Incidental Mutation 'R4374:Rpl11'
ID 325024
Institutional Source Beutler Lab
Gene Symbol Rpl11
Ensembl Gene ENSMUSG00000059291
Gene Name ribosomal protein L11
Synonyms 2010203J19Rik
MMRRC Submission 041118-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.940) question?
Stock # R4374 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 135776665-135780704 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) G to A at 135778454 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121108 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102536] [ENSMUST00000155873]
AlphaFold Q9CXW4
Predicted Effect probably benign
Transcript: ENSMUST00000102536
SMART Domains Protein: ENSMUSP00000099595
Gene: ENSMUSG00000059291

DomainStartEndE-ValueType
Pfam:Ribosomal_L5 10 63 6.9e-23 PFAM
Pfam:Ribosomal_L5_C 67 166 9.5e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125726
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128733
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133613
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137580
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142440
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150565
Predicted Effect probably benign
Transcript: ENSMUST00000155873
SMART Domains Protein: ENSMUSP00000121108
Gene: ENSMUSG00000059291

DomainStartEndE-ValueType
Pfam:Ribosomal_L5 13 66 8e-23 PFAM
Pfam:Ribosomal_L5_C 70 169 1.1e-26 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 97% (38/39)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd2 A G 7: 78,973,278 (GRCm39) M86V probably benign Het
Acin1 C A 14: 54,891,351 (GRCm39) probably benign Het
Aebp2 T A 6: 140,599,984 (GRCm39) probably benign Het
Akap13 A G 7: 75,258,732 (GRCm39) E452G probably damaging Het
Amz1 T C 5: 140,738,194 (GRCm39) S184P possibly damaging Het
Armh4 T A 14: 50,007,893 (GRCm39) T527S probably damaging Het
Ccdc83 A T 7: 89,875,986 (GRCm39) L295* probably null Het
Cd209c T C 8: 4,004,635 (GRCm39) noncoding transcript Het
Cpsf7 A T 19: 10,517,001 (GRCm39) I368F probably damaging Het
Csf1r G A 18: 61,252,078 (GRCm39) C520Y probably damaging Het
Dapk1 A G 13: 60,867,498 (GRCm39) D235G probably benign Het
Ercc1 G A 7: 19,081,057 (GRCm39) probably benign Het
Fktn T C 4: 53,720,201 (GRCm39) S72P probably damaging Het
Frem2 C A 3: 53,452,923 (GRCm39) V2189F possibly damaging Het
Gm10845 G T 14: 80,100,563 (GRCm39) noncoding transcript Het
Hk1 C A 10: 62,151,319 (GRCm39) K10N probably damaging Het
Lama1 A G 17: 68,111,513 (GRCm39) M2255V probably benign Het
Lrsam1 G T 2: 32,845,203 (GRCm39) T104K possibly damaging Het
Myh6 T A 14: 55,199,565 (GRCm39) I249F probably damaging Het
Myo7a G A 7: 97,751,881 (GRCm39) T54M probably damaging Het
Or52ae7 T C 7: 103,119,278 (GRCm39) S11P probably damaging Het
Or5k15 A C 16: 58,710,242 (GRCm39) C114G probably benign Het
Osbpl8 T A 10: 111,105,280 (GRCm39) I245N possibly damaging Het
Pfkp A G 13: 6,671,025 (GRCm39) S135P probably damaging Het
Phf20l1 C T 15: 66,476,686 (GRCm39) T260I possibly damaging Het
Pole T A 5: 110,485,071 (GRCm39) I395K possibly damaging Het
Ppp6r2 T G 15: 89,149,361 (GRCm39) C216W probably damaging Het
Pramel7 C T 2: 87,320,415 (GRCm39) A293T probably benign Het
Scamp3 G A 3: 89,089,234 (GRCm39) probably null Het
Setbp1 T C 18: 78,903,137 (GRCm39) R177G probably damaging Het
Sh2b3 G T 5: 121,966,549 (GRCm39) probably benign Het
Tbc1d30 A G 10: 121,130,617 (GRCm39) F271S probably damaging Het
Tpo T C 12: 30,153,151 (GRCm39) E401G possibly damaging Het
Zdhhc13 T C 7: 48,458,589 (GRCm39) Y308H probably damaging Het
Zfp112 C T 7: 23,825,798 (GRCm39) H589Y probably damaging Het
Zmiz1 T C 14: 25,636,434 (GRCm39) S140P probably damaging Het
Other mutations in Rpl11
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4373:Rpl11 UTSW 4 135,778,454 (GRCm39) intron probably benign
R4375:Rpl11 UTSW 4 135,778,454 (GRCm39) intron probably benign
R4377:Rpl11 UTSW 4 135,778,454 (GRCm39) intron probably benign
R4560:Rpl11 UTSW 4 135,778,522 (GRCm39) missense probably damaging 1.00
R4781:Rpl11 UTSW 4 135,777,599 (GRCm39) missense probably benign 0.00
R5541:Rpl11 UTSW 4 135,780,043 (GRCm39) splice site probably benign
R8186:Rpl11 UTSW 4 135,778,968 (GRCm39) missense possibly damaging 0.86
R9087:Rpl11 UTSW 4 135,780,000 (GRCm39) missense possibly damaging 0.55
Predicted Primers PCR Primer
(F):5'- AGGATGACCCAGAGAGCTTTG -3'
(R):5'- GCTCATGTTGGGCTACTTGAAC -3'

Sequencing Primer
(F):5'- GACCCAGAGAGCTTTGCAACG -3'
(R):5'- CATGATGGATAGCATGGTCACTTC -3'
Posted On 2015-07-06