Incidental Mutation 'R4359:Kif24'
ID 324789
Institutional Source Beutler Lab
Gene Symbol Kif24
Ensembl Gene ENSMUSG00000028438
Gene Name kinesin family member 24
Synonyms 4933425J19Rik
MMRRC Submission 041670-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4359 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 41390745-41464887 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 41413827 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103690 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030148] [ENSMUST00000108055]
AlphaFold Q6NWW5
Predicted Effect probably benign
Transcript: ENSMUST00000030148
SMART Domains Protein: ENSMUSP00000030148
Gene: ENSMUSG00000028438

DomainStartEndE-ValueType
KISc 216 413 2.51e-29 SMART
low complexity region 481 499 N/A INTRINSIC
low complexity region 563 574 N/A INTRINSIC
low complexity region 626 644 N/A INTRINSIC
low complexity region 678 695 N/A INTRINSIC
low complexity region 1119 1130 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000108055
SMART Domains Protein: ENSMUSP00000103690
Gene: ENSMUSG00000028438

DomainStartEndE-ValueType
Blast:KISc 82 205 1e-47 BLAST
KISc 216 547 3.09e-134 SMART
low complexity region 615 633 N/A INTRINSIC
low complexity region 697 708 N/A INTRINSIC
low complexity region 760 778 N/A INTRINSIC
low complexity region 812 829 N/A INTRINSIC
low complexity region 1253 1264 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141951
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154175
Meta Mutation Damage Score 0.9493 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kinesins, such as KIF24, are microtubule-dependent ATPases that function as molecular motors. They play important roles in intracellular vesicle transport and cell division (summary by Venturelli et al., 2010 [PubMed 20670673]).[supplied by OMIM, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 G T 11: 9,247,629 (GRCm39) V2459F probably benign Het
Acot1 T C 12: 84,061,314 (GRCm39) Y207H probably damaging Het
Anapc1 A G 2: 128,465,476 (GRCm39) V1668A possibly damaging Het
Atr T A 9: 95,833,589 (GRCm39) I2613N probably damaging Het
Baz2b A G 2: 59,731,957 (GRCm39) I2027T possibly damaging Het
C2cd3 T G 7: 100,090,296 (GRCm39) H466Q probably damaging Het
Cdc14b T A 13: 64,396,225 (GRCm39) I15F probably benign Het
Cep135 G T 5: 76,759,561 (GRCm39) K438N possibly damaging Het
Cnot1 T C 8: 96,466,476 (GRCm39) D1587G probably damaging Het
Cxcl16 C A 11: 70,349,631 (GRCm39) V65L possibly damaging Het
Dhx36 T A 3: 62,382,699 (GRCm39) T783S probably benign Het
Disp3 T C 4: 148,356,389 (GRCm39) N157S probably benign Het
Efcab3 G T 11: 104,624,547 (GRCm39) probably null Het
Fem1al A T 11: 29,774,669 (GRCm39) S263T probably benign Het
Gfod2 T C 8: 106,444,177 (GRCm39) N122S possibly damaging Het
Grin3b T A 10: 79,808,731 (GRCm39) D160E probably benign Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Htr1b C A 9: 81,514,404 (GRCm39) A68S probably benign Het
Ifit2 A T 19: 34,550,544 (GRCm39) D28V possibly damaging Het
Ifna15 G T 4: 88,476,079 (GRCm39) T135N probably benign Het
Igsf9b G A 9: 27,220,774 (GRCm39) V47I possibly damaging Het
Klhl25 T C 7: 75,516,480 (GRCm39) V462A probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
L3mbtl3 A G 10: 26,203,639 (GRCm39) V397A unknown Het
Lpcat2 C A 8: 93,599,734 (GRCm39) P234Q probably benign Het
Lrp1b A C 2: 40,793,077 (GRCm39) C2532W probably damaging Het
Malt1 T C 18: 65,609,300 (GRCm39) V768A probably benign Het
Mindy3 A T 2: 12,401,020 (GRCm39) W233R probably damaging Het
Ncor1 T C 11: 62,249,736 (GRCm39) K1054R probably damaging Het
Nin T A 12: 70,061,712 (GRCm39) T2051S probably benign Het
Or10j5 C A 1: 172,784,647 (GRCm39) A95E probably benign Het
Or51ac3 A G 7: 103,213,742 (GRCm39) F248S probably benign Het
Pcsk1 T C 13: 75,260,838 (GRCm39) S354P possibly damaging Het
Pilra T C 5: 137,829,576 (GRCm39) T160A probably benign Het
Plekha5 G C 6: 140,537,414 (GRCm39) E540D probably benign Het
Prps2 T A X: 166,146,545 (GRCm39) K176* probably null Het
Rasgrf2 C A 13: 92,038,796 (GRCm39) D1017Y probably damaging Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Spsb1 T C 4: 149,991,232 (GRCm39) H112R probably damaging Het
Srd5a3 T A 5: 76,295,547 (GRCm39) F79Y probably damaging Het
Stxbp4 C T 11: 90,385,470 (GRCm39) W506* probably null Het
Timeless C A 10: 128,083,211 (GRCm39) Q653K probably benign Het
Trio G A 15: 27,749,883 (GRCm39) Q1129* probably null Het
Vrk3 C T 7: 44,424,866 (GRCm39) T427M probably benign Het
Zzef1 T A 11: 72,714,334 (GRCm39) S275T probably damaging Het
Other mutations in Kif24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Kif24 APN 4 41,413,826 (GRCm39) splice site probably null
IGL00787:Kif24 APN 4 41,397,583 (GRCm39) missense probably damaging 1.00
IGL01065:Kif24 APN 4 41,423,639 (GRCm39) unclassified probably benign
IGL01716:Kif24 APN 4 41,393,454 (GRCm39) missense probably benign 0.40
IGL01796:Kif24 APN 4 41,392,978 (GRCm39) unclassified probably benign
IGL02307:Kif24 APN 4 41,395,274 (GRCm39) missense probably benign 0.02
IGL03061:Kif24 APN 4 41,394,323 (GRCm39) missense possibly damaging 0.86
IGL03080:Kif24 APN 4 41,394,417 (GRCm39) missense probably benign 0.12
IGL03100:Kif24 APN 4 41,394,446 (GRCm39) missense possibly damaging 0.59
R0226:Kif24 UTSW 4 41,414,939 (GRCm39) nonsense probably null
R0345:Kif24 UTSW 4 41,428,413 (GRCm39) missense probably benign 0.01
R0365:Kif24 UTSW 4 41,428,731 (GRCm39) missense probably benign 0.06
R0366:Kif24 UTSW 4 41,428,717 (GRCm39) missense possibly damaging 0.77
R0579:Kif24 UTSW 4 41,393,706 (GRCm39) missense probably damaging 0.97
R0682:Kif24 UTSW 4 41,428,620 (GRCm39) missense probably benign 0.01
R1611:Kif24 UTSW 4 41,423,552 (GRCm39) missense probably benign 0.02
R1634:Kif24 UTSW 4 41,393,529 (GRCm39) missense probably benign 0.02
R1772:Kif24 UTSW 4 41,409,787 (GRCm39) missense probably damaging 1.00
R1997:Kif24 UTSW 4 41,392,904 (GRCm39) missense possibly damaging 0.92
R3833:Kif24 UTSW 4 41,395,064 (GRCm39) missense probably damaging 1.00
R3849:Kif24 UTSW 4 41,404,734 (GRCm39) missense probably damaging 1.00
R4356:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4357:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4358:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4406:Kif24 UTSW 4 41,393,954 (GRCm39) missense probably damaging 1.00
R4580:Kif24 UTSW 4 41,395,287 (GRCm39) missense probably damaging 1.00
R4756:Kif24 UTSW 4 41,397,545 (GRCm39) critical splice donor site probably null
R4921:Kif24 UTSW 4 41,394,329 (GRCm39) missense probably damaging 0.99
R4935:Kif24 UTSW 4 41,394,939 (GRCm39) missense probably damaging 0.99
R5288:Kif24 UTSW 4 41,395,373 (GRCm39) missense probably benign 0.09
R5398:Kif24 UTSW 4 41,394,401 (GRCm39) missense possibly damaging 0.50
R5885:Kif24 UTSW 4 41,423,463 (GRCm39) missense probably damaging 1.00
R5901:Kif24 UTSW 4 41,428,604 (GRCm39) missense probably damaging 1.00
R5919:Kif24 UTSW 4 41,394,477 (GRCm39) missense possibly damaging 0.62
R5945:Kif24 UTSW 4 41,428,670 (GRCm39) nonsense probably null
R6278:Kif24 UTSW 4 41,423,498 (GRCm39) missense probably damaging 1.00
R6291:Kif24 UTSW 4 41,413,959 (GRCm39) missense probably damaging 1.00
R6891:Kif24 UTSW 4 41,394,168 (GRCm39) missense probably benign 0.33
R7178:Kif24 UTSW 4 41,395,085 (GRCm39) missense probably benign 0.00
R7437:Kif24 UTSW 4 41,404,687 (GRCm39) missense possibly damaging 0.70
R7453:Kif24 UTSW 4 41,394,673 (GRCm39) missense possibly damaging 0.91
R7543:Kif24 UTSW 4 41,413,993 (GRCm39) nonsense probably null
R7548:Kif24 UTSW 4 41,423,601 (GRCm39) missense possibly damaging 0.57
R8167:Kif24 UTSW 4 41,392,957 (GRCm39) missense possibly damaging 0.87
R8305:Kif24 UTSW 4 41,428,825 (GRCm39) missense probably damaging 1.00
R8407:Kif24 UTSW 4 41,394,488 (GRCm39) missense probably benign 0.05
R8722:Kif24 UTSW 4 41,394,233 (GRCm39) missense probably benign
R8916:Kif24 UTSW 4 41,394,963 (GRCm39) missense probably benign 0.23
R9093:Kif24 UTSW 4 41,428,691 (GRCm39) missense probably benign
R9172:Kif24 UTSW 4 41,400,442 (GRCm39) missense probably benign 0.44
R9468:Kif24 UTSW 4 41,404,794 (GRCm39) missense probably damaging 1.00
R9687:Kif24 UTSW 4 41,428,546 (GRCm39) missense probably damaging 0.99
Z1088:Kif24 UTSW 4 41,395,091 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGTCTTAGTAGATGGCTAAGGAAC -3'
(R):5'- GGAAAACCTATACCATGATAGGAAC -3'

Sequencing Primer
(F):5'- ATTCCATCACTTGGGAAGCTGAGTC -3'
(R):5'- CTCATCAAAACCCAGGATTGTATG -3'
Posted On 2015-07-06