|Institutional Source||Beutler Lab|
|Gene Name||ribosomal protein L11|
|Is this an essential gene?||Probably essential (E-score: 0.956)|
|Stock #||R4377 (G1)|
|Chromosomal Location||136028265-136053428 bp(-) (GRCm38)|
|Type of Mutation||intron|
|DNA Base Change (assembly)||G to A at 136051143 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000099595 (fasta)|
|Gene Model||predicted gene model for transcript(s):|
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.034|
|Coding Region Coverage||
|Validation Efficiency||98% (57/58)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Rpl11||
(F):5'- ATTCGAAGGGCAAATGCAGC -3'
(R):5'- ATGATGGATAGCATGGTCACTTC -3'
(F):5'- CCAGGATGACCCAGAGAGCTTTG -3'
(R):5'- ATAGCATGGTCACTTCTGTGTC -3'
|Posted On||Jul 06, 2015|