Incidental Mutation 'R4330:Zscan25'
ID 324562
Institutional Source Beutler Lab
Gene Symbol Zscan25
Ensembl Gene ENSMUSG00000070420
Gene Name zinc finger and SCAN domain containing 25
Synonyms Zfp498, EG666311
Accession Numbers
Essential gene? Probably non essential (E-score: 0.151) question?
Stock # R4330 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 145217310-145228088 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 145227361 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 342 (F342I)
Ref Sequence ENSEMBL: ENSMUSP00000091664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094116] [ENSMUST00000199563] [ENSMUST00000200246]
AlphaFold B2RX31
Predicted Effect probably damaging
Transcript: ENSMUST00000094116
AA Change: F342I

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000091664
Gene: ENSMUSG00000070420
AA Change: F342I

DomainStartEndE-ValueType
SCAN 38 150 5.94e-53 SMART
Blast:KRAB 231 288 4e-31 BLAST
ZnF_C2H2 346 368 2.15e-5 SMART
ZnF_C2H2 374 396 5.06e-2 SMART
ZnF_C2H2 402 424 8.34e-3 SMART
ZnF_C2H2 430 452 3.39e-3 SMART
ZnF_C2H2 458 479 1.08e1 SMART
ZnF_C2H2 485 507 4.47e-3 SMART
ZnF_C2H2 513 536 5.59e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197174
Predicted Effect probably benign
Transcript: ENSMUST00000199563
SMART Domains Protein: ENSMUSP00000143449
Gene: ENSMUSG00000070420

DomainStartEndE-ValueType
SCAN 38 150 2.1e-54 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000200246
SMART Domains Protein: ENSMUSP00000142367
Gene: ENSMUSG00000070420

DomainStartEndE-ValueType
SCAN 38 150 1.9e-55 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l T A 8: 44,079,287 (GRCm39) K312N probably benign Het
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 117,721,122 (GRCm39) probably benign Het
Cdh10 G A 15: 19,000,045 (GRCm39) V497I probably damaging Het
Chd4 T C 6: 125,078,565 (GRCm39) V229A probably benign Het
Cnr2 T A 4: 135,644,237 (GRCm39) I105N possibly damaging Het
Dnai1 A G 4: 41,637,966 (GRCm39) T701A probably damaging Het
Eri1 G A 8: 35,936,383 (GRCm39) R313* probably null Het
Hrh3 T C 2: 179,741,665 (GRCm39) probably benign Het
Hs3st5 T A 10: 36,708,726 (GRCm39) V87D probably benign Het
Jmy G C 13: 93,635,390 (GRCm39) P142R probably damaging Het
Jmy C A 13: 93,635,781 (GRCm39) D12Y probably damaging Het
Mfsd4a A C 1: 131,981,291 (GRCm39) M320R possibly damaging Het
Myocd A T 11: 65,114,590 (GRCm39) H49Q probably benign Het
Nlk A G 11: 78,481,774 (GRCm39) I229T possibly damaging Het
Rabl2 T C 15: 89,471,137 (GRCm39) D66G probably benign Het
Ramp1 C T 1: 91,151,067 (GRCm39) T144I possibly damaging Het
Rhbdf2 T C 11: 116,492,782 (GRCm39) K413R probably benign Het
Scpep1 G A 11: 88,826,729 (GRCm39) Q236* probably null Het
Stil A G 4: 114,862,176 (GRCm39) R40G probably damaging Het
Syt7 T C 19: 10,399,162 (GRCm39) V86A probably damaging Het
Ubr2 A T 17: 47,278,204 (GRCm39) L711Q probably null Het
Vmn1r78 T A 7: 11,886,386 (GRCm39) probably null Het
Zfp280d C T 9: 72,203,261 (GRCm39) T3I possibly damaging Het
Other mutations in Zscan25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Zscan25 APN 5 145,220,559 (GRCm39) missense probably damaging 1.00
IGL02622:Zscan25 APN 5 145,227,512 (GRCm39) missense probably damaging 1.00
IGL02881:Zscan25 APN 5 145,227,296 (GRCm39) missense probably benign 0.25
PIT4445001:Zscan25 UTSW 5 145,227,422 (GRCm39) missense probably damaging 1.00
R1713:Zscan25 UTSW 5 145,220,501 (GRCm39) missense probably damaging 0.99
R1828:Zscan25 UTSW 5 145,227,858 (GRCm39) missense possibly damaging 0.95
R2233:Zscan25 UTSW 5 145,220,502 (GRCm39) missense probably damaging 1.00
R3882:Zscan25 UTSW 5 145,227,862 (GRCm39) missense probably damaging 1.00
R4527:Zscan25 UTSW 5 145,220,268 (GRCm39) missense probably damaging 1.00
R4539:Zscan25 UTSW 5 145,225,201 (GRCm39) missense probably benign 0.01
R4598:Zscan25 UTSW 5 145,227,815 (GRCm39) missense probably benign 0.30
R4611:Zscan25 UTSW 5 145,227,926 (GRCm39) missense probably damaging 1.00
R4662:Zscan25 UTSW 5 145,223,120 (GRCm39) missense unknown
R6733:Zscan25 UTSW 5 145,227,723 (GRCm39) splice site probably null
R6751:Zscan25 UTSW 5 145,227,373 (GRCm39) missense probably damaging 1.00
R7161:Zscan25 UTSW 5 145,223,251 (GRCm39) missense probably benign 0.00
R7912:Zscan25 UTSW 5 145,227,321 (GRCm39) missense probably benign 0.00
R8746:Zscan25 UTSW 5 145,224,157 (GRCm39) missense possibly damaging 0.81
R8936:Zscan25 UTSW 5 145,223,200 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTTTGTCACACAGGTGC -3'
(R):5'- ACACACATAGGGCCTCTTGC -3'

Sequencing Primer
(F):5'- TGTCACACAGGTGCTGGGAG -3'
(R):5'- GCCTCTTGCCCAGGTGG -3'
Posted On 2015-06-24