging Het
Ppargc1b A T 18: 61,515,540 (GRCm39) C34* probably null Het
Ppp3cb A T 14: 20,581,016 (GRCm39) I136K probably damaging Het
Prep T C 10: 44,996,745 (GRCm39) V341A probably benign Het
Prickle4 C A 17: 47,999,543 (GRCm39) G337C probably damaging Het
Rabgap1 T A 2: 37,422,627 (GRCm39) Y627N probably damaging Het
Ryr1 T C 7: 28,782,484 (GRCm39) Y1953C probably damaging Het
Snrnp200 T A 2: 127,064,137 (GRCm39) V708D probably damaging Het
Tent5b C T 4: 133,213,914 (GRCm39) Q262* probably null Het
Tmem107 G T 11: 68,962,301 (GRCm39) probably null Het
Tmem62 T A 2: 120,810,991 (GRCm39) N156K probably damaging Het
Ttyh1 A T 7: 4,133,580 (GRCm39) D295V probably damaging Het
Twsg1 T C 17: 66,255,733 (GRCm39) T14A probably benign Het
Zfp184 T C 13: 22,144,072 (GRCm39) Y593H probably damaging Het
Zfp239 T C 6: 117,848,745 (GRCm39) L161P probably damaging Het
Zpbp2 A G 11: 98,448,432 (GRCm39) T199A probably benign Het
Other mutations in Cwf19l2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Cwf19l2 APN 9 3,409,990 (GRCm39) missense probably benign 0.01
IGL00573:Cwf19l2 APN 9 3,450,161 (GRCm39) splice site probably benign
IGL00757:Cwf19l2 APN 9 3,460,054 (GRCm39) missense probably damaging 1.00
IGL00803:Cwf19l2 APN 9 3,430,810 (GRCm39) missense probably benign 0.41
IGL01916:Cwf19l2 APN 9 3,477,869 (GRCm39) missense possibly damaging 0.82
IGL02315:Cwf19l2 APN 9 3,410,030 (GRCm39) missense probably damaging 1.00
IGL02419:Cwf19l2 APN 9 3,418,777 (GRCm39) critical splice donor site probably null
IGL02427:Cwf19l2 APN 9 3,456,817 (GRCm39) missense probably benign 0.00
IGL03026:Cwf19l2 APN 9 3,428,777 (GRCm39) missense probably benign 0.28
IGL03028:Cwf19l2 APN 9 3,430,622 (GRCm39) missense probably benign 0.26
IGL03199:Cwf19l2 APN 9 3,477,830 (GRCm39) missense probably damaging 1.00
R0015:Cwf19l2 UTSW 9 3,454,666 (GRCm39) missense probably benign 0.00
R0015:Cwf19l2 UTSW 9 3,454,666 (GRCm39) missense probably benign 0.00
R0532:Cwf19l2 UTSW 9 3,431,057 (GRCm39) missense probably benign 0.38
R0724:Cwf19l2 UTSW 9 3,421,377 (GRCm39) critical splice donor site probably null
R0924:Cwf19l2 UTSW 9 3,441,047 (GRCm39) splice site probably benign
R0947:Cwf19l2 UTSW 9 3,421,286 (GRCm39) missense probably benign 0.16
R1210:Cwf19l2 UTSW 9 3,430,810 (GRCm39) missense probably benign 0.00
R1393:Cwf19l2 UTSW 9 3,456,818 (GRCm39) missense probably benign 0.01
R1541:Cwf19l2 UTSW 9 3,456,760 (GRCm39) missense probably damaging 1.00
R1594:Cwf19l2 UTSW 9 3,430,973 (GRCm39) missense probably benign
R1870:Cwf19l2 UTSW 9 3,458,802 (GRCm39) missense possibly damaging 0.56
R1950:Cwf19l2 UTSW 9 3,418,674 (GRCm39) missense probably benign
R1996:Cwf19l2 UTSW 9 3,417,947 (GRCm39) missense probably benign 0.01
R2005:Cwf19l2 UTSW 9 3,430,720 (GRCm39) missense possibly damaging 0.92
R2246:Cwf19l2 UTSW 9 3,430,661 (GRCm39) missense probably benign 0.16
R2420:Cwf19l2 UTSW 9 3,411,341 (GRCm39) missense possibly damaging 0.80
R3051:Cwf19l2 UTSW 9 3,410,006 (GRCm39) missense probably benign 0.05
R3738:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R3915:Cwf19l2 UTSW 9 3,456,776 (GRCm39) missense probably damaging 1.00
R4034:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R4035:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R4323:Cwf19l2 UTSW 9 3,430,452 (GRCm39) missense probably damaging 0.99
R4329:Cwf19l2 UTSW 9 3,458,878 (GRCm39) missense probably damaging 1.00
R4692:Cwf19l2 UTSW 9 3,428,709 (GRCm39) missense probably damaging 1.00
R4775:Cwf19l2 UTSW 9 3,430,973 (GRCm39) missense probably benign
R4779:Cwf19l2 UTSW 9 3,410,035 (GRCm39) missense possibly damaging 0.95
R4822:Cwf19l2 UTSW 9 3,458,839 (GRCm39) missense probably damaging 1.00
R4833:Cwf19l2 UTSW 9 3,430,783 (GRCm39) missense probably benign 0.28
R5110:Cwf19l2 UTSW 9 3,450,012 (GRCm39) critical splice acceptor site probably null
R5120:Cwf19l2 UTSW 9 3,418,761 (GRCm39) nonsense probably null
R5164:Cwf19l2 UTSW 9 3,475,511 (GRCm39) missense probably damaging 1.00
R5440:Cwf19l2 UTSW 9 3,475,549 (GRCm39) missense probably damaging 1.00
R5567:Cwf19l2 UTSW 9 3,456,831 (GRCm39) missense probably damaging 1.00
R5594:Cwf19l2 UTSW 9 3,418,773 (GRCm39) missense probably benign 0.42
R5960:Cwf19l2 UTSW 9 3,411,404 (GRCm39) missense probably benign 0.43
R6222:Cwf19l2 UTSW 9 3,454,569 (GRCm39) nonsense probably null
R6259:Cwf19l2 UTSW 9 3,458,879 (GRCm39) missense probably damaging 1.00
R6688:Cwf19l2 UTSW 9 3,450,015 (GRCm39) missense probably benign 0.00
R6983:Cwf19l2 UTSW 9 3,477,817 (GRCm39) missense probably damaging 1.00
R7063:Cwf19l2 UTSW 9 3,430,532 (GRCm39) missense probably benign 0.03
R7506:Cwf19l2 UTSW 9 3,456,775 (GRCm39) missense probably damaging 1.00
R7733:Cwf19l2 UTSW 9 3,450,066 (GRCm39) missense probably benign 0.19
R7846:Cwf19l2 UTSW 9 3,477,889 (GRCm39) missense probably damaging 1.00
R7900:Cwf19l2 UTSW 9 3,460,107 (GRCm39) missense probably damaging 1.00
R8510:Cwf19l2 UTSW 9 3,454,732 (GRCm39) missense possibly damaging 0.89
R8709:Cwf19l2 UTSW 9 3,430,723 (GRCm39) missense probably benign 0.26
R8900:Cwf19l2 UTSW 9 3,447,245 (GRCm39) missense probably benign 0.01
R9031:Cwf19l2 UTSW 9 3,417,942 (GRCm39) missense probably benign 0.00
R9373:Cwf19l2 UTSW 9 3,454,718 (GRCm39) missense probably damaging 0.99
R9701:Cwf19l2 UTSW 9 3,430,454 (GRCm39) missense probably damaging 1.00
T0722:Cwf19l2 UTSW 9 3,456,755 (GRCm39) missense probably benign 0.00
X0003:Cwf19l2 UTSW 9 3,456,755 (GRCm39) missense probably benign 0.00
X0020:Cwf19l2 UTSW 9 3,418,662 (GRCm39) missense probably damaging 1.00
Z1177:Cwf19l2 UTSW 9 3,428,782 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAAGCAGTTCTGGAATATGTGC -3'
(R):5'- GCTGTTATTCCCTATTTATGAGTGC -3'

Sequencing Primer
(F):5'- CAGTTCTGGAATATGTGCCTTTTGTC -3'
(R):5'- GACTTGAACGTGTTTCATGGTAAAAC -3'
Posted On 2015-06-24