Incidental Mutation 'R4357:Kif24'
ID 324593
Institutional Source Beutler Lab
Gene Symbol Kif24
Ensembl Gene ENSMUSG00000028438
Gene Name kinesin family member 24
Synonyms 4933425J19Rik
MMRRC Submission 041109-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4357 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 41390745-41464887 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 41413827 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103690 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030148] [ENSMUST00000108055]
AlphaFold Q6NWW5
Predicted Effect probably benign
Transcript: ENSMUST00000030148
SMART Domains Protein: ENSMUSP00000030148
Gene: ENSMUSG00000028438

DomainStartEndE-ValueType
KISc 216 413 2.51e-29 SMART
low complexity region 481 499 N/A INTRINSIC
low complexity region 563 574 N/A INTRINSIC
low complexity region 626 644 N/A INTRINSIC
low complexity region 678 695 N/A INTRINSIC
low complexity region 1119 1130 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000108055
SMART Domains Protein: ENSMUSP00000103690
Gene: ENSMUSG00000028438

DomainStartEndE-ValueType
Blast:KISc 82 205 1e-47 BLAST
KISc 216 547 3.09e-134 SMART
low complexity region 615 633 N/A INTRINSIC
low complexity region 697 708 N/A INTRINSIC
low complexity region 760 778 N/A INTRINSIC
low complexity region 812 829 N/A INTRINSIC
low complexity region 1253 1264 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141951
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154175
Meta Mutation Damage Score 0.9493 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kinesins, such as KIF24, are microtubule-dependent ATPases that function as molecular motors. They play important roles in intracellular vesicle transport and cell division (summary by Venturelli et al., 2010 [PubMed 20670673]).[supplied by OMIM, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam20 A G 8: 41,248,084 (GRCm39) T65A possibly damaging Het
Alpk1 C T 3: 127,523,022 (GRCm39) V7M probably damaging Het
Ap4m1 A G 5: 138,171,311 (GRCm39) E125G probably damaging Het
Atp13a2 C A 4: 140,729,215 (GRCm39) D599E probably benign Het
Brme1 T C 8: 84,886,221 (GRCm39) L59P probably benign Het
Camkv G A 9: 107,825,145 (GRCm39) G354E probably benign Het
Casp8ap2 T A 4: 32,646,150 (GRCm39) M1741K probably benign Het
Chtf18 T C 17: 25,938,106 (GRCm39) D119G probably benign Het
Cnga1 T A 5: 72,775,595 (GRCm39) D42V probably damaging Het
Cysltr2 T C 14: 73,267,084 (GRCm39) I209V probably benign Het
Defa27 A T 8: 21,805,608 (GRCm39) Q16L probably null Het
Dnaja3 T C 16: 4,517,731 (GRCm39) I321T probably damaging Het
Eef2 GCCC GCCCC 10: 81,014,601 (GRCm39) probably null Het
Eif2ak3 T A 6: 70,861,859 (GRCm39) I467N probably damaging Het
Eif5b T A 1: 38,089,339 (GRCm39) V1105E probably damaging Het
Gfod2 T C 8: 106,444,177 (GRCm39) N122S possibly damaging Het
Gm10803 A G 2: 93,394,350 (GRCm39) R41G unknown Het
Gm38392 A T 3: 88,154,741 (GRCm39) I221N probably damaging Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Hsd17b6 G T 10: 127,829,637 (GRCm39) probably null Het
Ids C A X: 69,389,950 (GRCm39) G506C probably damaging Het
Ifna15 G T 4: 88,476,079 (GRCm39) T135N probably benign Het
Igsf9b G A 9: 27,220,774 (GRCm39) V47I possibly damaging Het
Lats2 A G 14: 57,936,840 (GRCm39) S550P probably damaging Het
Lmo7 A G 14: 102,125,091 (GRCm39) R406G probably null Het
Lpcat2 C A 8: 93,599,734 (GRCm39) P234Q probably benign Het
Lrp10 C T 14: 54,705,823 (GRCm39) R338C probably damaging Het
Lrrfip2 A G 9: 111,028,755 (GRCm39) E326G probably damaging Het
Megf8 T A 7: 25,055,174 (GRCm39) I1969N probably benign Het
Mib1 A G 18: 10,751,844 (GRCm39) N242S probably benign Het
Ngf A G 3: 102,427,521 (GRCm39) E94G probably benign Het
Oas2 C T 5: 120,876,734 (GRCm39) probably null Het
Odf2 A G 2: 29,782,256 (GRCm39) T75A probably benign Het
Or4f60 A G 2: 111,902,583 (GRCm39) L115P probably damaging Het
Or5w11 T A 2: 87,458,810 (GRCm39) M1K probably null Het
Pi4ka T A 16: 17,185,303 (GRCm39) I266F probably benign Het
Prps2 T A X: 166,146,545 (GRCm39) K176* probably null Het
Psmd2 T G 16: 20,475,402 (GRCm39) D393E probably benign Het
Rabep2 A G 7: 126,047,397 (GRCm39) I753T probably damaging Het
Rara A C 11: 98,858,937 (GRCm39) I129L probably damaging Het
Rasgrf2 C A 13: 92,038,796 (GRCm39) D1017Y probably damaging Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Spmip4 T C 6: 50,551,190 (GRCm39) T420A probably benign Het
Spsb1 T C 4: 149,991,232 (GRCm39) H112R probably damaging Het
Sptlc1 A T 13: 53,528,068 (GRCm39) I32K probably damaging Het
Srd5a3 T A 5: 76,295,547 (GRCm39) F79Y probably damaging Het
Ssrp1 A T 2: 84,871,495 (GRCm39) M306L probably benign Het
Sulf2 T C 2: 165,919,497 (GRCm39) E817G probably benign Het
Tiam2 C A 17: 3,501,128 (GRCm39) D922E probably damaging Het
Tle4 A G 19: 14,445,625 (GRCm39) V207A probably benign Het
Ttll12 A T 15: 83,465,958 (GRCm39) C413S probably damaging Het
Usp45 T A 4: 21,834,350 (GRCm39) Y809* probably null Het
Vmn2r59 G A 7: 41,661,644 (GRCm39) P724S probably damaging Het
Vrk3 C T 7: 44,424,866 (GRCm39) T427M probably benign Het
Other mutations in Kif24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Kif24 APN 4 41,413,826 (GRCm39) splice site probably null
IGL00787:Kif24 APN 4 41,397,583 (GRCm39) missense probably damaging 1.00
IGL01065:Kif24 APN 4 41,423,639 (GRCm39) unclassified probably benign
IGL01716:Kif24 APN 4 41,393,454 (GRCm39) missense probably benign 0.40
IGL01796:Kif24 APN 4 41,392,978 (GRCm39) unclassified probably benign
IGL02307:Kif24 APN 4 41,395,274 (GRCm39) missense probably benign 0.02
IGL03061:Kif24 APN 4 41,394,323 (GRCm39) missense possibly damaging 0.86
IGL03080:Kif24 APN 4 41,394,417 (GRCm39) missense probably benign 0.12
IGL03100:Kif24 APN 4 41,394,446 (GRCm39) missense possibly damaging 0.59
R0226:Kif24 UTSW 4 41,414,939 (GRCm39) nonsense probably null
R0345:Kif24 UTSW 4 41,428,413 (GRCm39) missense probably benign 0.01
R0365:Kif24 UTSW 4 41,428,731 (GRCm39) missense probably benign 0.06
R0366:Kif24 UTSW 4 41,428,717 (GRCm39) missense possibly damaging 0.77
R0579:Kif24 UTSW 4 41,393,706 (GRCm39) missense probably damaging 0.97
R0682:Kif24 UTSW 4 41,428,620 (GRCm39) missense probably benign 0.01
R1611:Kif24 UTSW 4 41,423,552 (GRCm39) missense probably benign 0.02
R1634:Kif24 UTSW 4 41,393,529 (GRCm39) missense probably benign 0.02
R1772:Kif24 UTSW 4 41,409,787 (GRCm39) missense probably damaging 1.00
R1997:Kif24 UTSW 4 41,392,904 (GRCm39) missense possibly damaging 0.92
R3833:Kif24 UTSW 4 41,395,064 (GRCm39) missense probably damaging 1.00
R3849:Kif24 UTSW 4 41,404,734 (GRCm39) missense probably damaging 1.00
R4356:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4358:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4359:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4406:Kif24 UTSW 4 41,393,954 (GRCm39) missense probably damaging 1.00
R4580:Kif24 UTSW 4 41,395,287 (GRCm39) missense probably damaging 1.00
R4756:Kif24 UTSW 4 41,397,545 (GRCm39) critical splice donor site probably null
R4921:Kif24 UTSW 4 41,394,329 (GRCm39) missense probably damaging 0.99
R4935:Kif24 UTSW 4 41,394,939 (GRCm39) missense probably damaging 0.99
R5288:Kif24 UTSW 4 41,395,373 (GRCm39) missense probably benign 0.09
R5398:Kif24 UTSW 4 41,394,401 (GRCm39) missense possibly damaging 0.50
R5885:Kif24 UTSW 4 41,423,463 (GRCm39) missense probably damaging 1.00
R5901:Kif24 UTSW 4 41,428,604 (GRCm39) missense probably damaging 1.00
R5919:Kif24 UTSW 4 41,394,477 (GRCm39) missense possibly damaging 0.62
R5945:Kif24 UTSW 4 41,428,670 (GRCm39) nonsense probably null
R6278:Kif24 UTSW 4 41,423,498 (GRCm39) missense probably damaging 1.00
R6291:Kif24 UTSW 4 41,413,959 (GRCm39) missense probably damaging 1.00
R6891:Kif24 UTSW 4 41,394,168 (GRCm39) missense probably benign 0.33
R7178:Kif24 UTSW 4 41,395,085 (GRCm39) missense probably benign 0.00
R7437:Kif24 UTSW 4 41,404,687 (GRCm39) missense possibly damaging 0.70
R7453:Kif24 UTSW 4 41,394,673 (GRCm39) missense possibly damaging 0.91
R7543:Kif24 UTSW 4 41,413,993 (GRCm39) nonsense probably null
R7548:Kif24 UTSW 4 41,423,601 (GRCm39) missense possibly damaging 0.57
R8167:Kif24 UTSW 4 41,392,957 (GRCm39) missense possibly damaging 0.87
R8305:Kif24 UTSW 4 41,428,825 (GRCm39) missense probably damaging 1.00
R8407:Kif24 UTSW 4 41,394,488 (GRCm39) missense probably benign 0.05
R8722:Kif24 UTSW 4 41,394,233 (GRCm39) missense probably benign
R8916:Kif24 UTSW 4 41,394,963 (GRCm39) missense probably benign 0.23
R9093:Kif24 UTSW 4 41,428,691 (GRCm39) missense probably benign
R9172:Kif24 UTSW 4 41,400,442 (GRCm39) missense probably benign 0.44
R9468:Kif24 UTSW 4 41,404,794 (GRCm39) missense probably damaging 1.00
R9687:Kif24 UTSW 4 41,428,546 (GRCm39) missense probably damaging 0.99
Z1088:Kif24 UTSW 4 41,395,091 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTCTTAGTAGATGGCTAAGGAACAG -3'
(R):5'- GCGGGGAAAACCTATACCATG -3'

Sequencing Primer
(F):5'- ATTCCATCACTTGGGAAGCTGAGTC -3'
(R):5'- CGGGGAAAACCTATACCATGATAGG -3'
Posted On 2015-06-24