Incidental Mutation 'R4359:Ifna15'
ID 324790
Institutional Source Beutler Lab
Gene Symbol Ifna15
Ensembl Gene ENSMUSG00000096011
Gene Name interferon alpha 15
Synonyms Gm12597, Ifnaa
MMRRC Submission 041670-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R4359 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 88475910-88476482 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 88476079 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Asparagine at position 135 (T135N)
Ref Sequence ENSEMBL: ENSMUSP00000099873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102809]
AlphaFold Q61718
Predicted Effect probably benign
Transcript: ENSMUST00000102809
AA Change: T135N

PolyPhen 2 Score 0.089 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000099873
Gene: ENSMUSG00000096011
AA Change: T135N

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 2.97e-68 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 G T 11: 9,247,629 (GRCm39) V2459F probably benign Het
Acot1 T C 12: 84,061,314 (GRCm39) Y207H probably damaging Het
Anapc1 A G 2: 128,465,476 (GRCm39) V1668A possibly damaging Het
Atr T A 9: 95,833,589 (GRCm39) I2613N probably damaging Het
Baz2b A G 2: 59,731,957 (GRCm39) I2027T possibly damaging Het
C2cd3 T G 7: 100,090,296 (GRCm39) H466Q probably damaging Het
Cdc14b T A 13: 64,396,225 (GRCm39) I15F probably benign Het
Cep135 G T 5: 76,759,561 (GRCm39) K438N possibly damaging Het
Cnot1 T C 8: 96,466,476 (GRCm39) D1587G probably damaging Het
Cxcl16 C A 11: 70,349,631 (GRCm39) V65L possibly damaging Het
Dhx36 T A 3: 62,382,699 (GRCm39) T783S probably benign Het
Disp3 T C 4: 148,356,389 (GRCm39) N157S probably benign Het
Efcab3 G T 11: 104,624,547 (GRCm39) probably null Het
Fem1al A T 11: 29,774,669 (GRCm39) S263T probably benign Het
Gfod2 T C 8: 106,444,177 (GRCm39) N122S possibly damaging Het
Grin3b T A 10: 79,808,731 (GRCm39) D160E probably benign Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Htr1b C A 9: 81,514,404 (GRCm39) A68S probably benign Het
Ifit2 A T 19: 34,550,544 (GRCm39) D28V possibly damaging Het
Igsf9b G A 9: 27,220,774 (GRCm39) V47I possibly damaging Het
Kif24 A G 4: 41,413,827 (GRCm39) probably null Het
Klhl25 T C 7: 75,516,480 (GRCm39) V462A probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
L3mbtl3 A G 10: 26,203,639 (GRCm39) V397A unknown Het
Lpcat2 C A 8: 93,599,734 (GRCm39) P234Q probably benign Het
Lrp1b A C 2: 40,793,077 (GRCm39) C2532W probably damaging Het
Malt1 T C 18: 65,609,300 (GRCm39) V768A probably benign Het
Mindy3 A T 2: 12,401,020 (GRCm39) W233R probably damaging Het
Ncor1 T C 11: 62,249,736 (GRCm39) K1054R probably damaging Het
Nin T A 12: 70,061,712 (GRCm39) T2051S probably benign Het
Or10j5 C A 1: 172,784,647 (GRCm39) A95E probably benign Het
Or51ac3 A G 7: 103,213,742 (GRCm39) F248S probably benign Het
Pcsk1 T C 13: 75,260,838 (GRCm39) S354P possibly damaging Het
Pilra T C 5: 137,829,576 (GRCm39) T160A probably benign Het
Plekha5 G C 6: 140,537,414 (GRCm39) E540D probably benign Het
Prps2 T A X: 166,146,545 (GRCm39) K176* probably null Het
Rasgrf2 C A 13: 92,038,796 (GRCm39) D1017Y probably damaging Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Spsb1 T C 4: 149,991,232 (GRCm39) H112R probably damaging Het
Srd5a3 T A 5: 76,295,547 (GRCm39) F79Y probably damaging Het
Stxbp4 C T 11: 90,385,470 (GRCm39) W506* probably null Het
Timeless C A 10: 128,083,211 (GRCm39) Q653K probably benign Het
Trio G A 15: 27,749,883 (GRCm39) Q1129* probably null Het
Vrk3 C T 7: 44,424,866 (GRCm39) T427M probably benign Het
Zzef1 T A 11: 72,714,334 (GRCm39) S275T probably damaging Het
Other mutations in Ifna15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01575:Ifna15 APN 4 88,476,044 (GRCm39) missense probably damaging 1.00
IGL01757:Ifna15 APN 4 88,476,322 (GRCm39) missense possibly damaging 0.79
IGL01824:Ifna15 APN 4 88,476,020 (GRCm39) missense probably benign 0.00
R3853:Ifna15 UTSW 4 88,476,046 (GRCm39) missense probably damaging 1.00
R4356:Ifna15 UTSW 4 88,476,079 (GRCm39) missense probably benign 0.09
R4357:Ifna15 UTSW 4 88,476,079 (GRCm39) missense probably benign 0.09
R4358:Ifna15 UTSW 4 88,476,079 (GRCm39) missense probably benign 0.09
R5038:Ifna15 UTSW 4 88,476,266 (GRCm39) missense probably benign 0.03
R5372:Ifna15 UTSW 4 88,476,338 (GRCm39) missense probably damaging 0.97
R6036:Ifna15 UTSW 4 88,476,310 (GRCm39) missense possibly damaging 0.65
R6036:Ifna15 UTSW 4 88,476,310 (GRCm39) missense possibly damaging 0.65
R7347:Ifna15 UTSW 4 88,476,220 (GRCm39) missense probably damaging 1.00
R8097:Ifna15 UTSW 4 88,475,938 (GRCm39) missense probably benign 0.01
R8132:Ifna15 UTSW 4 88,475,920 (GRCm39) missense possibly damaging 0.60
R8824:Ifna15 UTSW 4 88,475,998 (GRCm39) missense probably damaging 1.00
R9349:Ifna15 UTSW 4 88,476,283 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- AAGAGAGATAGAGTCCTCATTCAGG -3'
(R):5'- TGCCCAGCAGATCCAGAATG -3'

Sequencing Primer
(F):5'- GAGTCCTCTCTACTTTGTCTCAGGAC -3'
(R):5'- GAATGCTCAAGCCATCCCTGTC -3'
Posted On 2015-07-06