Incidental Mutation 'R4330:Vmn1r78'
| ID |
324564 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r78
|
| Ensembl Gene |
ENSMUSG00000061602 |
| Gene Name |
vomeronasal 1 receptor 78 |
| Synonyms |
V1rg7 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
R4330 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
11886391-11887332 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to A
at 11886386 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000077186
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078039]
[ENSMUST00000078039]
[ENSMUST00000078039]
[ENSMUST00000078039]
[ENSMUST00000228244]
[ENSMUST00000228664]
|
| AlphaFold |
K7N608 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000078039
|
| SMART Domains |
Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
3 |
304 |
5.7e-8 |
PFAM |
|
Pfam:V1R
|
12 |
301 |
1.5e-29 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000078039
|
| SMART Domains |
Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
3 |
304 |
5.7e-8 |
PFAM |
|
Pfam:V1R
|
12 |
301 |
1.5e-29 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000078039
|
| SMART Domains |
Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
3 |
304 |
5.7e-8 |
PFAM |
|
Pfam:V1R
|
12 |
301 |
1.5e-29 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000078039
|
| SMART Domains |
Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
3 |
304 |
5.7e-8 |
PFAM |
|
Pfam:V1R
|
12 |
301 |
1.5e-29 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000209489
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228244
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228664
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam34l |
T |
A |
8: 44,079,287 (GRCm39) |
K312N |
probably benign |
Het |
| Arl6ip1 |
AAAATAAATAAATAAATAAATAAATA |
AAAATAAATAAATAAATAAATAAATAAATA |
7: 117,721,122 (GRCm39) |
|
probably benign |
Het |
| Cdh10 |
G |
A |
15: 19,000,045 (GRCm39) |
V497I |
probably damaging |
Het |
| Chd4 |
T |
C |
6: 125,078,565 (GRCm39) |
V229A |
probably benign |
Het |
| Cnr2 |
T |
A |
4: 135,644,237 (GRCm39) |
I105N |
possibly damaging |
Het |
| Dnai1 |
A |
G |
4: 41,637,966 (GRCm39) |
T701A |
probably damaging |
Het |
| Eri1 |
G |
A |
8: 35,936,383 (GRCm39) |
R313* |
probably null |
Het |
| Hrh3 |
T |
C |
2: 179,741,665 (GRCm39) |
|
probably benign |
Het |
| Hs3st5 |
T |
A |
10: 36,708,726 (GRCm39) |
V87D |
probably benign |
Het |
| Jmy |
G |
C |
13: 93,635,390 (GRCm39) |
P142R |
probably damaging |
Het |
| Jmy |
C |
A |
13: 93,635,781 (GRCm39) |
D12Y |
probably damaging |
Het |
| Mfsd4a |
A |
C |
1: 131,981,291 (GRCm39) |
M320R |
possibly damaging |
Het |
| Myocd |
A |
T |
11: 65,114,590 (GRCm39) |
H49Q |
probably benign |
Het |
| Nlk |
A |
G |
11: 78,481,774 (GRCm39) |
I229T |
possibly damaging |
Het |
| Rabl2 |
T |
C |
15: 89,471,137 (GRCm39) |
D66G |
probably benign |
Het |
| Ramp1 |
C |
T |
1: 91,151,067 (GRCm39) |
T144I |
possibly damaging |
Het |
| Rhbdf2 |
T |
C |
11: 116,492,782 (GRCm39) |
K413R |
probably benign |
Het |
| Scpep1 |
G |
A |
11: 88,826,729 (GRCm39) |
Q236* |
probably null |
Het |
| Stil |
A |
G |
4: 114,862,176 (GRCm39) |
R40G |
probably damaging |
Het |
| Syt7 |
T |
C |
19: 10,399,162 (GRCm39) |
V86A |
probably damaging |
Het |
| Ubr2 |
A |
T |
17: 47,278,204 (GRCm39) |
L711Q |
probably null |
Het |
| Zfp280d |
C |
T |
9: 72,203,261 (GRCm39) |
T3I |
possibly damaging |
Het |
| Zscan25 |
T |
A |
5: 145,227,361 (GRCm39) |
F342I |
probably damaging |
Het |
|
| Other mutations in Vmn1r78 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01129:Vmn1r78
|
APN |
7 |
11,887,165 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02019:Vmn1r78
|
APN |
7 |
11,886,634 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02143:Vmn1r78
|
APN |
7 |
11,886,407 (GRCm39) |
missense |
probably benign |
|
|
IGL02154:Vmn1r78
|
APN |
7 |
11,886,472 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL02290:Vmn1r78
|
APN |
7 |
11,887,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Vmn1r78
|
APN |
7 |
11,887,291 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL03256:Vmn1r78
|
APN |
7 |
11,886,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03373:Vmn1r78
|
APN |
7 |
11,887,270 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL03384:Vmn1r78
|
APN |
7 |
11,887,136 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0016:Vmn1r78
|
UTSW |
7 |
11,887,279 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1445:Vmn1r78
|
UTSW |
7 |
11,886,508 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1748:Vmn1r78
|
UTSW |
7 |
11,887,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Vmn1r78
|
UTSW |
7 |
11,887,270 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2032:Vmn1r78
|
UTSW |
7 |
11,887,210 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2198:Vmn1r78
|
UTSW |
7 |
11,886,487 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4564:Vmn1r78
|
UTSW |
7 |
11,886,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4769:Vmn1r78
|
UTSW |
7 |
11,886,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn1r78
|
UTSW |
7 |
11,886,891 (GRCm39) |
nonsense |
probably null |
|
|
R4802:Vmn1r78
|
UTSW |
7 |
11,886,891 (GRCm39) |
nonsense |
probably null |
|
|
R4860:Vmn1r78
|
UTSW |
7 |
11,886,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4860:Vmn1r78
|
UTSW |
7 |
11,886,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5648:Vmn1r78
|
UTSW |
7 |
11,886,693 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6561:Vmn1r78
|
UTSW |
7 |
11,886,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6869:Vmn1r78
|
UTSW |
7 |
11,886,676 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6945:Vmn1r78
|
UTSW |
7 |
11,886,832 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7793:Vmn1r78
|
UTSW |
7 |
11,887,241 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7954:Vmn1r78
|
UTSW |
7 |
11,887,227 (GRCm39) |
nonsense |
probably null |
|
|
R8698:Vmn1r78
|
UTSW |
7 |
11,886,539 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8830:Vmn1r78
|
UTSW |
7 |
11,887,118 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9624:Vmn1r78
|
UTSW |
7 |
11,886,410 (GRCm39) |
missense |
probably benign |
|
|
Z1088:Vmn1r78
|
UTSW |
7 |
11,886,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTGTGTCTGTCCATTCATGATTAGG -3'
(R):5'- GCAGTTAGCAAAAGTCAAGTGC -3'
Sequencing Primer
(F):5'- AAAGACTGTCCTGGAACTGTCTCTG -3'
(R):5'- GTGCTTTATAATCACATCTTTGGGC -3'
|
| Posted On |
2015-06-24 |
Incidental Mutation